Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1w6a |
| GeneSet | HALLMARK_APOPTOSIS |
| Enrichment Score (ES) | 0.3743523 |
| Normalized Enrichment Score (NES) | 1.5330864 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.018943172 |
| FWER p-Value | 0.133 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | IGFBP6 | NA | IGFBP6 Entrez, Source | insulin-like growth factor binding protein 6 | 12 | 4.409 | 0.0381 | Yes |
| 2 | IL6 | NA | IL6 Entrez, Source | interleukin 6 (interferon, beta 2) | 15 | 4.383 | 0.0766 | Yes |
| 3 | ISG20 | NA | ISG20 Entrez, Source | interferon stimulated exonuclease gene 20kDa | 56 | 3.402 | 0.1037 | Yes |
| 4 | TNFRSF12A | NA | TNFRSF12A Entrez, Source | tumor necrosis factor receptor superfamily, member 12A | 128 | 2.638 | 0.1218 | Yes |
| 5 | BIRC3 | NA | BIRC3 Entrez, Source | baculoviral IAP repeat-containing 3 | 152 | 2.495 | 0.1422 | Yes |
| 6 | GADD45A | NA | GADD45A Entrez, Source | growth arrest and DNA-damage-inducible, alpha | 161 | 2.429 | 0.1631 | Yes |
| 7 | PMAIP1 | NA | PMAIP1 Entrez, Source | phorbol-12-myristate-13-acetate-induced protein 1 | 170 | 2.373 | 0.1834 | Yes |
| 8 | JUN | NA | JUN Entrez, Source | jun oncogene | 236 | 1.996 | 0.1963 | Yes |
| 9 | GNA15 | NA | GNA15 Entrez, Source | guanine nucleotide binding protein (G protein), alpha 15 (Gq class) | 249 | 1.957 | 0.2127 | Yes |
| 10 | IRF1 | NA | IRF1 Entrez, Source | interferon regulatory factor 1 | 252 | 1.947 | 0.2297 | Yes |
| 11 | CD44 | NA | CD44 Entrez, Source | CD44 molecule (Indian blood group) | 336 | 1.659 | 0.2383 | Yes |
| 12 | BCL2L1 | NA | BCL2L1 Entrez, Source | BCL2-like 1 | 406 | 1.495 | 0.2465 | Yes |
| 13 | GSTM1 | NA | GSTM1 Entrez, Source | glutathione S-transferase M1 | 451 | 1.408 | 0.2557 | Yes |
| 14 | PEA15 | NA | PEA15 Entrez, Source | phosphoprotein enriched in astrocytes 15 | 492 | 1.326 | 0.2645 | Yes |
| 15 | BIK | NA | BIK Entrez, Source | BCL2-interacting killer (apoptosis-inducing) | 512 | 1.296 | 0.2746 | Yes |
| 16 | KRT18 | NA | KRT18 Entrez, Source | keratin 18 | 664 | 1.127 | 0.2735 | Yes |
| 17 | MCL1 | NA | MCL1 Entrez, Source | myeloid cell leukemia sequence 1 (BCL2-related) | 684 | 1.113 | 0.2819 | Yes |
| 18 | TAP1 | NA | TAP1 Entrez, Source | transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) | 686 | 1.112 | 0.2917 | Yes |
| 19 | IL18 | NA | IL18 Entrez, Source | interleukin 18 (interferon-gamma-inducing factor) | 831 | 0.988 | 0.2899 | Yes |
| 20 | DDIT3 | NA | DDIT3 Entrez, Source | DNA-damage-inducible transcript 3 | 888 | 0.949 | 0.2942 | Yes |
| 21 | SOD2 | NA | SOD2 Entrez, Source | superoxide dismutase 2, mitochondrial | 897 | 0.945 | 0.3019 | Yes |
| 22 | NEDD9 | NA | NEDD9 Entrez, Source | neural precursor cell expressed, developmentally down-regulated 9 | 901 | 0.945 | 0.3101 | Yes |
| 23 | CREBBP | NA | CREBBP Entrez, Source | CREB binding protein (Rubinstein-Taybi syndrome) | 932 | 0.928 | 0.3161 | Yes |
| 24 | SLC20A1 | NA | SLC20A1 Entrez, Source | solute carrier family 20 (phosphate transporter), member 1 | 945 | 0.923 | 0.3233 | Yes |
| 25 | IL1A | NA | IL1A Entrez, Source | interleukin 1, alpha | 977 | 0.904 | 0.3291 | Yes |
| 26 | H1F0 | NA | H1F0 Entrez, Source | H1 histone family, member 0 | 1002 | 0.894 | 0.3352 | Yes |
