Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1w1a |
| GeneSet | KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY |
| Enrichment Score (ES) | 0.5784703 |
| Normalized Enrichment Score (NES) | 1.9191322 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0041660364 |
| FWER p-Value | 0.014 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | CCL5 | NA | CCL5 Entrez, Source | chemokine (C-C motif) ligand 5 | 6 | 4.768 | 0.1086 | Yes |
| 2 | IL6 | NA | IL6 Entrez, Source | interleukin 6 (interferon, beta 2) | 17 | 4.596 | 0.2130 | Yes |
| 3 | BIRC3 | NA | BIRC3 Entrez, Source | baculoviral IAP repeat-containing 3 | 182 | 2.484 | 0.2607 | Yes |
| 4 | CXCL2 | NA | CXCL2 Entrez, Source | chemokine (C-X-C motif) ligand 2 | 193 | 2.423 | 0.3155 | Yes |
| 5 | HSP90B1 | NA | HSP90B1 Entrez, Source | heat shock protein 90kDa beta (Grp94), member 1 | 196 | 2.412 | 0.3705 | Yes |
| 6 | TNFAIP3 | NA | TNFAIP3 Entrez, Source | tumor necrosis factor, alpha-induced protein 3 | 271 | 2.095 | 0.4143 | Yes |
| 7 | NFKBIA | NA | NFKBIA Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 460 | 1.595 | 0.4404 | Yes |
| 8 | CCL2 | NA | CCL2 Entrez, Source | chemokine (C-C motif) ligand 2 | 493 | 1.546 | 0.4739 | Yes |
| 9 | IL1B | NA | IL1B Entrez, Source | interleukin 1, beta | 779 | 1.262 | 0.4870 | Yes |
| 10 | CASP1 | NA | CASP1 Entrez, Source | caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) | 897 | 1.178 | 0.5075 | Yes |
| 11 | RELA | NA | RELA Entrez, Source | v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian) | 1150 | 1.047 | 0.5175 | Yes |
| 12 | TNF | NA | TNF Entrez, Source | tumor necrosis factor (TNF superfamily, member 2) | 1210 | 1.015 | 0.5374 | Yes |
| 13 | IKBKG | NA | IKBKG Entrez, Source | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | 1587 | 0.884 | 0.5368 | Yes |
| 14 | NFKB1 | NA | NFKB1 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 1767 | 0.835 | 0.5460 | Yes |
| 15 | IL18 | NA | IL18 Entrez, Source | interleukin 18 (interferon-gamma-inducing factor) | 1911 | 0.805 | 0.5565 | Yes |
| 16 | HSP90AB1 | NA | HSP90AB1 Entrez, Source | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 1912 | 0.805 | 0.5749 | Yes |
| 17 | TRIP6 | NA | TRIP6 Entrez, Source | thyroid hormone receptor interactor 6 | 2284 | 0.727 | 0.5711 | Yes |
| 18 | NLRC4 | NA | 2442 | 0.696 | 0.5783 | Yes | ||
| 19 | NOD1 | NA | 3005 | 0.596 | 0.5609 | Yes | ||
| 20 | CHUK | NA | CHUK Entrez, Source | conserved helix-loop-helix ubiquitous kinase | 3103 | 0.582 | 0.5688 | Yes |
| 21 | TAB1 | NA | 3372 | 0.540 | 0.5663 | Yes | ||
| 22 | BIRC2 | NA | BIRC2 Entrez, Source | baculoviral IAP repeat-containing 2 | 3377 | 0.540 | 0.5785 | Yes |
| 23 | MAPK11 | NA | MAPK11 Entrez, Source | mitogen-activated protein kinase 11 | 4342 | 0.417 | 0.5348 | No |
| 24 | CASP5 | NA | CASP5 Entrez, Source | caspase 5, apoptosis-related cysteine peptidase | 4552 | 0.397 | 0.5323 | No |
| 25 | MAPK3 | NA | MAPK3 Entrez, Source | mitogen-activated protein kinase 3 | 4770 | 0.376 | 0.5289 | No |
| 26 | TRAF6 | NA | TRAF6 Entrez, Source | TNF receptor-associated factor 6 | 5263 | 0.326 | 0.5092 | No |
