Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | HALLMARK_BILE_ACID_METABOLISM |
| Enrichment Score (ES) | -0.4614768 |
| Normalized Enrichment Score (NES) | -1.660756 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.010121969 |
| FWER p-Value | 0.065 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | ABCG4 | NA | ABCG4 Entrez, Source | ATP-binding cassette, sub-family G (WHITE), member 4 | 335 | 1.661 | 0.0052 | No |
| 2 | AR | NA | AR Entrez, Source | androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease) | 372 | 1.550 | 0.0303 | No |
| 3 | GCLM | NA | GCLM Entrez, Source | glutamate-cysteine ligase, modifier subunit | 426 | 1.464 | 0.0525 | No |
| 4 | HSD3B7 | NA | HSD3B7 Entrez, Source | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 | 543 | 1.261 | 0.0666 | No |
| 5 | BCAR3 | NA | BCAR3 Entrez, Source | breast cancer anti-estrogen resistance 3 | 568 | 1.221 | 0.0866 | No |
| 6 | NEDD4 | NA | NEDD4 Entrez, Source | neural precursor cell expressed, developmentally down-regulated 4 | 1114 | 0.845 | 0.0620 | No |
| 7 | AKR1D1 | NA | AKR1D1 Entrez, Source | aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase) | 1312 | 0.770 | 0.0614 | No |
| 8 | ABCA8 | NA | ABCA8 Entrez, Source | ATP-binding cassette, sub-family A (ABC1), member 8 | 1731 | 0.649 | 0.0426 | No |
| 9 | NPC1 | NA | NPC1 Entrez, Source | Niemann-Pick disease, type C1 | 1853 | 0.619 | 0.0448 | No |
| 10 | SLC29A1 | NA | SLC29A1 Entrez, Source | solute carrier family 29 (nucleoside transporters), member 1 | 2323 | 0.529 | 0.0201 | No |
| 11 | ABCD1 | NA | ABCD1 Entrez, Source | ATP-binding cassette, sub-family D (ALD), member 1 | 3434 | 0.362 | -0.0541 | No |
| 12 | LONP2 | NA | 3452 | 0.360 | -0.0490 | No | ||
| 13 | HSD17B6 | NA | HSD17B6 Entrez, Source | hydroxysteroid (17-beta) dehydrogenase 6 | 4078 | 0.290 | -0.0893 | No |
| 14 | ACSL5 | NA | ACSL5 Entrez, Source | acyl-CoA synthetase long-chain family member 5 | 4128 | 0.284 | -0.0878 | No |
| 15 | CYP7A1 | NA | CYP7A1 Entrez, Source | cytochrome P450, family 7, subfamily A, polypeptide 1 | 4593 | 0.232 | -0.1174 | No |
| 16 | CYP8B1 | NA | CYP8B1 Entrez, Source | cytochrome P450, family 8, subfamily B, polypeptide 1 | 4722 | 0.220 | -0.1228 | No |
| 17 | ALDH8A1 | NA | ALDH8A1 Entrez, Source | aldehyde dehydrogenase 8 family, member A1 | 4821 | 0.209 | -0.1262 | No |
| 18 | SLC23A2 | NA | SLC23A2 Entrez, Source | solute carrier family 23 (nucleobase transporters), member 2 | 5054 | 0.186 | -0.1397 | No |
| 19 | PEX1 | NA | PEX1 Entrez, Source | peroxisome biogenesis factor 1 | 5215 | 0.170 | -0.1483 | No |
| 20 | PEX16 | NA | PEX16 Entrez, Source | peroxisomal biogenesis factor 16 | 5312 | 0.161 | -0.1524 | No |
| 21 | PHYH | NA | PHYH Entrez, Source | phytanoyl-CoA 2-hydroxylase | 5481 | 0.141 | -0.1621 | No |
| 22 | HACL1 | NA | HACL1 Entrez, Source | 2-hydroxyacyl-CoA lyase 1 | 5512 | 0.138 | -0.1618 | No |
| 23 | GNMT | NA | GNMT Entrez, Source | glycine N-methyltransferase | 5596 | 0.128 | -0.1656 | No |
| 24 | ABCA5 | NA | ABCA5 Entrez, Source | ATP-binding cassette, sub-family A (ABC1), member 5 | 5811 | 0.106 | -0.1793 | No |
| 25 | SLCO1A2 | NA | SLCO1A2 Entrez, Source | solute carrier organic anion transporter family, member 1A2 | 5918 | 0.095 | -0.1853 | No |
| 26 | ABCA9 | NA | ABCA9 Entrez, Source | ATP-binding cassette, sub-family A (ABC1), member 9 | 6195 | 0.067 | -0.2042 | No |
