Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1w1a |
| GeneSet | KEGG_PRION_DISEASES |
| Enrichment Score (ES) | 0.5682669 |
| Normalized Enrichment Score (NES) | 1.6908798 |
| Nominal p-value | 0.008695652 |
| FDR q-value | 0.038754266 |
| FWER p-Value | 0.322 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | CCL5 | NA | CCL5 Entrez, Source | chemokine (C-C motif) ligand 5 | 6 | 4.768 | 0.1666 | Yes |
| 2 | IL6 | NA | IL6 Entrez, Source | interleukin 6 (interferon, beta 2) | 17 | 4.596 | 0.3270 | Yes |
| 3 | HSPA1A | NA | HSPA1A Entrez, Source | heat shock 70kDa protein 1A | 339 | 1.855 | 0.3743 | Yes |
| 4 | IL1A | NA | IL1A Entrez, Source | interleukin 1, alpha | 647 | 1.371 | 0.4053 | Yes |
| 5 | NOTCH1 | NA | NOTCH1 Entrez, Source | Notch homolog 1, translocation-associated (Drosophila) | 715 | 1.313 | 0.4476 | Yes |
| 6 | HSPA5 | NA | HSPA5 Entrez, Source | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 777 | 1.263 | 0.4885 | Yes |
| 7 | IL1B | NA | IL1B Entrez, Source | interleukin 1, beta | 779 | 1.262 | 0.5326 | Yes |
| 8 | C5 | NA | C5 Entrez, Source | complement component 5 | 1122 | 1.055 | 0.5507 | Yes |
| 9 | C8G | NA | C8G Entrez, Source | complement component 8, gamma polypeptide | 1405 | 0.945 | 0.5683 | Yes |
| 10 | MAP2K2 | NA | MAP2K2 Entrez, Source | mitogen-activated protein kinase kinase 2 | 2222 | 0.740 | 0.5492 | No |
| 11 | NCAM1 | NA | NCAM1 Entrez, Source | neural cell adhesion molecule 1 | 3139 | 0.577 | 0.5189 | No |
| 12 | C8A | NA | C8A Entrez, Source | complement component 8, alpha polypeptide | 4637 | 0.388 | 0.4499 | No |
| 13 | MAPK3 | NA | MAPK3 Entrez, Source | mitogen-activated protein kinase 3 | 4770 | 0.376 | 0.4558 | No |
| 14 | LAMC1 | NA | LAMC1 Entrez, Source | laminin, gamma 1 (formerly LAMB2) | 5595 | 0.296 | 0.4207 | No |
| 15 | C9 | NA | C9 Entrez, Source | complement component 9 | 5665 | 0.290 | 0.4271 | No |
| 16 | BAX | NA | BAX Entrez, Source | BCL2-associated X protein | 5783 | 0.280 | 0.4304 | No |
| 17 | STIP1 | NA | STIP1 Entrez, Source | stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing protein) | 7217 | 0.166 | 0.3572 | No |
| 18 | PRKACB | NA | PRKACB Entrez, Source | protein kinase, cAMP-dependent, catalytic, beta | 8188 | 0.094 | 0.3070 | No |
| 19 | ELK1 | NA | ELK1 Entrez, Source | ELK1, member of ETS oncogene family | 8346 | 0.082 | 0.3012 | No |
| 20 | C1QC | NA | C1QC Entrez, Source | complement component 1, q subcomponent, C chain | 9437 | 0.004 | 0.2412 | No |
| 21 | C1QA | NA | C1QA Entrez, Source | complement component 1, q subcomponent, A chain | 9581 | 0.000 | 0.2333 | No |
| 22 | MAP2K1 | NA | MAP2K1 Entrez, Source | mitogen-activated protein kinase kinase 1 | 9745 | -0.001 | 0.2244 | No |
| 23 | PRNP | NA | PRNP Entrez, Source | prion protein (p27-30) (Creutzfeldt-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia) | 9809 | -0.007 | 0.2212 | No |
| 24 | PRKACG | NA | PRKACG Entrez, Source | protein kinase, cAMP-dependent, catalytic, gamma | 10762 | -0.063 | 0.1709 | No |
| 25 | C8B | NA | C8B Entrez, Source | complement component 8, beta polypeptide | 11187 | -0.090 | 0.1507 | No |
| 26 | C6 | NA | C6 Entrez, Source | complement component 6 | 13182 | -0.261 | 0.0498 | No |
| 27 | FYN | NA | FYN Entrez, Source | FYN oncogene related to SRC, FGR, YES | 13562 | -0.297 | 0.0394 | No |
| 28 | SOD1 | NA | SOD1 Entrez, Source | superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) | 13992 | -0.344 | 0.0278 | No |
| 29 | PRKACA | NA | PRKACA Entrez, Source | protein kinase, cAMP-dependent, catalytic, alpha | 14764 | -0.438 | 0.0006 | No |
| 30 | MAPK1 | NA | MAPK1 Entrez, Source | mitogen-activated protein kinase 1 | 14765 | -0.439 | 0.0159 | No |
| 31 | C7 | NA | C7 Entrez, Source | complement component 7 | 15400 | -0.532 | -0.0004 | No |
| 32 | PRKX | NA | PRKX Entrez, Source | protein kinase, X-linked | 15462 | -0.544 | 0.0153 | No |
| 33 | EGR1 | NA | EGR1 Entrez, Source | early growth response 1 | 16089 | -0.678 | 0.0045 | No |
| 34 | NCAM2 | NA | NCAM2 Entrez, Source | neural cell adhesion molecule 2 | 18108 | -3.142 | 0.0033 | No |
