Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1w6a |
| GeneSet | HALLMARK_ALLOGRAFT_REJECTION |
| Enrichment Score (ES) | 0.40031087 |
| Normalized Enrichment Score (NES) | 1.6510923 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.008716024 |
| FWER p-Value | 0.052 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | CCL5 | NA | CCL5 Entrez, Source | chemokine (C-C motif) ligand 5 | 10 | 4.462 | 0.0487 | Yes |
| 2 | IL6 | NA | IL6 Entrez, Source | interleukin 6 (interferon, beta 2) | 15 | 4.383 | 0.0971 | Yes |
| 3 | IL2RG | NA | IL2RG Entrez, Source | interleukin 2 receptor, gamma (severe combined immunodeficiency) | 79 | 3.132 | 0.1272 | Yes |
| 4 | CTSS | NA | CTSS Entrez, Source | cathepsin S | 97 | 2.972 | 0.1589 | Yes |
| 5 | CCL2 | NA | CCL2 Entrez, Source | chemokine (C-C motif) ligand 2 | 98 | 2.964 | 0.1918 | Yes |
| 6 | WARS | NA | WARS Entrez, Source | tryptophanyl-tRNA synthetase | 167 | 2.385 | 0.2132 | Yes |
| 7 | HDAC9 | NA | HDAC9 Entrez, Source | histone deacetylase 9 | 179 | 2.349 | 0.2385 | Yes |
| 8 | ICAM1 | NA | ICAM1 Entrez, Source | intercellular adhesion molecule 1 (CD54), human rhinovirus receptor | 251 | 1.952 | 0.2549 | Yes |
| 9 | TLR3 | NA | TLR3 Entrez, Source | toll-like receptor 3 | 284 | 1.798 | 0.2726 | Yes |
| 10 | IL12B | NA | IL12B Entrez, Source | interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) | 366 | 1.567 | 0.2840 | Yes |
| 11 | IL27RA | NA | IL27RA Entrez, Source | interleukin 27 receptor, alpha | 493 | 1.326 | 0.2895 | Yes |
| 12 | ETS1 | NA | ETS1 Entrez, Source | v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) | 498 | 1.319 | 0.3039 | Yes |
| 13 | EGFR | NA | EGFR Entrez, Source | epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) | 637 | 1.150 | 0.3065 | Yes |
| 14 | FLNA | NA | FLNA Entrez, Source | filamin A, alpha (actin binding protein 280) | 640 | 1.148 | 0.3191 | Yes |
| 15 | TAP1 | NA | TAP1 Entrez, Source | transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) | 686 | 1.112 | 0.3282 | Yes |
| 16 | IL4R | NA | IL4R Entrez, Source | interleukin 4 receptor | 732 | 1.063 | 0.3367 | Yes |
| 17 | LIF | NA | LIF Entrez, Source | leukemia inhibitory factor (cholinergic differentiation factor) | 745 | 1.056 | 0.3475 | Yes |
| 18 | JAK2 | NA | JAK2 Entrez, Source | Janus kinase 2 (a protein tyrosine kinase) | 756 | 1.045 | 0.3584 | Yes |
| 19 | CCL22 | NA | CCL22 Entrez, Source | chemokine (C-C motif) ligand 22 | 758 | 1.042 | 0.3698 | Yes |
| 20 | IL11 | NA | IL11 Entrez, Source | interleukin 11 | 773 | 1.035 | 0.3803 | Yes |
| 21 | IL18 | NA | IL18 Entrez, Source | interleukin 18 (interferon-gamma-inducing factor) | 831 | 0.988 | 0.3871 | Yes |
| 22 | TAP2 | NA | TAP2 Entrez, Source | transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) | 930 | 0.929 | 0.3902 | Yes |
| 23 | BCL10 | NA | BCL10 Entrez, Source | B-cell CLL/lymphoma 10 | 1088 | 0.855 | 0.3883 | Yes |
