Datasetw6a_vs_wt_vs_wt.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp_repos
Phenotypew6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos
Upregulated in classago1w6a
GeneSetHALLMARK_APICAL_JUNCTION
Enrichment Score (ES)0.35186353
Normalized Enrichment Score (NES)1.492072
Nominal p-value0.005602241
FDR q-value0.02754373
FWER p-Value0.202
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_APICAL_JUNCTION   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1COL17A1NACOL17A1
Entrez,  Source
collagen, type XVII, alpha 1274.0450.0371Yes
2TRAF1NATRAF1
Entrez,  Source
TNF receptor-associated factor 1883.0290.0619Yes
3CLDN4NACLDN4
Entrez,  Source
claudin 41202.6960.0856Yes
4ACTG2NAACTG2
Entrez,  Source
actin, gamma 2, smooth muscle, enteric1342.5990.1098Yes
5PDZD3NAPDZD3
Entrez,  Source
PDZ domain containing 31532.4850.1324Yes
6ITGA10NAITGA10
Entrez,  Source
integrin, alpha 101642.4150.1550Yes
7ITGA2NAITGA2
Entrez,  Source
integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)1922.2660.1749Yes
8CDH3NACDH3
Entrez,  Source
cadherin 3, type 1, P-cadherin (placental)2272.0710.1924Yes
9ICAM1NAICAM1
Entrez,  Source
intercellular adhesion molecule 1 (CD54), human rhinovirus receptor2511.9520.2096Yes
10LAMC2NALAMC2
Entrez,  Source
laminin, gamma 22601.9310.2276Yes
11COL16A1NACOL16A1
Entrez,  Source
collagen, type XVI, alpha 12751.8470.2444Yes
12RAC2NARAC2
Entrez,  Source
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)3231.7070.2575Yes
13ITGB4NAITGB4
Entrez,  Source
integrin, beta 43271.6960.2736Yes
14ACTG1NAACTG1
Entrez,  Source
actin, gamma 15831.2010.2665Yes
15IRS1NAIRS1
Entrez,  Source
insulin receptor substrate 15871.1980.2779Yes
16EGFRNAEGFR
Entrez,  Source
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)6371.1500.2854Yes
17WNK4NAWNK4
Entrez,  Source
WNK lysine deficient protein kinase 46661.1250.2942Yes
18STX4NASTX4
Entrez,  Source
syntaxin 47601.0410.2975Yes
19BAIAP2NABAIAP2
Entrez,  Source
BAI1-associated protein 27981.0090.3045Yes
20CD276NACD276
Entrez,  Source
CD276 molecule8480.9780.3103Yes
21ACTN1NAACTN1
Entrez,  Source
actinin, alpha 18490.9780.3198Yes
22VWFNAVWF
Entrez,  Source
von Willebrand factor9190.9330.3237Yes
23CDSNNACDSN
Entrez,  Source
corneodesmosin9410.9260.3311Yes
24ZYXNAZYX
Entrez,  Source
zyxin9600.9160.3386Yes
25ITGA3NAITGA3
Entrez,  Source
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)10150.8840.3432Yes
26ACTBNAACTB
Entrez,  Source
actin, beta11270.8400.3432Yes
27ACTN4NAACTN4
Entrez,  Source
actinin, alpha 412700.7890.3404Yes
28MSNNAMSN
Entrez,  Source
moesin13160.7680.3446Yes
29VCLNAVCL
Entrez,  Source
vinculin13440.7580.3499Yes
30SRCNASRC
Entrez,  Source
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)14690.7240.3478Yes
31MYH9NAMYH9
Entrez,  Source
myosin, heavy chain 9, non-muscle15900.6920.3457Yes
32LIMA1NALIMA1
Entrez,  Source
LIM domain and actin binding 115980.6890.3519Yes
33ARHGEF6NAARHGEF6
Entrez,  Source
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 617950.6340.3436No
34FLNCNAFLNC
Entrez,  Source
filamin C, gamma (actin binding protein 280)19620.5940.3372No
35MPZL1NAMPZL1
Entrez,  Source
myelin protein zero-like 120100.5840.3394No
36HRASNAHRAS
Entrez,  Source
v-Ha-ras Harvey rat sarcoma viral oncogene homolog22530.5410.3270No
37DHX16NADHX16
Entrez,  Source
DEAH (Asp-Glu-Ala-His) box polypeptide 1623950.5170.3216No
38IKBKGNAIKBKG
Entrez,  Source
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma23960.5170.3266No