| 27 | CCND1 | NA | CCND1 Entrez, Source | cyclin D1 | 1033 | 0.877 | 0.3407 | Yes |
| 28 | BCL10 | NA | BCL10 Entrez, Source | B-cell CLL/lymphoma 10 | 1088 | 0.855 | 0.3443 | Yes |
| 29 | ANXA1 | NA | ANXA1 Entrez, Source | annexin A1 | 1105 | 0.849 | 0.3507 | Yes |
| 30 | DNAJA1 | NA | DNAJA1 Entrez, Source | DnaJ (Hsp40) homolog, subfamily A, member 1 | 1115 | 0.845 | 0.3575 | Yes |
| 31 | SQSTM1 | NA | SQSTM1 Entrez, Source | sequestosome 1 | 1130 | 0.838 | 0.3639 | Yes |
| 32 | EMP1 | NA | EMP1 Entrez, Source | epithelial membrane protein 1 | 1239 | 0.797 | 0.3630 | Yes |
| 33 | IER3 | NA | IER3 Entrez, Source | immediate early response 3 | 1272 | 0.788 | 0.3676 | Yes |
| 34 | CASP4 | NA | CASP4 Entrez, Source | caspase 4, apoptosis-related cysteine peptidase | 1276 | 0.785 | 0.3744 | Yes |
| 35 | RELA | NA | RELA Entrez, Source | v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian) | 1570 | 0.698 | 0.3591 | No |
| 36 | CASP2 | NA | CASP2 Entrez, Source | caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) | 1851 | 0.619 | 0.3441 | No |
| 37 | CYLD | NA | CYLD Entrez, Source | cylindromatosis (turban tumor syndrome) | 2081 | 0.572 | 0.3325 | No |
| 38 | CASP3 | NA | CASP3 Entrez, Source | caspase 3, apoptosis-related cysteine peptidase | 2546 | 0.492 | 0.3029 | No |
| 39 | TGFBR3 | NA | TGFBR3 Entrez, Source | transforming growth factor, beta receptor III (betaglycan, 300kDa) | 2547 | 0.492 | 0.3073 | No |
| 40 | GPX3 | NA | GPX3 Entrez, Source | glutathione peroxidase 3 (plasma) | 2570 | 0.489 | 0.3100 | No |
| 41 | IL1B | NA | IL1B Entrez, Source | interleukin 1, beta | 2581 | 0.487 | 0.3136 | No |
| 42 | MMP2 | NA | MMP2 Entrez, Source | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | 2663 | 0.473 | 0.3118 | No |
| 43 | SAT1 | NA | SAT1 Entrez, Source | spermidine/spermine N1-acetyltransferase 1 | 2943 | 0.428 | 0.2952 | No |
| 44 | LMNA | NA | LMNA Entrez, Source | lamin A/C | 3378 | 0.371 | 0.2668 | No |
| 45 | RARA | NA | RARA Entrez, Source | retinoic acid receptor, alpha | 3400 | 0.368 | 0.2685 | No |
| 46 | CDC25B | NA | CDC25B Entrez, Source | cell division cycle 25B | 3450 | 0.360 | 0.2681 | No |
| 47 | FAS | NA | FAS Entrez, Source | Fas (TNF receptor superfamily, member 6) | 3457 | 0.360 | 0.2708 | No |
| 48 | CAV1 | NA | CAV1 Entrez, Source | caveolin 1, caveolae protein, 22kDa | 3483 | 0.356 | 0.2722 | No |
| 49 | F2R | NA | F2R Entrez, Source | coagulation factor II (thrombin) receptor | 3598 | 0.344 | 0.2669 | No |
| 50 | ETF1 | NA | ETF1 Entrez, Source | eukaryotic translation termination factor 1 | 3708 | 0.332 | 0.2618 | No |
| 51 | PPP3R1 | NA | PPP3R1 Entrez, Source | protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I) | 3750 | 0.328 | 0.2617 | No |
| 52 | CASP7 | NA | CASP7 Entrez, Source | caspase 7, apoptosis-related cysteine peptidase | 3757 | 0.327 | 0.2642 | No |
| 53 | DNM1L | NA | DNM1L Entrez, Source | dynamin 1-like | 3859 | 0.315 | 0.2596 | No |
| 54 | DFFA | NA | DFFA Entrez, Source | DNA fragmentation factor, 45kDa, alpha polypeptide | 3903 | 0.309 | 0.2592 | No |
| 55 | TIMP1 | NA | TIMP1 Entrez, Source | TIMP metallopeptidase inhibitor 1 | 4124 | 0.284 | 0.2456 | No |
| 56 | IFNGR1 | NA | IFNGR1 Entrez, Source | interferon gamma receptor 1 | 4135 | 0.284 | 0.2474 | No |
