Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | KEGG_PARKINSONS_DISEASE |
| Enrichment Score (ES) | -0.5577749 |
| Normalized Enrichment Score (NES) | -2.2375486 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0010625 |
| FWER p-Value | 0.001 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | UBA7 | NA | 169 | 2.572 | 0.0279 | No | ||
| 2 | COX6B2 | NA | COX6B2 Entrez, Source | cytochrome c oxidase subunit VIb polypeptide 2 (testis) | 273 | 2.087 | 0.0524 | No |
| 3 | SLC6A3 | NA | SLC6A3 Entrez, Source | solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 | 760 | 1.276 | 0.0440 | No |
| 4 | ATP5D | NA | ATP5D Entrez, Source | ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit | 1832 | 0.822 | -0.0034 | No |
| 5 | PPID | NA | PPID Entrez, Source | peptidylprolyl isomerase D (cyclophilin D) | 2869 | 0.620 | -0.0518 | No |
| 6 | CASP3 | NA | CASP3 Entrez, Source | caspase 3, apoptosis-related cysteine peptidase | 2903 | 0.613 | -0.0448 | No |
| 7 | NDUFB7 | NA | NDUFB7 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa | 3283 | 0.554 | -0.0578 | No |
| 8 | HTRA2 | NA | HTRA2 Entrez, Source | HtrA serine peptidase 2 | 3611 | 0.509 | -0.0685 | No |
| 9 | NDUFS8 | NA | NDUFS8 Entrez, Source | NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase) | 4581 | 0.395 | -0.1164 | No |
| 10 | UBE2G2 | NA | UBE2G2 Entrez, Source | ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast) | 4881 | 0.364 | -0.1277 | No |
| 11 | UBE2J2 | NA | UBE2J2 Entrez, Source | ubiquitin-conjugating enzyme E2, J2 (UBC6 homolog, yeast) | 5141 | 0.338 | -0.1372 | No |
| 12 | COX7A1 | NA | COX7A1 Entrez, Source | cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) | 5681 | 0.288 | -0.1628 | No |
| 13 | UBE2L3 | NA | UBE2L3 Entrez, Source | ubiquitin-conjugating enzyme E2L 3 | 5698 | 0.286 | -0.1596 | No |
| 14 | NDUFV3 | NA | NDUFV3 Entrez, Source | NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa | 5751 | 0.282 | -0.1584 | No |
| 15 | NDUFB10 | NA | NDUFB10 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa | 5951 | 0.266 | -0.1655 | No |
| 16 | NDUFS7 | NA | NDUFS7 Entrez, Source | NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) | 6279 | 0.238 | -0.1802 | No |
| 17 | UBE2G1 | NA | UBE2G1 Entrez, Source | ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast) | 7147 | 0.170 | -0.2258 | No |
| 18 | UQCR11 | NA | 7511 | 0.144 | -0.2438 | No | ||
| 19 | APAF1 | NA | APAF1 Entrez, Source | apoptotic peptidase activating factor | 7927 | 0.113 | -0.2651 | No |
| 20 | TH | NA | TH Entrez, Source | tyrosine hydroxylase | 8897 | 0.043 | -0.3182 | No |
| 21 | UBA1 | NA | 9080 | 0.029 | -0.3278 | No | ||
| 22 | COX8C | NA | COX8C Entrez, Source | cytochrome c oxidase subunit 8C | 9478 | 0.003 | -0.3498 | No |
| 23 | COX4I2 | NA | COX4I2 Entrez, Source | cytochrome c oxidase subunit IV isoform 2 (lung) | 9626 | 0.000 | -0.3579 | No |
| 24 | VDAC3 | NA | VDAC3 Entrez, Source | voltage-dependent anion channel 3 | 9739 | -0.001 | -0.3641 | No |
| 25 | NDUFS6 | NA | NDUFS6 Entrez, Source | NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) | 9787 | -0.005 | -0.3666 | No |
| 26 | SLC18A1 | NA | SLC18A1 Entrez, Source | solute carrier family 18 (vesicular monoamine), member 1 | 10076 | -0.023 | -0.3822 | No |
| 27 | SNCAIP | NA | SNCAIP Entrez, Source | synuclein, alpha interacting protein (synphilin) | 10901 | -0.071 | -0.4268 | No |
