Datasetw6a_vs_wt_vs_wt.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp.w6a_vs_wt.cls
#ago1w6a_versus_ago1gfp_repos
Phenotypew6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos
Upregulated in classago1gfp
GeneSetHALLMARK_ADIPOGENESIS
Enrichment Score (ES)-0.43721482
Normalized Enrichment Score (NES)-1.7618433
Nominal p-value0.0
FDR q-value0.0062030437
FWER p-Value0.024
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_ADIPOGENESIS   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1LAMA4NALAMA4
Entrez,  Source
laminin, alpha 41032.9270.0216No
2GADD45ANAGADD45A
Entrez,  Source
growth arrest and DNA-damage-inducible, alpha1612.4290.0416No
3SLC5A6NASLC5A6
Entrez,  Source
solute carrier family 5 (sodium-dependent vitamin transporter), member 610590.866-0.0154No
4STAT5ANASTAT5A
Entrez,  Source
signal transducer and activator of transcription 5A12380.797-0.0205No
5SLC19A1NASLC19A1
Entrez,  Source
solute carrier family 19 (folate transporter), member 114270.736-0.0270No
6SLC1A5NASLC1A5
Entrez,  Source
solute carrier family 1 (neutral amino acid transporter), member 516240.681-0.0345No
7SPARCL1NASPARCL1
Entrez,  Source
SPARC-like 1 (mast9, hevin)16580.672-0.0303No
8LEPNALEP
Entrez,  Source
leptin (obesity homolog, mouse)17710.638-0.0321No
9MYLKNAMYLK
Entrez,  Source
myosin, light chain kinase18060.632-0.0283No
10GRPEL1NAGRPEL1
Entrez,  Source
GrpE-like 1, mitochondrial (E. coli)18500.619-0.0253No
11PPM1BNAPPM1B
Entrez,  Source
protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform20230.582-0.0321No
12PFKFB3NAPFKFB3
Entrez,  Source
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 321410.563-0.0350No
13PPARGNAPPARG
Entrez,  Source
peroxisome proliferative activated receptor, gamma22780.537-0.0397No
14STOMNASTOM
Entrez,  Source
stomatin23570.523-0.0402No
15COL4A1NACOL4A1
Entrez,  Source
collagen, type IV, alpha 124080.514-0.0387No
16GPX3NAGPX3
Entrez,  Source
glutathione peroxidase 3 (plasma)25700.489-0.0456No
17ATL2NA25970.485-0.0427No
18MAP4K3NAMAP4K3
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 326660.473-0.0430No
19ARL4ANAARL4A
Entrez,  Source
ADP-ribosylation factor-like 4A29010.434-0.0558No
20CHUKNACHUK
Entrez,  Source
conserved helix-loop-helix ubiquitous kinase29970.421-0.0585No
21HSPB8NAHSPB8
Entrez,  Source
heat shock 22kDa protein 830860.410-0.0609No
22GPHNNAGPHN
Entrez,  Source
gephyrin31390.402-0.0607No
23DBTNADBT
Entrez,  Source
dihydrolipoamide branched chain transacylase E233160.380-0.0698No
24UBQLN1NAUBQLN1
Entrez,  Source
ubiquilin 134070.367-0.0727No
25CSNACS
Entrez,  Source
citrate synthase34610.359-0.0731No
26ITIH5NAITIH5
Entrez,  Source
inter-alpha (globulin) inhibitor H536140.343-0.0808No
27UBCNAUBC
Entrez,  Source
ubiquitin C40900.288-0.1127No
28IFNGR1NAIFNGR1
Entrez,  Source
interferon gamma receptor 141350.284-0.1131No
29GBE1NAGBE1
Entrez,  Source
glucan (1,4-alpha-), branching enzyme 1 (glycogen branching enzyme, Andersen disease, glycogen storage disease type IV)45450.237-0.1407No
30IDH3ANAIDH3A
Entrez,  Source
isocitrate dehydrogenase 3 (NAD+) alpha46550.228-0.1464No
31QDPRNAQDPR
Entrez,  Source
quinoid dihydropteridine reductase46760.225-0.1456No
32PEMTNAPEMT
Entrez,  Source
phosphatidylethanolamine N-methyltransferase47820.214-0.1511No
