Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | HALLMARK_ANDROGEN_RESPONSE |
| Enrichment Score (ES) | -0.30708814 |
| Normalized Enrichment Score (NES) | -1.1157019 |
| Nominal p-value | 0.28292683 |
| FDR q-value | 0.3514177 |
| FWER p-Value | 1.0 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | INPP4B | NA | INPP4B Entrez, Source | inositol polyphosphate-4-phosphatase, type II, 105kDa | 203 | 2.198 | 0.0297 | No |
| 2 | MERTK | NA | MERTK Entrez, Source | c-mer proto-oncogene tyrosine kinase | 271 | 1.877 | 0.0628 | No |
| 3 | HSD17B14 | NA | 733 | 1.062 | 0.0508 | No | ||
| 4 | ACTN1 | NA | ACTN1 Entrez, Source | actinin, alpha 1 | 849 | 0.978 | 0.0622 | No |
| 5 | RRP12 | NA | 887 | 0.950 | 0.0787 | No | ||
| 6 | KRT8 | NA | KRT8 Entrez, Source | keratin 8 | 949 | 0.922 | 0.0930 | No |
| 7 | H1F0 | NA | H1F0 Entrez, Source | H1 histone family, member 0 | 1002 | 0.894 | 0.1073 | No |
| 8 | CCND1 | NA | CCND1 Entrez, Source | cyclin D1 | 1033 | 0.877 | 0.1228 | No |
| 9 | SRF | NA | SRF Entrez, Source | serum response factor (c-fos serum response element-binding transcription factor) | 1071 | 0.862 | 0.1376 | No |
| 10 | MAK | NA | MAK Entrez, Source | male germ cell-associated kinase | 1132 | 0.838 | 0.1502 | No |
| 11 | TMEM50A | NA | TMEM50A Entrez, Source | transmembrane protein 50A | 1173 | 0.822 | 0.1639 | No |
| 12 | PDLIM5 | NA | PDLIM5 Entrez, Source | PDZ and LIM domain 5 | 1269 | 0.789 | 0.1730 | No |
| 13 | CDK6 | NA | CDK6 Entrez, Source | cyclin-dependent kinase 6 | 1478 | 0.722 | 0.1724 | No |
| 14 | SMS | NA | SMS Entrez, Source | spermine synthase | 1517 | 0.711 | 0.1841 | No |
| 15 | ADRM1 | NA | ADRM1 Entrez, Source | adhesion regulating molecule 1 | 1661 | 0.671 | 0.1872 | No |
| 16 | UBE2I | NA | UBE2I Entrez, Source | ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) | 2240 | 0.543 | 0.1562 | No |
| 17 | UAP1 | NA | UAP1 Entrez, Source | UDP-N-acteylglucosamine pyrophosphorylase 1 | 2305 | 0.533 | 0.1623 | No |
| 18 | PA2G4 | NA | PA2G4 Entrez, Source | proliferation-associated 2G4, 38kDa | 2480 | 0.503 | 0.1598 | No |
| 19 | ABHD2 | NA | ABHD2 Entrez, Source | abhydrolase domain containing 2 | 2754 | 0.460 | 0.1493 | No |
| 20 | SAT1 | NA | SAT1 Entrez, Source | spermidine/spermine N1-acetyltransferase 1 | 2943 | 0.428 | 0.1443 | No |
| 21 | GNAI3 | NA | GNAI3 Entrez, Source | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 3439 | 0.361 | 0.1156 | No |
| 22 | HMGCS1 | NA | HMGCS1 Entrez, Source | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) | 3649 | 0.338 | 0.1072 | No |
| 23 | SRP19 | NA | SRP19 Entrez, Source | signal recognition particle 19kDa | 3650 | 0.338 | 0.1140 | No |
| 24 | B2M | NA | B2M Entrez, Source | beta-2-microglobulin | 3752 | 0.328 | 0.1133 | No |
| 25 | MYL12A | NA | 3767 | 0.326 | 0.1189 | No | ||
| 26 | ALDH1A3 | NA | ALDH1A3 Entrez, Source | aldehyde dehydrogenase 1 family, member A3 | 3877 | 0.313 | 0.1173 | No |
| 27 | SLC38A2 | NA | SLC38A2 Entrez, Source | solute carrier family 38, member 2 | 4269 | 0.269 | 0.0943 | No |
| 28 | TPD52 | NA | TPD52 Entrez, Source | tumor protein D52 | 4775 | 0.214 | 0.0619 | No |
| 29 | PTPN21 | NA | PTPN21 Entrez, Source | protein tyrosine phosphatase, non-receptor type 21 | 5225 | 0.169 | 0.0327 | No |
