Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | HALLMARK_COAGULATION |
| Enrichment Score (ES) | -0.3225438 |
| Normalized Enrichment Score (NES) | -1.1838859 |
| Nominal p-value | 0.18729097 |
| FDR q-value | 0.25989985 |
| FWER p-Value | 0.994 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | ACOX2 | NA | ACOX2 Entrez, Source | acyl-Coenzyme A oxidase 2, branched chain | 42 | 3.774 | 0.0431 | No |
| 2 | THBS1 | NA | THBS1 Entrez, Source | thrombospondin 1 | 81 | 3.120 | 0.0786 | No |
| 3 | SERPINE1 | NA | SERPINE1 Entrez, Source | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 109 | 2.840 | 0.1113 | No |
| 4 | F3 | NA | F3 Entrez, Source | coagulation factor III (thromboplastin, tissue factor) | 184 | 2.322 | 0.1344 | No |
| 5 | ITGA2 | NA | ITGA2 Entrez, Source | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 192 | 2.266 | 0.1616 | No |
| 6 | OLR1 | NA | OLR1 Entrez, Source | oxidised low density lipoprotein (lectin-like) receptor 1 | 209 | 2.171 | 0.1870 | No |
| 7 | CFB | NA | CFB Entrez, Source | complement factor B | 282 | 1.804 | 0.2038 | No |
| 8 | RAPGEF3 | NA | RAPGEF3 Entrez, Source | Rap guanine nucleotide exchange factor (GEF) 3 | 479 | 1.350 | 0.2061 | No |
| 9 | CAPN2 | NA | CAPN2 Entrez, Source | calpain 2, (m/II) large subunit | 499 | 1.315 | 0.2208 | No |
| 10 | F2RL2 | NA | F2RL2 Entrez, Source | coagulation factor II (thrombin) receptor-like 2 | 578 | 1.204 | 0.2299 | No |
| 11 | VWF | NA | VWF Entrez, Source | von Willebrand factor | 919 | 0.933 | 0.2165 | No |
| 12 | MAFF | NA | MAFF Entrez, Source | v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian) | 1023 | 0.882 | 0.2198 | No |
| 13 | THBD | NA | THBD Entrez, Source | thrombomodulin | 1044 | 0.873 | 0.2291 | No |
| 14 | ANXA1 | NA | ANXA1 Entrez, Source | annexin A1 | 1105 | 0.849 | 0.2351 | No |
| 15 | RABIF | NA | RABIF Entrez, Source | RAB interacting factor | 1518 | 0.710 | 0.2138 | No |
| 16 | MMP7 | NA | MMP7 Entrez, Source | matrix metallopeptidase 7 (matrilysin, uterine) | 1602 | 0.689 | 0.2162 | No |
| 17 | USP11 | NA | USP11 Entrez, Source | ubiquitin specific peptidase 11 | 1688 | 0.662 | 0.2181 | No |
| 18 | PRSS23 | NA | PRSS23 Entrez, Source | protease, serine, 23 | 1770 | 0.639 | 0.2200 | No |
| 19 | CSRP1 | NA | CSRP1 Entrez, Source | cysteine and glycine-rich protein 1 | 1777 | 0.637 | 0.2274 | No |
| 20 | SERPINC1 | NA | SERPINC1 Entrez, Source | serpin peptidase inhibitor, clade C (antithrombin), member 1 | 2358 | 0.522 | 0.1916 | No |
| 21 | C8A | NA | C8A Entrez, Source | complement component 8, alpha polypeptide | 2399 | 0.516 | 0.1950 | No |
| 22 | F12 | NA | F12 Entrez, Source | coagulation factor XII (Hageman factor) | 2606 | 0.483 | 0.1859 | No |
| 23 | MMP2 | NA | MMP2 Entrez, Source | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | 2663 | 0.473 | 0.1876 | No |
| 24 | WDR1 | NA | WDR1 Entrez, Source | WD repeat domain 1 | 2834 | 0.446 | 0.1807 | No |
| 25 | CAPN5 | NA | CAPN5 Entrez, Source | calpain 5 | 3011 | 0.420 | 0.1730 | No |
| 26 | PEF1 | NA | PEF1 Entrez, Source | penta-EF-hand domain containing 1 | 3605 | 0.343 | 0.1341 | No |
| 27 | MMP14 | NA | MMP14 Entrez, Source | matrix metallopeptidase 14 (membrane-inserted) | 3870 | 0.314 | 0.1187 | No |
| 28 | FBN1 | NA | FBN1 Entrez, Source | fibrillin 1 | 3982 | 0.298 | 0.1143 | No |
| 29 | PREP | NA | PREP Entrez, Source | prolyl endopeptidase | 4026 | 0.294 | 0.1148 | No |
| 30 | TIMP1 | NA | TIMP1 Entrez, Source | TIMP metallopeptidase inhibitor 1 | 4124 | 0.284 | 0.1112 | No |