| 24 | CD1D | NA | CD1D Entrez, Source | CD1d molecule | 1162 | 0.827 | 0.3921 | Yes |
| 25 | CSK | NA | CSK Entrez, Source | c-src tyrosine kinase | 1191 | 0.815 | 0.3991 | Yes |
| 26 | SRGN | NA | 1409 | 0.741 | 0.3915 | Yes | ||
| 27 | PRKCG | NA | PRKCG Entrez, Source | protein kinase C, gamma | 1414 | 0.740 | 0.3994 | Yes |
| 28 | TGFB1 | NA | TGFB1 Entrez, Source | transforming growth factor, beta 1 (Camurati-Engelmann disease) | 1560 | 0.700 | 0.3966 | Yes |
| 29 | CRTAM | NA | CRTAM Entrez, Source | cytotoxic and regulatory T cell molecule | 1617 | 0.684 | 0.4001 | Yes |
| 30 | GLMN | NA | GLMN Entrez, Source | glomulin, FKBP associated protein | 1714 | 0.654 | 0.4003 | Yes |
| 31 | HIF1A | NA | HIF1A Entrez, Source | hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 1871 | 0.613 | 0.3957 | No |
| 32 | PSMB10 | NA | PSMB10 Entrez, Source | proteasome (prosome, macropain) subunit, beta type, 10 | 2030 | 0.581 | 0.3906 | No |
| 33 | DYRK3 | NA | DYRK3 Entrez, Source | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 | 2120 | 0.566 | 0.3904 | No |
| 34 | RARS | NA | RARS Entrez, Source | arginyl-tRNA synthetase | 2282 | 0.536 | 0.3846 | No |
| 35 | UBE2D1 | NA | UBE2D1 Entrez, Source | ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) | 2303 | 0.533 | 0.3891 | No |
| 36 | TAPBP | NA | TAPBP Entrez, Source | TAP binding protein (tapasin) | 2339 | 0.526 | 0.3923 | No |
| 37 | STAT1 | NA | STAT1 Entrez, Source | signal transducer and activator of transcription 1, 91kDa | 2374 | 0.520 | 0.3956 | No |
| 38 | BCL3 | NA | BCL3 Entrez, Source | B-cell CLL/lymphoma 3 | 2421 | 0.512 | 0.3979 | No |
| 39 | IL1B | NA | IL1B Entrez, Source | interleukin 1, beta | 2581 | 0.487 | 0.3917 | No |
| 40 | INHBB | NA | INHBB Entrez, Source | inhibin, beta B (activin AB beta polypeptide) | 2833 | 0.446 | 0.3784 | No |
| 41 | HLA-DOB | NA | HLA-DOB Entrez, Source | major histocompatibility complex, class II, DO beta | 2939 | 0.428 | 0.3755 | No |
| 42 | IFNAR2 | NA | IFNAR2 Entrez, Source | interferon (alpha, beta and omega) receptor 2 | 3310 | 0.381 | 0.3527 | No |
| 43 | HLA-E | NA | HLA-E Entrez, Source | major histocompatibility complex, class I, E | 3341 | 0.377 | 0.3547 | No |
| 44 | IL2RA | NA | IL2RA Entrez, Source | interleukin 2 receptor, alpha | 3404 | 0.367 | 0.3542 | No |
| 45 | FAS | NA | FAS Entrez, Source | Fas (TNF receptor superfamily, member 6) | 3457 | 0.360 | 0.3544 | No |
| 46 | LYN | NA | LYN Entrez, Source | v-yes-1 Yamaguchi sarcoma viral related oncogene homolog | 3567 | 0.347 | 0.3503 | No |
| 47 | F2R | NA | F2R Entrez, Source | coagulation factor II (thrombin) receptor | 3598 | 0.344 | 0.3519 | No |
| 48 | HLA-A | NA | HLA-A Entrez, Source | major histocompatibility complex, class I, A | 3659 | 0.337 | 0.3513 | No |
| 49 | UBE2N | NA | UBE2N Entrez, Source | ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast) | 3666 | 0.336 | 0.3546 | No |
