Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1w1a |
| GeneSet | KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY |
| Enrichment Score (ES) | 0.49239925 |
| Normalized Enrichment Score (NES) | 1.7588743 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.01798478 |
| FWER p-Value | 0.151 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | CXCL11 | NA | CXCL11 Entrez, Source | chemokine (C-X-C motif) ligand 11 | 0 | 4.872 | 0.0702 | Yes |
| 2 | CCL5 | NA | CCL5 Entrez, Source | chemokine (C-C motif) ligand 5 | 6 | 4.768 | 0.1387 | Yes |
| 3 | CXCL10 | NA | CXCL10 Entrez, Source | chemokine (C-X-C motif) ligand 10 | 16 | 4.631 | 0.2049 | Yes |
| 4 | IL6 | NA | IL6 Entrez, Source | interleukin 6 (interferon, beta 2) | 17 | 4.596 | 0.2711 | Yes |
| 5 | TLR3 | NA | TLR3 Entrez, Source | toll-like receptor 3 | 190 | 2.443 | 0.2968 | Yes |
| 6 | PIK3R1 | NA | PIK3R1 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha) | 366 | 1.786 | 0.3129 | Yes |
| 7 | NFKBIA | NA | NFKBIA Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 460 | 1.595 | 0.3307 | Yes |
| 8 | JUN | NA | JUN Entrez, Source | jun oncogene | 718 | 1.312 | 0.3354 | Yes |
| 9 | IL1B | NA | IL1B Entrez, Source | interleukin 1, beta | 779 | 1.262 | 0.3503 | Yes |
| 10 | IKBKE | NA | IKBKE Entrez, Source | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 866 | 1.200 | 0.3628 | Yes |
| 11 | IRF3 | NA | IRF3 Entrez, Source | interferon regulatory factor 3 | 1012 | 1.113 | 0.3708 | Yes |
| 12 | RELA | NA | RELA Entrez, Source | v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian) | 1150 | 1.047 | 0.3783 | Yes |
| 13 | TNF | NA | TNF Entrez, Source | tumor necrosis factor (TNF superfamily, member 2) | 1210 | 1.015 | 0.3897 | Yes |
| 14 | MAP2K3 | NA | MAP2K3 Entrez, Source | mitogen-activated protein kinase kinase 3 | 1373 | 0.955 | 0.3945 | Yes |
| 15 | FADD | NA | FADD Entrez, Source | Fas (TNFRSF6)-associated via death domain | 1402 | 0.946 | 0.4066 | Yes |
| 16 | PIK3CD | NA | PIK3CD Entrez, Source | phosphoinositide-3-kinase, catalytic, delta polypeptide | 1572 | 0.890 | 0.4100 | Yes |
| 17 | IKBKG | NA | IKBKG Entrez, Source | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | 1587 | 0.884 | 0.4220 | Yes |
| 18 | IL12B | NA | IL12B Entrez, Source | interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) | 1607 | 0.880 | 0.4336 | Yes |
| 19 | RIPK1 | NA | RIPK1 Entrez, Source | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 1659 | 0.863 | 0.4433 | Yes |
| 20 | IRAK1 | NA | IRAK1 Entrez, Source | interleukin-1 receptor-associated kinase 1 | 1676 | 0.857 | 0.4547 | Yes |
| 21 | TICAM1 | NA | TICAM1 Entrez, Source | toll-like receptor adaptor molecule 1 | 1761 | 0.837 | 0.4621 | Yes |
| 22 | NFKB1 | NA | NFKB1 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 1767 | 0.835 | 0.4739 | Yes |
| 23 | IRAK4 | NA | IRAK4 Entrez, Source | interleukin-1 receptor-associated kinase 4 | 2128 | 0.759 | 0.4649 | Yes |
| 24 | MAP2K2 | NA | MAP2K2 Entrez, Source | mitogen-activated protein kinase kinase 2 | 2222 | 0.740 | 0.4704 | Yes |
| 25 | MYD88 | NA | MYD88 Entrez, Source | myeloid differentiation primary response gene (88) | 2759 | 0.638 | 0.4500 | Yes |
| 26 | TIRAP | NA | TIRAP Entrez, Source | toll-interleukin 1 receptor (TIR) domain containing adaptor protein | 2790 | 0.631 | 0.4574 | Yes |
| 27 | IFNAR1 | NA | IFNAR1 Entrez, Source | interferon (alpha, beta and omega) receptor 1 | 2807 | 0.630 | 0.4656 | Yes |
| 28 | STAT1 | NA | STAT1 Entrez, Source | signal transducer and activator of transcription 1, 91kDa | 2854 | 0.622 | 0.4720 | Yes |
