Datasetw1a_vs_wt_vs_wt.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp_repos
Phenotypew1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos
Upregulated in classago1w1a
GeneSetKEGG_PATHWAYS_IN_CANCER
Enrichment Score (ES)0.3408451
Normalized Enrichment Score (NES)1.4297991
Nominal p-value0.0013927576
FDR q-value0.24870817
FWER p-Value0.988
Table: GSEA Results Summary



Fig 1: Enrichment plot: KEGG_PATHWAYS_IN_CANCER   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1IL6NAIL6
Entrez,  Source
interleukin 6 (interferon, beta 2)174.5960.0224Yes
2TRAF1NATRAF1
Entrez,  Source
TNF receptor-associated factor 1893.3230.0353Yes
3PLCG2NAPLCG2
Entrez,  Source
phospholipase C, gamma 2 (phosphatidylinositol-specific)923.3020.0520Yes
4LAMA4NALAMA4
Entrez,  Source
laminin, alpha 41242.9380.0651Yes
5TCF7L1NATCF7L1
Entrez,  Source
transcription factor 7-like 1 (T-cell specific, HMG-box)1322.8490.0792Yes
6NFKB2NANFKB2
Entrez,  Source
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)1382.8040.0932Yes
7FGF2NAFGF2
Entrez,  Source
fibroblast growth factor 2 (basic)1422.7780.1071Yes
8ITGA2NAITGA2
Entrez,  Source
integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)1482.7200.1207Yes
9BIRC3NABIRC3
Entrez,  Source
baculoviral IAP repeat-containing 31822.4840.1314Yes
10HSP90B1NAHSP90B1
Entrez,  Source
heat shock protein 90kDa beta (Grp94), member 11962.4120.1430Yes
11FGF1NAFGF1
Entrez,  Source
fibroblast growth factor 1 (acidic)2142.3350.1539Yes
12PMLNAPML
Entrez,  Source
promyelocytic leukemia3071.9560.1587Yes
13LAMB3NALAMB3
Entrez,  Source
laminin, beta 33431.8460.1661Yes
14PIK3R1NAPIK3R1
Entrez,  Source
phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha)3661.7860.1739Yes
15CSF2RANACSF2RA
Entrez,  Source
colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)4311.6520.1787Yes
16FZD4NAFZD4
Entrez,  Source
frizzled homolog 4 (Drosophila)4491.6100.1860Yes
17NFKBIANANFKBIA
Entrez,  Source
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha4601.5950.1935Yes
18WNT7BNAWNT7B
Entrez,  Source
wingless-type MMTV integration site family, member 7B4681.5860.2012Yes
19FZD8NAFZD8
Entrez,  Source
frizzled homolog 8 (Drosophila)4961.5410.2075Yes
20BCL2L1NABCL2L1
Entrez,  Source
BCL2-like 15121.5260.2144Yes
21DAPK1NADAPK1
Entrez,  Source
death-associated protein kinase 15561.4770.2195Yes
22TGFB2NATGFB2
Entrez,  Source
transforming growth factor, beta 25891.4290.2250Yes
23TGFB1NATGFB1
Entrez,  Source
transforming growth factor, beta 1 (Camurati-Engelmann disease)5931.4250.2320Yes
24PAX8NAPAX8
Entrez,  Source
paired box gene 86821.3350.2339Yes
25FGF21NAFGF21
Entrez,  Source
fibroblast growth factor 217161.3130.2387Yes
26JUNNAJUN
Entrez,  Source
jun oncogene7181.3120.2453Yes
27COL4A2NACOL4A2
Entrez,  Source
collagen, type IV, alpha 27941.2520.2475Yes
28FN1NAFN1
Entrez,  Source
fibronectin 18031.2440.2533Yes
29RXRGNARXRG
Entrez,  Source
retinoid X receptor, gamma8941.1790.2543Yes
30LAMC2NALAMC2
Entrez,  Source
laminin, gamma 29171.1600.2589Yes
31ITGA3NAITGA3
Entrez,  Source
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)9611.1380.2623Yes
32EGFRNAEGFR
Entrez,  Source
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)10421.0980.2634Yes
33PDGFANAPDGFA
Entrez,  Source
platelet-derived growth factor alpha polypeptide11461.0480.2630Yes
34RELANARELA
Entrez,  Source
v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian)11501.0470.2681Yes
35DVL1NADVL1
Entrez,  Source
dishevelled, dsh homolog 1 (Drosophila)12980.9830.2649Yes
36LAMA5NALAMA5
Entrez,  Source
laminin, alpha 513260.9750.2683Yes
37FADDNAFADD
Entrez,  Source
Fas (TNFRSF6)-associated via death domain14020.9460.2689Yes
38PIAS4NAPIAS4
