Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS |
| Enrichment Score (ES) | -0.43692514 |
| Normalized Enrichment Score (NES) | -1.7548372 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.019075574 |
| FWER p-Value | 0.164 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | TRIM21 | NA | TRIM21 Entrez, Source | tripartite motif-containing 21 | 202 | 2.388 | 0.0224 | No |
| 2 | FCGR3A | NA | FCGR3A Entrez, Source | Fc fragment of IgG, low affinity IIIa, receptor (CD16a) | 413 | 1.686 | 0.0345 | No |
| 3 | H3F3C | NA | 1015 | 1.111 | 0.0168 | No | ||
| 4 | C5 | NA | C5 Entrez, Source | complement component 5 | 1122 | 1.055 | 0.0257 | No |
| 5 | TNF | NA | TNF Entrez, Source | tumor necrosis factor (TNF superfamily, member 2) | 1210 | 1.015 | 0.0352 | No |
| 6 | C8G | NA | C8G Entrez, Source | complement component 8, gamma polypeptide | 1405 | 0.945 | 0.0377 | No |
| 7 | ACTN1 | NA | ACTN1 Entrez, Source | actinin, alpha 1 | 1755 | 0.838 | 0.0302 | No |
| 8 | H3F3B | NA | H3F3B Entrez, Source | H3 histone, family 3B (H3.3B) | 1972 | 0.793 | 0.0293 | No |
| 9 | HIST1H3B | NA | HIST1H3B Entrez, Source | histone cluster 1, H3b | 2273 | 0.729 | 0.0230 | No |
| 10 | HIST1H2BL | NA | HIST1H2BL Entrez, Source | histone cluster 1, H2bl | 2295 | 0.725 | 0.0320 | No |
| 11 | ACTN4 | NA | ACTN4 Entrez, Source | actinin, alpha 4 | 2321 | 0.719 | 0.0407 | No |
| 12 | TROVE2 | NA | TROVE2 Entrez, Source | TROVE domain family, member 2 | 2558 | 0.674 | 0.0371 | No |
| 13 | FCGR2A | NA | FCGR2A Entrez, Source | Fc fragment of IgG, low affinity IIa, receptor (CD32) | 2645 | 0.658 | 0.0416 | No |
| 14 | HIST2H2AC | NA | HIST2H2AC Entrez, Source | histone cluster 2, H2ac | 2669 | 0.654 | 0.0495 | No |
| 15 | H2AFX | NA | H2AFX Entrez, Source | H2A histone family, member X | 2849 | 0.623 | 0.0484 | No |
| 16 | HIST2H3A | NA | HIST2H3A Entrez, Source | histone cluster 2, H3a | 3074 | 0.585 | 0.0442 | No |
| 17 | HLA-DOB | NA | HLA-DOB Entrez, Source | major histocompatibility complex, class II, DO beta | 3137 | 0.577 | 0.0489 | No |
| 18 | HIST1H2AL | NA | HIST1H2AL Entrez, Source | histone cluster 1, H2al | 3697 | 0.498 | 0.0249 | No |
| 19 | C8A | NA | C8A Entrez, Source | complement component 8, alpha polypeptide | 4637 | 0.388 | -0.0217 | No |
| 20 | HIST3H2BB | NA | HIST3H2BB Entrez, Source | histone cluster 3, H2bb | 4980 | 0.353 | -0.0357 | No |
| 21 | HLA-DPA1 | NA | HLA-DPA1 Entrez, Source | major histocompatibility complex, class II, DP alpha 1 | 5082 | 0.343 | -0.0365 | No |
| 22 | C2 | NA | C2 Entrez, Source | complement component 2 | 5139 | 0.338 | -0.0348 | No |
| 23 | CD40LG | NA | CD40LG Entrez, Source | CD40 ligand (TNF superfamily, member 5, hyper-IgM syndrome) | 5545 | 0.300 | -0.0530 | No |
