Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1w1a |
| GeneSet | KEGG_PYRIMIDINE_METABOLISM |
| Enrichment Score (ES) | 0.37601346 |
| Normalized Enrichment Score (NES) | 1.3455372 |
| Nominal p-value | 0.05305466 |
| FDR q-value | 0.35944456 |
| FWER p-Value | 1.0 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | NT5E | NA | NT5E Entrez, Source | 5'-nucleotidase, ecto (CD73) | 96 | 3.242 | 0.0702 | Yes |
| 2 | TYMP | NA | 117 | 3.024 | 0.1394 | Yes | ||
| 3 | POLD4 | NA | POLD4 Entrez, Source | polymerase (DNA-directed), delta 4 | 247 | 2.181 | 0.1831 | Yes |
| 4 | POLR3C | NA | POLR3C Entrez, Source | polymerase (RNA) III (DNA directed) polypeptide C (62kD) | 997 | 1.121 | 0.1677 | Yes |
| 5 | NME6 | NA | NME6 Entrez, Source | non-metastatic cells 6, protein expressed in (nucleoside-diphosphate kinase) | 1172 | 1.034 | 0.1822 | Yes |
| 6 | RRM2 | NA | RRM2 Entrez, Source | ribonucleotide reductase M2 polypeptide | 1205 | 1.016 | 0.2040 | Yes |
| 7 | ENTPD3 | NA | ENTPD3 Entrez, Source | ectonucleoside triphosphate diphosphohydrolase 3 | 1208 | 1.015 | 0.2275 | Yes |
| 8 | NT5M | NA | NT5M Entrez, Source | 5',3'-nucleotidase, mitochondrial | 1327 | 0.974 | 0.2437 | Yes |
| 9 | POLR3H | NA | POLR3H Entrez, Source | polymerase (RNA) III (DNA directed) polypeptide H (22.9kD) | 1384 | 0.951 | 0.2627 | Yes |
| 10 | UPP2 | NA | UPP2 Entrez, Source | uridine phosphorylase 2 | 1499 | 0.911 | 0.2776 | Yes |
| 11 | POLR3G | NA | POLR3G Entrez, Source | polymerase (RNA) III (DNA directed) polypeptide G (32kD) | 1585 | 0.885 | 0.2935 | Yes |
| 12 | POLD1 | NA | POLD1 Entrez, Source | polymerase (DNA directed), delta 1, catalytic subunit 125kDa | 1763 | 0.836 | 0.3032 | Yes |
| 13 | CMPK2 | NA | 1792 | 0.832 | 0.3210 | Yes | ||
| 14 | POLD3 | NA | POLD3 Entrez, Source | polymerase (DNA-directed), delta 3, accessory subunit | 2264 | 0.732 | 0.3120 | Yes |
| 15 | ENTPD6 | NA | ENTPD6 Entrez, Source | ectonucleoside triphosphate diphosphohydrolase 6 (putative function) | 2480 | 0.688 | 0.3161 | Yes |
| 16 | UCK1 | NA | UCK1 Entrez, Source | uridine-cytidine kinase 1 | 2574 | 0.671 | 0.3266 | Yes |
| 17 | POLR1A | NA | POLR1A Entrez, Source | polymerase (RNA) I polypeptide A, 194kDa | 2857 | 0.622 | 0.3254 | Yes |
| 18 | NT5C1B | NA | NT5C1B Entrez, Source | 5'-nucleotidase, cytosolic IB | 3011 | 0.595 | 0.3308 | Yes |
| 19 | PNP | NA | 3025 | 0.592 | 0.3439 | Yes | ||
| 20 | ENTPD5 | NA | ENTPD5 Entrez, Source | ectonucleoside triphosphate diphosphohydrolase 5 | 3040 | 0.590 | 0.3568 | Yes |
| 21 | POLR2D | NA | POLR2D Entrez, Source | polymerase (RNA) II (DNA directed) polypeptide D | 3131 | 0.578 | 0.3653 | Yes |
| 22 | POLR3K | NA | POLR3K Entrez, Source | polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa | 3379 | 0.540 | 0.3642 | Yes |