| 50 | ELF4 | NA | ELF4 Entrez, Source | E74-like factor 4 (ets domain transcription factor) | 3673 | 0.336 | 0.3579 | No |
| 51 | EIF3J | NA | 3696 | 0.333 | 0.3599 | No | ||
| 52 | B2M | NA | B2M Entrez, Source | beta-2-microglobulin | 3752 | 0.328 | 0.3596 | No |
| 53 | PTPRC | NA | PTPRC Entrez, Source | protein tyrosine phosphatase, receptor type, C | 3881 | 0.312 | 0.3537 | No |
| 54 | WAS | NA | WAS Entrez, Source | Wiskott-Aldrich syndrome (eczema-thrombocytopenia) | 3921 | 0.307 | 0.3542 | No |
| 55 | TIMP1 | NA | TIMP1 Entrez, Source | TIMP metallopeptidase inhibitor 1 | 4124 | 0.284 | 0.3426 | No |
| 56 | IFNGR1 | NA | IFNGR1 Entrez, Source | interferon gamma receptor 1 | 4135 | 0.284 | 0.3451 | No |
| 57 | ABCE1 | NA | ABCE1 Entrez, Source | ATP-binding cassette, sub-family E (OABP), member 1 | 4437 | 0.250 | 0.3259 | No |
| 58 | NLRP3 | NA | 4507 | 0.242 | 0.3235 | No | ||
| 59 | CD28 | NA | CD28 Entrez, Source | CD28 molecule | 4530 | 0.239 | 0.3246 | No |
| 60 | ACVR2A | NA | ACVR2A Entrez, Source | activin A receptor, type IIA | 4566 | 0.235 | 0.3246 | No |
| 61 | EIF5A | NA | EIF5A Entrez, Source | eukaryotic translation initiation factor 5A | 4571 | 0.235 | 0.3269 | No |
| 62 | RIPK2 | NA | RIPK2 Entrez, Source | receptor-interacting serine-threonine kinase 2 | 4588 | 0.233 | 0.3284 | No |
| 63 | TGFB2 | NA | TGFB2 Entrez, Source | transforming growth factor, beta 2 | 4731 | 0.219 | 0.3204 | No |
| 64 | TPD52 | NA | TPD52 Entrez, Source | tumor protein D52 | 4775 | 0.214 | 0.3197 | No |
| 65 | NPM1 | NA | NPM1 Entrez, Source | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 4781 | 0.214 | 0.3217 | No |
| 66 | MMP9 | NA | MMP9 Entrez, Source | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | 4824 | 0.209 | 0.3209 | No |
| 67 | MTIF2 | NA | MTIF2 Entrez, Source | mitochondrial translational initiation factor 2 | 4853 | 0.206 | 0.3212 | No |
| 68 | IL15 | NA | IL15 Entrez, Source | interleukin 15 | 5495 | 0.140 | 0.2759 | No |
| 69 | CCND3 | NA | CCND3 Entrez, Source | cyclin D3 | 5722 | 0.114 | 0.2607 | No |
| 70 | EREG | NA | EREG Entrez, Source | epiregulin | 5954 | 0.092 | 0.2449 | No |
| 71 | ABI1 | NA | ABI1 Entrez, Source | abl-interactor 1 | 6119 | 0.075 | 0.2337 | No |
| 72 | MRPL3 | NA | MRPL3 Entrez, Source | mitochondrial ribosomal protein L3 | 6213 | 0.066 | 0.2277 | No |
| 73 | TRAF2 | NA | TRAF2 Entrez, Source | TNF receptor-associated factor 2 | 6274 | 0.060 | 0.2240 | No |
| 74 | HLA-G | NA | HLA-G Entrez, Source | HLA-G histocompatibility antigen, class I, G | 6560 | 0.031 | 0.2035 | No |
| 75 | GALNT1 | NA | GALNT1 Entrez, Source | UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1) | 6629 | 0.025 | 0.1988 | No |
| 76 | EIF3A | NA | 6675 | 0.021 | 0.1958 | No | ||
| 77 | TLR6 | NA | TLR6 Entrez, Source | toll-like receptor 6 | 7027 | -0.016 | 0.1703 | No |
| 78 | LY75 | NA | LY75 Entrez, Source | lymphocyte antigen 75 | 7225 | -0.036 | 0.1564 | No |
| 79 | DARS | NA | DARS Entrez, Source | aspartyl-tRNA synthetase | 7426 | -0.059 | 0.1424 | No |