| 24 | C9 | NA | C9 Entrez, Source | complement component 9 | 5665 | 0.290 | -0.0556 | No |
| 25 | HLA-DRB4 | NA | HLA-DRB4 Entrez, Source | major histocompatibility complex, class II, DR beta 4 | 5733 | 0.284 | -0.0553 | No |
| 26 | HIST1H2AJ | NA | HIST1H2AJ Entrez, Source | histone cluster 1, H2aj | 5795 | 0.278 | -0.0547 | No |
| 27 | H2AFY | NA | H2AFY Entrez, Source | H2A histone family, member Y | 6203 | 0.245 | -0.0739 | No |
| 28 | HIST1H4G | NA | HIST1H4G Entrez, Source | histone cluster 1, H4g | 6826 | 0.194 | -0.1056 | No |
| 29 | HIST1H2AK | NA | HIST1H2AK Entrez, Source | histone cluster 1, H2ak | 6901 | 0.188 | -0.1071 | No |
| 30 | HIST1H4K | NA | HIST1H4K Entrez, Source | histone cluster 1, H4k | 7055 | 0.176 | -0.1131 | No |
| 31 | H2BFM | NA | H2BFM Entrez, Source | H2B histone family, member M | 7067 | 0.176 | -0.1112 | No |
| 32 | HIST3H2A | NA | HIST3H2A Entrez, Source | histone cluster 3, H2a | 7210 | 0.166 | -0.1167 | No |
| 33 | HIST2H3D | NA | HIST2H3D Entrez, Source | histone cluster 2, H3d | 7242 | 0.164 | -0.1161 | No |
| 34 | HIST1H3F | NA | HIST1H3F Entrez, Source | histone cluster 1, H3f | 7346 | 0.156 | -0.1196 | No |
| 35 | HIST1H2BA | NA | HIST1H2BA Entrez, Source | histone cluster 1, H2ba | 7396 | 0.151 | -0.1202 | No |
| 36 | HIST1H3I | NA | HIST1H3I Entrez, Source | histone cluster 1, H3i | 7534 | 0.142 | -0.1258 | No |
| 37 | FCGR3B | NA | FCGR3B Entrez, Source | Fc fragment of IgG, low affinity IIIb, receptor (CD16b) | 7861 | 0.118 | -0.1422 | No |
| 38 | HIST4H4 | NA | HIST4H4 Entrez, Source | histone cluster 4, H4 | 7877 | 0.117 | -0.1414 | No |
| 39 | ELANE | NA | 8171 | 0.095 | -0.1563 | No | ||
| 40 | C4A | NA | C4A Entrez, Source | complement component 4A (Rodgers blood group) | 8455 | 0.075 | -0.1710 | No |
| 41 | H2AFY2 | NA | H2AFY2 Entrez, Source | H2A histone family, member Y2 | 9146 | 0.024 | -0.2089 | No |
| 42 | CD28 | NA | CD28 Entrez, Source | CD28 molecule | 9247 | 0.017 | -0.2142 | No |
| 43 | C1QC | NA | C1QC Entrez, Source | complement component 1, q subcomponent, C chain | 9437 | 0.004 | -0.2246 | No |
| 44 | HLA-DRB5 | NA | HLA-DRB5 Entrez, Source | major histocompatibility complex, class II, DR beta 5 | 9537 | 0.000 | -0.2301 | No |
| 45 | C1QA | NA | C1QA Entrez, Source | complement component 1, q subcomponent, A chain | 9581 | 0.000 | -0.2324 | No |
| 46 | HIST1H2AB | NA | HIST1H2AB Entrez, Source | histone cluster 1, H2ab | 9620 | 0.000 | -0.2346 | No |
| 47 | HIST1H2BI | NA | HIST1H2BI Entrez, Source | histone cluster 1, H2bi | 9896 | -0.012 | -0.2496 | No |
| 48 | HIST1H2BE | NA | HIST1H2BE Entrez, Source | histone cluster 1, H2be | 10042 | -0.021 | -0.2574 | No |
| 49 | SNRPB | NA | SNRPB Entrez, Source | small nuclear ribonucleoprotein polypeptides B and B1 | 10059 | -0.023 | -0.2579 | No |