33TANKNATANK
Entrez,  Source
TRAF family member-associated NFKB activator47900.213-0.1495No
34ARAFNAARAF
Entrez,  Source
v-raf murine sarcoma 3611 viral oncogene homolog48180.209-0.1494No
35MGLLNAMGLL
Entrez,  Source
monoglyceride lipase48760.204-0.1516No
36BAZ2ANABAZ2A
Entrez,  Source
bromodomain adjacent to zinc finger domain, 2A50010.192-0.1587No
37MRPL15NAMRPL15
Entrez,  Source
mitochondrial ribosomal protein L1550140.190-0.1577No
38NKIRAS1NANKIRAS1
Entrez,  Source
NFKB inhibitor interacting Ras-like 150790.183-0.1606No
39YWHAGNAYWHAG
Entrez,  Source
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide51160.180-0.1614No
40AGPAT3NAAGPAT3
Entrez,  Source
1-acylglycerol-3-phosphate O-acyltransferase 352330.168-0.1683No
41PHYHNAPHYH
Entrez,  Source
phytanoyl-CoA 2-hydroxylase54810.141-0.1849No
42ANGPT1NAANGPT1
Entrez,  Source
angiopoietin 154940.140-0.1844No
43NMT1NANMT1
Entrez,  Source
N-myristoyltransferase 155350.136-0.1860No
44RNF11NARNF11
Entrez,  Source
ring finger protein 1155790.130-0.1878No
45PREBNAPREB
Entrez,  Source
prolactin regulatory element binding56310.123-0.1903No
46AK2NAAK2
Entrez,  Source
adenylate kinase 256320.123-0.1891No
47FAHNAFAH
Entrez,  Source
fumarylacetoacetate hydrolase (fumarylacetoacetase)58190.105-0.2017No
48ALDOANAALDOA
Entrez,  Source
aldolase A, fructose-bisphosphate58800.100-0.2051No
49DHRS7BNADHRS7B
Entrez,  Source
dehydrogenase/reductase (SDR family) member 7B58820.100-0.2042No
50ESRRANAESRRA
Entrez,  Source
estrogen-related receptor alpha59940.088-0.2114No
51RETSATNARETSAT
Entrez,  Source
retinol saturase (all-trans-retinol 13,14-reductase)63620.053-0.2378No
52CMPK1NA63830.051-0.2387No
53UCK1NAUCK1
Entrez,  Source
uridine-cytidine kinase 164060.049-0.2399No
54ELMOD3NA65350.035-0.2489No
55ELOVL6NAELOVL6
Entrez,  Source
ELOVL family member 6, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)66450.023-0.2566No
56SAMM50NASAMM50
Entrez,  Source
sorting and assembly machinery component 50 homolog (S. cerevisiae)66910.018-0.2597No
57RAB34NARAB34
Entrez,  Source
RAB34, member RAS oncogene family67500.012-0.2639No
58JAGN1NAJAGN1
Entrez,  Source
jagunal homolog 1 (Drosophila)7053-0.019-0.2858No
59ESYT1NA7258-0.040-0.3003No
60DNAJC15NADNAJC15
Entrez,  Source
DnaJ (Hsp40) homolog, subfamily C, member 157340-0.049-0.3058No
61PEX14NAPEX14
Entrez,  Source
peroxisomal biogenesis factor 147364-0.052-0.3069No
62PHLDB1NAPHLDB1
Entrez,  Source
pleckstrin homology-like domain, family B, member 17424-0.058-0.3107No
63DNAJB9NADNAJB9
Entrez,  Source
DnaJ (Hsp40) homolog, subfamily B, member 97519-0.068-0.3169No
64RIOK3NARIOK3
Entrez,  Source
RIO kinase 3 (yeast)7551-0.071-0.3184No
65UQCR11NA7644-0.079-0.3244No
66PLIN2NA7654-0.080-0.3242No
67NDUFB7NANDUFB7
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa7777-0.092-0.3323No
68ADCY6NAADCY6
Entrez,  Source
adenylate cyclase 67804-0.095-0.3332No
69ANGPTL4NAANGPTL4
Entrez,  Source
angiopoietin-like 47970-0.111-0.3442No
70TKTNATKT
Entrez,  Source
transketolase (Wernicke-Korsakoff syndrome)7997-0.113-0.3450No
71PTCD3NAPTCD3
Entrez,  Source
Pentatricopeptide repeat domain 38154-0.132-0.3551No
72ME1NAME1
Entrez,  Source
malic enzyme 1, NADP(+)-dependent, cytosolic8293-0.146-0.3637No