Entrez,  Source
protein inhibitor of activated STAT, 414450.9310.2713Yes
39BCRNABCR
Entrez,  Source
breakpoint cluster region14960.9110.2731Yes
40CREBBPNACREBBP
Entrez,  Source
CREB binding protein (Rubinstein-Taybi syndrome)15280.9030.2760Yes
41CCNA1NACCNA1
Entrez,  Source
cyclin A115710.8910.2781Yes
42PIK3CDNAPIK3CD
Entrez,  Source
phosphoinositide-3-kinase, catalytic, delta polypeptide15720.8900.2827Yes
43IKBKGNAIKBKG
Entrez,  Source
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma15870.8840.2864Yes
44FASNAFAS
Entrez,  Source
Fas (TNF receptor superfamily, member 6)16000.8810.2902Yes
45EGLN2NAEGLN2
Entrez,  Source
egl nine homolog 2 (C. elegans)17300.8440.2872Yes
46RAC2NARAC2
Entrez,  Source
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)17480.8390.2905Yes
47NFKB1NANFKB1
Entrez,  Source
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)17670.8350.2938Yes
48HRASNAHRAS
Entrez,  Source
v-Ha-ras Harvey rat sarcoma viral oncogene homolog17990.8310.2963Yes
49COL4A1NACOL4A1
Entrez,  Source
collagen, type IV, alpha 118180.8250.2994Yes
50FGFR1NAFGFR1
Entrez,  Source
fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)18200.8250.3036Yes
51HSP90AB1NAHSP90AB1
Entrez,  Source
heat shock protein 90kDa alpha (cytosolic), class B member 119120.8050.3026Yes
52PPARDNAPPARD
Entrez,  Source
peroxisome proliferative activated receptor, delta19920.7900.3022Yes
53AXIN1NAAXIN1
Entrez,  Source
axin 120200.7840.3046Yes
54FZD2NAFZD2
Entrez,  Source
frizzled homolog 2 (Drosophila)20270.7830.3083Yes
55TGFBR2NATGFBR2
Entrez,  Source
transforming growth factor, beta receptor II (70/80kDa)20570.7760.3106Yes
56EGLN1NAEGLN1
Entrez,  Source
egl nine homolog 1 (C. elegans)21210.7620.3109Yes
57CCDC6NACCDC6
Entrez,  Source
coiled-coil domain containing 621980.7450.3104Yes
58EP300NAEP300
Entrez,  Source
E1A binding protein p30022100.7420.3136Yes
59WNT3NAWNT3
Entrez,  Source
wingless-type MMTV integration site family, member 322140.7410.3172Yes
60MAP2K2NAMAP2K2
Entrez,  Source
mitogen-activated protein kinase kinase 222220.7400.3206Yes
61RARANARARA
Entrez,  Source
retinoic acid receptor, alpha22900.7260.3205Yes
62APC2NAAPC2
Entrez,  Source
adenomatosis polyposis coli 223080.7230.3232Yes
63RUNX1NARUNX1
Entrez,  Source
runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene)23230.7180.3261Yes
64WNT4NAWNT4
Entrez,  Source
wingless-type MMTV integration site family, member 423240.7180.3297Yes
65PRKCGNAPRKCG
Entrez,  Source
protein kinase C, gamma23510.7110.3319Yes
66STK36NASTK36
Entrez,  Source
serine/threonine kinase 36 (fused homolog, Drosophila)24930.6850.3275Yes
67DAPK3NADAPK3
Entrez,  Source
death-associated protein kinase 325480.6760.3279Yes
68FZD9NAFZD9
Entrez,  Source
frizzled homolog 9 (Drosophila)25640.6730.3305Yes
69BADNABAD
Entrez,  Source
BCL2-antagonist of cell death27640.6370.3225Yes
70GLI1NAGLI1
Entrez,  Source
glioma-associated oncogene homolog 1 (zinc finger protein)27690.6360.3256Yes
71RAD51NARAD51
Entrez,  Source
RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)27880.6310.3278Yes
72RXRANARXRA
Entrez,  Source
retinoid X receptor, alpha28350.6260.3284Yes
73ARNAAR
Entrez,  Source
androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease)28500.6230.3307Yes
74STAT1NASTAT1
Entrez,  Source
signal transducer and activator of transcription 1, 91kDa28540.6220.3337Yes
75BRCA2NABRCA2
Entrez,  Source
breast cancer 2, early onset28550.6220.3369Yes
76CASP3NACASP3
Entrez,  Source
caspase 3, apoptosis-related cysteine peptidase29030.6130.3374Yes
77ITGA6NAITGA6
Entrez,  Source
integrin, alpha 630330.5910.3331Yes
78TGFANATGFA
Entrez,  Source
transforming growth factor, alpha30750.5850.3338Yes