| 23 | DCTD | NA | DCTD Entrez, Source | dCMP deaminase | 3393 | 0.538 | 0.3760 | Yes |
| 24 | ZNRD1 | NA | ZNRD1 Entrez, Source | zinc ribbon domain containing 1 | 3940 | 0.469 | 0.3567 | No |
| 25 | POLR1D | NA | POLR1D Entrez, Source | polymerase (RNA) I polypeptide D, 16kDa | 4280 | 0.425 | 0.3478 | No |
| 26 | CANT1 | NA | CANT1 Entrez, Source | calcium activated nucleotidase 1 | 4420 | 0.409 | 0.3497 | No |
| 27 | UPRT | NA | 4647 | 0.388 | 0.3462 | No | ||
| 28 | POLR2L | NA | POLR2L Entrez, Source | polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa | 4931 | 0.358 | 0.3389 | No |
| 29 | TK2 | NA | TK2 Entrez, Source | thymidine kinase 2, mitochondrial | 5076 | 0.343 | 0.3389 | No |
| 30 | POLR2I | NA | POLR2I Entrez, Source | polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa | 5087 | 0.343 | 0.3463 | No |
| 31 | POLR2A | NA | POLR2A Entrez, Source | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 5191 | 0.332 | 0.3483 | No |
| 32 | DTYMK | NA | DTYMK Entrez, Source | deoxythymidylate kinase (thymidylate kinase) | 5259 | 0.326 | 0.3522 | No |
| 33 | CAD | NA | CAD Entrez, Source | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase | 5722 | 0.284 | 0.3333 | No |
| 34 | POLR1E | NA | POLR1E Entrez, Source | polymerase (RNA) I polypeptide E, 53kDa | 5807 | 0.278 | 0.3351 | No |
| 35 | POLR3B | NA | POLR3B Entrez, Source | polymerase (RNA) III (DNA directed) polypeptide B | 5881 | 0.271 | 0.3374 | No |
| 36 | POLA2 | NA | POLA2 Entrez, Source | polymerase (DNA directed), alpha 2 (70kD subunit) | 6090 | 0.255 | 0.3318 | No |
| 37 | POLR2F | NA | POLR2F Entrez, Source | polymerase (RNA) II (DNA directed) polypeptide F | 6159 | 0.249 | 0.3338 | No |
| 38 | POLR1C | NA | POLR1C Entrez, Source | polymerase (RNA) I polypeptide C, 30kDa | 6200 | 0.245 | 0.3373 | No |
| 39 | POLE2 | NA | POLE2 Entrez, Source | polymerase (DNA directed), epsilon 2 (p59 subunit) | 6201 | 0.245 | 0.3430 | No |
| 40 | POLE3 | NA | POLE3 Entrez, Source | polymerase (DNA directed), epsilon 3 (p17 subunit) | 6512 | 0.220 | 0.3310 | No |
| 41 | POLR3F | NA | POLR3F Entrez, Source | polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa | 6543 | 0.216 | 0.3344 | No |
| 42 | POLR1B | NA | POLR1B Entrez, Source | polymerase (RNA) I polypeptide B, 128kDa | 6619 | 0.210 | 0.3351 | No |
| 43 | POLR2C | NA | POLR2C Entrez, Source | polymerase (RNA) II (DNA directed) polypeptide C, 33kDa | 6700 | 0.203 | 0.3354 | No |
| 44 | POLA1 | NA | POLA1 Entrez, Source | polymerase (DNA directed), alpha 1 | 6717 | 0.202 | 0.3392 | No |
| 45 | POLR3D | NA | POLR3D Entrez, Source | polymerase (RNA) III (DNA directed) polypeptide D, 44kDa | 6892 | 0.189 | 0.3340 | No |
| 46 | ENTPD1 | NA | ENTPD1 Entrez, Source | ectonucleoside triphosphate diphosphohydrolase 1 | 7078 | 0.175 | 0.3279 | No |