| 80 | BCAT1 | NA | BCAT1 Entrez, Source | branched chain aminotransferase 1, cytosolic | 7455 | -0.062 | 0.1411 | No |
| 81 | DEGS1 | NA | DEGS1 Entrez, Source | degenerative spermatocyte homolog 1, lipid desaturase (Drosophila) | 7676 | -0.082 | 0.1259 | No |
| 82 | EIF3D | NA | 7762 | -0.091 | 0.1207 | No | ||
| 83 | CD4 | NA | CD4 Entrez, Source | CD4 molecule | 7841 | -0.098 | 0.1161 | No |
| 84 | FASLG | NA | FASLG Entrez, Source | Fas ligand (TNF superfamily, member 6) | 7920 | -0.106 | 0.1116 | No |
| 85 | C2 | NA | C2 Entrez, Source | complement component 2 | 8029 | -0.117 | 0.1050 | No |
| 86 | IL18RAP | NA | IL18RAP Entrez, Source | interleukin 18 receptor accessory protein | 8072 | -0.123 | 0.1033 | No |
| 87 | EIF4G3 | NA | EIF4G3 Entrez, Source | eukaryotic translation initiation factor 4 gamma, 3 | 8089 | -0.125 | 0.1035 | No |
| 88 | GPR65 | NA | GPR65 Entrez, Source | G protein-coupled receptor 65 | 8400 | -0.157 | 0.0827 | No |
| 89 | IRF4 | NA | IRF4 Entrez, Source | interferon regulatory factor 4 | 8687 | -0.189 | 0.0639 | No |
| 90 | ICOSLG | NA | ICOSLG Entrez, Source | inducible T-cell co-stimulator ligand | 8708 | -0.192 | 0.0645 | No |
| 91 | SOCS5 | NA | SOCS5 Entrez, Source | suppressor of cytokine signaling 5 | 8711 | -0.192 | 0.0665 | No |
| 92 | STAT4 | NA | STAT4 Entrez, Source | signal transducer and activator of transcription 4 | 8849 | -0.208 | 0.0588 | No |
| 93 | BRCA1 | NA | BRCA1 Entrez, Source | breast cancer 1, early onset | 8895 | -0.214 | 0.0579 | No |
| 94 | MAP3K7 | NA | MAP3K7 Entrez, Source | mitogen-activated protein kinase kinase kinase 7 | 8905 | -0.215 | 0.0597 | No |
| 95 | NCK1 | NA | NCK1 Entrez, Source | NCK adaptor protein 1 | 8954 | -0.220 | 0.0586 | No |
| 96 | CCND2 | NA | CCND2 Entrez, Source | cyclin D2 | 8965 | -0.222 | 0.0603 | No |
| 97 | IL2RB | NA | IL2RB Entrez, Source | interleukin 2 receptor, beta | 8981 | -0.223 | 0.0617 | No |
| 98 | GCNT1 | NA | GCNT1 Entrez, Source | glucosaminyl (N-acetyl) transferase 1, core 2 (beta-1,6-N-acetylglucosaminyltransferase) | 8988 | -0.224 | 0.0637 | No |
| 99 | CDKN2A | NA | CDKN2A Entrez, Source | cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) | 9023 | -0.228 | 0.0638 | No |
| 100 | KLRD1 | NA | KLRD1 Entrez, Source | killer cell lectin-like receptor subfamily D, member 1 | 9157 | -0.244 | 0.0568 | No |
| 101 | RPS9 | NA | RPS9 Entrez, Source | ribosomal protein S9 | 9271 | -0.259 | 0.0514 | No |
| 102 | NME1 | NA | NME1 Entrez, Source | non-metastatic cells 1, protein (NM23A) expressed in | 9382 | -0.276 | 0.0465 | No |
| 103 | RPL3L | NA | RPL3L Entrez, Source | ribosomal protein L3-like | 9427 | -0.283 | 0.0464 | No |
| 104 | CAPG | NA | CAPG Entrez, Source | capping protein (actin filament), gelsolin-like | 9453 | -0.286 | 0.0477 | No |
| 105 | CD96 | NA | CD96 Entrez, Source | CD96 molecule | 9476 | -0.290 | 0.0493 | No |