| 31 | MMP9 | NA | MMP9 Entrez, Source | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | 4824 | 0.209 | 0.0629 | No |
| 32 | KLF7 | NA | KLF7 Entrez, Source | Kruppel-like factor 7 (ubiquitous) | 5029 | 0.188 | 0.0503 | No |
| 33 | PLAT | NA | PLAT Entrez, Source | plasminogen activator, tissue | 5083 | 0.183 | 0.0487 | No |
| 34 | GNB2 | NA | GNB2 Entrez, Source | guanine nucleotide binding protein (G protein), beta polypeptide 2 | 5280 | 0.164 | 0.0364 | No |
| 35 | ARF4 | NA | ARF4 Entrez, Source | ADP-ribosylation factor 4 | 5301 | 0.162 | 0.0370 | No |
| 36 | RAC1 | NA | RAC1 Entrez, Source | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | 5556 | 0.134 | 0.0201 | No |
| 37 | DUSP6 | NA | DUSP6 Entrez, Source | dual specificity phosphatase 6 | 5614 | 0.125 | 0.0175 | No |
| 38 | DUSP14 | NA | DUSP14 Entrez, Source | dual specificity phosphatase 14 | 5621 | 0.125 | 0.0186 | No |
| 39 | TIMP3 | NA | TIMP3 Entrez, Source | TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory) | 5786 | 0.108 | 0.0080 | No |
| 40 | FN1 | NA | FN1 Entrez, Source | fibronectin 1 | 6142 | 0.073 | -0.0170 | No |
| 41 | PECAM1 | NA | PECAM1 Entrez, Source | platelet/endothelial cell adhesion molecule (CD31 antigen) | 6545 | 0.033 | -0.0458 | No |
| 42 | SH2B2 | NA | SH2B2 Entrez, Source | SH2B adaptor protein 2 | 7286 | -0.044 | -0.0991 | No |
| 43 | LGMN | NA | LGMN Entrez, Source | legumain | 7414 | -0.057 | -0.1077 | No |
| 44 | GDA | NA | GDA Entrez, Source | guanine deaminase | 7456 | -0.062 | -0.1099 | No |
| 45 | MMP8 | NA | MMP8 Entrez, Source | matrix metallopeptidase 8 (neutrophil collagenase) | 7576 | -0.073 | -0.1177 | No |
| 46 | ITGB3 | NA | ITGB3 Entrez, Source | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | 7628 | -0.078 | -0.1204 | No |
| 47 | CTSB | NA | CTSB Entrez, Source | cathepsin B | 7647 | -0.079 | -0.1207 | No |
| 48 | PROZ | NA | PROZ Entrez, Source | protein Z, vitamin K-dependent plasma glycoprotein | 7735 | -0.088 | -0.1260 | No |
| 49 | C2 | NA | C2 Entrez, Source | complement component 2 | 8029 | -0.117 | -0.1459 | No |
| 50 | PLEK | NA | PLEK Entrez, Source | pleckstrin | 8123 | -0.128 | -0.1511 | No |
| 51 | S100A13 | NA | S100A13 Entrez, Source | S100 calcium binding protein A13 | 8804 | -0.203 | -0.1981 | No |
| 52 | CTSK | NA | CTSK Entrez, Source | cathepsin K (pycnodysostosis) | 8839 | -0.207 | -0.1980 | No |
| 53 | ISCU | NA | 8913 | -0.215 | -0.2007 | No | ||
| 54 | LTA4H | NA | LTA4H Entrez, Source | leukotriene A4 hydrolase | 9221 | -0.253 | -0.2200 | No |
| 55 | CTSO | NA | CTSO Entrez, Source | cathepsin O | 9536 | -0.299 | -0.2392 | No |
| 56 | ADAM9 | NA | ADAM9 Entrez, Source | ADAM metallopeptidase domain 9 (meltrin gamma) | 9607 | -0.307 | -0.2405 | No |
| 57 | LAMP2 | NA | LAMP2 Entrez, Source | lysosomal-associated membrane protein 2 | 9988 | -0.362 | -0.2637 | No |
| 58 | GNG12 | NA | GNG12 Entrez, Source | guanine nucleotide binding protein (G protein), gamma 12 | 10289 | -0.408 | -0.2805 | No |
| 59 | S100A1 | NA | S100A1 Entrez, Source | S100 calcium binding protein A1 | 10539 | -0.448 | -0.2932 | No |
| 60 | SIRT2 | NA | SIRT2 Entrez, Source | sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae) | 10723 | -0.479 | -0.3006 | No |
| 61 | MST1 | NA | MST1 Entrez, Source | macrophage stimulating 1 (hepatocyte growth factor-like) | 10772 | -0.488 | -0.2982 | No |
| 62 | C9 | NA | C9 Entrez, Source | complement component 9 | 10832 | -0.499 | -0.2963 | No |