| 28 | VDAC1 | NA | VDAC1 Entrez, Source | voltage-dependent anion channel 1 | 11475 | -0.113 | -0.4569 | No |
| 29 | NDUFB9 | NA | NDUFB9 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa | 11657 | -0.128 | -0.4651 | No |
| 30 | SLC25A31 | NA | SLC25A31 Entrez, Source | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 | 11934 | -0.150 | -0.4782 | No |
| 31 | SLC25A5 | NA | SLC25A5 Entrez, Source | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | 12109 | -0.165 | -0.4855 | No |
| 32 | NDUFV2 | NA | NDUFV2 Entrez, Source | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | 12646 | -0.214 | -0.5120 | No |
| 33 | CYC1 | NA | CYC1 Entrez, Source | cytochrome c-1 | 12899 | -0.235 | -0.5226 | No |
| 34 | NDUFB2 | NA | NDUFB2 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa | 13224 | -0.265 | -0.5367 | No |
| 35 | COX7A2L | NA | COX7A2L Entrez, Source | cytochrome c oxidase subunit VIIa polypeptide 2 like | 13373 | -0.279 | -0.5408 | No |
| 36 | SLC25A4 | NA | SLC25A4 Entrez, Source | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 | 13504 | -0.292 | -0.5438 | No |
| 37 | SDHC | NA | SDHC Entrez, Source | succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa | 13605 | -0.301 | -0.5450 | No |
| 38 | CYCS | NA | CYCS Entrez, Source | cytochrome c, somatic | 13663 | -0.308 | -0.5437 | No |
| 39 | ATP5G2 | NA | ATP5G2 Entrez, Source | ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C2 (subunit 9) | 13780 | -0.318 | -0.5455 | No |
| 40 | NDUFA6 | NA | NDUFA6 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa | 13931 | -0.335 | -0.5490 | No |
| 41 | ATP5H | NA | ATP5H Entrez, Source | ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d | 13940 | -0.337 | -0.5445 | No |
| 42 | COX7B2 | NA | COX7B2 Entrez, Source | cytochrome c oxidase subunit VIIb2 | 13956 | -0.340 | -0.5404 | No |
| 43 | UQCRC1 | NA | UQCRC1 Entrez, Source | ubiquinol-cytochrome c reductase core protein I | 14122 | -0.360 | -0.5444 | No |
| 44 | COX6A1 | NA | COX6A1 Entrez, Source | cytochrome c oxidase subunit VIa polypeptide 1 | 14365 | -0.387 | -0.5522 | Yes |
| 45 | NDUFA8 | NA | NDUFA8 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa | 14368 | -0.388 | -0.5467 | Yes |
| 46 | COX5A | NA | COX5A Entrez, Source | cytochrome c oxidase subunit Va | 14438 | -0.397 | -0.5447 | Yes |
| 47 | VDAC2 | NA | VDAC2 Entrez, Source | voltage-dependent anion channel 2 | 14442 | -0.398 | -0.5391 | Yes |
| 48 | PARK7 | NA | PARK7 Entrez, Source | Parkinson disease (autosomal recessive, early onset) 7 | 14545 | -0.412 | -0.5388 | Yes |
| 49 | SLC25A6 | NA | SLC25A6 Entrez, Source | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 | 14590 | -0.418 | -0.5352 | Yes |
| 50 | UBB | NA | UBB Entrez, Source | ubiquitin B | 14715 | -0.431 | -0.5358 | Yes |
| 51 | NDUFS4 | NA | NDUFS4 Entrez, Source | NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) | 14729 | -0.433 | -0.5303 | Yes |
| 52 | UQCRQ | NA | UQCRQ Entrez, Source | ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa | 14817 | -0.449 | -0.5286 | Yes |
| 53 | UBE2L6 | NA | UBE2L6 Entrez, Source | ubiquitin-conjugating enzyme E2L 6 | 14820 | -0.450 | -0.5222 | Yes |
| 54 | NDUFV1 | NA | NDUFV1 Entrez, Source | NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa | 14914 | -0.463 | -0.5207 | Yes |
| 55 | SDHA | NA | SDHA Entrez, Source | succinate dehydrogenase complex, subunit A, flavoprotein (Fp) | 14927 | -0.465 | -0.5146 | Yes |