| 30 | CDC14B | NA | CDC14B Entrez, Source | CDC14 cell division cycle 14 homolog B (S. cerevisiae) | 5462 | 0.144 | 0.0184 | No |
| 31 | HMGCR | NA | HMGCR Entrez, Source | 3-hydroxy-3-methylglutaryl-Coenzyme A reductase | 5547 | 0.134 | 0.0150 | No |
| 32 | SPCS3 | NA | SPCS3 Entrez, Source | signal peptidase complex subunit 3 homolog (S. cerevisiae) | 5683 | 0.118 | 0.0076 | No |
| 33 | CCND3 | NA | CCND3 Entrez, Source | cyclin D3 | 5722 | 0.114 | 0.0072 | No |
| 34 | RPS6KA3 | NA | RPS6KA3 Entrez, Source | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 5805 | 0.107 | 0.0033 | No |
| 35 | ELK4 | NA | ELK4 Entrez, Source | ELK4, ETS-domain protein (SRF accessory protein 1) | 5863 | 0.101 | 0.0012 | No |
| 36 | NGLY1 | NA | NGLY1 Entrez, Source | N-glycanase 1 | 6153 | 0.072 | -0.0183 | No |
| 37 | GSR | NA | GSR Entrez, Source | glutathione reductase | 6231 | 0.064 | -0.0226 | No |
| 38 | FKBP5 | NA | FKBP5 Entrez, Source | FK506 binding protein 5 | 6309 | 0.057 | -0.0271 | No |
| 39 | XRCC5 | NA | XRCC5 Entrez, Source | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining; Ku autoantigen, 80kDa) | 6704 | 0.016 | -0.0554 | No |
| 40 | CENPN | NA | CENPN Entrez, Source | centromere protein N | 6707 | 0.016 | -0.0552 | No |
| 41 | ITGAV | NA | ITGAV Entrez, Source | integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) | 7059 | -0.019 | -0.0804 | No |
| 42 | PIAS1 | NA | PIAS1 Entrez, Source | protein inhibitor of activated STAT, 1 | 7416 | -0.058 | -0.1051 | No |
| 43 | DNAJB9 | NA | DNAJB9 Entrez, Source | DnaJ (Hsp40) homolog, subfamily B, member 9 | 7519 | -0.068 | -0.1111 | No |
| 44 | ZMIZ1 | NA | 7627 | -0.078 | -0.1173 | No | ||
| 45 | SORD | NA | SORD Entrez, Source | sorbitol dehydrogenase | 7660 | -0.081 | -0.1180 | No |
| 46 | NCOA4 | NA | NCOA4 Entrez, Source | nuclear receptor coactivator 4 | 7687 | -0.083 | -0.1182 | No |
| 47 | ELL2 | NA | ELL2 Entrez, Source | elongation factor, RNA polymerase II, 2 | 7768 | -0.092 | -0.1222 | No |
| 48 | PGM3 | NA | PGM3 Entrez, Source | phosphoglucomutase 3 | 7869 | -0.101 | -0.1274 | No |
| 49 | ARID5B | NA | ARID5B Entrez, Source | AT rich interactive domain 5B (MRF1-like) | 7932 | -0.107 | -0.1298 | No |
| 50 | APPBP2 | NA | APPBP2 Entrez, Source | amyloid beta precursor protein (cytoplasmic tail) binding protein 2 | 8230 | -0.141 | -0.1485 | No |
| 51 | SEC24D | NA | SEC24D Entrez, Source | SEC24 related gene family, member D (S. cerevisiae) | 8258 | -0.143 | -0.1476 | No |
| 52 | DHCR24 | NA | DHCR24 Entrez, Source | 24-dehydrocholesterol reductase | 8270 | -0.144 | -0.1455 | No |
| 53 | SLC26A2 | NA | SLC26A2 Entrez, Source | solute carrier family 26 (sulfate transporter), member 2 | 8371 | -0.154 | -0.1496 | No |
| 54 | ELOVL5 | NA | ELOVL5 Entrez, Source | ELOVL family member 5, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast) | 8468 | -0.166 | -0.1533 | No |
| 55 | CAMKK2 | NA | CAMKK2 Entrez, Source | calcium/calmodulin-dependent protein kinase kinase 2, beta | 8862 | -0.209 | -0.1776 | No |
| 56 | ACSL3 | NA | ACSL3 Entrez, Source | acyl-CoA synthetase long-chain family member 3 | 8881 | -0.212 | -0.1746 | No |
| 57 | LIFR | NA | LIFR Entrez, Source | leukemia inhibitory factor receptor alpha | 8985 | -0.224 | -0.1776 | No |