79CCNE2NACCNE2
Entrez,  Source
cyclin E230780.5850.3367Yes
80CHUKNACHUK
Entrez,  Source
conserved helix-loop-helix ubiquitous kinase31030.5820.3383Yes
81RALBNARALB
Entrez,  Source
v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)31110.5800.3408Yes
82TRAF2NATRAF2
Entrez,  Source
TNF receptor-associated factor 232210.5640.3376No
83STAT3NASTAT3
Entrez,  Source
signal transducer and activator of transcription 3 (acute-phase response factor)33050.5500.3357No
84ETS1NAETS1
Entrez,  Source
v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)33600.5420.3355No
85BIRC2NABIRC2
Entrez,  Source
baculoviral IAP repeat-containing 233770.5400.3373No
86MSH6NAMSH6
Entrez,  Source
mutS homolog 6 (E. coli)36430.5050.3250No
87ERBB2NAERBB2
Entrez,  Source
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)37540.4910.3214No
88DCCNADCC
Entrez,  Source
deleted in colorectal carcinoma38520.4800.3184No
89ARAFNAARAF
Entrez,  Source
v-raf murine sarcoma 3611 viral oncogene homolog38650.4790.3201No
90STAT5ANASTAT5A
Entrez,  Source
signal transducer and activator of transcription 5A38750.4780.3221No
91ABL1NAABL1
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 138890.4770.3238No
92MSH2NAMSH2
Entrez,  Source
mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)39450.4680.3231No
93GLI2NAGLI2
Entrez,  Source
GLI-Kruppel family member GLI240100.4600.3218No
94WNT2BNAWNT2B
Entrez,  Source
wingless-type MMTV integration site family, member 2B41310.4420.3173No
95BRAFNABRAF
Entrez,  Source
v-raf murine sarcoma viral oncogene homolog B141350.4420.3194No
96KITNAKIT
Entrez,  Source
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog42610.4270.3146No
97ARNT2NAARNT2
Entrez,  Source
aryl-hydrocarbon receptor nuclear translocator 243460.4170.3120No
98PTGS2NAPTGS2
Entrez,  Source
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)44060.4100.3108No
99PPARGNAPPARG
Entrez,  Source
peroxisome proliferative activated receptor, gamma44280.4080.3117No
100MECOMNA44360.4070.3133No
101CCND1NACCND1
Entrez,  Source
cyclin D144400.4070.3152No
102MAXNAMAX
Entrez,  Source
MYC associated factor X45040.4000.3137No
103SKP2NASKP2
Entrez,  Source
S-phase kinase-associated protein 2 (p45)46920.3840.3052No
104PTCH1NAPTCH1
Entrez,  Source
patched homolog 1 (Drosophila)47250.3800.3053No
105MAPK3NAMAPK3
Entrez,  Source
mitogen-activated protein kinase 347700.3760.3048No
106RASSF1NARASSF1
Entrez,  Source
Ras association (RalGDS/AF-6) domain family 148360.3690.3030No
107MSH3NAMSH3
Entrez,  Source
mutS homolog 3 (E. coli)48970.3620.3015No
108TFGNATFG
Entrez,  Source
TRK-fused gene50410.3470.2953No
109ZBTB16NAZBTB16
Entrez,  Source
zinc finger and BTB domain containing 1650560.3450.2962No
110PIK3R3NAPIK3R3
Entrez,  Source
phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma)51620.3350.2920No
111LEF1NALEF1
Entrez,  Source
lymphoid enhancer-binding factor 152060.3310.2913No
112NRASNANRAS
Entrez,  Source
neuroblastoma RAS viral (v-ras) oncogene homolog52500.3270.2906No
113TRAF6NATRAF6
Entrez,  Source
TNF receptor-associated factor 652630.3260.2916No
114SLC2A1NASLC2A1
Entrez,  Source
solute carrier family 2 (facilitated glucose transporter), member 154580.3070.2822No
115CDKN2BNACDKN2B
Entrez,  Source
cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)55380.3000.2793No
116JAK1NAJAK1
Entrez,  Source
Janus kinase 1 (a protein tyrosine kinase)55490.3000.2803No
117LAMC1NALAMC1
Entrez,  Source
laminin, gamma 1 (formerly LAMB2)55950.2960.2793No
118BMP4NABMP4
Entrez,  Source
bone morphogenetic protein 456270.2940.2790No
119HSP90AA1NAHSP90AA1
Entrez,  Source
heat shock protein 90kDa alpha (cytosolic), class A member 156630.2900.2786No