73ITSN1NAITSN1
Entrez,  Source
intersectin 1 (SH3 domain protein)8436-0.161-0.3725No
74DLATNADLAT
Entrez,  Source
dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)8620-0.182-0.3841No
75PIM3NAPIM3
Entrez,  Source
pim-3 oncogene8628-0.183-0.3828No
76RREB1NARREB1
Entrez,  Source
ras responsive element binding protein 18649-0.185-0.3824No
77ADIPOR2NAADIPOR2
Entrez,  Source
adiponectin receptor 28728-0.194-0.3862No
78GPD2NAGPD2
Entrez,  Source
glycerol-3-phosphate dehydrogenase 2 (mitochondrial)8930-0.218-0.3987No
79G3BP2NAG3BP2
Entrez,  Source
-8956-0.221-0.3984No
80CDKN2CNACDKN2C
Entrez,  Source
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)8975-0.223-0.3975No
81LIFRNALIFR
Entrez,  Source
leukemia inhibitory factor receptor alpha8985-0.224-0.3959No
82ADIPOQNAADIPOQ
Entrez,  Source
adiponectin, C1Q and collagen domain containing9154-0.244-0.4058No
83ACLYNAACLY
Entrez,  Source
ATP citrate lyase9171-0.246-0.4045No
84CPT2NACPT2
Entrez,  Source
carnitine palmitoyltransferase II9235-0.255-0.4066No
85DHRS7NADHRS7
Entrez,  Source
dehydrogenase/reductase (SDR family) member 79330-0.268-0.4108No
86SSPNNASSPN
Entrez,  Source
sarcospan (Kras oncogene-associated gene)9467-0.288-0.4179No
87IDH3GNAIDH3G
Entrez,  Source
isocitrate dehydrogenase 3 (NAD+) gamma9487-0.293-0.4164No
88BCL2L13NABCL2L13
Entrez,  Source
BCL2-like 13 (apoptosis facilitator)9505-0.296-0.4147No
89GPAMNAGPAM
Entrez,  Source
glycerol-3-phosphate acyltransferase, mitochondrial9543-0.299-0.4144No
90NDUFAB1NANDUFAB1
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa9593-0.305-0.4149No
91DLDNADLD
Entrez,  Source
dihydrolipoamide dehydrogenase9719-0.325-0.4209No
92APLP2NAAPLP2
Entrez,  Source
amyloid beta (A4) precursor-like protein 29906-0.351-0.4310No
93NDUFS3NANDUFS3
Entrez,  Source
NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase)9933-0.354-0.4294No
94BCL6NABCL6
Entrez,  Source
B-cell CLL/lymphoma 6 (zinc finger protein 51)9958-0.358-0.4276No
95HIBCHNAHIBCH
Entrez,  Source
3-hydroxyisobutyryl-Coenzyme A hydrolase9987-0.362-0.4260No
96ABCB8NAABCB8
Entrez,  Source
ATP-binding cassette, sub-family B (MDR/TAP), member 810009-0.365-0.4239No
97TALDO1NATALDO1
Entrez,  Source
transaldolase 110011-0.366-0.4203No
98AIFM1NA10050-0.372-0.4194No
99MTCH2NAMTCH2
Entrez,  Source
mitochondrial carrier homolog 2 (C. elegans)10082-0.376-0.4179No
100GHITMNAGHITM
Entrez,  Source
growth hormone inducible transmembrane protein10311-0.411-0.4305No
101IMMTNAIMMT
Entrez,  Source
inner membrane protein, mitochondrial (mitofilin)10357-0.419-0.4297No
102SDHBNASDHB
Entrez,  Source
succinate dehydrogenase complex, subunit B, iron sulfur (Ip)10461-0.436-0.4329Yes
103CD151NACD151
Entrez,  Source
CD151 molecule (Raph blood group)10463-0.436-0.4286Yes
104REEP5NAREEP5
Entrez,  Source
receptor accessory protein 510483-0.439-0.4256Yes
105MDH2NAMDH2
Entrez,  Source
malate dehydrogenase 2, NAD (mitochondrial)10593-0.456-0.4291Yes
106ACAA2NAACAA2
Entrez,  Source
acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase)10640-0.466-0.4278Yes
107UQCRC1NAUQCRC1
Entrez,  Source
ubiquinol-cytochrome c reductase core protein I10695-0.475-0.4270Yes
108ETFBNAETFB
Entrez,  Source
electron-transfer-flavoprotein, beta polypeptide10709-0.477-0.4232Yes