| 50 | HIST3H3 | NA | HIST3H3 Entrez, Source | histone cluster 3, H3 | 10562 | -0.051 | -0.2850 | No |
| 51 | HLA-DQB1 | NA | HLA-DQB1 Entrez, Source | major histocompatibility complex, class II, DQ beta 1 | 10613 | -0.055 | -0.2870 | No |
| 52 | CD40 | NA | CD40 Entrez, Source | CD40 molecule, TNF receptor superfamily member 5 | 10873 | -0.070 | -0.3004 | No |
| 53 | HIST1H4J | NA | HIST1H4J Entrez, Source | histone cluster 1, H4j | 10883 | -0.070 | -0.2999 | No |
| 54 | HLA-DRB1 | NA | HLA-DRB1 Entrez, Source | major histocompatibility complex, class II, DR beta 1 | 10903 | -0.071 | -0.3000 | No |
| 55 | HIST1H2AH | NA | HIST1H2AH Entrez, Source | histone cluster 1, H2ah | 11022 | -0.079 | -0.3054 | No |
| 56 | C8B | NA | C8B Entrez, Source | complement component 8, beta polypeptide | 11187 | -0.090 | -0.3132 | No |
| 57 | ACTN3 | NA | ACTN3 Entrez, Source | actinin, alpha 3 | 11241 | -0.094 | -0.3148 | No |
| 58 | HIST1H4C | NA | HIST1H4C Entrez, Source | histone cluster 1, H4c | 11248 | -0.095 | -0.3138 | No |
| 59 | HLA-DQA1 | NA | HLA-DQA1 Entrez, Source | major histocompatibility complex, class II, DQ alpha 1 | 11431 | -0.108 | -0.3224 | No |
| 60 | H2AFB2 | NA | H2AFB2 Entrez, Source | H2A histone family, member B2 | 11673 | -0.130 | -0.3339 | No |
| 61 | HIST1H3C | NA | HIST1H3C Entrez, Source | histone cluster 1, H3c | 12074 | -0.162 | -0.3538 | No |
| 62 | FCGR2B | NA | FCGR2B Entrez, Source | Fc fragment of IgG, low affinity IIb, receptor (CD32) | 12103 | -0.164 | -0.3531 | No |
| 63 | SNRPD1 | NA | SNRPD1 Entrez, Source | small nuclear ribonucleoprotein D1 polypeptide 16kDa | 12116 | -0.166 | -0.3514 | No |
| 64 | HIST1H4A | NA | HIST1H4A Entrez, Source | histone cluster 1, H4a | 12386 | -0.190 | -0.3636 | No |
| 65 | HIST1H2BM | NA | HIST1H2BM Entrez, Source | histone cluster 1, H2bm | 12681 | -0.218 | -0.3769 | No |
| 66 | HIST1H4I | NA | HIST1H4I Entrez, Source | histone cluster 1, H4i | 12717 | -0.221 | -0.3757 | No |
| 67 | C6 | NA | C6 Entrez, Source | complement component 6 | 13182 | -0.261 | -0.3978 | No |
| 68 | FCGR1A | NA | FCGR1A Entrez, Source | Fc fragment of IgG, high affinity Ia, receptor (CD64) | 13208 | -0.263 | -0.3954 | No |
| 69 | CD86 | NA | CD86 Entrez, Source | CD86 molecule | 13386 | -0.280 | -0.4013 | No |
| 70 | H2AFJ | NA | H2AFJ Entrez, Source | H2A histone family, member J | 13544 | -0.295 | -0.4059 | No |
| 71 | HIST1H4E | NA | HIST1H4E Entrez, Source | histone cluster 1, H4e | 13650 | -0.307 | -0.4074 | No |
| 72 | C4B | NA | C4B Entrez, Source | complement component 4B (Childo blood group) | 13661 | -0.308 | -0.4036 | No |
| 73 | HLA-DQA2 | NA | HLA-DQA2 Entrez, Source | major histocompatibility complex, class II, DQ alpha 2 | 13710 | -0.312 | -0.4019 | No |