120CASP8NACASP8
Entrez,  Source
caspase 8, apoptosis-related cysteine peptidase56770.2880.2793No
121CDK4NACDK4
Entrez,  Source
cyclin-dependent kinase 456790.2880.2807No
122E2F2NAE2F2
Entrez,  Source
E2F transcription factor 257270.2840.2795No
123TPM3NATPM3
Entrez,  Source
tropomyosin 357670.2810.2788No
124NTRK1NANTRK1
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 157730.2800.2799No
125BAXNABAX
Entrez,  Source
BCL2-associated X protein57830.2800.2808No
126FGF5NAFGF5
Entrez,  Source
fibroblast growth factor 559620.2660.2722No
127LAMB4NALAMB4
Entrez,  Source
laminin, beta 460800.2560.2669No
128TPRNATPR
Entrez,  Source
translocated promoter region (to activated MET oncogene)60890.2550.2678No
129AKT2NAAKT2
Entrez,  Source
v-akt murine thymoma viral oncogene homolog 261440.2500.2660No
130E2F3NAE2F3
Entrez,  Source
E2F transcription factor 361480.2500.2671No
131CTBP1NACTBP1
Entrez,  Source
C-terminal binding protein 162660.2390.2618No
132TRAF4NATRAF4
Entrez,  Source
TNF receptor-associated factor 462820.2380.2622No
133FLT3LGNAFLT3LG
Entrez,  Source
fms-related tyrosine kinase 3 ligand64530.2250.2538No
134GLI3NAGLI3
Entrez,  Source
GLI-Kruppel family member GLI3 (Greig cephalopolysyndactyly syndrome)64680.2240.2541No
135FLT3NAFLT3
Entrez,  Source
fms-related tyrosine kinase 364700.2240.2552No
136RUNX1T1NARUNX1T1
Entrez,  Source
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)65210.2180.2535No
137MMP2NAMMP2
Entrez,  Source
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)66020.2120.2501No
138CCNE1NACCNE1
Entrez,  Source
cyclin E167720.1980.2417No
139TRAF3NATRAF3
Entrez,  Source
TNF receptor-associated factor 369340.1850.2336No
140MMP1NAMMP1
Entrez,  Source
matrix metallopeptidase 1 (interstitial collagenase)70530.1760.2279No
141JUPNAJUP
Entrez,  Source
junction plakoglobin70790.1750.2273No
142CRKLNACRKL
Entrez,  Source
v-crk sarcoma virus CT10 oncogene homolog (avian)-like71190.1720.2260No
143CDK6NACDK6
Entrez,  Source
cyclin-dependent kinase 671450.1700.2255No
144HIF1ANAHIF1A
Entrez,  Source
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)72120.1660.2226No
145FZD3NAFZD3
Entrez,  Source
frizzled homolog 3 (Drosophila)72750.1610.2200No
146MDM2NAMDM2
Entrez,  Source
Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse)72890.1600.2201No
147FGF9NAFGF9
Entrez,  Source
fibroblast growth factor 9 (glia-activating factor)74030.1510.2145No
148MITFNAMITF
Entrez,  Source
microphthalmia-associated transcription factor74560.1470.2123No
149CDKN1ANACDKN1A
Entrez,  Source
cyclin-dependent kinase inhibitor 1A (p21, Cip1)75230.1430.2094No
150PIAS3NAPIAS3
Entrez,  Source
protein inhibitor of activated STAT, 375320.1420.2096No
151RARBNARARB
Entrez,  Source
retinoic acid receptor, beta75580.1400.2090No
152WNT9ANAWNT9A
Entrez,  Source
wingless-type MMTV integration site family, member 9A76360.1340.2053No
153FGF10NAFGF10
Entrez,  Source
fibroblast growth factor 1076760.1320.2038No
154EPAS1NAEPAS1
Entrez,  Source
endothelial PAS domain protein 177950.1230.1978No
155DAPK2NADAPK2
Entrez,  Source
death-associated protein kinase 278950.1150.1929No
156FGF6NAFGF6
Entrez,  Source
fibroblast growth factor 678960.1150.1934No
157VEGFANA79030.1150.1937No
158AKT1NAAKT1
Entrez,  Source
v-akt murine thymoma viral oncogene homolog 179220.1130.1933No
159MLH1NAMLH1
Entrez,  Source
mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)79410.1120.1928No
160HGFNAHGF
Entrez,  Source
hepatocyte growth factor (hepapoietin A; scatter factor)81930.0930.1792No
161FGF11NAFGF11
Entrez,  Source
fibroblast growth factor 1182780.0870.1750No
162CTNNA3NACTNNA3
Entrez,  Source
catenin (cadherin-associated protein), alpha 382840.0870.1751No