| 27 | RETSAT | NA | RETSAT Entrez, Source | retinol saturase (all-trans-retinol 13,14-reductase) | 6362 | 0.053 | -0.2153 | No |
| 28 | DIO2 | NA | DIO2 Entrez, Source | deiodinase, iodothyronine, type II | 6425 | 0.046 | -0.2190 | No |
| 29 | RXRA | NA | RXRA Entrez, Source | retinoid X receptor, alpha | 6525 | 0.036 | -0.2255 | No |
| 30 | PEX6 | NA | PEX6 Entrez, Source | peroxisomal biogenesis factor 6 | 7187 | -0.031 | -0.2731 | No |
| 31 | PFKM | NA | PFKM Entrez, Source | phosphofructokinase, muscle | 7219 | -0.035 | -0.2747 | No |
| 32 | PEX12 | NA | PEX12 Entrez, Source | peroxisomal biogenesis factor 12 | 7296 | -0.045 | -0.2794 | No |
| 33 | TFCP2L1 | NA | TFCP2L1 Entrez, Source | transcription factor CP2-like 1 | 7521 | -0.068 | -0.2945 | No |
| 34 | PEX19 | NA | PEX19 Entrez, Source | peroxisomal biogenesis factor 19 | 8046 | -0.120 | -0.3305 | No |
| 35 | CROT | NA | CROT Entrez, Source | carnitine O-octanoyltransferase | 8051 | -0.121 | -0.3286 | No |
| 36 | DHCR24 | NA | DHCR24 Entrez, Source | 24-dehydrocholesterol reductase | 8270 | -0.144 | -0.3419 | No |
| 37 | RBP1 | NA | RBP1 Entrez, Source | retinol binding protein 1, cellular | 8350 | -0.151 | -0.3449 | No |
| 38 | KLF1 | NA | KLF1 Entrez, Source | Kruppel-like factor 1 (erythroid) | 8778 | -0.200 | -0.3724 | No |
| 39 | MLYCD | NA | MLYCD Entrez, Source | malonyl-CoA decarboxylase | 8788 | -0.201 | -0.3695 | No |
| 40 | GNPAT | NA | GNPAT Entrez, Source | glyceronephosphate O-acyltransferase | 9189 | -0.248 | -0.3942 | No |
| 41 | PNPLA8 | NA | PNPLA8 Entrez, Source | patatin-like phospholipase domain containing 8 | 9599 | -0.306 | -0.4185 | No |
| 42 | ISOC1 | NA | ISOC1 Entrez, Source | isochorismatase domain containing 1 | 9741 | -0.327 | -0.4229 | No |
| 43 | ABCD3 | NA | ABCD3 Entrez, Source | ATP-binding cassette, sub-family D (ALD), member 3 | 9890 | -0.349 | -0.4274 | No |
| 44 | SLC27A2 | NA | SLC27A2 Entrez, Source | solute carrier family 27 (fatty acid transporter), member 2 | 9957 | -0.357 | -0.4259 | No |
| 45 | PEX26 | NA | PEX26 Entrez, Source | peroxisome biogenesis factor 26 | 10002 | -0.364 | -0.4226 | No |
| 46 | SLC35B2 | NA | SLC35B2 Entrez, Source | solute carrier family 35, member B2 | 10077 | -0.375 | -0.4213 | No |
| 47 | PEX13 | NA | PEX13 Entrez, Source | peroxisome biogenesis factor 13 | 10631 | -0.464 | -0.4532 | Yes |
| 48 | HSD17B11 | NA | 10655 | -0.468 | -0.4465 | Yes | ||
| 49 | OPTN | NA | OPTN Entrez, Source | optineurin | 10676 | -0.473 | -0.4396 | Yes |
| 50 | SCP2 | NA | SCP2 Entrez, Source | sterol carrier protein 2 | 10711 | -0.477 | -0.4335 | Yes |
| 51 | NUDT12 | NA | NUDT12 Entrez, Source | nudix (nucleoside diphosphate linked moiety X)-type motif 12 | 10774 | -0.488 | -0.4293 | Yes |
| 52 | AMACR | NA | AMACR Entrez, Source | alpha-methylacyl-CoA racemase | 10776 | -0.488 | -0.4207 | Yes |
| 53 | PEX11A | NA | PEX11A Entrez, Source | peroxisomal biogenesis factor 11A | 10928 | -0.514 | -0.4225 | Yes |
| 54 | ALDH9A1 | NA | ALDH9A1 Entrez, Source | aldehyde dehydrogenase 9 family, member A1 | 10955 | -0.519 | -0.4152 | Yes |
| 55 | CYP27A1 | NA | CYP27A1 Entrez, Source | cytochrome P450, family 27, subfamily A, polypeptide 1 | 11221 | -0.567 | -0.4243 | Yes |
| 56 | GSTK1 | NA | GSTK1 Entrez, Source | glutathione S-transferase kappa 1 | 11268 | -0.579 | -0.4174 | Yes |
| 57 | FDXR | NA | FDXR Entrez, Source | ferredoxin reductase | 11725 | -0.677 | -0.4385 | Yes |