39TAOK2NATAOK2
Entrez,  Source
TAO kinase 224520.5080.3275No
40TIAL1NATIAL1
Entrez,  Source
TIA1 cytotoxic granule-associated RNA binding protein-like 125540.4920.3249No
41MMP2NAMMP2
Entrez,  Source
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)26630.4730.3215No
42PFN1NAPFN1
Entrez,  Source
profilin 126910.4690.3241No
43TUBG1NATUBG1
Entrez,  Source
tubulin, gamma 129120.4330.3122No
44CDK8NACDK8
Entrez,  Source
cyclin-dependent kinase 829300.4300.3151No
45NF2NANF2
Entrez,  Source
neurofibromin 2 (bilateral acoustic neuroma)32950.3830.2922No
46SORBS3NASORBS3
Entrez,  Source
sorbin and SH3 domain containing 334660.3590.2832No
47PKD1NAPKD1
Entrez,  Source
polycystic kidney disease 1 (autosomal dominant)35180.3520.2828No
48GTF2F1NAGTF2F1
Entrez,  Source
general transcription factor IIF, polypeptide 1, 74kDa38070.3200.2649No
49VAV2NAVAV2
Entrez,  Source
vav 2 oncogene38350.3170.2660No
50CNN2NACNN2
Entrez,  Source
calponin 238790.3120.2658No
51PTPRCNAPTPRC
Entrez,  Source
protein tyrosine phosphatase, receptor type, C38810.3120.2688No
52AMIGO2NAAMIGO2
Entrez,  Source
adhesion molecule with Ig-like domain 239800.2980.2645No
53FBN1NAFBN1
Entrez,  Source
fibrillin 139820.2980.2673No
54NEXNNANEXN
Entrez,  Source
nexilin (F actin binding protein)40950.2880.2619No
55RSU1NARSU1
Entrez,  Source
Ras suppressor protein 144050.2530.2417No
56YWHAHNAYWHAH
Entrez,  Source
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide45140.2410.2361No
57TJP1NATJP1
Entrez,  Source
tight junction protein 1 (zona occludens 1)46330.2290.2297No
58CLDN18NACLDN18
Entrez,  Source
claudin 1848200.2090.2181No
59MMP9NAMMP9
Entrez,  Source
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)48240.2090.2199No
60VASPNAVASP
Entrez,  Source
vasodilator-stimulated phosphoprotein49500.1970.2127No
61SYMPKNASYMPK
Entrez,  Source
symplekin51590.1750.1992No
62CAP1NACAP1
Entrez,  Source
CAP, adenylate cyclase-associated protein 1 (yeast)52200.1700.1964No
63PARD6GNAPARD6G
Entrez,  Source
par-6 partitioning defective 6 homolog gamma (C. elegans)52280.1680.1975No
64MPP5NAMPP5
Entrez,  Source
membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)52580.1650.1970No
65PIK3CBNAPIK3CB
Entrez,  Source
phosphoinositide-3-kinase, catalytic, beta polypeptide52930.1620.1961No
66INPPL1NAINPPL1
Entrez,  Source
inositol polyphosphate phosphatase-like 153480.1570.1936No
67CDH8NACDH8
Entrez,  Source
cadherin 8, type 253720.1540.1934No
68MPZL2NA54860.1410.1865No
69CLDN19NACLDN19
Entrez,  Source
claudin 1955750.1310.1814No
70RHOFNARHOF
Entrez,  Source
ras homolog gene family, member F (in filopodia)56220.1250.1792No
71CDH4NACDH4
Entrez,  Source
cadherin 4, type 1, R-cadherin (retinal)57160.1150.1735No
72CD99NACD99
Entrez,  Source
CD99 molecule57250.1140.1740No
73ACTN2NAACTN2
Entrez,  Source
actinin, alpha 258380.1030.1668No
74CDH1NACDH1
Entrez,  Source
cadherin 1, type 1, E-cadherin (epithelial)58590.1020.1663No
75LDLRAP1NALDLRAP1
Entrez,  Source
low density lipoprotein receptor adaptor protein 159690.0900.1593No
76SHROOM2NASHROOM2
Entrez,  Source
shroom family member 260130.0860.1569No
77ARPC2NAARPC2
Entrez,  Source
actin related protein 2/3 complex, subunit 2, 34kDa60550.0810.1547No
78VCANNA60560.0810.1555No
79CLDN9NACLDN9
Entrez,  Source
claudin 960760.0790.1549No
80EPB41L2NAEPB41L2
Entrez,  Source
erythrocyte membrane protein band 4.1-like 261130.0760.1530No
81PBX2NAPBX2
Entrez,  Source
pre-B-cell leukemia transcription factor 261500.0720.1510No
