Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1w1a |
| GeneSet | KEGG_NOTCH_SIGNALING_PATHWAY |
| Enrichment Score (ES) | 0.57153195 |
| Normalized Enrichment Score (NES) | 1.794696 |
| Nominal p-value | 0.0033783785 |
| FDR q-value | 0.014891369 |
| FWER p-Value | 0.096 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | HES5 | NA | HES5 Entrez, Source | hairy and enhancer of split 5 (Drosophila) | 321 | 1.905 | 0.0497 | Yes |
| 2 | DTX3L | NA | DTX3L Entrez, Source | deltex 3-like (Drosophila) | 385 | 1.745 | 0.1080 | Yes |
| 3 | DTX2 | NA | DTX2 Entrez, Source | deltex homolog 2 (Drosophila) | 389 | 1.738 | 0.1693 | Yes |
| 4 | JAG1 | NA | JAG1 Entrez, Source | jagged 1 (Alagille syndrome) | 516 | 1.523 | 0.2163 | Yes |
| 5 | NOTCH1 | NA | NOTCH1 Entrez, Source | Notch homolog 1, translocation-associated (Drosophila) | 715 | 1.313 | 0.2518 | Yes |
| 6 | DTX4 | NA | DTX4 Entrez, Source | deltex 4 homolog (Drosophila) | 737 | 1.294 | 0.2965 | Yes |
| 7 | MAML3 | NA | MAML3 Entrez, Source | mastermind-like 3 (Drosophila) | 740 | 1.292 | 0.3421 | Yes |
| 8 | HES1 | NA | HES1 Entrez, Source | hairy and enhancer of split 1, (Drosophila) | 1072 | 1.082 | 0.3621 | Yes |
| 9 | DLL4 | NA | DLL4 Entrez, Source | delta-like 4 (Drosophila) | 1261 | 0.997 | 0.3871 | Yes |
| 10 | DVL1 | NA | DVL1 Entrez, Source | dishevelled, dsh homolog 1 (Drosophila) | 1298 | 0.983 | 0.4199 | Yes |
| 11 | CREBBP | NA | CREBBP Entrez, Source | CREB binding protein (Rubinstein-Taybi syndrome) | 1528 | 0.903 | 0.4392 | Yes |
| 12 | ADAM17 | NA | ADAM17 Entrez, Source | ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme) | 1826 | 0.823 | 0.4519 | Yes |
| 13 | KAT2A | NA | 2044 | 0.780 | 0.4675 | Yes | ||
| 14 | MAML1 | NA | MAML1 Entrez, Source | mastermind-like 1 (Drosophila) | 2068 | 0.773 | 0.4936 | Yes |
| 15 | RFNG | NA | RFNG Entrez, Source | radical fringe homolog (Drosophila) | 2191 | 0.746 | 0.5133 | Yes |
| 16 | EP300 | NA | EP300 Entrez, Source | E1A binding protein p300 | 2210 | 0.742 | 0.5386 | Yes |
| 17 | JAG2 | NA | JAG2 Entrez, Source | jagged 2 | 2293 | 0.726 | 0.5597 | Yes |
| 18 | APH1A | NA | APH1A Entrez, Source | anterior pharynx defective 1 homolog A (C. elegans) | 2775 | 0.635 | 0.5557 | Yes |
| 19 | NUMBL | NA | NUMBL Entrez, Source | numb homolog (Drosophila)-like | 2884 | 0.617 | 0.5715 | Yes |
| 20 | PSENEN | NA | PSENEN Entrez, Source | presenilin enhancer 2 homolog (C. elegans) | 3581 | 0.513 | 0.5513 | No |
| 21 | RBPJL | NA | 3863 | 0.479 | 0.5527 | No | ||
| 22 | DTX3 | NA | DTX3 Entrez, Source | deltex 3 homolog (Drosophila) | 4007 | 0.461 | 0.5611 | No |
| 23 | PSEN1 | NA | PSEN1 Entrez, Source | presenilin 1 (Alzheimer disease 3) | 4203 | 0.434 | 0.5657 | No |
| 24 | DTX1 | NA | DTX1 Entrez, Source | deltex homolog 1 (Drosophila) | 4603 | 0.393 | 0.5576 | No |
| 25 | CIR1 | NA | 4962 | 0.355 | 0.5504 | No | ||
| 26 | NOTCH3 | NA | NOTCH3 Entrez, Source | Notch homolog 3 (Drosophila) | 5910 | 0.269 | 0.5077 | No |
| 27 | CTBP1 | NA | CTBP1 Entrez, Source | C-terminal binding protein 1 | 6266 | 0.239 | 0.4965 | No |
| 28 | PSEN2 | NA | PSEN2 Entrez, Source | presenilin 2 (Alzheimer disease 4) | 6478 | 0.223 | 0.4928 | No |
| 29 | NCSTN | NA | NCSTN Entrez, Source | nicastrin | 6514 | 0.220 | 0.4987 | No |
| 30 | NUMB | NA | NUMB Entrez, Source | numb homolog (Drosophila) | 7677 | 0.132 | 0.4392 | No |
| 31 | SNW1 | NA | SNW1 Entrez, Source | SNW domain containing 1 | 8180 | 0.094 | 0.4148 | No |
| 32 | NOTCH2 | NA | NOTCH2 Entrez, Source | Notch homolog 2 (Drosophila) | 8565 | 0.067 | 0.3960 | No |
| 33 | DVL2 | NA | DVL2 Entrez, Source | dishevelled, dsh homolog 2 (Drosophila) | 8664 | 0.060 | 0.3927 | No |
| 34 | NCOR2 | NA | NCOR2 Entrez, Source | nuclear receptor co-repressor 2 | 8816 | 0.050 | 0.3862 | No |
| 35 | LFNG | NA | LFNG Entrez, Source | lunatic fringe homolog (Drosophila) | 8994 | 0.035 | 0.3776 | No |
| 36 | MAML2 | NA | MAML2 Entrez, Source | mastermind-like 2 (Drosophila) | 9733 | -0.001 | 0.3369 | No |
| 37 | HDAC2 | NA | HDAC2 Entrez, Source | histone deacetylase 2 | 10429 | -0.044 | 0.3002 | No |
| 38 | DLL1 | NA | DLL1 Entrez, Source | delta-like 1 (Drosophila) | 10604 | -0.054 | 0.2925 | No |
| 39 | DLL3 | NA | DLL3 Entrez, Source | delta-like 3 (Drosophila) | 10652 | -0.058 | 0.2919 | No |
| 40 | PTCRA | NA | PTCRA Entrez, Source | pre T-cell antigen receptor alpha | 10666 | -0.059 | 0.2933 | No |
| 41 | DVL3 | NA | DVL3 Entrez, Source | dishevelled, dsh homolog 3 (Drosophila) | 10751 | -0.063 | 0.2909 | No |
| 42 | CTBP2 | NA | CTBP2 Entrez, Source | C-terminal binding protein 2 | 10837 | -0.067 | 0.2885 | No |
| 43 | NOTCH4 | NA | NOTCH4 Entrez, Source | Notch homolog 4 (Drosophila) | 12030 | -0.158 | 0.2284 | No |
| 44 | RBPJ | NA | 13620 | -0.305 | 0.1515 | No | ||
| 45 | HDAC1 | NA | HDAC1 Entrez, Source | histone deacetylase 1 | 13850 | -0.326 | 0.1504 | No |
| 46 | MFNG | NA | MFNG Entrez, Source | manic fringe homolog (Drosophila) | 16943 | -0.944 | 0.0131 | No |
| 47 | KAT2B | NA | 17749 | -1.536 | 0.0231 | No |