| 106 | IFNGR2 | NA | IFNGR2 Entrez, Source | interferon gamma receptor 2 (interferon gamma transducer 1) | 9538 | -0.299 | 0.0482 | No |
| 107 | MAP4K1 | NA | MAP4K1 Entrez, Source | mitogen-activated protein kinase kinase kinase kinase 1 | 9763 | -0.331 | 0.0355 | No |
| 108 | IKBKB | NA | IKBKB Entrez, Source | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | 9844 | -0.344 | 0.0335 | No |
| 109 | RPS19 | NA | RPS19 Entrez, Source | ribosomal protein S19 | 9856 | -0.346 | 0.0365 | No |
| 110 | CD3G | NA | CD3G Entrez, Source | CD3g molecule, gamma (CD3-TCR complex) | 9937 | -0.355 | 0.0346 | No |
| 111 | NOS2 | NA | 10051 | -0.372 | 0.0305 | No | ||
| 112 | AKT1 | NA | AKT1 Entrez, Source | v-akt murine thymoma viral oncogene homolog 1 | 10063 | -0.374 | 0.0338 | No |
| 113 | HLA-DOA | NA | HLA-DOA Entrez, Source | major histocompatibility complex, class II, DO alpha | 10548 | -0.449 | 0.0035 | No |
| 114 | IL10 | NA | IL10 Entrez, Source | interleukin 10 | 10658 | -0.469 | 0.0008 | No |
| 115 | RPL9 | NA | RPL9 Entrez, Source | ribosomal protein L9 | 11054 | -0.538 | -0.0221 | No |
| 116 | RPL39 | NA | RPL39 Entrez, Source | ribosomal protein L39 | 11073 | -0.541 | -0.0174 | No |
| 117 | RPS3A | NA | RPS3A Entrez, Source | ribosomal protein S3A | 11403 | -0.606 | -0.0347 | No |
| 118 | ST8SIA4 | NA | ST8SIA4 Entrez, Source | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 | 11534 | -0.632 | -0.0372 | No |
| 119 | ITGAL | NA | ITGAL Entrez, Source | integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) | 11792 | -0.695 | -0.0482 | No |
| 120 | ITGB2 | NA | ITGB2 Entrez, Source | integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) | 11846 | -0.711 | -0.0442 | No |
| 121 | TLR1 | NA | TLR1 Entrez, Source | toll-like receptor 1 | 11940 | -0.736 | -0.0428 | No |
| 122 | CFP | NA | CFP Entrez, Source | complement factor properdin | 12040 | -0.769 | -0.0415 | No |
| 123 | CD47 | NA | CD47 Entrez, Source | CD47 molecule | 12103 | -0.788 | -0.0373 | No |
| 124 | CD80 | NA | CD80 Entrez, Source | CD80 molecule | 12189 | -0.816 | -0.0345 | No |
| 125 | IL16 | NA | IL16 Entrez, Source | interleukin 16 (lymphocyte chemoattractant factor) | 12513 | -0.945 | -0.0476 | No |
| 126 | PTPN6 | NA | PTPN6 Entrez, Source | protein tyrosine phosphatase, non-receptor type 6 | 12791 | -1.084 | -0.0558 | No |
| 127 | AARS | NA | AARS Entrez, Source | alanyl-tRNA synthetase | 12872 | -1.135 | -0.0490 | No |
| 128 | CCR1 | NA | CCR1 Entrez, Source | chemokine (C-C motif) receptor 1 | 13495 | -1.800 | -0.0745 | No |
| 129 | STAB1 | NA | STAB1 Entrez, Source | stabilin 1 | 13598 | -2.061 | -0.0591 | No |
| 130 | GBP2 | NA | GBP2 Entrez, Source | guanylate binding protein 2, interferon-inducible | 13642 | -2.224 | -0.0375 | No |
| 131 | PRKCB | NA | 13643 | -2.224 | -0.0129 | No | ||
| 132 | HLA-DMA | NA | HLA-DMA Entrez, Source | major histocompatibility complex, class II, DM alpha | 13683 | -2.412 | 0.0110 | No |
