Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | HALLMARK_CHOLESTEROL_HOMEOSTASIS |
| Enrichment Score (ES) | -0.45447278 |
| Normalized Enrichment Score (NES) | -1.581338 |
| Nominal p-value | 0.003327787 |
| FDR q-value | 0.015832765 |
| FWER p-Value | 0.141 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | TNFRSF12A | NA | TNFRSF12A Entrez, Source | tumor necrosis factor receptor superfamily, member 12A | 128 | 2.638 | 0.0358 | No |
| 2 | PLAUR | NA | PLAUR Entrez, Source | plasminogen activator, urokinase receptor | 187 | 2.308 | 0.0709 | No |
| 3 | ATF5 | NA | ATF5 Entrez, Source | activating transcription factor 5 | 331 | 1.683 | 0.0893 | No |
| 4 | JAG1 | NA | JAG1 Entrez, Source | jagged 1 (Alagille syndrome) | 432 | 1.447 | 0.1067 | No |
| 5 | S100A11 | NA | S100A11 Entrez, Source | S100 calcium binding protein A11 | 545 | 1.259 | 0.1201 | No |
| 6 | ACTG1 | NA | ACTG1 Entrez, Source | actin, gamma 1 | 583 | 1.201 | 0.1379 | No |
| 7 | FAM129A | NA | 704 | 1.095 | 0.1479 | No | ||
| 8 | LDLR | NA | LDLR Entrez, Source | low density lipoprotein receptor (familial hypercholesterolemia) | 803 | 1.007 | 0.1580 | No |
| 9 | CPEB2 | NA | CPEB2 Entrez, Source | cytoplasmic polyadenylation element binding protein 2 | 911 | 0.939 | 0.1662 | No |
| 10 | GLDC | NA | GLDC Entrez, Source | glycine dehydrogenase (decarboxylating) | 1321 | 0.766 | 0.1496 | No |
| 11 | PLSCR1 | NA | PLSCR1 Entrez, Source | phospholipid scramblase 1 | 1527 | 0.708 | 0.1468 | No |
| 12 | MAL2 | NA | MAL2 Entrez, Source | mal, T-cell differentiation protein 2 | 1773 | 0.638 | 0.1399 | No |
| 13 | PPARG | NA | PPARG Entrez, Source | peroxisome proliferative activated receptor, gamma | 2278 | 0.537 | 0.1125 | No |
| 14 | HMGCS1 | NA | HMGCS1 Entrez, Source | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) | 3649 | 0.338 | 0.0187 | No |
| 15 | FABP5 | NA | FABP5 Entrez, Source | fatty acid binding protein 5 (psoriasis-associated) | 3670 | 0.336 | 0.0230 | No |
| 16 | AVPR1A | NA | AVPR1A Entrez, Source | arginine vasopressin receptor 1A | 4211 | 0.276 | -0.0115 | No |
| 17 | CHKA | NA | CHKA Entrez, Source | choline kinase alpha | 4235 | 0.273 | -0.0085 | No |
| 18 | FBXO6 | NA | FBXO6 Entrez, Source | F-box protein 6 | 4275 | 0.268 | -0.0068 | No |
| 19 | GPX8 | NA | 4335 | 0.262 | -0.0066 | No | ||
| 20 | ANXA5 | NA | ANXA5 Entrez, Source | annexin A5 | 5197 | 0.172 | -0.0662 | No |
| 21 | SQLE | NA | SQLE Entrez, Source | squalene epoxidase | 5440 | 0.147 | -0.0813 | No |
| 22 | GUSB | NA | GUSB Entrez, Source | glucuronidase, beta | 5526 | 0.137 | -0.0851 | No |
| 23 | HMGCR | NA | HMGCR Entrez, Source | 3-hydroxy-3-methylglutaryl-Coenzyme A reductase | 5547 | 0.134 | -0.0843 | No |