| 57 | AVPR1A | NA | AVPR1A Entrez, Source | arginine vasopressin receptor 1A | 4211 | 0.276 | 0.2444 | No |
| 58 | PAK1 | NA | PAK1 Entrez, Source | p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast) | 4258 | 0.271 | 0.2434 | No |
| 59 | ROCK1 | NA | ROCK1 Entrez, Source | Rho-associated, coiled-coil containing protein kinase 1 | 4370 | 0.257 | 0.2376 | No |
| 60 | GADD45B | NA | GADD45B Entrez, Source | growth arrest and DNA-damage-inducible, beta | 4506 | 0.242 | 0.2299 | No |
| 61 | XIAP | NA | 4549 | 0.237 | 0.2289 | No | ||
| 62 | TGFB2 | NA | TGFB2 Entrez, Source | transforming growth factor, beta 2 | 4731 | 0.219 | 0.2176 | No |
| 63 | CASP8 | NA | CASP8 Entrez, Source | caspase 8, apoptosis-related cysteine peptidase | 5043 | 0.187 | 0.1965 | No |
| 64 | RNASEL | NA | RNASEL Entrez, Source | ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) | 5050 | 0.187 | 0.1977 | No |
| 65 | PLAT | NA | PLAT Entrez, Source | plasminogen activator, tissue | 5083 | 0.183 | 0.1970 | No |
| 66 | GCH1 | NA | GCH1 Entrez, Source | GTP cyclohydrolase 1 (dopa-responsive dystonia) | 5304 | 0.161 | 0.1824 | No |
| 67 | PSEN1 | NA | PSEN1 Entrez, Source | presenilin 1 (Alzheimer disease 3) | 5361 | 0.155 | 0.1797 | No |
| 68 | DNAJC3 | NA | DNAJC3 Entrez, Source | DnaJ (Hsp40) homolog, subfamily C, member 3 | 5366 | 0.154 | 0.1807 | No |
| 69 | RHOT2 | NA | RHOT2 Entrez, Source | ras homolog gene family, member T2 | 5562 | 0.133 | 0.1677 | No |
| 70 | CDKN1A | NA | CDKN1A Entrez, Source | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 5707 | 0.115 | 0.1582 | No |
| 71 | TIMP3 | NA | TIMP3 Entrez, Source | TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory) | 5786 | 0.108 | 0.1534 | No |
| 72 | HMOX1 | NA | HMOX1 Entrez, Source | heme oxygenase (decycling) 1 | 5804 | 0.107 | 0.1531 | No |
| 73 | EREG | NA | EREG Entrez, Source | epiregulin | 5954 | 0.092 | 0.1431 | No |
| 74 | DIABLO | NA | DIABLO Entrez, Source | diablo homolog (Drosophila) | 6121 | 0.075 | 0.1316 | No |
| 75 | DAP3 | NA | DAP3 Entrez, Source | death associated protein 3 | 6183 | 0.069 | 0.1277 | No |
| 76 | GSR | NA | GSR Entrez, Source | glutathione reductase | 6231 | 0.064 | 0.1249 | No |
| 77 | DPYD | NA | DPYD Entrez, Source | dihydropyrimidine dehydrogenase | 6259 | 0.061 | 0.1234 | No |
| 78 | BCAP31 | NA | BCAP31 Entrez, Source | B-cell receptor-associated protein 31 | 6310 | 0.057 | 0.1203 | No |
| 79 | CFLAR | NA | CFLAR Entrez, Source | CASP8 and FADD-like apoptosis regulator | 6359 | 0.053 | 0.1173 | No |
| 80 | RETSAT | NA | RETSAT Entrez, Source | retinol saturase (all-trans-retinol 13,14-reductase) | 6362 | 0.053 | 0.1176 | No |
| 81 | PSEN2 | NA | PSEN2 Entrez, Source | presenilin 2 (Alzheimer disease 4) | 6448 | 0.043 | 0.1118 | No |
| 82 | APP | NA | APP Entrez, Source | amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease) | 6652 | 0.022 | 0.0971 | No |
| 83 | IFITM3 | NA | IFITM3 Entrez, Source | interferon induced transmembrane protein 3 (1-8U) | 6694 | 0.018 | 0.0943 | No |
| 84 | BCL2L11 | NA | BCL2L11 Entrez, Source | BCL2-like 11 (apoptosis facilitator) | 6975 | -0.012 | 0.0739 | No |
| 85 | GPX1 | NA | GPX1 Entrez, Source | glutathione peroxidase 1 | 7302 | -0.045 | 0.0505 | No |