109SCP2NASCP2
Entrez,  Source
sterol carrier protein 210711-0.477-0.4185Yes
110RTN3NARTN3
Entrez,  Source
reticulon 310778-0.490-0.4185Yes
111SULT1A1NASULT1A1
Entrez,  Source
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 110805-0.494-0.4155Yes
112ATP1B3NAATP1B3
Entrez,  Source
ATPase, Na+/K+ transporting, beta 3 polypeptide10869-0.505-0.4151Yes
113DRAM2NA10882-0.507-0.4109Yes
114SDHCNASDHC
Entrez,  Source
succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa10930-0.514-0.4092Yes
115CMBLNACMBL
Entrez,  Source
carboxymethylenebutenolidase homolog (Pseudomonas)11070-0.540-0.4140Yes
116SCARB1NASCARB1
Entrez,  Source
scavenger receptor class B, member 111081-0.543-0.4094Yes
117LPCAT3NA11163-0.557-0.4097Yes
118CYC1NACYC1
Entrez,  Source
cytochrome c-111222-0.567-0.4083Yes
119UCP2NAUCP2
Entrez,  Source
uncoupling protein 2 (mitochondrial, proton carrier)11373-0.598-0.4134Yes
120HADHNAHADH
Entrez,  Source
hydroxyacyl-Coenzyme A dehydrogenase11456-0.615-0.4132Yes
121ACOX1NAACOX1
Entrez,  Source
acyl-Coenzyme A oxidase 1, palmitoyl11472-0.619-0.4082Yes
122COQ3NACOQ3
Entrez,  Source
coenzyme Q3 homolog, methyltransferase (S. cerevisiae)11611-0.653-0.4118Yes
123UQCRQNAUQCRQ
Entrez,  Source
ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa11614-0.653-0.4054Yes
124PPP1R15BNAPPP1R15B
Entrez,  Source
protein phosphatase 1, regulatory (inhibitor) subunit 15B11634-0.657-0.4003Yes
125PGM1NAPGM1
Entrez,  Source
phosphoglucomutase 111686-0.669-0.3973Yes
126SOD1NASOD1
Entrez,  Source
superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult))11746-0.684-0.3949Yes
127ATP5ONAATP5O
Entrez,  Source
ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit (oligomycin sensitivity conferring protein)11766-0.689-0.3894Yes
128COX6A1NACOX6A1
Entrez,  Source
cytochrome c oxidase subunit VIa polypeptide 111769-0.690-0.3827Yes
129TOB1NATOB1
Entrez,  Source
transducer of ERBB2, 111787-0.694-0.3770Yes
130ABCA1NAABCA1
Entrez,  Source
ATP-binding cassette, sub-family A (ABC1), member 111871-0.716-0.3759Yes
131DDTNADDT
Entrez,  Source
D-dopachrome tautomerase11882-0.721-0.3695Yes
132LIPENALIPE
Entrez,  Source
lipase, hormone-sensitive11935-0.735-0.3660Yes
133ECHS1NAECHS1
Entrez,  Source
enoyl Coenzyme A hydratase, short chain, 1, mitochondrial11963-0.742-0.3606Yes
134CD36NACD36
Entrez,  Source
CD36 molecule (thrombospondin receptor)11998-0.756-0.3555Yes
135COQ9NACOQ9
Entrez,  Source
coenzyme Q9 homolog (S. cerevisiae)12002-0.758-0.3482Yes
136PRDX3NAPRDX3
Entrez,  Source
peroxiredoxin 312033-0.766-0.3428Yes
137PQLC3NAPQLC3
Entrez,  Source
PQ loop repeat containing 312065-0.777-0.3373Yes
138UQCR10NA12066-0.777-0.3296Yes
139SUCLG1NASUCLG1
Entrez,  Source
succinate-CoA ligase, GDP-forming, alpha subunit12083-0.781-0.3230Yes
140ACADMNAACADM
Entrez,  Source
acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain12101-0.786-0.3164Yes
141DHCR7NADHCR7
Entrez,  Source
7-dehydrocholesterol reductase12147-0.804-0.3117Yes
142ACO2NAACO2
Entrez,  Source
aconitase 2, mitochondrial12178-0.814-0.3058Yes
143COQ5NACOQ5
Entrez,  Source
coenzyme Q5 homolog, methyltransferase (S. cerevisiae)12184-0.815-0.2980Yes
144COX8ANACOX8A
Entrez,  Source
cytochrome c oxidase subunit 8A (ubiquitous)12241-0.834-0.2938Yes
