Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION |
| Enrichment Score (ES) | -0.58037513 |
| Normalized Enrichment Score (NES) | -1.9201101 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.00615026 |
| FWER p-Value | 0.021 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | IL4I1 | NA | IL4I1 Entrez, Source | interleukin 4 induced 1 | 666 | 1.355 | 0.0159 | No |
| 2 | HMGCS1 | NA | HMGCS1 Entrez, Source | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) | 1289 | 0.985 | 0.0198 | No |
| 3 | DBT | NA | DBT Entrez, Source | dihydrolipoamide branched chain transacylase E2 | 4724 | 0.380 | -0.1549 | No |
| 4 | AOX1 | NA | AOX1 Entrez, Source | aldehyde oxidase 1 | 5374 | 0.315 | -0.1784 | No |
| 5 | ACAA1 | NA | ACAA1 Entrez, Source | acetyl-Coenzyme A acyltransferase 1 (peroxisomal 3-oxoacyl-Coenzyme A thiolase) | 8617 | 0.064 | -0.3548 | No |
| 6 | HSD17B10 | NA | 10055 | -0.023 | -0.4333 | No | ||
| 7 | ALDH1B1 | NA | ALDH1B1 Entrez, Source | aldehyde dehydrogenase 1 family, member B1 | 11847 | -0.144 | -0.5265 | No |
| 8 | ACAA2 | NA | ACAA2 Entrez, Source | acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase) | 12565 | -0.207 | -0.5580 | No |
| 9 | HIBCH | NA | HIBCH Entrez, Source | 3-hydroxyisobutyryl-Coenzyme A hydrolase | 12823 | -0.228 | -0.5633 | No |
| 10 | HMGCL | NA | HMGCL Entrez, Source | 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (hydroxymethylglutaricaciduria) | 13133 | -0.256 | -0.5704 | Yes |
| 11 | HMGCS2 | NA | HMGCS2 Entrez, Source | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial) | 13152 | -0.258 | -0.5614 | Yes |
| 12 | ALDH7A1 | NA | ALDH7A1 Entrez, Source | aldehyde dehydrogenase 7 family, member A1 | 13180 | -0.261 | -0.5528 | Yes |
| 13 | ECHS1 | NA | ECHS1 Entrez, Source | enoyl Coenzyme A hydratase, short chain, 1, mitochondrial | 13439 | -0.286 | -0.5559 | Yes |
| 14 | BCKDHA | NA | BCKDHA Entrez, Source | branched chain keto acid dehydrogenase E1, alpha polypeptide | 13726 | -0.313 | -0.5595 | Yes |
| 15 | IVD | NA | IVD Entrez, Source | isovaleryl Coenzyme A dehydrogenase | 13765 | -0.317 | -0.5493 | Yes |
| 16 | ACAT2 | NA | ACAT2 Entrez, Source | acetyl-Coenzyme A acetyltransferase 2 (acetoacetyl Coenzyme A thiolase) | 13792 | -0.320 | -0.5383 | Yes |
| 17 | ALDH9A1 | NA | ALDH9A1 Entrez, Source | aldehyde dehydrogenase 9 family, member A1 | 13994 | -0.345 | -0.5360 | Yes |
| 18 | ACAD8 | NA | ACAD8 Entrez, Source | acyl-Coenzyme A dehydrogenase family, member 8 | 14030 | -0.349 | -0.5244 | Yes |
| 19 | ACADSB | NA | ACADSB Entrez, Source | acyl-Coenzyme A dehydrogenase, short/branched chain | 14143 | -0.362 | -0.5165 | Yes |
| 20 | ALDH3A2 | NA | ALDH3A2 Entrez, Source | aldehyde dehydrogenase 3 family, member A2 | 14517 | -0.407 | -0.5212 | Yes |
| 21 | HADH | NA | HADH Entrez, Source | hydroxyacyl-Coenzyme A dehydrogenase | 14585 | -0.417 | -0.5087 | Yes |