| 29 | TOLLIP | NA | TOLLIP Entrez, Source | toll interacting protein | 2856 | 0.622 | 0.4809 | Yes |
| 30 | CD14 | NA | CD14 Entrez, Source | CD14 molecule | 2918 | 0.610 | 0.4863 | Yes |
| 31 | CHUK | NA | CHUK Entrez, Source | conserved helix-loop-helix ubiquitous kinase | 3103 | 0.582 | 0.4845 | Yes |
| 32 | IFNAR2 | NA | IFNAR2 Entrez, Source | interferon (alpha, beta and omega) receptor 2 | 3113 | 0.580 | 0.4924 | Yes |
| 33 | TAB1 | NA | 3372 | 0.540 | 0.4859 | No | ||
| 34 | MAP2K7 | NA | MAP2K7 Entrez, Source | mitogen-activated protein kinase kinase 7 | 3666 | 0.501 | 0.4769 | No |
| 35 | TLR6 | NA | TLR6 Entrez, Source | toll-like receptor 6 | 3957 | 0.467 | 0.4676 | No |
| 36 | MAPK11 | NA | MAPK11 Entrez, Source | mitogen-activated protein kinase 11 | 4342 | 0.417 | 0.4524 | No |
| 37 | TLR2 | NA | TLR2 Entrez, Source | toll-like receptor 2 | 4677 | 0.385 | 0.4394 | No |
| 38 | MAP3K8 | NA | MAP3K8 Entrez, Source | mitogen-activated protein kinase kinase kinase 8 | 4764 | 0.376 | 0.4401 | No |
| 39 | MAPK3 | NA | MAPK3 Entrez, Source | mitogen-activated protein kinase 3 | 4770 | 0.376 | 0.4452 | No |
| 40 | PIK3R3 | NA | PIK3R3 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma) | 5162 | 0.335 | 0.4284 | No |
| 41 | TRAF6 | NA | TRAF6 Entrez, Source | TNF receptor-associated factor 6 | 5263 | 0.326 | 0.4276 | No |
| 42 | CASP8 | NA | CASP8 Entrez, Source | caspase 8, apoptosis-related cysteine peptidase | 5677 | 0.288 | 0.4089 | No |
| 43 | IRF5 | NA | IRF5 Entrez, Source | interferon regulatory factor 5 | 5850 | 0.274 | 0.4033 | No |
| 44 | IFNA21 | NA | IFNA21 Entrez, Source | interferon, alpha 21 | 5854 | 0.273 | 0.4071 | No |
| 45 | MAPK12 | NA | MAPK12 Entrez, Source | mitogen-activated protein kinase 12 | 6059 | 0.258 | 0.3995 | No |
| 46 | AKT2 | NA | AKT2 Entrez, Source | v-akt murine thymoma viral oncogene homolog 2 | 6144 | 0.250 | 0.3985 | No |
| 47 | TRAF3 | NA | TRAF3 Entrez, Source | TNF receptor-associated factor 3 | 6934 | 0.185 | 0.3575 | No |
| 48 | IFNB1 | NA | IFNB1 Entrez, Source | interferon, beta 1, fibroblast | 7718 | 0.129 | 0.3160 | No |
| 49 | AKT1 | NA | AKT1 Entrez, Source | v-akt murine thymoma viral oncogene homolog 1 | 7922 | 0.113 | 0.3064 | No |
| 50 | MAP2K4 | NA | MAP2K4 Entrez, Source | mitogen-activated protein kinase kinase 4 | 8148 | 0.096 | 0.2954 | No |
| 51 | IFNA17 | NA | IFNA17 Entrez, Source | interferon, alpha 17 | 8248 | 0.090 | 0.2912 | No |
| 52 | MAP2K6 | NA | MAP2K6 Entrez, Source | mitogen-activated protein kinase kinase 6 | 8737 | 0.055 | 0.2650 | No |
| 53 | PIK3CA | NA | PIK3CA Entrez, Source | phosphoinositide-3-kinase, catalytic, alpha polypeptide | 8784 | 0.052 | 0.2632 | No |
| 54 | MAPK14 | NA | MAPK14 Entrez, Source | mitogen-activated protein kinase 14 | 8878 | 0.045 | 0.2587 | No |
| 55 | TLR1 | NA | TLR1 Entrez, Source | toll-like receptor 1 | 8972 | 0.037 | 0.2541 | No |
| 56 | IRF7 | NA | IRF7 Entrez, Source | interferon regulatory factor 7 | 9107 | 0.027 | 0.2470 | No |
| 57 | IFNA13 | NA | IFNA13 Entrez, Source | interferon, alpha 13 | 9539 | 0.000 | 0.2232 | No |
| 58 | CCL3 | NA | CCL3 Entrez, Source | chemokine (C-C motif) ligand 3 | 9708 | 0.000 | 0.2139 | No |
| 59 | MAP2K1 | NA | MAP2K1 Entrez, Source | mitogen-activated protein kinase kinase 1 | 9745 | -0.001 | 0.2119 | No |
| 60 | IFNA8 | NA | IFNA8 Entrez, Source | interferon, alpha 8 | 9853 | -0.010 | 0.2061 | No |
| 61 | RAC1 | NA | RAC1 Entrez, Source | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | 9857 | -0.010 | 0.2061 | No |
| 62 | MAPK8 | NA | MAPK8 Entrez, Source | mitogen-activated protein kinase 8 | 10132 | -0.028 | 0.1914 | No |