| 24 | NSDHL | NA | NSDHL Entrez, Source | NAD(P) dependent steroid dehydrogenase-like | 6215 | 0.065 | -0.1316 | No |
| 25 | ATXN2 | NA | ATXN2 Entrez, Source | ataxin 2 | 6617 | 0.027 | -0.1603 | No |
| 26 | GNAI1 | NA | GNAI1 Entrez, Source | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 6771 | 0.010 | -0.1713 | No |
| 27 | ANTXR2 | NA | ANTXR2 Entrez, Source | anthrax toxin receptor 2 | 6885 | -0.002 | -0.1794 | No |
| 28 | ERRFI1 | NA | ERRFI1 Entrez, Source | ERBB receptor feedback inhibitor 1 | 7234 | -0.037 | -0.2041 | No |
| 29 | PMVK | NA | PMVK Entrez, Source | phosphomevalonate kinase | 7324 | -0.047 | -0.2097 | No |
| 30 | LGMN | NA | LGMN Entrez, Source | legumain | 7414 | -0.057 | -0.2152 | No |
| 31 | CYP51A1 | NA | CYP51A1 Entrez, Source | cytochrome P450, family 51, subfamily A, polypeptide 1 | 7479 | -0.065 | -0.2188 | No |
| 32 | ETHE1 | NA | ETHE1 Entrez, Source | ethylmalonic encephalopathy 1 | 8106 | -0.126 | -0.2621 | No |
| 33 | TMEM97 | NA | TMEM97 Entrez, Source | transmembrane protein 97 | 8392 | -0.157 | -0.2801 | No |
| 34 | ADH4 | NA | ADH4 Entrez, Source | alcohol dehydrogenase 4 (class II), pi polypeptide | 9477 | -0.290 | -0.3539 | No |
| 35 | TRIB3 | NA | TRIB3 Entrez, Source | tribbles homolog 3 (Drosophila) | 9660 | -0.315 | -0.3618 | No |
| 36 | LGALS3 | NA | LGALS3 Entrez, Source | lectin, galactoside-binding, soluble, 3 (galectin 3) | 9870 | -0.347 | -0.3710 | No |
| 37 | EBP | NA | EBP Entrez, Source | emopamil binding protein (sterol isomerase) | 10175 | -0.390 | -0.3864 | No |
| 38 | STARD4 | NA | STARD4 Entrez, Source | START domain containing 4, sterol regulated | 10322 | -0.412 | -0.3900 | No |
| 39 | STX5 | NA | STX5 Entrez, Source | syntaxin 5 | 10524 | -0.445 | -0.3970 | No |
| 40 | ACSS2 | NA | ACSS2 Entrez, Source | acyl-CoA synthetase short-chain family member 2 | 11071 | -0.540 | -0.4274 | No |
| 41 | GSTM2 | NA | GSTM2 Entrez, Source | glutathione S-transferase M2 (muscle) | 11444 | -0.613 | -0.4440 | Yes |
| 42 | PCYT2 | NA | PCYT2 Entrez, Source | phosphate cytidylyltransferase 2, ethanolamine | 11493 | -0.623 | -0.4369 | Yes |
| 43 | CD9 | NA | CD9 Entrez, Source | CD9 molecule | 11497 | -0.623 | -0.4264 | Yes |
| 44 | HSD17B7 | NA | HSD17B7 Entrez, Source | hydroxysteroid (17-beta) dehydrogenase 7 | 11557 | -0.637 | -0.4198 | Yes |
| 45 | FASN | NA | FASN Entrez, Source | fatty acid synthase | 11589 | -0.645 | -0.4111 | Yes |
| 46 | FDFT1 | NA | FDFT1 Entrez, Source | farnesyl-diphosphate farnesyltransferase 1 | 11896 | -0.723 | -0.4210 | Yes |
| 47 | CTNNB1 | NA | CTNNB1 Entrez, Source | catenin (cadherin-associated protein), beta 1, 88kDa | 12021 | -0.762 | -0.4170 | Yes |