| 22 | ACADS | NA | ACADS Entrez, Source | acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain | 14739 | -0.435 | -0.5002 | Yes |
| 23 | BCAT1 | NA | BCAT1 Entrez, Source | branched chain aminotransferase 1, cytosolic | 14948 | -0.468 | -0.4936 | Yes |
| 24 | PCCB | NA | PCCB Entrez, Source | propionyl Coenzyme A carboxylase, beta polypeptide | 15012 | -0.477 | -0.4785 | Yes |
| 25 | BCAT2 | NA | BCAT2 Entrez, Source | branched chain aminotransferase 2, mitochondrial | 15354 | -0.526 | -0.4769 | Yes |
| 26 | OXCT1 | NA | OXCT1 Entrez, Source | 3-oxoacid CoA transferase 1 | 15398 | -0.531 | -0.4586 | Yes |
| 27 | DLD | NA | DLD Entrez, Source | dihydrolipoamide dehydrogenase | 15418 | -0.535 | -0.4389 | Yes |
| 28 | OXCT2 | NA | OXCT2 Entrez, Source | 3-oxoacid CoA transferase 2 | 15598 | -0.569 | -0.4266 | Yes |
| 29 | MCCC2 | NA | MCCC2 Entrez, Source | methylcrotonoyl-Coenzyme A carboxylase 2 (beta) | 15749 | -0.598 | -0.4116 | Yes |
| 30 | MCEE | NA | MCEE Entrez, Source | methylmalonyl CoA epimerase | 15857 | -0.622 | -0.3934 | Yes |
| 31 | MUT | NA | MUT Entrez, Source | methylmalonyl Coenzyme A mutase | 16077 | -0.674 | -0.3792 | Yes |
| 32 | HADHB | NA | HADHB Entrez, Source | hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit | 16132 | -0.688 | -0.3555 | Yes |
| 33 | MCCC1 | NA | MCCC1 Entrez, Source | methylcrotonoyl-Coenzyme A carboxylase 1 (alpha) | 16243 | -0.719 | -0.3336 | Yes |
| 34 | EHHADH | NA | EHHADH Entrez, Source | enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase | 16508 | -0.801 | -0.3171 | Yes |
| 35 | AUH | NA | AUH Entrez, Source | AU RNA binding protein/enoyl-Coenzyme A hydratase | 16610 | -0.830 | -0.2904 | Yes |
| 36 | ALDH2 | NA | ALDH2 Entrez, Source | aldehyde dehydrogenase 2 family (mitochondrial) | 16658 | -0.842 | -0.2603 | Yes |
| 37 | HIBADH | NA | HIBADH Entrez, Source | 3-hydroxyisobutyrate dehydrogenase | 16676 | -0.847 | -0.2283 | Yes |
| 38 | HADHA | NA | HADHA Entrez, Source | hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit | 16783 | -0.880 | -0.1999 | Yes |
| 39 | PCCA | NA | PCCA Entrez, Source | propionyl Coenzyme A carboxylase, alpha polypeptide | 17004 | -0.969 | -0.1744 | Yes |
| 40 | ACADM | NA | ACADM Entrez, Source | acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain | 17198 | -1.057 | -0.1440 | Yes |
| 41 | ALDH6A1 | NA | ALDH6A1 Entrez, Source | aldehyde dehydrogenase 6 family, member A1 | 17307 | -1.122 | -0.1063 | Yes |
| 42 | ABAT | NA | ABAT Entrez, Source | 4-aminobutyrate aminotransferase | 17441 | -1.211 | -0.0666 | Yes |
| 43 | BCKDHB | NA | BCKDHB Entrez, Source | branched chain keto acid dehydrogenase E1, beta polypeptide (maple syrup urine disease) | 17499 | -1.258 | -0.0209 | Yes |
| 44 | ACAT1 | NA | ACAT1 Entrez, Source | acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase) | 17713 | -1.484 | 0.0250 | Yes |