| 63 | CXCL9 | NA | CXCL9 Entrez, Source | chemokine (C-X-C motif) ligand 9 | 10624 | -0.055 | 0.1650 | No |
| 64 | IL12A | NA | IL12A Entrez, Source | interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) | 10711 | -0.061 | 0.1611 | No |
| 65 | CD40 | NA | CD40 Entrez, Source | CD40 molecule, TNF receptor superfamily member 5 | 10873 | -0.070 | 0.1532 | No |
| 66 | IKBKB | NA | IKBKB Entrez, Source | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | 10944 | -0.074 | 0.1504 | No |
| 67 | PIK3R5 | NA | PIK3R5 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 5, p101 | 11049 | -0.081 | 0.1458 | No |
| 68 | IFNA10 | NA | IFNA10 Entrez, Source | interferon, alpha 10 | 11188 | -0.090 | 0.1395 | No |
| 69 | IFNA16 | NA | IFNA16 Entrez, Source | interferon, alpha 16 | 11217 | -0.092 | 0.1393 | No |
| 70 | IFNA1 | NA | IFNA1 Entrez, Source | interferon, alpha 1 | 11267 | -0.096 | 0.1379 | No |
| 71 | TAB2 | NA | 11271 | -0.096 | 0.1392 | No | ||
| 72 | PIK3CB | NA | PIK3CB Entrez, Source | phosphoinositide-3-kinase, catalytic, beta polypeptide | 11650 | -0.127 | 0.1201 | No |
| 73 | IFNA6 | NA | IFNA6 Entrez, Source | interferon, alpha 6 | 11724 | -0.134 | 0.1180 | No |
| 74 | TLR7 | NA | TLR7 Entrez, Source | toll-like receptor 7 | 11948 | -0.151 | 0.1078 | No |
| 75 | LBP | NA | LBP Entrez, Source | lipopolysaccharide binding protein | 12160 | -0.169 | 0.0986 | No |
| 76 | PIK3R2 | NA | PIK3R2 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta) | 12247 | -0.177 | 0.0964 | No |
| 77 | TBK1 | NA | TBK1 Entrez, Source | TANK-binding kinase 1 | 12301 | -0.183 | 0.0961 | No |
| 78 | TLR8 | NA | TLR8 Entrez, Source | toll-like receptor 8 | 12696 | -0.219 | 0.0774 | No |
| 79 | IFNA2 | NA | IFNA2 Entrez, Source | interferon, alpha 2 | 13213 | -0.263 | 0.0527 | No |
| 80 | CD86 | NA | CD86 Entrez, Source | CD86 molecule | 13386 | -0.280 | 0.0472 | No |
| 81 | MAPK9 | NA | MAPK9 Entrez, Source | mitogen-activated protein kinase 9 | 13521 | -0.294 | 0.0440 | No |
| 82 | CTSK | NA | CTSK Entrez, Source | cathepsin K (pycnodysostosis) | 13842 | -0.325 | 0.0310 | No |
| 83 | MAP3K7 | NA | MAP3K7 Entrez, Source | mitogen-activated protein kinase kinase kinase 7 | 14046 | -0.351 | 0.0248 | No |
| 84 | MAPK10 | NA | MAPK10 Entrez, Source | mitogen-activated protein kinase 10 | 14334 | -0.383 | 0.0144 | No |
| 85 | FOS | NA | FOS Entrez, Source | v-fos FBJ murine osteosarcoma viral oncogene homolog | 14425 | -0.395 | 0.0151 | No |
| 86 | MAPK1 | NA | MAPK1 Entrez, Source | mitogen-activated protein kinase 1 | 14765 | -0.439 | 0.0027 | No |
| 87 | MAPK13 | NA | MAPK13 Entrez, Source | mitogen-activated protein kinase 13 | 14840 | -0.454 | 0.0051 | No |
| 88 | TLR5 | NA | TLR5 Entrez, Source | toll-like receptor 5 | 14852 | -0.455 | 0.0111 | No |
| 89 | SPP1 | NA | SPP1 Entrez, Source | secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1) | 15059 | -0.484 | 0.0067 | No |
| 90 | CD80 | NA | CD80 Entrez, Source | CD80 molecule | 16598 | -0.825 | -0.0665 | No |
| 91 | TLR9 | NA | TLR9 Entrez, Source | toll-like receptor 9 | 17612 | -1.363 | -0.1029 | No |
| 92 | PIK3CG | NA | PIK3CG Entrez, Source | phosphoinositide-3-kinase, catalytic, gamma polypeptide | 17630 | -1.385 | -0.0839 | No |
| 93 | AKT3 | NA | AKT3 Entrez, Source | v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) | 17766 | -1.559 | -0.0689 | No |
| 94 | LY96 | NA | LY96 Entrez, Source | lymphocyte antigen 96 | 17781 | -1.580 | -0.0469 | No |
| 95 | TLR4 | NA | TLR4 Entrez, Source | toll-like receptor 4 | 18161 | -4.735 | 0.0003 | No |