| 56 | NDUFS3 | NA | NDUFS3 Entrez, Source | NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase) | 15047 | -0.482 | -0.5142 | Yes |
| 57 | NDUFS2 | NA | NDUFS2 Entrez, Source | NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) | 15173 | -0.499 | -0.5139 | Yes |
| 58 | UQCRFS1 | NA | UQCRFS1 Entrez, Source | ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 | 15206 | -0.503 | -0.5084 | Yes |
| 59 | ATP5O | NA | ATP5O Entrez, Source | ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit (oligomycin sensitivity conferring protein) | 15213 | -0.505 | -0.5014 | Yes |
| 60 | NDUFA3 | NA | NDUFA3 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa | 15224 | -0.505 | -0.4946 | Yes |
| 61 | ATP5G3 | NA | ATP5G3 Entrez, Source | ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9) | 15229 | -0.506 | -0.4875 | Yes |
| 62 | ATP5G1 | NA | ATP5G1 Entrez, Source | ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C1 (subunit 9) | 15261 | -0.511 | -0.4818 | Yes |
| 63 | COX4I1 | NA | COX4I1 Entrez, Source | cytochrome c oxidase subunit IV isoform 1 | 15269 | -0.512 | -0.4748 | Yes |
| 64 | ATP5C1 | NA | ATP5C1 Entrez, Source | ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 | 15544 | -0.560 | -0.4819 | Yes |
| 65 | NDUFA10 | NA | NDUFA10 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa | 15560 | -0.563 | -0.4746 | Yes |
| 66 | ATP5J | NA | ATP5J Entrez, Source | ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F6 | 15585 | -0.568 | -0.4677 | Yes |
| 67 | NDUFAB1 | NA | NDUFAB1 Entrez, Source | NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa | 15592 | -0.569 | -0.4598 | Yes |
| 68 | SDHB | NA | SDHB Entrez, Source | succinate dehydrogenase complex, subunit B, iron sulfur (Ip) | 15593 | -0.569 | -0.4515 | Yes |
| 69 | NDUFA7 | NA | NDUFA7 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa | 15694 | -0.588 | -0.4485 | Yes |
| 70 | NDUFB6 | NA | NDUFB6 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa | 15771 | -0.603 | -0.4440 | Yes |
| 71 | NDUFB8 | NA | NDUFB8 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa | 15852 | -0.621 | -0.4394 | Yes |
| 72 | UBE2J1 | NA | UBE2J1 Entrez, Source | ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast) | 15907 | -0.634 | -0.4333 | Yes |
| 73 | COX8A | NA | COX8A Entrez, Source | cytochrome c oxidase subunit 8A (ubiquitous) | 15949 | -0.642 | -0.4262 | Yes |
| 74 | COX5B | NA | COX5B Entrez, Source | cytochrome c oxidase subunit Vb | 15956 | -0.644 | -0.4172 | Yes |
| 75 | NDUFC2 | NA | NDUFC2 Entrez, Source | NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa | 16000 | -0.656 | -0.4101 | Yes |
| 76 | UQCRHL | NA | 16025 | -0.661 | -0.4019 | Yes | ||
| 77 | COX6B1 | NA | COX6B1 Entrez, Source | cytochrome c oxidase subunit Vib polypeptide 1 (ubiquitous) | 16035 | -0.665 | -0.3928 | Yes |
| 78 | NDUFB4 | NA | NDUFB4 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa | 16185 | -0.702 | -0.3909 | Yes |
| 79 | GPR37 | NA | GPR37 Entrez, Source | G protein-coupled receptor 37 (endothelin receptor type B-like) | 16221 | -0.711 | -0.3825 | Yes |
| 80 | NDUFA1 | NA | NDUFA1 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa | 16223 | -0.711 | -0.3723 | Yes |
| 81 | NDUFA9 | NA | NDUFA9 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa | 16239 | -0.717 | -0.3627 | Yes |
| 82 | NDUFS1 | NA | NDUFS1 Entrez, Source | NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) | 16420 | -0.771 | -0.3615 | Yes |