| 58 | BMPR1B | NA | BMPR1B Entrez, Source | bone morphogenetic protein receptor, type IB | 9027 | -0.229 | -0.1759 | No |
| 59 | TNFAIP8 | NA | TNFAIP8 Entrez, Source | tumor necrosis factor, alpha-induced protein 8 | 9099 | -0.237 | -0.1763 | No |
| 60 | XRCC6 | NA | XRCC6 Entrez, Source | X-ray repair complementing defective repair in Chinese hamster cells 6 (Ku autoantigen, 70kDa) | 9129 | -0.241 | -0.1735 | No |
| 61 | UBE2J1 | NA | UBE2J1 Entrez, Source | ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast) | 9353 | -0.272 | -0.1842 | No |
| 62 | TSC22D1 | NA | TSC22D1 Entrez, Source | TSC22 domain family, member 1 | 9700 | -0.321 | -0.2029 | No |
| 63 | LMAN1 | NA | LMAN1 Entrez, Source | lectin, mannose-binding, 1 | 9794 | -0.336 | -0.2029 | No |
| 64 | HERC3 | NA | HERC3 Entrez, Source | hect domain and RLD 3 | 9991 | -0.363 | -0.2098 | No |
| 65 | AKT1 | NA | AKT1 Entrez, Source | v-akt murine thymoma viral oncogene homolog 1 | 10063 | -0.374 | -0.2074 | No |
| 66 | VAPA | NA | VAPA Entrez, Source | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | 10267 | -0.405 | -0.2140 | No |
| 67 | PTK2B | NA | PTK2B Entrez, Source | PTK2B protein tyrosine kinase 2 beta | 10406 | -0.428 | -0.2154 | No |
| 68 | ABCC4 | NA | ABCC4 Entrez, Source | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | 10559 | -0.451 | -0.2173 | No |
| 69 | B4GALT1 | NA | B4GALT1 Entrez, Source | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 | 11626 | -0.655 | -0.2816 | No |
| 70 | AKAP12 | NA | AKAP12 Entrez, Source | A kinase (PRKA) anchor protein (gravin) 12 | 11847 | -0.711 | -0.2832 | No |
| 71 | GPD1L | NA | GPD1L Entrez, Source | glycerol-3-phosphate dehydrogenase 1-like | 12177 | -0.814 | -0.2906 | Yes |
| 72 | HOMER2 | NA | HOMER2 Entrez, Source | homer homolog 2 (Drosophila) | 12321 | -0.861 | -0.2836 | Yes |
| 73 | PMEPA1 | NA | 12482 | -0.930 | -0.2764 | Yes | ||
| 74 | ADAMTS1 | NA | ADAMTS1 Entrez, Source | ADAM metallopeptidase with thrombospondin type 1 motif, 1 | 12511 | -0.944 | -0.2593 | Yes |
| 75 | SGK1 | NA | 12552 | -0.961 | -0.2428 | Yes | ||
| 76 | DBI | NA | DBI Entrez, Source | diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein) | 12700 | -1.036 | -0.2325 | Yes |
| 77 | RAB4A | NA | RAB4A Entrez, Source | RAB4A, member RAS oncogene family | 12718 | -1.043 | -0.2127 | Yes |
| 78 | IDI1 | NA | IDI1 Entrez, Source | isopentenyl-diphosphate delta isomerase 1 | 13058 | -1.264 | -0.2117 | Yes |
| 79 | FADS1 | NA | FADS1 Entrez, Source | fatty acid desaturase 1 | 13062 | -1.268 | -0.1863 | Yes |
| 80 | MAP7 | NA | MAP7 Entrez, Source | microtubule-associated protein 7 | 13136 | -1.329 | -0.1647 | Yes |
| 81 | ZBTB10 | NA | ZBTB10 Entrez, Source | zinc finger and BTB domain containing 10 | 13360 | -1.592 | -0.1487 | Yes |
| 82 | STEAP4 | NA | STEAP4 Entrez, Source | STEAP family member 4 | 13370 | -1.609 | -0.1168 | Yes |
| 83 | INSIG1 | NA | INSIG1 Entrez, Source | insulin induced gene 1 | 13484 | -1.784 | -0.0889 | Yes |
| 84 | ANKH | NA | ANKH Entrez, Source | ankylosis, progressive homolog (mouse) | 13490 | -1.794 | -0.0530 | Yes |
| 85 | NDRG1 | NA | NDRG1 Entrez, Source | N-myc downstream regulated gene 1 | 13498 | -1.810 | -0.0169 | Yes |
| 86 | SCD | NA | SCD Entrez, Source | stearoyl-CoA desaturase (delta-9-desaturase) | 13591 | -2.038 | 0.0177 | Yes |