163FOXO1NA84760.0740.1648No
164FZD7NAFZD7
Entrez,  Source
frizzled homolog 7 (Drosophila)85750.0670.1596No
165CUL2NACUL2
Entrez,  Source
cullin 286050.0650.1583No
166DVL2NADVL2
Entrez,  Source
dishevelled, dsh homolog 2 (Drosophila)86640.0600.1554No
167PIK3CANAPIK3CA
Entrez,  Source
phosphoinositide-3-kinase, catalytic, alpha polypeptide87840.0520.1490No
168KLK3NAKLK3
Entrez,  Source
kallikrein 3, (prostate specific antigen)88200.0500.1473No
169COL4A6NACOL4A6
Entrez,  Source
collagen, type IV, alpha 688530.0470.1457No
170WNT16NAWNT16
Entrez,  Source
wingless-type MMTV integration site family, member 1689390.0400.1412No
171MTORNA89510.0390.1408No
172SUFUNASUFU
Entrez,  Source
suppressor of fused homolog (Drosophila)90520.0310.1353No
173IGF1NAIGF1
Entrez,  Source
insulin-like growth factor 1 (somatomedin C)93060.0140.1212No
174PIAS1NAPIAS1
Entrez,  Source
protein inhibitor of activated STAT, 194510.0040.1132No
175CKS1BNACKS1B
Entrez,  Source
CDC28 protein kinase regulatory subunit 1B9735-0.0010.0973No
176MAP2K1NAMAP2K1
Entrez,  Source
mitogen-activated protein kinase kinase 19745-0.0010.0968No
177RALBP1NARALBP1
Entrez,  Source
ralA binding protein 19759-0.0030.0961No
178FGF4NAFGF4
Entrez,  Source
fibroblast growth factor 4 (heparin secretory transforming protein 1, Kaposi sarcoma oncogene)9815-0.0070.0931No
179PDGFBNAPDGFB
Entrez,  Source
platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)9832-0.0080.0922No
180CDKN2ANACDKN2A
Entrez,  Source
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)9855-0.0100.0910No
181RAC1NARAC1
Entrez,  Source
ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)9857-0.0100.0910No
182FGF8NAFGF8
Entrez,  Source
fibroblast growth factor 8 (androgen-induced)9986-0.0180.0839No
183FGF17NAFGF17
Entrez,  Source
fibroblast growth factor 179997-0.0180.0835No
184IGF1RNAIGF1R
Entrez,  Source
insulin-like growth factor 1 receptor10119-0.0270.0768No
185MAPK8NAMAPK8
Entrez,  Source
mitogen-activated protein kinase 810132-0.0280.0763No
186APPL1NA10235-0.0330.0708No
187CRKNACRK
Entrez,  Source
v-crk sarcoma virus CT10 oncogene homolog (avian)10244-0.0340.0705No
188VHLNAVHL
Entrez,  Source
von Hippel-Lindau tumor suppressor10397-0.0420.0622No
189HDAC2NAHDAC2
Entrez,  Source
histone deacetylase 210429-0.0440.0607No
190XIAPNA10443-0.0450.0602No
191CBLCNACBLC
Entrez,  Source
Cas-Br-M (murine) ecotropic retroviral transforming sequence c10474-0.0460.0587No
192FZD5NAFZD5
Entrez,  Source
frizzled homolog 5 (Drosophila)10529-0.0490.0559No
193RETNARET
Entrez,  Source
ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)10661-0.0590.0489No
194SHHNASHH
Entrez,  Source
sonic hedgehog homolog (Drosophila)10664-0.0590.0491No
195CBLBNACBLB
Entrez,  Source
Cas-Br-M (murine) ecotropic retroviral transforming sequence b10677-0.0590.0487No
196WNT9BNAWNT9B
Entrez,  Source
wingless-type MMTV integration site family, member 9B10696-0.0610.0480No
197SMAD4NASMAD4
Entrez,  Source
SMAD, mothers against DPP homolog 4 (Drosophila)10712-0.0620.0475No
198DVL3NADVL3
Entrez,  Source
dishevelled, dsh homolog 3 (Drosophila)10751-0.0630.0457No
199FGF3NAFGF3
Entrez,  Source
fibroblast growth factor 3 (murine mammary tumor virus integration site (v-int-2) oncogene homolog)10785-0.0640.0442No
200CTBP2NACTBP2
Entrez,  Source
C-terminal binding protein 210837-0.0670.0416No
201PLCG1NAPLCG1
Entrez,  Source
phospholipase C, gamma 110890-0.0710.0391No
202IKBKBNAIKBKB
Entrez,  Source
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta10944-0.0740.0365No
203LAMA2NALAMA2
Entrez,  Source
laminin, alpha 2 (merosin, congenital muscular dystrophy)10978-0.0760.0350No
204SMONASMO