82FSCN1NAFSCN1
Entrez,  Source
fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)63010.0570.1406No
83CLDN11NACLDN11
Entrez,  Source
claudin 11 (oligodendrocyte transmembrane protein)63210.0560.1398No
84LAMB3NALAMB3
Entrez,  Source
laminin, beta 363570.0540.1377No
85NF1NANF1
Entrez,  Source
neurofibromin 1 (neurofibromatosis, von Recklinghausen disease, Watson disease)65080.0380.1271No
86PECAM1NAPECAM1
Entrez,  Source
platelet/endothelial cell adhesion molecule (CD31 antigen)65450.0330.1248No
87TSC1NATSC1
Entrez,  Source
tuberous sclerosis 165710.0310.1233No
88ICAM4NAICAM4
Entrez,  Source
intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)66480.0230.1179No
89GNAI1NAGNAI1
Entrez,  Source
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 167710.0100.1091No
90RASA1NARASA1
Entrez,  Source
RAS p21 protein activator (GTPase activating protein) 168260.0040.1052No
91DSC1NADSC1
Entrez,  Source
desmocollin 16911-0.0050.0991No
92ALOX15BNAALOX15B
Entrez,  Source
arachidonate 15-lipoxygenase, type B6956-0.0100.0960No
93PTENNAPTEN
Entrez,  Source
phosphatase and tensin homolog (mutated in multiple advanced cancers 1)6985-0.0130.0941No
94CDH6NACDH6
Entrez,  Source
cadherin 6, type 2, K-cadherin (fetal kidney)7111-0.0240.0852No
95CERCAMNA7114-0.0240.0853No
96AKT2NAAKT2
Entrez,  Source
v-akt murine thymoma viral oncogene homolog 27140-0.0270.0837No
97SPEGNASPEG
Entrez,  Source
SPEG complex locus7157-0.0290.0828No
98DSC3NADSC3
Entrez,  Source
desmocollin 37177-0.0310.0817No
99WASLNAWASL
Entrez,  Source
Wiskott-Aldrich syndrome-like7201-0.0330.0803No
100AMHNAAMH
Entrez,  Source
anti-Mullerian hormone7261-0.0400.0764No
101TSPAN4NATSPAN4
Entrez,  Source
tetraspanin 47328-0.0480.0720No
102JAM3NAJAM3
Entrez,  Source
junctional adhesion molecule 37360-0.0520.0703No
103MAPK14NAMAPK14
Entrez,  Source
mitogen-activated protein kinase 147577-0.0730.0552No
104SHC1NASHC1
Entrez,  Source
SHC (Src homology 2 domain containing) transforming protein 17588-0.0740.0552No
105CRB3NACRB3
Entrez,  Source
crumbs homolog 3 (Drosophila)7679-0.0820.0494No
106CLDN15NACLDN15
Entrez,  Source
claudin 157781-0.0930.0429No
107CTNND1NACTNND1
Entrez,  Source
catenin (cadherin-associated protein), delta 17982-0.1120.0293No
108EVLNAEVL
Entrez,  Source
Enah/Vasp-like8129-0.1290.0199No
109PTK2NAPTK2
Entrez,  Source
PTK2 protein tyrosine kinase 28268-0.1440.0112No
110PLCG1NAPLCG1
Entrez,  Source
phospholipase C, gamma 18316-0.1480.0092No
111SYKNASYK
Entrez,  Source
spleen tyrosine kinase8333-0.1500.0095No
112PIK3R3NAPIK3R3
Entrez,  Source
phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma)8472-0.1660.0010No
113MYL12BNA8537-0.172-0.0020No
114SKAP2NASKAP2
Entrez,  Source
src kinase associated phosphoprotein 28576-0.177-0.0031No
115ADAM15NAADAM15
Entrez,  Source
ADAM metallopeptidase domain 15 (metargidin)8779-0.200-0.0160No
116PCDH1NAPCDH1
Entrez,  Source
protocadherin 1 (cadherin-like 1)8969-0.222-0.0276No
117VCAM1NAVCAM1
Entrez,  Source
vascular cell adhesion molecule 19432-0.284-0.0587No
118CD274NACD274
Entrez,  Source
CD274 molecule9469-0.289-0.0585No
119ADAM9NAADAM9
Entrez,  Source
ADAM metallopeptidase domain 9 (meltrin gamma)9607-0.307-0.0656No
120SIRPANASIRPA
Entrez,  Source
signal-regulatory protein alpha9671-0.317-0.0671No
121CD209NACD209
Entrez,  Source
CD209 molecule9751-0.329-0.0697No
122GNAI2NAGNAI2
Entrez,  Source
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 210025-0.368-0.0861No
123CTNNA1NACTNNA1
Entrez,  Source