| 86 | FEZ1 | NA | FEZ1 Entrez, Source | fasciculation and elongation protein zeta 1 (zygin I) | 7335 | -0.049 | 0.0486 | No |
| 87 | IGF2R | NA | IGF2R Entrez, Source | insulin-like growth factor 2 receptor | 7634 | -0.078 | 0.0276 | No |
| 88 | SPTAN1 | NA | SPTAN1 Entrez, Source | spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) | 7714 | -0.086 | 0.0226 | No |
| 89 | FASLG | NA | FASLG Entrez, Source | Fas ligand (TNF superfamily, member 6) | 7920 | -0.106 | 0.0085 | No |
| 90 | CASP6 | NA | CASP6 Entrez, Source | caspase 6, apoptosis-related cysteine peptidase | 7942 | -0.108 | 0.0079 | No |
| 91 | ADD1 | NA | ADD1 Entrez, Source | adducin 1 (alpha) | 8140 | -0.130 | -0.0053 | No |
| 92 | BAX | NA | BAX Entrez, Source | BCL2-associated X protein | 8170 | -0.133 | -0.0062 | No |
| 93 | PTK2 | NA | PTK2 Entrez, Source | PTK2 protein tyrosine kinase 2 | 8268 | -0.144 | -0.0121 | No |
| 94 | HSPB1 | NA | HSPB1 Entrez, Source | heat shock 27kDa protein 1 | 8404 | -0.158 | -0.0205 | No |
| 95 | BCL2L2 | NA | BCL2L2 Entrez, Source | BCL2-like 2 | 8614 | -0.181 | -0.0342 | No |
| 96 | BTG3 | NA | BTG3 Entrez, Source | BTG family, member 3 | 8698 | -0.191 | -0.0386 | No |
| 97 | MADD | NA | MADD Entrez, Source | MAP-kinase activating death domain | 8722 | -0.193 | -0.0385 | No |
| 98 | TXNIP | NA | TXNIP Entrez, Source | thioredoxin interacting protein | 8817 | -0.205 | -0.0436 | No |
| 99 | BID | NA | BID Entrez, Source | BH3 interacting domain death agonist | 8885 | -0.213 | -0.0466 | No |
| 100 | BRCA1 | NA | BRCA1 Entrez, Source | breast cancer 1, early onset | 8895 | -0.214 | -0.0454 | No |
| 101 | CCND2 | NA | CCND2 Entrez, Source | cyclin D2 | 8965 | -0.222 | -0.0485 | No |
| 102 | PPT1 | NA | PPT1 Entrez, Source | palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile) | 9042 | -0.231 | -0.0520 | No |
| 103 | SMAD7 | NA | SMAD7 Entrez, Source | SMAD, mothers against DPP homolog 7 (Drosophila) | 9217 | -0.252 | -0.0625 | No |
| 104 | TOP2A | NA | TOP2A Entrez, Source | topoisomerase (DNA) II alpha 170kDa | 9333 | -0.268 | -0.0685 | No |
| 105 | VDAC2 | NA | VDAC2 Entrez, Source | voltage-dependent anion channel 2 | 9826 | -0.340 | -0.1014 | No |
| 106 | LGALS3 | NA | LGALS3 Entrez, Source | lectin, galactoside-binding, soluble, 3 (galectin 3) | 9870 | -0.347 | -0.1015 | No |
| 107 | ERBB2 | NA | ERBB2 Entrez, Source | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) | 9967 | -0.359 | -0.1053 | No |
| 108 | EBP | NA | EBP Entrez, Source | emopamil binding protein (sterol isomerase) | 10175 | -0.390 | -0.1170 | No |
| 109 | CASP1 | NA | CASP1 Entrez, Source | caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) | 10265 | -0.405 | -0.1199 | No |
| 110 | TSPO | NA | TSPO Entrez, Source | translocator protein (18kDa) | 10302 | -0.410 | -0.1189 | No |
| 111 | ENO2 | NA | ENO2 Entrez, Source | enolase 2 (gamma, neuronal) | 10819 | -0.496 | -0.1522 | No |
| 112 | WEE1 | NA | WEE1 Entrez, Source | WEE1 homolog (S. pombe) | 10908 | -0.510 | -0.1542 | No |
| 113 | CDK2 | NA | CDK2 Entrez, Source | cyclin-dependent kinase 2 | 11096 | -0.546 | -0.1630 | No |
| 114 | SATB1 | NA | SATB1 Entrez, Source | special AT-rich sequence binding protein 1 (binds to nuclear matrix/scaffold-associating DNA's) | 11127 | -0.550 | -0.1603 | No |