| 63 | GP9 | NA | GP9 Entrez, Source | glycoprotein IX (platelet) | 10872 | -0.505 | -0.2930 | No |
| 64 | F8 | NA | F8 Entrez, Source | coagulation factor VIII, procoagulant component (hemophilia A) | 10971 | -0.522 | -0.2937 | No |
| 65 | CRIP2 | NA | CRIP2 Entrez, Source | cysteine-rich protein 2 | 11244 | -0.573 | -0.3065 | No |
| 66 | MASP2 | NA | MASP2 Entrez, Source | mannan-binding lectin serine peptidase 2 | 11465 | -0.618 | -0.3150 | Yes |
| 67 | SPARC | NA | SPARC Entrez, Source | secreted protein, acidic, cysteine-rich (osteonectin) | 11483 | -0.621 | -0.3086 | Yes |
| 68 | CD9 | NA | CD9 Entrez, Source | CD9 molecule | 11497 | -0.623 | -0.3019 | Yes |
| 69 | BMP1 | NA | BMP1 Entrez, Source | bone morphogenetic protein 1 | 11506 | -0.624 | -0.2949 | Yes |
| 70 | FURIN | NA | FURIN Entrez, Source | furin (paired basic amino acid cleaving enzyme) | 11593 | -0.646 | -0.2932 | Yes |
| 71 | HNF4A | NA | HNF4A Entrez, Source | hepatocyte nuclear factor 4, alpha | 11862 | -0.714 | -0.3040 | Yes |
| 72 | F10 | NA | F10 Entrez, Source | coagulation factor X | 11889 | -0.721 | -0.2971 | Yes |
| 73 | MMP15 | NA | MMP15 Entrez, Source | matrix metallopeptidase 15 (membrane-inserted) | 11945 | -0.737 | -0.2920 | Yes |
| 74 | PLAU | NA | PLAU Entrez, Source | plasminogen activator, urokinase | 12310 | -0.855 | -0.3081 | Yes |
| 75 | GSN | NA | GSN Entrez, Source | gelsolin (amyloidosis, Finnish type) | 12312 | -0.856 | -0.2977 | Yes |
| 76 | PDGFB | NA | PDGFB Entrez, Source | platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) | 12572 | -0.972 | -0.3046 | Yes |
| 77 | CFD | NA | CFD Entrez, Source | complement factor D (adipsin) | 12784 | -1.080 | -0.3067 | Yes |
| 78 | RGN | NA | RGN Entrez, Source | regucalcin (senescence marker protein-30) | 12817 | -1.098 | -0.2956 | Yes |
| 79 | MSRB2 | NA | MSRB2 Entrez, Source | methionine sulfoxide reductase B2 | 13013 | -1.230 | -0.2948 | Yes |
| 80 | FYN | NA | FYN Entrez, Source | FYN oncogene related to SRC, FGR, YES | 13049 | -1.256 | -0.2819 | Yes |
| 81 | C1S | NA | C1S Entrez, Source | complement component 1, s subcomponent | 13114 | -1.307 | -0.2706 | Yes |
| 82 | C1R | NA | C1R Entrez, Source | complement component 1, r subcomponent | 13304 | -1.520 | -0.2658 | Yes |
| 83 | HTRA1 | NA | HTRA1 Entrez, Source | HtrA serine peptidase 1 | 13310 | -1.528 | -0.2474 | Yes |
| 84 | SERPING1 | NA | SERPING1 Entrez, Source | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary) | 13330 | -1.553 | -0.2298 | Yes |
| 85 | GP1BA | NA | GP1BA Entrez, Source | glycoprotein Ib (platelet), alpha polypeptide | 13339 | -1.568 | -0.2112 | Yes |
| 86 | LRP1 | NA | LRP1 Entrez, Source | low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor) | 13358 | -1.589 | -0.1930 | Yes |
| 87 | PLG | NA | PLG Entrez, Source | plasminogen | 13466 | -1.757 | -0.1793 | Yes |
| 88 | ANG | NA | ANG Entrez, Source | angiogenin, ribonuclease, RNase A family, 5 | 13529 | -1.891 | -0.1607 | Yes |
| 89 | C3 | NA | C3 Entrez, Source | complement component 3 | 13533 | -1.896 | -0.1377 | Yes |
| 90 | PROS1 | NA | PROS1 Entrez, Source | protein S (alpha) | 13569 | -1.987 | -0.1159 | Yes |
| 91 | A2M | NA | A2M Entrez, Source | alpha-2-macroglobulin | 13580 | -2.010 | -0.0921 | Yes |
| 92 | CFH | NA | CFH Entrez, Source | complement factor H | 13608 | -2.094 | -0.0684 | Yes |
| 93 | CASP9 | NA | CASP9 Entrez, Source | caspase 9, apoptosis-related cysteine peptidase | 13696 | -2.469 | -0.0445 | Yes |
| 94 | CFI | NA | CFI Entrez, Source | complement factor I | 13823 | -4.452 | 0.0008 | Yes |