| 83 | UQCR10 | NA | 16475 | -0.787 | -0.3531 | Yes | ||
| 84 | NDUFS5 | NA | NDUFS5 Entrez, Source | NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase) | 16478 | -0.790 | -0.3418 | Yes |
| 85 | NDUFA2 | NA | NDUFA2 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa | 16488 | -0.793 | -0.3308 | Yes |
| 86 | UCHL1 | NA | UCHL1 Entrez, Source | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) | 16625 | -0.832 | -0.3263 | Yes |
| 87 | COX7A2 | NA | COX7A2 Entrez, Source | cytochrome c oxidase subunit VIIa polypeptide 2 (liver) | 16640 | -0.835 | -0.3150 | Yes |
| 88 | NDUFC1 | NA | NDUFC1 Entrez, Source | NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa | 16657 | -0.841 | -0.3037 | Yes |
| 89 | NDUFA4 | NA | NDUFA4 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa | 16700 | -0.853 | -0.2936 | Yes |
| 90 | UQCRH | NA | UQCRH Entrez, Source | ubiquinol-cytochrome c reductase hinge protein | 16759 | -0.873 | -0.2842 | Yes |
| 91 | SDHD | NA | SDHD Entrez, Source | succinate dehydrogenase complex, subunit D, integral membrane protein | 16792 | -0.886 | -0.2732 | Yes |
| 92 | COX6C | NA | COX6C Entrez, Source | cytochrome c oxidase subunit VIc | 16973 | -0.957 | -0.2693 | Yes |
| 93 | PINK1 | NA | PINK1 Entrez, Source | PTEN induced putative kinase 1 | 17030 | -0.985 | -0.2581 | Yes |
| 94 | ATP5A1 | NA | ATP5A1 Entrez, Source | ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle | 17098 | -1.012 | -0.2471 | Yes |
| 95 | NDUFB5 | NA | NDUFB5 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa | 17105 | -1.017 | -0.2327 | Yes |
| 96 | ATP5B | NA | ATP5B Entrez, Source | ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide | 17107 | -1.018 | -0.2181 | Yes |
| 97 | ATP5F1 | NA | ATP5F1 Entrez, Source | ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B1 | 17165 | -1.039 | -0.2062 | Yes |
| 98 | COX7B | NA | COX7B Entrez, Source | cytochrome c oxidase subunit VIIb | 17181 | -1.049 | -0.1918 | Yes |
| 99 | NDUFB3 | NA | NDUFB3 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa | 17222 | -1.073 | -0.1785 | Yes |
| 100 | NDUFB1 | NA | NDUFB1 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa | 17262 | -1.097 | -0.1648 | Yes |
| 101 | UQCRB | NA | UQCRB Entrez, Source | ubiquinol-cytochrome c reductase binding protein | 17309 | -1.123 | -0.1511 | Yes |
| 102 | SEPT5 | NA | SEPT5 Entrez, Source | septin 5 | 17436 | -1.210 | -0.1405 | Yes |
| 103 | COX7C | NA | COX7C Entrez, Source | cytochrome c oxidase subunit VIIc | 17459 | -1.227 | -0.1240 | Yes |
| 104 | UQCRC2 | NA | UQCRC2 Entrez, Source | ubiquinol-cytochrome c reductase core protein II | 17465 | -1.232 | -0.1064 | Yes |
| 105 | NDUFA5 | NA | NDUFA5 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5, 13kDa | 17656 | -1.422 | -0.0963 | Yes |
| 106 | LRRK2 | NA | LRRK2 Entrez, Source | leucine-rich repeat kinase 2 | 17659 | -1.426 | -0.0758 | Yes |
| 107 | CASP9 | NA | CASP9 Entrez, Source | caspase 9, apoptosis-related cysteine peptidase | 17671 | -1.437 | -0.0556 | Yes |
| 108 | SLC18A2 | NA | SLC18A2 Entrez, Source | solute carrier family 18 (vesicular monoamine), member 2 | 17680 | -1.444 | -0.0351 | Yes |
| 109 | NDUFA4L2 | NA | NDUFA4L2 Entrez, Source | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2 | 17899 | -1.860 | -0.0203 | Yes |
| 110 | SNCA | NA | SNCA Entrez, Source | synuclein, alpha (non A4 component of amyloid precursor) | 18027 | -2.421 | 0.0078 | Yes |