| 47 | NT5C2 | NA | NT5C2 Entrez, Source | 5'-nucleotidase, cytosolic II | 7087 | 0.175 | 0.3315 | No |
| 48 | POLR2J2 | NA | POLR2J2 Entrez, Source | - | 7221 | 0.165 | 0.3280 | No |
| 49 | DHODH | NA | DHODH Entrez, Source | dihydroorotate dehydrogenase | 7296 | 0.160 | 0.3276 | No |
| 50 | UPB1 | NA | UPB1 Entrez, Source | ureidopropionase, beta | 7506 | 0.144 | 0.3194 | No |
| 51 | POLR2E | NA | POLR2E Entrez, Source | polymerase (RNA) II (DNA directed) polypeptide E, 25kDa | 7555 | 0.140 | 0.3200 | No |
| 52 | NME2 | NA | NME2 Entrez, Source | non-metastatic cells 2, protein (NM23B) expressed in | 7615 | 0.135 | 0.3199 | No |
| 53 | UCKL1 | NA | UCKL1 Entrez, Source | uridine-cytidine kinase 1-like 1 | 7762 | 0.125 | 0.3147 | No |
| 54 | POLE | NA | POLE Entrez, Source | polymerase (DNA directed), epsilon | 7835 | 0.120 | 0.3135 | No |
| 55 | POLR2J | NA | POLR2J Entrez, Source | polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa | 7871 | 0.117 | 0.3143 | No |
| 56 | DCK | NA | DCK Entrez, Source | deoxycytidine kinase | 7935 | 0.113 | 0.3134 | No |
| 57 | NME4 | NA | NME4 Entrez, Source | non-metastatic cells 4, protein expressed in | 7945 | 0.111 | 0.3155 | No |
| 58 | PNPT1 | NA | PNPT1 Entrez, Source | polyribonucleotide nucleotidyltransferase 1 | 8210 | 0.092 | 0.3031 | No |
| 59 | CTPS2 | NA | CTPS2 Entrez, Source | CTP synthase II | 8642 | 0.061 | 0.2807 | No |
| 60 | RRM2B | NA | RRM2B Entrez, Source | ribonucleotide reductase M2 B (TP53 inducible) | 8798 | 0.051 | 0.2733 | No |
| 61 | NME3 | NA | NME3 Entrez, Source | non-metastatic cells 3, protein expressed in | 8854 | 0.047 | 0.2713 | No |
| 62 | POLR3A | NA | POLR3A Entrez, Source | polymerase (RNA) III (DNA directed) polypeptide A, 155kDa | 8857 | 0.047 | 0.2723 | No |
| 63 | NT5C | NA | NT5C Entrez, Source | 5', 3'-nucleotidase, cytosolic | 8938 | 0.040 | 0.2688 | No |
| 64 | UCK2 | NA | UCK2 Entrez, Source | uridine-cytidine kinase 2 | 9228 | 0.019 | 0.2533 | No |
| 65 | UMPS | NA | UMPS Entrez, Source | uridine monophosphate synthetase (orotate phosphoribosyl transferase and orotidine-5'-decarboxylase) | 9751 | -0.002 | 0.2244 | No |
| 66 | PRIM2 | NA | 9771 | -0.004 | 0.2235 | No | ||
| 67 | ENTPD8 | NA | ENTPD8 Entrez, Source | ectonucleoside triphosphate diphosphohydrolase 8 | 10064 | -0.023 | 0.2078 | No |
| 68 | DPYS | NA | DPYS Entrez, Source | dihydropyrimidinase | 10307 | -0.039 | 0.1954 | No |
| 69 | NT5C1A | NA | NT5C1A Entrez, Source | 5'-nucleotidase, cytosolic IA | 11044 | -0.080 | 0.1565 | No |
| 70 | NME7 | NA | NME7 Entrez, Source | non-metastatic cells 7, protein expressed in (nucleoside-diphosphate kinase) | 11122 | -0.086 | 0.1542 | No |