catenin (cadherin-associated protein), alpha 1, 102kDa10049-0.372-0.0842No
124NLGN2NANLGN2
Entrez,  Source
neuroligin 210150-0.385-0.0878No
125CX3CL1NACX3CL1
Entrez,  Source
chemokine (C-X3-C motif) ligand 110321-0.412-0.0963No
126EXOC4NAEXOC4
Entrez,  Source
exocyst complex component 410346-0.416-0.0940No
127AMIGO1NAAMIGO1
Entrez,  Source
adhesion molecule with Ig-like domain 110476-0.438-0.0992No
128MAPK11NAMAPK11
Entrez,  Source
mitogen-activated protein kinase 1110697-0.475-0.1107No
129ITGB1NAITGB1
Entrez,  Source
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)10722-0.479-0.1079No
130MAPK13NAMAPK13
Entrez,  Source
mitogen-activated protein kinase 1310850-0.502-0.1123No
131NLGN3NANLGN3
Entrez,  Source
neuroligin 310909-0.511-0.1116No
132DLG1NADLG1
Entrez,  Source
discs, large homolog 1 (Drosophila)10936-0.516-0.1086No
133ADAM23NAADAM23
Entrez,  Source
ADAM metallopeptidase domain 2311004-0.529-0.1084No
134JUPNAJUP
Entrez,  Source
junction plakoglobin11011-0.531-0.1037No
135HADHNAHADH
Entrez,  Source
hydroxyacyl-Coenzyme A dehydrogenase11456-0.615-0.1302No
136BMP1NABMP1
Entrez,  Source
bone morphogenetic protein 111506-0.624-0.1278No
137B4GALT1NAB4GALT1
Entrez,  Source
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 111626-0.655-0.1301No
138ATP1A3NAATP1A3
Entrez,  Source
ATPase, Na+/K+ transporting, alpha 3 polypeptide11734-0.680-0.1314No
139NRTNNANRTN
Entrez,  Source
neurturin11859-0.714-0.1336No
140SGCENASGCE
Entrez,  Source
sarcoglycan, epsilon11980-0.746-0.1352No
141ICAM5NAICAM5
Entrez,  Source
intercellular adhesion molecule 5, telencephalin12245-0.835-0.1464No
142SDC3NASDC3
Entrez,  Source
syndecan 3 (N-syndecan)12261-0.839-0.1394No
143GAMTNAGAMT
Entrez,  Source
guanidinoacetate N-methyltransferase12335-0.868-0.1364No
144NEGR1NANEGR1
Entrez,  Source
neuronal growth regulator 112337-0.868-0.1281No
145MVDNAMVD
Entrez,  Source
mevalonate (diphospho) decarboxylase12441-0.911-0.1268No
146GRB7NAGRB7
Entrez,  Source
growth factor receptor-bound protein 712520-0.948-0.1234No
147PARVANAPARVA
Entrez,  Source
parvin, alpha12599-0.981-0.1196No
148ADAMTS5NAADAMTS5
Entrez,  Source
ADAM metallopeptidase with thrombospondin type 1 motif, 5 (aggrecanase-2)12632-1.002-0.1123No
149RRASNARRAS
Entrez,  Source
related RAS viral (r-ras) oncogene homolog12696-1.033-0.1069No
150MAP4K2NAMAP4K2
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 212726-1.048-0.0989No
151THBS3NATHBS3
Entrez,  Source
thrombospondin 312840-1.116-0.0964No
152MYH10NAMYH10
Entrez,  Source
myosin, heavy chain 10, non-muscle12955-1.188-0.0933No
153TMEM8BNA12958-1.190-0.0819No
154CRATNACRAT
Entrez,  Source
carnitine acetyltransferase13125-1.314-0.0814No
155LAMA3NALAMA3
Entrez,  Source
laminin, alpha 313132-1.319-0.0691No
156AKT3NAAKT3
Entrez,  Source
v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)13407-1.667-0.0731No
157TGFBINATGFBI
Entrez,  Source
transforming growth factor, beta-induced, 68kDa13453-1.742-0.0595No
158INSIG1NAINSIG1
Entrez,  Source
insulin induced gene 113484-1.784-0.0445No
159CNTN1NACNTN1
Entrez,  Source
contactin 113555-1.946-0.0309No
160ACTC1NAACTC1
Entrez,  Source
actin, alpha, cardiac muscle 113620-2.138-0.0149No
161CLDN7NACLDN7
Entrez,  Source
claudin 713774-3.1600.0044No
Table: GSEA details [plain text format]



Fig 2: HALLMARK_APICAL_JUNCTION   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_APICAL_JUNCTION: Random ES distribution   
Gene set null distribution of ES for HALLMARK_APICAL_JUNCTION