145SLC25A10NASLC25A10
Entrez,  Source
solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 1012255-0.837-0.2864Yes
146NDUFA5NANDUFA5
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5, 13kDa12296-0.850-0.2809Yes
147SORBS1NASORBS1
Entrez,  Source
sorbin and SH3 domain containing 112303-0.852-0.2728Yes
148FZD4NAFZD4
Entrez,  Source
frizzled homolog 4 (Drosophila)12329-0.865-0.2661Yes
149VEGFBNAVEGFB
Entrez,  Source
vascular endothelial growth factor B12361-0.878-0.2596Yes
150ITGA7NAITGA7
Entrez,  Source
integrin, alpha 712379-0.885-0.2520Yes
151LPLNALPL
Entrez,  Source
lipoprotein lipase12381-0.886-0.2433Yes
152DGAT1NADGAT1
Entrez,  Source
diacylglycerol O-acyltransferase homolog 1 (mouse)12403-0.891-0.2359Yes
153TSTNATST
Entrez,  Source
thiosulfate sulfurtransferase (rhodanese)12431-0.907-0.2289Yes
154SLC25A1NASLC25A1
Entrez,  Source
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 112442-0.911-0.2205Yes
155SLC27A1NASLC27A1
Entrez,  Source
solute carrier family 27 (fatty acid transporter), member 112488-0.932-0.2145Yes
156MCCC1NAMCCC1
Entrez,  Source
methylcrotonoyl-Coenzyme A carboxylase 1 (alpha)12490-0.932-0.2053Yes
157PORNAPOR
Entrez,  Source
P450 (cytochrome) oxidoreductase12492-0.933-0.1961Yes
158BCKDHANABCKDHA
Entrez,  Source
branched chain keto acid dehydrogenase E1, alpha polypeptide12554-0.963-0.1910Yes
159CHCHD10NA12687-1.030-0.1904Yes
160GPX4NAGPX4
Entrez,  Source
glutathione peroxidase 4 (phospholipid hydroperoxidase)12713-1.042-0.1819Yes
161DECR1NADECR1
Entrez,  Source
2,4-dienoyl CoA reductase 1, mitochondrial12865-1.131-0.1817Yes
162ACADSNAACADS
Entrez,  Source
acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain12961-1.190-0.1768Yes
163COX7BNACOX7B
Entrez,  Source
cytochrome c oxidase subunit VIIb12976-1.199-0.1659Yes
164IDH1NAIDH1
Entrez,  Source
isocitrate dehydrogenase 1 (NADP+), soluble13083-1.285-0.1608Yes
165ALDH2NAALDH2
Entrez,  Source
aldehyde dehydrogenase 2 family (mitochondrial)13109-1.302-0.1497Yes
166COL15A1NACOL15A1
Entrez,  Source
collagen, type XV, alpha 113119-1.313-0.1373Yes
167CRATNACRAT
Entrez,  Source
carnitine acetyltransferase13125-1.314-0.1246Yes
168PTGER3NAPTGER3
Entrez,  Source
prostaglandin E receptor 3 (subtype EP3)13180-1.375-0.1148Yes
169PFKLNAPFKL
Entrez,  Source
phosphofructokinase, liver13274-1.484-0.1069Yes
170PDCD4NAPDCD4
Entrez,  Source
programmed cell death 4 (neoplastic transformation inhibitor)13296-1.508-0.0934Yes
171ECH1NAECH1
Entrez,  Source
enoyl Coenzyme A hydratase 1, peroxisomal13349-1.579-0.0815Yes
172CATNACAT
Entrez,  Source
catalase13474-1.769-0.0729Yes
173MGST3NAMGST3
Entrez,  Source
microsomal glutathione S-transferase 313497-1.809-0.0565Yes
174C3NAC3
Entrez,  Source
complement component 313533-1.896-0.0402Yes
175REEP6NAREEP6
Entrez,  Source
receptor accessory protein 613536-1.900-0.0214Yes
176SNCGNASNCG
Entrez,  Source
synuclein, gamma (breast cancer-specific protein 1)13585-2.026-0.0048Yes
177CCNG2NACCNG2
Entrez,  Source
cyclin G213664-2.3020.0124Yes
Table: GSEA details [plain text format]



Fig 2: HALLMARK_ADIPOGENESIS   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_ADIPOGENESIS: Random ES distribution   
Gene set null distribution of ES for HALLMARK_ADIPOGENESIS