| 71 | POLE4 | NA | POLE4 Entrez, Source | polymerase (DNA-directed), epsilon 4 (p12 subunit) | 11174 | -0.090 | 0.1535 | No |
| 72 | TYMS | NA | TYMS Entrez, Source | thymidylate synthetase | 11640 | -0.127 | 0.1307 | No |
| 73 | POLR2H | NA | POLR2H Entrez, Source | polymerase (RNA) II (DNA directed) polypeptide H | 11856 | -0.145 | 0.1222 | No |
| 74 | TXNRD2 | NA | TXNRD2 Entrez, Source | thioredoxin reductase 2 | 11884 | -0.147 | 0.1241 | No |
| 75 | CMPK1 | NA | 11921 | -0.149 | 0.1256 | No | ||
| 76 | DUT | NA | DUT Entrez, Source | dUTP pyrophosphatase | 12168 | -0.170 | 0.1159 | No |
| 77 | POLD2 | NA | POLD2 Entrez, Source | polymerase (DNA directed), delta 2, regulatory subunit 50kDa | 12324 | -0.185 | 0.1117 | No |
| 78 | CDA | NA | CDA Entrez, Source | cytidine deaminase | 12461 | -0.197 | 0.1087 | No |
| 79 | POLR2J3 | NA | POLR2J3 Entrez, Source | - | 13125 | -0.255 | 0.0780 | No |
| 80 | TK1 | NA | TK1 Entrez, Source | thymidine kinase 1, soluble | 13165 | -0.259 | 0.0819 | No |
| 81 | PRIM1 | NA | PRIM1 Entrez, Source | primase, polypeptide 1, 49kDa | 13665 | -0.309 | 0.0614 | No |
| 82 | NUDT2 | NA | NUDT2 Entrez, Source | nudix (nucleoside diphosphate linked moiety X)-type motif 2 | 13752 | -0.316 | 0.0640 | No |
| 83 | ITPA | NA | ITPA Entrez, Source | inosine triphosphatase (nucleoside triphosphate pyrophosphatase) | 13899 | -0.331 | 0.0636 | No |
| 84 | POLR2G | NA | POLR2G Entrez, Source | polymerase (RNA) II (DNA directed) polypeptide G | 13962 | -0.340 | 0.0681 | No |
| 85 | RRM1 | NA | RRM1 Entrez, Source | ribonucleotide reductase M1 polypeptide | 14073 | -0.355 | 0.0703 | No |
| 86 | NME1-NME2 | NA | NME1-NME2 Entrez, Source | - | 14198 | -0.367 | 0.0720 | No |
| 87 | TXNRD1 | NA | TXNRD1 Entrez, Source | thioredoxin reductase 1 | 14431 | -0.396 | 0.0684 | No |
| 88 | POLR3GL | NA | POLR3GL Entrez, Source | polymerase (RNA) III (DNA directed) polypeptide G (32kD) like | 14500 | -0.405 | 0.0740 | No |
| 89 | NME1 | NA | NME1 Entrez, Source | non-metastatic cells 1, protein (NM23A) expressed in | 14686 | -0.429 | 0.0738 | No |
| 90 | ENTPD4 | NA | ENTPD4 Entrez, Source | ectonucleoside triphosphate diphosphohydrolase 4 | 15573 | -0.566 | 0.0379 | No |
| 91 | POLR2K | NA | POLR2K Entrez, Source | polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa | 15768 | -0.603 | 0.0412 | No |
| 92 | POLR2B | NA | POLR2B Entrez, Source | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa | 15791 | -0.609 | 0.0542 | No |
| 93 | DPYD | NA | DPYD Entrez, Source | dihydropyrimidine dehydrogenase | 15908 | -0.634 | 0.0625 | No |
| 94 | AK3 | NA | AK3 Entrez, Source | adenylate kinase 3 | 17483 | -1.245 | 0.0044 | No |
| 95 | NME5 | NA | NME5 Entrez, Source | non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase) | 17667 | -1.434 | 0.0277 | No |
