Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1w1a |
| GeneSet | KEGG_SMALL_CELL_LUNG_CANCER |
| Enrichment Score (ES) | 0.43074834 |
| Normalized Enrichment Score (NES) | 1.5174482 |
| Nominal p-value | 0.010186757 |
| FDR q-value | 0.14116716 |
| FWER p-Value | 0.864 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | TRAF1 | NA | TRAF1 Entrez, Source | TNF receptor-associated factor 1 | 89 | 3.323 | 0.0527 | Yes |
| 2 | LAMA4 | NA | LAMA4 Entrez, Source | laminin, alpha 4 | 124 | 2.938 | 0.1018 | Yes |
| 3 | ITGA2 | NA | ITGA2 Entrez, Source | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 148 | 2.720 | 0.1476 | Yes |
| 4 | BIRC3 | NA | BIRC3 Entrez, Source | baculoviral IAP repeat-containing 3 | 182 | 2.484 | 0.1889 | Yes |
| 5 | LAMB3 | NA | LAMB3 Entrez, Source | laminin, beta 3 | 343 | 1.846 | 0.2121 | Yes |
| 6 | PIK3R1 | NA | PIK3R1 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha) | 366 | 1.786 | 0.2418 | Yes |
| 7 | NFKBIA | NA | NFKBIA Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 460 | 1.595 | 0.2643 | Yes |
| 8 | BCL2L1 | NA | BCL2L1 Entrez, Source | BCL2-like 1 | 512 | 1.526 | 0.2880 | Yes |
| 9 | COL4A2 | NA | COL4A2 Entrez, Source | collagen, type IV, alpha 2 | 794 | 1.252 | 0.2941 | Yes |
| 10 | FN1 | NA | FN1 Entrez, Source | fibronectin 1 | 803 | 1.244 | 0.3153 | Yes |
| 11 | RXRG | NA | RXRG Entrez, Source | retinoid X receptor, gamma | 894 | 1.179 | 0.3307 | Yes |
| 12 | LAMC2 | NA | LAMC2 Entrez, Source | laminin, gamma 2 | 917 | 1.160 | 0.3496 | Yes |
| 13 | ITGA3 | NA | ITGA3 Entrez, Source | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 961 | 1.138 | 0.3670 | Yes |
| 14 | RELA | NA | RELA Entrez, Source | v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian) | 1150 | 1.047 | 0.3748 | Yes |
| 15 | LAMA5 | NA | LAMA5 Entrez, Source | laminin, alpha 5 | 1326 | 0.975 | 0.3820 | Yes |
| 16 | PIAS4 | NA | PIAS4 Entrez, Source | protein inhibitor of activated STAT, 4 | 1445 | 0.931 | 0.3916 | Yes |
| 17 | PIK3CD | NA | PIK3CD Entrez, Source | phosphoinositide-3-kinase, catalytic, delta polypeptide | 1572 | 0.890 | 0.4001 | Yes |
| 18 | IKBKG | NA | IKBKG Entrez, Source | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | 1587 | 0.884 | 0.4146 | Yes |
| 19 | NFKB1 | NA | NFKB1 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 1767 | 0.835 | 0.4192 | Yes |
| 20 | COL4A1 | NA | COL4A1 Entrez, Source | collagen, type IV, alpha 1 | 1818 | 0.825 | 0.4307 | Yes |
| 21 | RXRA | NA | RXRA Entrez, Source | retinoid X receptor, alpha | 2835 | 0.626 | 0.3854 | No |
| 22 | ITGA6 | NA | ITGA6 Entrez, Source | integrin, alpha 6 | 3033 | 0.591 | 0.3848 | No |
| 23 | CCNE2 | NA | CCNE2 Entrez, Source | cyclin E2 | 3078 | 0.585 | 0.3925 | No |
| 24 | CHUK | NA | CHUK Entrez, Source | conserved helix-loop-helix ubiquitous kinase | 3103 | 0.582 | 0.4012 | No |
| 25 | TRAF2 | NA | TRAF2 Entrez, Source | TNF receptor-associated factor 2 | 3221 | 0.564 | 0.4045 | No |
| 26 | BIRC2 | NA | BIRC2 Entrez, Source | baculoviral IAP repeat-containing 2 | 3377 | 0.540 | 0.4053 | No |
| 27 | FHIT | NA | FHIT Entrez, Source | fragile histidine triad gene | 4331 | 0.418 | 0.3599 | No |