| 74 | HIST2H2BF | NA | HIST2H2BF Entrez, Source | histone cluster 2, H2bf | 13860 | -0.326 | -0.4055 | No |
| 75 | H2AFV | NA | H2AFV Entrez, Source | H2A histone family, member V | 14238 | -0.372 | -0.4212 | No |
| 76 | HIST1H3E | NA | HIST1H3E Entrez, Source | histone cluster 1, H3e | 14422 | -0.394 | -0.4258 | No |
| 77 | HIST1H3A | NA | HIST1H3A Entrez, Source | histone cluster 1, H3a | 14487 | -0.404 | -0.4237 | No |
| 78 | IFNG | NA | IFNG Entrez, Source | interferon, gamma | 14617 | -0.420 | -0.4249 | No |
| 79 | HIST1H2BB | NA | HIST1H2BB Entrez, Source | histone cluster 1, H2bb | 14687 | -0.429 | -0.4227 | No |
| 80 | HIST1H4B | NA | HIST1H4B Entrez, Source | histone cluster 1, H4b | 14844 | -0.454 | -0.4250 | No |
| 81 | SSB | NA | SSB Entrez, Source | Sjogren syndrome antigen B (autoantigen La) | 15061 | -0.484 | -0.4301 | Yes |
| 82 | HIST1H2AD | NA | HIST1H2AD Entrez, Source | histone cluster 1, H2ad | 15153 | -0.496 | -0.4282 | Yes |
| 83 | SNRPD3 | NA | SNRPD3 Entrez, Source | small nuclear ribonucleoprotein D3 polypeptide 18kDa | 15227 | -0.506 | -0.4251 | Yes |
| 84 | GRIN2A | NA | GRIN2A Entrez, Source | glutamate receptor, ionotropic, N-methyl D-aspartate 2A | 15241 | -0.508 | -0.4187 | Yes |
| 85 | HLA-DOA | NA | HLA-DOA Entrez, Source | major histocompatibility complex, class II, DO alpha | 15257 | -0.511 | -0.4123 | Yes |
| 86 | HIST1H2BN | NA | HIST1H2BN Entrez, Source | histone cluster 1, H2bn | 15302 | -0.515 | -0.4075 | Yes |
| 87 | C7 | NA | C7 Entrez, Source | complement component 7 | 15400 | -0.532 | -0.4054 | Yes |
| 88 | HIST1H3J | NA | HIST1H3J Entrez, Source | histone cluster 1, H3j | 15515 | -0.555 | -0.4040 | Yes |
| 89 | HLA-DMB | NA | HLA-DMB Entrez, Source | major histocompatibility complex, class II, DM beta | 15525 | -0.556 | -0.3966 | Yes |
| 90 | IL10 | NA | IL10 Entrez, Source | interleukin 10 | 15556 | -0.562 | -0.3904 | Yes |
| 91 | HIST2H2AB | NA | HIST2H2AB Entrez, Source | histone cluster 2, H2ab | 15581 | -0.568 | -0.3837 | Yes |
| 92 | HIST1H3D | NA | HIST1H3D Entrez, Source | histone cluster 1, H3d | 15601 | -0.570 | -0.3768 | Yes |
| 93 | GRIN2B | NA | GRIN2B Entrez, Source | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | 15610 | -0.573 | -0.3692 | Yes |
| 94 | ACTN2 | NA | ACTN2 Entrez, Source | actinin, alpha 2 | 15627 | -0.577 | -0.3619 | Yes |
| 95 | HIST1H2AG | NA | HIST1H2AG Entrez, Source | histone cluster 1, H2ag | 15683 | -0.587 | -0.3567 | Yes |
| 96 | H2AFZ | NA | H2AFZ Entrez, Source | H2A histone family, member Z | 15685 | -0.587 | -0.3486 | Yes |
| 97 | HIST1H3H | NA | HIST1H3H Entrez, Source | histone cluster 1, H3h | 16379 | -0.758 | -0.3763 | Yes |
| 98 | C3 | NA | C3 Entrez, Source | complement component 3 | 16387 | -0.761 | -0.3660 | Yes |