| 27 | HSP90AA1 | NA | HSP90AA1 Entrez, Source | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 5663 | 0.290 | 0.4938 | No |
| 28 | CASP8 | NA | CASP8 Entrez, Source | caspase 8, apoptosis-related cysteine peptidase | 5677 | 0.288 | 0.4997 | No |
| 29 | SUGT1 | NA | SUGT1 Entrez, Source | SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae) | 5919 | 0.268 | 0.4925 | No |
| 30 | MAPK12 | NA | MAPK12 Entrez, Source | mitogen-activated protein kinase 12 | 6059 | 0.258 | 0.4907 | No |
| 31 | CCL11 | NA | CCL11 Entrez, Source | chemokine (C-C motif) ligand 11 | 6398 | 0.228 | 0.4772 | No |
| 32 | RIPK2 | NA | RIPK2 Entrez, Source | receptor-interacting serine-threonine kinase 2 | 6804 | 0.196 | 0.4594 | No |
| 33 | PSTPIP1 | NA | PSTPIP1 Entrez, Source | proline-serine-threonine phosphatase interacting protein 1 | 7689 | 0.131 | 0.4135 | No |
| 34 | NLRP3 | NA | 7867 | 0.117 | 0.4064 | No | ||
| 35 | CCL7 | NA | CCL7 Entrez, Source | chemokine (C-C motif) ligand 7 | 8211 | 0.092 | 0.3896 | No |
| 36 | MAPK14 | NA | MAPK14 Entrez, Source | mitogen-activated protein kinase 14 | 8878 | 0.045 | 0.3538 | No |
| 37 | CCL8 | NA | CCL8 Entrez, Source | chemokine (C-C motif) ligand 8 | 9168 | 0.022 | 0.3384 | No |
| 38 | PYCARD | NA | PYCARD Entrez, Source | PYD and CARD domain containing | 9666 | 0.000 | 0.3110 | No |
| 39 | MAPK8 | NA | MAPK8 Entrez, Source | mitogen-activated protein kinase 8 | 10132 | -0.028 | 0.2859 | No |
| 40 | XIAP | NA | 10443 | -0.045 | 0.2698 | No | ||
| 41 | IKBKB | NA | IKBKB Entrez, Source | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | 10944 | -0.074 | 0.2439 | No |
| 42 | CXCL1 | NA | CXCL1 Entrez, Source | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 11070 | -0.082 | 0.2389 | No |
| 43 | TAB2 | NA | 11271 | -0.096 | 0.2300 | No | ||
| 44 | CARD18 | NA | 11605 | -0.123 | 0.2144 | No | ||
| 45 | PYDC1 | NA | PYDC1 Entrez, Source | PYD (pyrin domain) containing 1 | 11824 | -0.142 | 0.2057 | No |
| 46 | CARD8 | NA | CARD8 Entrez, Source | caspase recruitment domain family, member 8 | 11938 | -0.150 | 0.2028 | No |
| 47 | CARD9 | NA | CARD9 Entrez, Source | caspase recruitment domain family, member 9 | 12847 | -0.230 | 0.1580 | No |
| 48 | MEFV | NA | MEFV Entrez, Source | Mediterranean fever | 13269 | -0.269 | 0.1409 | No |
| 49 | MAPK9 | NA | MAPK9 Entrez, Source | mitogen-activated protein kinase 9 | 13521 | -0.294 | 0.1337 | No |
| 50 | NOD2 | NA | 13543 | -0.295 | 0.1393 | No | ||
| 51 | MAP3K7 | NA | MAP3K7 Entrez, Source | mitogen-activated protein kinase kinase kinase 7 | 14046 | -0.351 | 0.1196 | No |
| 52 | MAPK10 | NA | MAPK10 Entrez, Source | mitogen-activated protein kinase 10 | 14334 | -0.383 | 0.1125 | No |
| 53 | TAB3 | NA | 14589 | -0.418 | 0.1080 | No | ||
| 54 | MAPK1 | NA | MAPK1 Entrez, Source | mitogen-activated protein kinase 1 | 14765 | -0.439 | 0.1084 | No |
| 55 | MAPK13 | NA | MAPK13 Entrez, Source | mitogen-activated protein kinase 13 | 14840 | -0.454 | 0.1146 | No |
| 56 | NAIP | NA | NAIP Entrez, Source | - | 16631 | -0.833 | 0.0348 | No |
| 57 | NLRP1 | NA | 17194 | -1.056 | 0.0279 | No | ||
| 58 | CARD6 | NA | CARD6 Entrez, Source | caspase recruitment domain family, member 6 | 17316 | -1.127 | 0.0470 | No |