| 28 | PTGS2 | NA | PTGS2 Entrez, Source | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 4406 | 0.410 | 0.3629 | No |
| 29 | CCND1 | NA | CCND1 Entrez, Source | cyclin D1 | 4440 | 0.407 | 0.3681 | No |
| 30 | MAX | NA | MAX Entrez, Source | MYC associated factor X | 4504 | 0.400 | 0.3716 | No |
| 31 | SKP2 | NA | SKP2 Entrez, Source | S-phase kinase-associated protein 2 (p45) | 4692 | 0.384 | 0.3679 | No |
| 32 | PIK3R3 | NA | PIK3R3 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma) | 5162 | 0.335 | 0.3478 | No |
| 33 | TRAF6 | NA | TRAF6 Entrez, Source | TNF receptor-associated factor 6 | 5263 | 0.326 | 0.3479 | No |
| 34 | CDKN2B | NA | CDKN2B Entrez, Source | cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) | 5538 | 0.300 | 0.3380 | No |
| 35 | LAMC1 | NA | LAMC1 Entrez, Source | laminin, gamma 1 (formerly LAMB2) | 5595 | 0.296 | 0.3400 | No |
| 36 | CDK4 | NA | CDK4 Entrez, Source | cyclin-dependent kinase 4 | 5679 | 0.288 | 0.3404 | No |
| 37 | E2F2 | NA | E2F2 Entrez, Source | E2F transcription factor 2 | 5727 | 0.284 | 0.3427 | No |
| 38 | LAMB4 | NA | LAMB4 Entrez, Source | laminin, beta 4 | 6080 | 0.256 | 0.3277 | No |
| 39 | AKT2 | NA | AKT2 Entrez, Source | v-akt murine thymoma viral oncogene homolog 2 | 6144 | 0.250 | 0.3286 | No |
| 40 | E2F3 | NA | E2F3 Entrez, Source | E2F transcription factor 3 | 6148 | 0.250 | 0.3327 | No |
| 41 | TRAF4 | NA | TRAF4 Entrez, Source | TNF receptor-associated factor 4 | 6282 | 0.238 | 0.3295 | No |
| 42 | CCNE1 | NA | CCNE1 Entrez, Source | cyclin E1 | 6772 | 0.198 | 0.3059 | No |
| 43 | TRAF3 | NA | TRAF3 Entrez, Source | TNF receptor-associated factor 3 | 6934 | 0.185 | 0.3002 | No |
| 44 | CDK6 | NA | CDK6 Entrez, Source | cyclin-dependent kinase 6 | 7145 | 0.170 | 0.2915 | No |
| 45 | PIAS3 | NA | PIAS3 Entrez, Source | protein inhibitor of activated STAT, 3 | 7532 | 0.142 | 0.2726 | No |
| 46 | RARB | NA | RARB Entrez, Source | retinoic acid receptor, beta | 7558 | 0.140 | 0.2737 | No |
| 47 | AKT1 | NA | AKT1 Entrez, Source | v-akt murine thymoma viral oncogene homolog 1 | 7922 | 0.113 | 0.2556 | No |
| 48 | APAF1 | NA | APAF1 Entrez, Source | apoptotic peptidase activating factor | 7927 | 0.113 | 0.2573 | No |
| 49 | PIK3CA | NA | PIK3CA Entrez, Source | phosphoinositide-3-kinase, catalytic, alpha polypeptide | 8784 | 0.052 | 0.2109 | No |
| 50 | COL4A6 | NA | COL4A6 Entrez, Source | collagen, type IV, alpha 6 | 8853 | 0.047 | 0.2079 | No |
| 51 | PIAS1 | NA | PIAS1 Entrez, Source | protein inhibitor of activated STAT, 1 | 9451 | 0.004 | 0.1750 | No |
| 52 | CKS1B | NA | CKS1B Entrez, Source | CDC28 protein kinase regulatory subunit 1B | 9735 | -0.001 | 0.1593 | No |
| 53 | XIAP | NA | 10443 | -0.045 | 0.1210 | No | ||
| 54 | IKBKB | NA | IKBKB Entrez, Source | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | 10944 | -0.074 | 0.0947 | No |
| 55 | LAMA2 | NA | LAMA2 Entrez, Source | laminin, alpha 2 (merosin, congenital muscular dystrophy) | 10978 | -0.076 | 0.0942 | No |
| 56 | PIK3R5 | NA | PIK3R5 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 5, p101 | 11049 | -0.081 | 0.0917 | No |