Entrez,  Source
smoothened homolog (Drosophila)11027-0.0790.0327No
205PIK3R5NAPIK3R5
Entrez,  Source
phosphoinositide-3-kinase, regulatory subunit 5, p10111049-0.0810.0320No
206NCOA4NANCOA4
Entrez,  Source
nuclear receptor coactivator 411050-0.0810.0324No
207WNT5ANAWNT5A
Entrez,  Source
wingless-type MMTV integration site family, member 5A11202-0.0920.0244No
208WNT7ANAWNT7A
Entrez,  Source
wingless-type MMTV integration site family, member 7A11205-0.0920.0248No
209WNT3ANAWNT3A
Entrez,  Source
wingless-type MMTV integration site family, member 3A11289-0.0970.0206No
210PDGFRANAPDGFRA
Entrez,  Source
platelet-derived growth factor receptor, alpha polypeptide11392-0.1050.0154No
211RBX1NARBX1
Entrez,  Source
ring-box 111485-0.1140.0108No
212FZD1NAFZD1
Entrez,  Source
frizzled homolog 1 (Drosophila)11515-0.1160.0098No
213BIDNABID
Entrez,  Source
BH3 interacting domain death agonist11556-0.1190.0082No
214PIK3CBNAPIK3CB
Entrez,  Source
phosphoinositide-3-kinase, catalytic, beta polypeptide11650-0.1270.0036No
215STK4NASTK4
Entrez,  Source
serine/threonine kinase 411685-0.1300.0024No
216LAMA1NALAMA1
Entrez,  Source
laminin, alpha 111699-0.1320.0023No
217PTK2NAPTK2
Entrez,  Source
PTK2 protein tyrosine kinase 211849-0.144-0.0053No
218FGF19NAFGF19
Entrez,  Source
fibroblast growth factor 1911913-0.149-0.0081No
219FZD6NAFZD6
Entrez,  Source
frizzled homolog 6 (Drosophila)11922-0.149-0.0078No
220CSF3RNACSF3R
Entrez,  Source
colony stimulating factor 3 receptor (granulocyte)11935-0.150-0.0077No
221WNT5BNAWNT5B
Entrez,  Source
wingless-type MMTV integration site family, member 5B12031-0.158-0.0122No
222PTENNAPTEN
Entrez,  Source
phosphatase and tensin homolog (mutated in multiple advanced cancers 1)12081-0.162-0.0141No
223CDH1NACDH1
Entrez,  Source
cadherin 1, type 1, E-cadherin (epithelial)12145-0.168-0.0168No
224PIK3R2NAPIK3R2
Entrez,  Source
phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta)12247-0.177-0.0216No
225PGFNAPGF
Entrez,  Source
placental growth factor, vascular endothelial growth factor-related protein12272-0.179-0.0220No
226SOS1NASOS1
Entrez,  Source
son of sevenless homolog 1 (Drosophila)12302-0.183-0.0227No
227FGF16NAFGF16
Entrez,  Source
fibroblast growth factor 1612426-0.195-0.0286No
228CDC42NACDC42
Entrez,  Source
cell division cycle 42 (GTP binding protein, 25kDa)12435-0.196-0.0281No
229CTNNB1NACTNNB1
Entrez,  Source
catenin (cadherin-associated protein), beta 1, 88kDa12660-0.216-0.0395No
230PIAS2NAPIAS2
Entrez,  Source
protein inhibitor of activated STAT, 212701-0.219-0.0406No
231RHOANARHOA
Entrez,  Source
ras homolog gene family, member A12705-0.219-0.0397No
232CBLNACBL
Entrez,  Source
Cas-Br-M (murine) ecotropic retroviral transforming sequence12715-0.220-0.0391No
233RALGDSNARALGDS
Entrez,  Source
ral guanine nucleotide dissociation stimulator12778-0.226-0.0414No
234VEGFBNAVEGFB
Entrez,  Source
vascular endothelial growth factor B12945-0.240-0.0495No
235LAMC3NALAMC3
Entrez,  Source
laminin, gamma 312947-0.240-0.0483No
236NOS2NA12973-0.243-0.0485No
237MMP9NAMMP9
Entrez,  Source
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)13001-0.245-0.0487No
238FZD10NAFZD10
Entrez,  Source
frizzled homolog 10 (Drosophila)13043-0.248-0.0498No
239APCNAAPC
Entrez,  Source
adenomatosis polyposis coli13130-0.256-0.0533No
240E2F1NAE2F1
Entrez,  Source
E2F transcription factor 113216-0.264-0.0567No
241CTNNA1NACTNNA1
Entrez,  Source
catenin (cadherin-associated protein), alpha 1, 102kDa13267-0.269-0.0582No
242LAMB2NALAMB2
Entrez,  Source
laminin, beta 2 (laminin S)13505-0.292-0.0700No
243RB1NARB1
Entrez,  Source
retinoblastoma 1 (including osteosarcoma)13520-0.294-0.0693No
244MAPK9NAMAPK9