| 48 | TM7SF2 | NA | TM7SF2 Entrez, Source | transmembrane 7 superfamily member 2 | 12120 | -0.792 | -0.4106 | Yes |
| 49 | CXCL16 | NA | CXCL16 Entrez, Source | chemokine (C-X-C motif) ligand 16 | 12141 | -0.801 | -0.3983 | Yes |
| 50 | DHCR7 | NA | DHCR7 Entrez, Source | 7-dehydrocholesterol reductase | 12147 | -0.804 | -0.3850 | Yes |
| 51 | FADS2 | NA | FADS2 Entrez, Source | fatty acid desaturase 2 | 12211 | -0.823 | -0.3755 | Yes |
| 52 | SREBF2 | NA | SREBF2 Entrez, Source | sterol regulatory element binding transcription factor 2 | 12318 | -0.860 | -0.3685 | Yes |
| 53 | LPL | NA | LPL Entrez, Source | lipoprotein lipase | 12381 | -0.886 | -0.3579 | Yes |
| 54 | MVD | NA | MVD Entrez, Source | mevalonate (diphospho) decarboxylase | 12441 | -0.911 | -0.3466 | Yes |
| 55 | FDPS | NA | FDPS Entrez, Source | farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) | 12663 | -1.017 | -0.3453 | Yes |
| 56 | ACAT2 | NA | ACAT2 Entrez, Source | acetyl-Coenzyme A acetyltransferase 2 (acetoacetyl Coenzyme A thiolase) | 12819 | -1.099 | -0.3378 | Yes |
| 57 | PDK3 | NA | PDK3 Entrez, Source | pyruvate dehydrogenase kinase, isozyme 3 | 12825 | -1.102 | -0.3193 | Yes |
| 58 | SEMA3B | NA | SEMA3B Entrez, Source | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | 12853 | -1.122 | -0.3021 | Yes |
| 59 | LSS | NA | LSS Entrez, Source | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) | 12936 | -1.175 | -0.2880 | Yes |
| 60 | CBS | NA | CBS Entrez, Source | cystathionine-beta-synthase | 12964 | -1.192 | -0.2696 | Yes |
| 61 | MVK | NA | MVK Entrez, Source | mevalonate kinase (mevalonic aciduria) | 12984 | -1.203 | -0.2505 | Yes |
| 62 | IDI1 | NA | IDI1 Entrez, Source | isopentenyl-diphosphate delta isomerase 1 | 13058 | -1.264 | -0.2342 | Yes |
| 63 | ABCA2 | NA | ABCA2 Entrez, Source | ATP-binding cassette, sub-family A (ABC1), member 2 | 13211 | -1.413 | -0.2211 | Yes |
| 64 | NFIL3 | NA | NFIL3 Entrez, Source | nuclear factor, interleukin 3 regulated | 13322 | -1.542 | -0.2027 | Yes |
| 65 | ECH1 | NA | ECH1 Entrez, Source | enoyl Coenzyme A hydratase 1, peroxisomal | 13349 | -1.579 | -0.1777 | Yes |
| 66 | PNRC1 | NA | PNRC1 Entrez, Source | proline-rich nuclear receptor coactivator 1 | 13437 | -1.721 | -0.1546 | Yes |
| 67 | SCD | NA | SCD Entrez, Source | stearoyl-CoA desaturase (delta-9-desaturase) | 13591 | -2.038 | -0.1309 | Yes |
| 68 | ALDOC | NA | ALDOC Entrez, Source | aldolase C, fructose-bisphosphate | 13596 | -2.047 | -0.0963 | Yes |
| 69 | TP53INP1 | NA | TP53INP1 Entrez, Source | tumor protein p53 inducible nuclear protein 1 | 13617 | -2.122 | -0.0615 | Yes |
| 70 | ALCAM | NA | ALCAM Entrez, Source | activated leukocyte cell adhesion molecule | 13826 | -4.519 | 0.0006 | Yes |
