Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1w1a |
| GeneSet | KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY |
| Enrichment Score (ES) | 0.62690336 |
| Normalized Enrichment Score (NES) | 2.1348097 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0 |
| FWER p-Value | 0.0 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | ISG15 | NA | ISG15 Entrez, Source | ISG15 ubiquitin-like modifier | 5 | 4.784 | 0.0935 | Yes |
| 2 | DDX58 | NA | DDX58 Entrez, Source | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 | 15 | 4.649 | 0.1840 | Yes |
| 3 | CXCL10 | NA | CXCL10 Entrez, Source | chemokine (C-X-C motif) ligand 10 | 16 | 4.631 | 0.2748 | Yes |
| 4 | DHX58 | NA | 40 | 4.231 | 0.3564 | Yes | ||
| 5 | IFIH1 | NA | IFIH1 Entrez, Source | interferon induced with helicase C domain 1 | 60 | 3.930 | 0.4324 | Yes |
| 6 | TMEM173 | NA | TMEM173 Entrez, Source | transmembrane protein 173 | 207 | 2.372 | 0.4708 | Yes |
| 7 | NFKBIA | NA | NFKBIA Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 460 | 1.595 | 0.4881 | Yes |
| 8 | IKBKE | NA | IKBKE Entrez, Source | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 866 | 1.200 | 0.4893 | Yes |
| 9 | IRF3 | NA | IRF3 Entrez, Source | interferon regulatory factor 3 | 1012 | 1.113 | 0.5031 | Yes |
| 10 | RELA | NA | RELA Entrez, Source | v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian) | 1150 | 1.047 | 0.5160 | Yes |
| 11 | TNF | NA | TNF Entrez, Source | tumor necrosis factor (TNF superfamily, member 2) | 1210 | 1.015 | 0.5326 | Yes |
| 12 | FADD | NA | FADD Entrez, Source | Fas (TNFRSF6)-associated via death domain | 1402 | 0.946 | 0.5406 | Yes |
| 13 | MAP3K1 | NA | MAP3K1 Entrez, Source | mitogen-activated protein kinase kinase kinase 1 | 1406 | 0.945 | 0.5590 | Yes |
| 14 | IKBKG | NA | IKBKG Entrez, Source | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | 1587 | 0.884 | 0.5664 | Yes |
| 15 | IL12B | NA | IL12B Entrez, Source | interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) | 1607 | 0.880 | 0.5825 | Yes |
| 16 | RIPK1 | NA | RIPK1 Entrez, Source | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 1659 | 0.863 | 0.5966 | Yes |
| 17 | TRADD | NA | TRADD Entrez, Source | TNFRSF1A-associated via death domain | 1709 | 0.848 | 0.6105 | Yes |
| 18 | NFKB1 | NA | NFKB1 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 1767 | 0.835 | 0.6238 | Yes |
| 19 | CYLD | NA | CYLD Entrez, Source | cylindromatosis (turban tumor syndrome) | 2158 | 0.752 | 0.6170 | Yes |
| 20 | DDX3X | NA | DDX3X Entrez, Source | DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked | 2240 | 0.736 | 0.6269 | Yes |
| 21 | CHUK | NA | CHUK Entrez, Source | conserved helix-loop-helix ubiquitous kinase | 3103 | 0.582 | 0.5907 | No |
| 22 | TRAF2 | NA | TRAF2 Entrez, Source | TNF receptor-associated factor 2 | 3221 | 0.564 | 0.5953 | No |
| 23 | CASP10 | NA | CASP10 Entrez, Source | caspase 10, apoptosis-related cysteine peptidase | 3347 | 0.544 | 0.5990 | No |
| 24 | TANK | NA | TANK Entrez, Source | TRAF family member-associated NFKB activator | 3630 | 0.507 | 0.5934 | No |
| 25 | NLRX1 | NA | 3815 | 0.483 | 0.5927 | No | ||
| 26 | SIKE1 | NA | 4306 | 0.422 | 0.5739 | No | ||
| 27 | MAPK11 | NA | MAPK11 Entrez, Source | mitogen-activated protein kinase 11 | 4342 | 0.417 | 0.5801 | No |
| 28 | TBKBP1 | NA | TBKBP1 Entrez, Source | TBK1 binding protein 1 | 4635 | 0.389 | 0.5716 | No |
| 29 | OTUD5 | NA | OTUD5 Entrez, Source | OTU domain containing 5 | 4876 | 0.365 | 0.5655 | No |
| 30 | TRAF6 | NA | TRAF6 Entrez, Source | TNF receptor-associated factor 6 | 5263 | 0.326 | 0.5506 | No |