Entrez,  Source
mitogen-activated protein kinase 913521-0.294-0.0678No
245CYCSNACYCS
Entrez,  Source
cytochrome c, somatic13663-0.308-0.0741No
246SMAD3NASMAD3
Entrez,  Source
SMAD, mothers against DPP homolog 3 (Drosophila)13718-0.312-0.0755No
247RAC3NARAC3
Entrez,  Source
ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)13740-0.315-0.0751No
248MYCNAMYC
Entrez,  Source
v-myc myelocytomatosis viral oncogene homolog (avian)13741-0.315-0.0735No
249HDAC1NAHDAC1
Entrez,  Source
histone deacetylase 113850-0.326-0.0779No
250FASLGNAFASLG
Entrez,  Source
Fas ligand (TNF superfamily, member 6)13862-0.326-0.0769No
251SPI1NASPI1
Entrez,  Source
spleen focus forming virus (SFFV) proviral integration oncogene spi113887-0.329-0.0765No
252RAF1NARAF1
Entrez,  Source
v-raf-1 murine leukemia viral oncogene homolog 113934-0.335-0.0774No
253GRB2NAGRB2
Entrez,  Source
growth factor receptor-bound protein 214005-0.345-0.0796No
254HHIPNAHHIP
Entrez,  Source
hedgehog interacting protein14091-0.357-0.0825No
255PTCH2NAPTCH2
Entrez,  Source
patched homolog 2 (Drosophila)14147-0.363-0.0838No
256WNT1NAWNT1
Entrez,  Source
wingless-type MMTV integration site family, member 114168-0.365-0.0830No
257RALANARALA
Entrez,  Source
v-ral simian leukemia viral oncogene homolog A (ras related)14203-0.368-0.0831No
258WNT2NAWNT2
Entrez,  Source
wingless-type MMTV integration site family member 214295-0.379-0.0862No
259ITGAVNAITGAV
Entrez,  Source
integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)14332-0.383-0.0863No
260MAPK10NAMAPK10
Entrez,  Source
mitogen-activated protein kinase 1014334-0.383-0.0844No
261BCL2NABCL2
Entrez,  Source
B-cell CLL/lymphoma 214397-0.390-0.0859No
262FOSNAFOS
Entrez,  Source
v-fos FBJ murine osteosarcoma viral oncogene homolog14425-0.395-0.0854No
263TGFB3NATGFB3
Entrez,  Source
transforming growth factor, beta 314478-0.403-0.0863No
264FGF13NAFGF13
Entrez,  Source
fibroblast growth factor 1314593-0.418-0.0905No
265VEGFCNAVEGFC
Entrez,  Source
vascular endothelial growth factor C14653-0.425-0.0917No
266CDK2NACDK2
Entrez,  Source
cyclin-dependent kinase 214672-0.427-0.0905No
267FGF20NAFGF20
Entrez,  Source
fibroblast growth factor 2014699-0.429-0.0898No
268WNT10BNAWNT10B
Entrez,  Source
wingless-type MMTV integration site family, member 10B14760-0.438-0.0909No
269MAPK1NAMAPK1
Entrez,  Source
mitogen-activated protein kinase 114765-0.439-0.0889No
270RASSF5NARASSF5
Entrez,  Source
Ras association (RalGDS/AF-6) domain family 514890-0.460-0.0935No
271FGF18NAFGF18
Entrez,  Source
fibroblast growth factor 1814949-0.468-0.0944No
272STAT5BNASTAT5B
Entrez,  Source
signal transducer and activator of transcription 5B15023-0.478-0.0961No
273FHNAFH
Entrez,  Source
fumarate hydratase15028-0.479-0.0939No
274WNT8ANAWNT8A
Entrez,  Source
wingless-type MMTV integration site family, member 8A15163-0.497-0.0989No
275BIRC5NABIRC5
Entrez,  Source
baculoviral IAP repeat-containing 5 (survivin)15435-0.539-0.1113No
276KRASNAKRAS
Entrez,  Source
v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog15437-0.539-0.1086No
277PRKCBNA15489-0.550-0.1087No
278AXIN2NAAXIN2
Entrez,  Source
axin 2 (conductin, axil)15616-0.574-0.1128No
279RXRBNARXRB
Entrez,  Source
retinoid X receptor, beta15636-0.578-0.1110No
280GSK3BNAGSK3B
Entrez,  Source
glycogen synthase kinase 3 beta15693-0.588-0.1111No
281ARNTNAARNT
Entrez,  Source
aryl hydrocarbon receptor nuclear translocator15944-0.641-0.1219No
282TP53NATP53
Entrez,  Source
tumor protein p53 (Li-Fraumeni syndrome)15988-0.654-0.1209No
283TRAF5NATRAF5
Entrez,  Source
TNF receptor-associated factor 516085-0.677-0.1229No
284COL4A4NACOL4A4
Entrez,  Source
collagen, type IV, alpha 416105-0.682-0.1205No
