Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | KEGG_PYRUVATE_METABOLISM |
| Enrichment Score (ES) | -0.5459833 |
| Normalized Enrichment Score (NES) | -1.7849591 |
| Nominal p-value | 0.0022522523 |
| FDR q-value | 0.015839154 |
| FWER p-Value | 0.127 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | PCK2 | NA | PCK2 Entrez, Source | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | 3604 | 0.510 | -0.1706 | No |
| 2 | LDHAL6B | NA | LDHAL6B Entrez, Source | lactate dehydrogenase A-like 6B | 3846 | 0.481 | -0.1574 | No |
| 3 | PDHA2 | NA | PDHA2 Entrez, Source | pyruvate dehydrogenase (lipoamide) alpha 2 | 6115 | 0.253 | -0.2686 | No |
| 4 | AKR1B1 | NA | AKR1B1 Entrez, Source | aldo-keto reductase family 1, member B1 (aldose reductase) | 6256 | 0.240 | -0.2630 | No |
| 5 | LDHAL6A | NA | LDHAL6A Entrez, Source | lactate dehydrogenase A-like 6A | 6991 | 0.181 | -0.2935 | No |
| 6 | ACSS2 | NA | ACSS2 Entrez, Source | acyl-CoA synthetase short-chain family member 2 | 7022 | 0.178 | -0.2854 | No |
| 7 | ACACB | NA | ACACB Entrez, Source | acetyl-Coenzyme A carboxylase beta | 8150 | 0.096 | -0.3422 | No |
| 8 | PKLR | NA | PKLR Entrez, Source | pyruvate kinase, liver and RBC | 10370 | -0.040 | -0.4625 | No |
| 9 | ME3 | NA | ME3 Entrez, Source | malic enzyme 3, NADP(+)-dependent, mitochondrial | 10971 | -0.076 | -0.4914 | No |
| 10 | DLAT | NA | DLAT Entrez, Source | dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) | 11362 | -0.102 | -0.5072 | No |
| 11 | GLO1 | NA | GLO1 Entrez, Source | glyoxalase I | 11430 | -0.108 | -0.5049 | No |
| 12 | PCK1 | NA | PCK1 Entrez, Source | phosphoenolpyruvate carboxykinase 1 (soluble) | 11490 | -0.114 | -0.5019 | No |
| 13 | MDH2 | NA | MDH2 Entrez, Source | malate dehydrogenase 2, NAD (mitochondrial) | 11787 | -0.139 | -0.5106 | No |
| 14 | LDHA | NA | LDHA Entrez, Source | lactate dehydrogenase A | 11836 | -0.143 | -0.5053 | No |
| 15 | ALDH1B1 | NA | ALDH1B1 Entrez, Source | aldehyde dehydrogenase 1 family, member B1 | 11847 | -0.144 | -0.4980 | No |
| 16 | ACSS1 | NA | ACSS1 Entrez, Source | acyl-CoA synthetase short-chain family member 1 | 12088 | -0.163 | -0.5022 | No |
| 17 | GRHPR | NA | GRHPR Entrez, Source | glyoxylate reductase/hydroxypyruvate reductase | 12477 | -0.199 | -0.5127 | No |
| 18 | ME1 | NA | ME1 Entrez, Source | malic enzyme 1, NADP(+)-dependent, cytosolic | 12526 | -0.204 | -0.5041 | No |
| 19 | LDHC | NA | LDHC Entrez, Source | lactate dehydrogenase C | 12974 | -0.243 | -0.5154 | No |
| 20 | ALDH7A1 | NA | ALDH7A1 Entrez, Source | aldehyde dehydrogenase 7 family, member A1 | 13180 | -0.261 | -0.5123 | No |
| 21 | ACAT2 | NA | ACAT2 Entrez, Source | acetyl-Coenzyme A acetyltransferase 2 (acetoacetyl Coenzyme A thiolase) | 13792 | -0.320 | -0.5284 | Yes |
| 22 | ALDH9A1 | NA | ALDH9A1 Entrez, Source | aldehyde dehydrogenase 9 family, member A1 | 13994 | -0.345 | -0.5204 | Yes |
| 23 | ACOT12 | NA | ACOT12 Entrez, Source | acyl-CoA thioesterase 12 | 14170 | -0.365 | -0.5100 | Yes |
| 24 | ME2 | NA | ME2 Entrez, Source | malic enzyme 2, NAD(+)-dependent, mitochondrial | 14177 | -0.365 | -0.4901 | Yes |
| 25 | ALDH3A2 | NA | ALDH3A2 Entrez, Source | aldehyde dehydrogenase 3 family, member A2 | 14517 | -0.407 | -0.4864 | Yes |
| 26 | HAGH | NA | HAGH Entrez, Source | hydroxyacylglutathione hydrolase | 14741 | -0.436 | -0.4746 | Yes |
| 27 | PDHA1 | NA | PDHA1 Entrez, Source | pyruvate dehydrogenase (lipoamide) alpha 1 | 15056 | -0.483 | -0.4653 | Yes |
| 28 | ACYP2 | NA | ACYP2 Entrez, Source | acylphosphatase 2, muscle type | 15145 | -0.495 | -0.4428 | Yes |
| 29 | DLD | NA | DLD Entrez, Source | dihydrolipoamide dehydrogenase | 15418 | -0.535 | -0.4283 | Yes |
| 30 | LDHB | NA | LDHB Entrez, Source | lactate dehydrogenase B | 15651 | -0.581 | -0.4091 | Yes |
| 31 | ACACA | NA | ACACA Entrez, Source | acetyl-Coenzyme A carboxylase alpha | 16537 | -0.808 | -0.4133 | Yes |
| 32 | PDHB | NA | PDHB Entrez, Source | pyruvate dehydrogenase (lipoamide) beta | 16571 | -0.817 | -0.3700 | Yes |
| 33 | ALDH2 | NA | ALDH2 Entrez, Source | aldehyde dehydrogenase 2 family (mitochondrial) | 16658 | -0.842 | -0.3283 | Yes |
| 34 | HAGHL | NA | HAGHL Entrez, Source | hydroxyacylglutathione hydrolase-like | 17095 | -1.011 | -0.2966 | Yes |
| 35 | MDH1 | NA | MDH1 Entrez, Source | malate dehydrogenase 1, NAD (soluble) | 17345 | -1.146 | -0.2471 | Yes |
| 36 | ACAT1 | NA | ACAT1 Entrez, Source | acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase) | 17713 | -1.484 | -0.1855 | Yes |
| 37 | PC | NA | PC Entrez, Source | pyruvate carboxylase | 17856 | -1.750 | -0.0968 | Yes |
| 38 | LDHD | NA | LDHD Entrez, Source | lactate dehydrogenase D | 17961 | -2.065 | 0.0114 | Yes |