| 99 | CD80 | NA | CD80 Entrez, Source | CD80 molecule | 16598 | -0.825 | -0.3660 | Yes |
| 100 | HIST2H2AA3 | NA | HIST2H2AA3 Entrez, Source | histone cluster 2, H2aa3 | 16667 | -0.844 | -0.3579 | Yes |
| 101 | HIST2H4B | NA | HIST2H4B Entrez, Source | histone cluster 2, H4b | 16705 | -0.855 | -0.3479 | Yes |
| 102 | HIST1H2AI | NA | HIST1H2AI Entrez, Source | histone cluster 1, H2ai | 16706 | -0.856 | -0.3359 | Yes |
| 103 | CTSG | NA | CTSG Entrez, Source | cathepsin G | 16712 | -0.857 | -0.3241 | Yes |
| 104 | HIST1H2BH | NA | HIST1H2BH Entrez, Source | histone cluster 1, H2bh | 16802 | -0.889 | -0.3166 | Yes |
| 105 | HIST1H4D | NA | HIST1H4D Entrez, Source | histone cluster 1, H4d | 16833 | -0.900 | -0.3056 | Yes |
| 106 | HIST1H2BK | NA | HIST1H2BK Entrez, Source | histone cluster 1, H2bk | 17001 | -0.968 | -0.3012 | Yes |
| 107 | HLA-DPB1 | NA | HLA-DPB1 Entrez, Source | major histocompatibility complex, class II, DP beta 1 | 17189 | -1.052 | -0.2968 | Yes |
| 108 | C1S | NA | C1S Entrez, Source | complement component 1, s subcomponent | 17205 | -1.061 | -0.2827 | Yes |
| 109 | HIST1H3G | NA | HIST1H3G Entrez, Source | histone cluster 1, H3g | 17311 | -1.125 | -0.2727 | Yes |
| 110 | HIST1H2BO | NA | HIST1H2BO Entrez, Source | histone cluster 1, H2bo | 17423 | -1.203 | -0.2620 | Yes |
| 111 | HIST1H2BJ | NA | HIST1H2BJ Entrez, Source | histone cluster 1, H2bj | 17425 | -1.204 | -0.2451 | Yes |
| 112 | HIST1H4H | NA | HIST1H4H Entrez, Source | histone cluster 1, H4h | 17454 | -1.222 | -0.2294 | Yes |
| 113 | HIST1H2AC | NA | HIST1H2AC Entrez, Source | histone cluster 1, H2ac | 17490 | -1.251 | -0.2138 | Yes |
| 114 | HIST1H2BD | NA | HIST1H2BD Entrez, Source | histone cluster 1, H2bd | 17578 | -1.319 | -0.2001 | Yes |
| 115 | H3F3A | NA | H3F3A Entrez, Source | H3 histone, family 3A | 17585 | -1.328 | -0.1817 | Yes |
| 116 | HIST1H2AM | NA | HIST1H2AM Entrez, Source | histone cluster 1, H2am | 17624 | -1.378 | -0.1644 | Yes |
| 117 | HIST1H2AE | NA | HIST1H2AE Entrez, Source | histone cluster 1, H2ae | 17737 | -1.512 | -0.1494 | Yes |
| 118 | HIST1H2BG | NA | HIST1H2BG Entrez, Source | histone cluster 1, H2bg | 17786 | -1.593 | -0.1297 | Yes |
| 119 | HIST1H2BF | NA | HIST1H2BF Entrez, Source | histone cluster 1, H2bf | 17879 | -1.799 | -0.1095 | Yes |
| 120 | C1R | NA | C1R Entrez, Source | complement component 1, r subcomponent | 17902 | -1.865 | -0.0845 | Yes |
| 121 | HIST1H2BC | NA | HIST1H2BC Entrez, Source | histone cluster 1, H2bc | 17920 | -1.910 | -0.0586 | Yes |
| 122 | HIST2H2BE | NA | HIST2H2BE Entrez, Source | histone cluster 2, H2be | 18004 | -2.281 | -0.0311 | Yes |
| 123 | HLA-DMA | NA | HLA-DMA Entrez, Source | major histocompatibility complex, class II, DM alpha | 18085 | -2.849 | 0.0045 | Yes |