285WNT8BNAWNT8B
Entrez,  Source
wingless-type MMTV integration site family, member 8B16212-0.709-0.1228No
286SOS2NASOS2
Entrez,  Source
son of sevenless homolog 2 (Drosophila)16328-0.741-0.1255No
287KITLGNAKITLG
Entrez,  Source
KIT ligand16352-0.749-0.1230No
288BMP2NABMP2
Entrez,  Source
bone morphogenetic protein 216401-0.765-0.1218No
289FGFR2NAFGFR2
Entrez,  Source
ffer syndrome, Jackson-Weiss syndrome)16434-0.774-0.1196No
290FGF23NAFGF23
Entrez,  Source
fibroblast growth factor 2316437-0.775-0.1158No
291SMAD2NASMAD2
Entrez,  Source
SMAD, mothers against DPP homolog 2 (Drosophila)16594-0.824-0.1204No
292FGF7NAFGF7
Entrez,  Source
fibroblast growth factor 7 (keratinocyte growth factor)16741-0.869-0.1241No
293WNT11NAWNT11
Entrez,  Source
wingless-type MMTV integration site family, member 1116831-0.900-0.1246No
294CDKN1BNACDKN1B
Entrez,  Source
cyclin-dependent kinase inhibitor 1B (p27, Kip1)16862-0.909-0.1216No
295NKX3-1NANKX3-1
Entrez,  Source
NK3 transcription factor related, locus 1 (Drosophila)16875-0.915-0.1176No
296ITGB1NAITGB1
Entrez,  Source
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)16942-0.944-0.1165No
297LAMA3NALAMA3
Entrez,  Source
laminin, alpha 316986-0.962-0.1141No
298FGF12NAFGF12
Entrez,  Source
fibroblast growth factor 1217048-0.990-0.1125No
299METNAMET
Entrez,  Source
met proto-oncogene (hepatocyte growth factor receptor)17207-1.062-0.1159No
300LAMB1NALAMB1
Entrez,  Source
laminin, beta 117257-1.095-0.1131No
301CTNNA2NACTNNA2
Entrez,  Source
catenin (cadherin-associated protein), alpha 217310-1.125-0.1103No
302CEBPANACEBPA
Entrez,  Source
CCAAT/enhancer binding protein (C/EBP), alpha17537-1.286-0.1164No
303WNT10ANAWNT10A
Entrez,  Source
wingless-type MMTV integration site family, member 10A17538-1.287-0.1099No
304PIK3CGNAPIK3CG
Entrez,  Source
phosphoinositide-3-kinase, catalytic, gamma polypeptide17630-1.385-0.1079No
305TCF7L2NATCF7L2
Entrez,  Source
transcription factor 7-like 2 (T-cell specific, HMG-box)17649-1.413-0.1018No
306FGF14NAFGF14
Entrez,  Source
fibroblast growth factor 1417654-1.419-0.0948No
307CASP9NACASP9
Entrez,  Source
caspase 9, apoptosis-related cysteine peptidase17671-1.437-0.0884No
308EGFNAEGF
Entrez,  Source
epidermal growth factor (beta-urogastrone)17704-1.472-0.0827No
309WNT6NAWNT6
Entrez,  Source
wingless-type MMTV integration site family, member 617757-1.546-0.0778No
310AKT3NAAKT3
Entrez,  Source
v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)17766-1.559-0.0703No
311TCF7NATCF7
Entrez,  Source
transcription factor 7 (T-cell specific, HMG-box)17768-1.562-0.0624No
312TGFBR1NATGFBR1
Entrez,  Source
transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa)17790-1.602-0.0554No
313PLD1NAPLD1
Entrez,  Source
phospholipase D1, phosphatidylcholine-specific17808-1.634-0.0481No
314EGLN3NAEGLN3
Entrez,  Source
egl nine homolog 3 (C. elegans)17889-1.826-0.0433No
315FGFR3NAFGFR3
Entrez,  Source
fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism)17891-1.831-0.0341No
316PRKCANAPRKCA
Entrez,  Source
protein kinase C, alpha17892-1.832-0.0247No
317PDGFRBNAPDGFRB
Entrez,  Source
platelet-derived growth factor receptor, beta polypeptide17904-1.866-0.0159No
318ITGA2BNAITGA2B
Entrez,  Source
integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)18009-2.323-0.0099No
319CSF1RNACSF1R
Entrez,  Source
colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog18138-3.6820.0016No
Table: GSEA details [plain text format]



Fig 2: KEGG_PATHWAYS_IN_CANCER   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: KEGG_PATHWAYS_IN_CANCER: Random ES distribution   
Gene set null distribution of ES for KEGG_PATHWAYS_IN_CANCER