| 31 | CASP8 | NA | CASP8 Entrez, Source | caspase 8, apoptosis-related cysteine peptidase | 5677 | 0.288 | 0.5334 | No |
| 32 | IFNA21 | NA | IFNA21 Entrez, Source | interferon, alpha 21 | 5854 | 0.273 | 0.5290 | No |
| 33 | MAPK12 | NA | MAPK12 Entrez, Source | mitogen-activated protein kinase 12 | 6059 | 0.258 | 0.5228 | No |
| 34 | TRAF3 | NA | TRAF3 Entrez, Source | TNF receptor-associated factor 3 | 6934 | 0.185 | 0.4782 | No |
| 35 | IFNB1 | NA | IFNB1 Entrez, Source | interferon, beta 1, fibroblast | 7718 | 0.129 | 0.4374 | No |
| 36 | IFNA17 | NA | IFNA17 Entrez, Source | interferon, alpha 17 | 8248 | 0.090 | 0.4100 | No |
| 37 | MAPK14 | NA | MAPK14 Entrez, Source | mitogen-activated protein kinase 14 | 8878 | 0.045 | 0.3761 | No |
| 38 | IRF7 | NA | IRF7 Entrez, Source | interferon regulatory factor 7 | 9107 | 0.027 | 0.3640 | No |
| 39 | IFNA13 | NA | IFNA13 Entrez, Source | interferon, alpha 13 | 9539 | 0.000 | 0.3402 | No |
| 40 | IFNA8 | NA | IFNA8 Entrez, Source | interferon, alpha 8 | 9853 | -0.010 | 0.3231 | No |
| 41 | DDX3Y | NA | DDX3Y Entrez, Source | DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked | 9911 | -0.013 | 0.3202 | No |
| 42 | MAPK8 | NA | MAPK8 Entrez, Source | mitogen-activated protein kinase 8 | 10132 | -0.028 | 0.3086 | No |
| 43 | IL12A | NA | IL12A Entrez, Source | interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) | 10711 | -0.061 | 0.2779 | No |
| 44 | IKBKB | NA | IKBKB Entrez, Source | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | 10944 | -0.074 | 0.2665 | No |
| 45 | IFNA10 | NA | IFNA10 Entrez, Source | interferon, alpha 10 | 11188 | -0.090 | 0.2549 | No |
| 46 | IFNA16 | NA | IFNA16 Entrez, Source | interferon, alpha 16 | 11217 | -0.092 | 0.2552 | No |
| 47 | ATG5 | NA | ATG5 Entrez, Source | ATG5 autophagy related 5 homolog (S. cerevisiae) | 11265 | -0.096 | 0.2544 | No |
| 48 | IFNA1 | NA | IFNA1 Entrez, Source | interferon, alpha 1 | 11267 | -0.096 | 0.2563 | No |
| 49 | IFNA6 | NA | IFNA6 Entrez, Source | interferon, alpha 6 | 11724 | -0.134 | 0.2337 | No |
| 50 | TBK1 | NA | TBK1 Entrez, Source | TANK-binding kinase 1 | 12301 | -0.183 | 0.2055 | No |
| 51 | MAVS | NA | 12412 | -0.192 | 0.2031 | No | ||
| 52 | ATG12 | NA | ATG12 Entrez, Source | ATG12 autophagy related 12 homolog (S. cerevisiae) | 12485 | -0.199 | 0.2031 | No |
| 53 | IFNK | NA | IFNK Entrez, Source | interferon, kappa | 12516 | -0.203 | 0.2054 | No |
| 54 | PIN1 | NA | PIN1 Entrez, Source | protein (peptidylprolyl cis/trans isomerase) NIMA-interacting 1 | 12612 | -0.211 | 0.2043 | No |
| 55 | IFNA2 | NA | IFNA2 Entrez, Source | interferon, alpha 2 | 13213 | -0.263 | 0.1763 | No |
| 56 | MAPK9 | NA | MAPK9 Entrez, Source | mitogen-activated protein kinase 9 | 13521 | -0.294 | 0.1651 | No |
| 57 | TRIM25 | NA | TRIM25 Entrez, Source | tripartite motif-containing 25 | 13538 | -0.295 | 0.1700 | No |
| 58 | MAP3K7 | NA | MAP3K7 Entrez, Source | mitogen-activated protein kinase kinase kinase 7 | 14046 | -0.351 | 0.1488 | No |
| 59 | IFNE | NA | 14107 | -0.358 | 0.1525 | No | ||
| 60 | MAPK10 | NA | MAPK10 Entrez, Source | mitogen-activated protein kinase 10 | 14334 | -0.383 | 0.1476 | No |
| 61 | AZI2 | NA | AZI2 Entrez, Source | 5-azacytidine induced 2 | 14704 | -0.429 | 0.1356 | No |
| 62 | MAPK13 | NA | MAPK13 Entrez, Source | mitogen-activated protein kinase 13 | 14840 | -0.454 | 0.1370 | No |
| 63 | RNF125 | NA | RNF125 Entrez, Source | ring finger protein 125 | 17066 | -0.997 | 0.0337 | No |
| 64 | IFNW1 | NA | IFNW1 Entrez, Source | interferon, omega 1 | 17627 | -1.383 | 0.0298 | No |