| 57 | PIK3CB | NA | PIK3CB Entrez, Source | phosphoinositide-3-kinase, catalytic, beta polypeptide | 11650 | -0.127 | 0.0607 | No |
| 58 | LAMA1 | NA | LAMA1 Entrez, Source | laminin, alpha 1 | 11699 | -0.132 | 0.0604 | No |
| 59 | PTK2 | NA | PTK2 Entrez, Source | PTK2 protein tyrosine kinase 2 | 11849 | -0.144 | 0.0546 | No |
| 60 | PTEN | NA | PTEN Entrez, Source | phosphatase and tensin homolog (mutated in multiple advanced cancers 1) | 12081 | -0.162 | 0.0446 | No |
| 61 | PIK3R2 | NA | PIK3R2 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta) | 12247 | -0.177 | 0.0386 | No |
| 62 | PIAS2 | NA | PIAS2 Entrez, Source | protein inhibitor of activated STAT, 2 | 12701 | -0.219 | 0.0173 | No |
| 63 | LAMC3 | NA | LAMC3 Entrez, Source | laminin, gamma 3 | 12947 | -0.240 | 0.0080 | No |
| 64 | NOS2 | NA | 12973 | -0.243 | 0.0108 | No | ||
| 65 | E2F1 | NA | E2F1 Entrez, Source | E2F transcription factor 1 | 13216 | -0.264 | 0.0020 | No |
| 66 | LAMB2 | NA | LAMB2 Entrez, Source | laminin, beta 2 (laminin S) | 13505 | -0.292 | -0.0089 | No |
| 67 | RB1 | NA | RB1 Entrez, Source | retinoblastoma 1 (including osteosarcoma) | 13520 | -0.294 | -0.0046 | No |
| 68 | CYCS | NA | CYCS Entrez, Source | cytochrome c, somatic | 13663 | -0.308 | -0.0071 | No |
| 69 | MYC | NA | MYC Entrez, Source | v-myc myelocytomatosis viral oncogene homolog (avian) | 13741 | -0.315 | -0.0059 | No |
| 70 | ITGAV | NA | ITGAV Entrez, Source | integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) | 14332 | -0.383 | -0.0319 | No |
| 71 | BCL2 | NA | BCL2 Entrez, Source | B-cell CLL/lymphoma 2 | 14397 | -0.390 | -0.0286 | No |
| 72 | CDK2 | NA | CDK2 Entrez, Source | cyclin-dependent kinase 2 | 14672 | -0.427 | -0.0364 | No |
| 73 | RXRB | NA | RXRB Entrez, Source | retinoid X receptor, beta | 15636 | -0.578 | -0.0796 | No |
| 74 | TP53 | NA | TP53 Entrez, Source | tumor protein p53 (Li-Fraumeni syndrome) | 15988 | -0.654 | -0.0877 | No |
| 75 | TRAF5 | NA | TRAF5 Entrez, Source | TNF receptor-associated factor 5 | 16085 | -0.677 | -0.0812 | No |
| 76 | COL4A4 | NA | COL4A4 Entrez, Source | collagen, type IV, alpha 4 | 16105 | -0.682 | -0.0705 | No |
| 77 | CDKN1B | NA | CDKN1B Entrez, Source | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | 16862 | -0.909 | -0.0965 | No |
| 78 | ITGB1 | NA | ITGB1 Entrez, Source | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 16942 | -0.944 | -0.0845 | No |
| 79 | LAMA3 | NA | LAMA3 Entrez, Source | laminin, alpha 3 | 16986 | -0.962 | -0.0702 | No |
| 80 | LAMB1 | NA | LAMB1 Entrez, Source | laminin, beta 1 | 17257 | -1.095 | -0.0662 | No |
| 81 | PIK3CG | NA | PIK3CG Entrez, Source | phosphoinositide-3-kinase, catalytic, gamma polypeptide | 17630 | -1.385 | -0.0627 | No |
| 82 | CASP9 | NA | CASP9 Entrez, Source | caspase 9, apoptosis-related cysteine peptidase | 17671 | -1.437 | -0.0400 | No |
| 83 | AKT3 | NA | AKT3 Entrez, Source | v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) | 17766 | -1.559 | -0.0182 | No |
| 84 | ITGA2B | NA | ITGA2B Entrez, Source | integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) | 18009 | -2.323 | 0.0087 | No |