| 58 | SOD1 | NA | SOD1 Entrez, Source | superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) | 11746 | -0.684 | -0.4277 | Yes |
| 59 | SLC27A5 | NA | SLC27A5 Entrez, Source | solute carrier family 27 (fatty acid transporter), member 5 | 11778 | -0.692 | -0.4176 | Yes |
| 60 | PXMP2 | NA | PXMP2 Entrez, Source | peroxisomal membrane protein 2, 22kDa | 11866 | -0.715 | -0.4112 | Yes |
| 61 | HSD17B4 | NA | HSD17B4 Entrez, Source | hydroxysteroid (17-beta) dehydrogenase 4 | 11867 | -0.715 | -0.3985 | Yes |
| 62 | ABCA1 | NA | ABCA1 Entrez, Source | ATP-binding cassette, sub-family A (ABC1), member 1 | 11871 | -0.716 | -0.3859 | Yes |
| 63 | PRDX5 | NA | PRDX5 Entrez, Source | peroxiredoxin 5 | 11922 | -0.730 | -0.3765 | Yes |
| 64 | LIPE | NA | LIPE Entrez, Source | lipase, hormone-sensitive | 11935 | -0.735 | -0.3643 | Yes |
| 65 | BMP6 | NA | BMP6 Entrez, Source | bone morphogenetic protein 6 | 11939 | -0.736 | -0.3514 | Yes |
| 66 | EFHC1 | NA | EFHC1 Entrez, Source | EF-hand domain (C-terminal) containing 1 | 12155 | -0.806 | -0.3527 | Yes |
| 67 | ABCA4 | NA | ABCA4 Entrez, Source | ATP-binding cassette, sub-family A (ABC1), member 4 | 12171 | -0.812 | -0.3393 | Yes |
| 68 | FADS2 | NA | FADS2 Entrez, Source | fatty acid desaturase 2 | 12211 | -0.823 | -0.3274 | Yes |
| 69 | PEX7 | NA | PEX7 Entrez, Source | peroxisomal biogenesis factor 7 | 12422 | -0.903 | -0.3266 | Yes |
| 70 | PECR | NA | PECR Entrez, Source | peroxisomal trans-2-enoyl-CoA reductase | 12622 | -0.994 | -0.3234 | Yes |
| 71 | SLC23A1 | NA | SLC23A1 Entrez, Source | solute carrier family 23 (nucleobase transporters), member 1 | 12723 | -1.047 | -0.3120 | Yes |
| 72 | NR3C2 | NA | NR3C2 Entrez, Source | nuclear receptor subfamily 3, group C, member 2 | 12883 | -1.138 | -0.3033 | Yes |
| 73 | CYP39A1 | NA | CYP39A1 Entrez, Source | cytochrome P450, family 39, subfamily A, polypeptide 1 | 12999 | -1.215 | -0.2900 | Yes |
| 74 | SLC22A18 | NA | SLC22A18 Entrez, Source | solute carrier family 22 (organic cation transporter), member 18 | 13002 | -1.216 | -0.2684 | Yes |
| 75 | ATXN1 | NA | ATXN1 Entrez, Source | ataxin 1 | 13051 | -1.257 | -0.2495 | Yes |
| 76 | IDI1 | NA | IDI1 Entrez, Source | isopentenyl-diphosphate delta isomerase 1 | 13058 | -1.264 | -0.2274 | Yes |
| 77 | FADS1 | NA | FADS1 Entrez, Source | fatty acid desaturase 1 | 13062 | -1.268 | -0.2050 | Yes |
| 78 | IDH1 | NA | IDH1 Entrez, Source | isocitrate dehydrogenase 1 (NADP+), soluble | 13083 | -1.285 | -0.1836 | Yes |
| 79 | ABCA3 | NA | ABCA3 Entrez, Source | ATP-binding cassette, sub-family A (ABC1), member 3 | 13179 | -1.375 | -0.1660 | Yes |
| 80 | ABCA2 | NA | ABCA2 Entrez, Source | ATP-binding cassette, sub-family A (ABC1), member 2 | 13211 | -1.413 | -0.1430 | Yes |
| 81 | PIPOX | NA | PIPOX Entrez, Source | pipecolic acid oxidase | 13313 | -1.530 | -0.1231 | Yes |
| 82 | PEX11G | NA | PEX11G Entrez, Source | peroxisomal biogenesis factor 11 gamma | 13346 | -1.577 | -0.0973 | Yes |
| 83 | IDH2 | NA | IDH2 Entrez, Source | isocitrate dehydrogenase 2 (NADP+), mitochondrial | 13440 | -1.724 | -0.0733 | Yes |
| 84 | CAT | NA | CAT Entrez, Source | catalase | 13474 | -1.769 | -0.0442 | Yes |
| 85 | SULT2B1 | NA | SULT2B1 Entrez, Source | sulfotransferase family, cytosolic, 2B, member 1 | 13538 | -1.902 | -0.0149 | Yes |
| 86 | ACSL1 | NA | ACSL1 Entrez, Source | acyl-CoA synthetase long-chain family member 1 | 13590 | -2.037 | 0.0177 | Yes |