| 115 | CD14 | NA | CD14 Entrez, Source | CD14 molecule | 11218 | -0.567 | -0.1619 | No |
| 116 | DAP | NA | DAP Entrez, Source | death-associated protein | 11309 | -0.586 | -0.1633 | No |
| 117 | NEFH | NA | NEFH Entrez, Source | neurofilament, heavy polypeptide 200kDa | 11311 | -0.587 | -0.1582 | No |
| 118 | PPP2R5B | NA | PPP2R5B Entrez, Source | protein phosphatase 2, regulatory subunit B (B56), beta isoform | 11415 | -0.608 | -0.1604 | No |
| 119 | FDXR | NA | FDXR Entrez, Source | ferredoxin reductase | 11725 | -0.677 | -0.1769 | No |
| 120 | SOD1 | NA | SOD1 Entrez, Source | superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) | 11746 | -0.684 | -0.1724 | No |
| 121 | HMGB2 | NA | HMGB2 Entrez, Source | high-mobility group box 2 | 11791 | -0.695 | -0.1694 | No |
| 122 | CTNNB1 | NA | CTNNB1 Entrez, Source | catenin (cadherin-associated protein), beta 1, 88kDa | 12021 | -0.762 | -0.1794 | No |
| 123 | GSN | NA | GSN Entrez, Source | gelsolin (amyloidosis, Finnish type) | 12312 | -0.856 | -0.1931 | No |
| 124 | PLCB2 | NA | PLCB2 Entrez, Source | phospholipase C, beta 2 | 12339 | -0.869 | -0.1873 | No |
| 125 | TIMP2 | NA | TIMP2 Entrez, Source | TIMP metallopeptidase inhibitor 2 | 12411 | -0.896 | -0.1846 | No |
| 126 | CDKN1B | NA | CDKN1B Entrez, Source | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | 12505 | -0.942 | -0.1830 | No |
| 127 | TNFSF10 | NA | TNFSF10 Entrez, Source | tumor necrosis factor (ligand) superfamily, member 10 | 12683 | -1.028 | -0.1869 | No |
| 128 | GPX4 | NA | GPX4 Entrez, Source | glutathione peroxidase 4 (phospholipid hydroperoxidase) | 12713 | -1.042 | -0.1798 | No |
| 129 | RHOB | NA | RHOB Entrez, Source | ras homolog gene family, member B | 13181 | -1.375 | -0.2018 | No |
| 130 | PDCD4 | NA | PDCD4 Entrez, Source | programmed cell death 4 (neoplastic transformation inhibitor) | 13296 | -1.508 | -0.1968 | No |
| 131 | PDGFRB | NA | PDGFRB Entrez, Source | platelet-derived growth factor receptor, beta polypeptide | 13337 | -1.562 | -0.1859 | No |
| 132 | BNIP3L | NA | BNIP3L Entrez, Source | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 13391 | -1.641 | -0.1753 | No |
| 133 | BMP2 | NA | BMP2 Entrez, Source | bone morphogenetic protein 2 | 13439 | -1.723 | -0.1635 | No |
| 134 | ERBB3 | NA | ERBB3 Entrez, Source | v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) | 13454 | -1.742 | -0.1491 | No |
| 135 | CCNA1 | NA | CCNA1 Entrez, Source | cyclin A1 | 13467 | -1.757 | -0.1345 | No |
| 136 | ANKH | NA | ANKH Entrez, Source | ankylosis, progressive homolog (mouse) | 13490 | -1.794 | -0.1203 | No |
| 137 | CTH | NA | CTH Entrez, Source | cystathionase (cystathionine gamma-lyase) | 13546 | -1.929 | -0.1072 | No |
| 138 | BTG2 | NA | BTG2 Entrez, Source | BTG family, member 2 | 13659 | -2.285 | -0.0953 | No |
| 139 | CASP9 | NA | CASP9 Entrez, Source | caspase 9, apoptosis-related cysteine peptidase | 13696 | -2.469 | -0.0761 | No |
| 140 | LUM | NA | LUM Entrez, Source | lumican | 13701 | -2.519 | -0.0541 | No |
| 141 | BMF | NA | BMF Entrez, Source | Bcl2 modifying factor | 13777 | -3.187 | -0.0315 | No |
| 142 | DCN | NA | DCN Entrez, Source | decorin | 13811 | -4.027 | 0.0017 | No |
