Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1w1a |
| GeneSet | KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY |
| Enrichment Score (ES) | 0.4151731 |
| Normalized Enrichment Score (NES) | 1.5554689 |
| Nominal p-value | 0.00155521 |
| FDR q-value | 0.10940342 |
| FWER p-Value | 0.784 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | RAET1L | NA | RAET1L Entrez, Source | retinoic acid early transcript 1L | 52 | 4.009 | 0.0486 | Yes |
| 2 | SH2D1B | NA | SH2D1B Entrez, Source | SH2 domain containing 1B | 74 | 3.591 | 0.0935 | Yes |
| 3 | PLCG2 | NA | PLCG2 Entrez, Source | phospholipase C, gamma 2 (phosphatidylinositol-specific) | 92 | 3.302 | 0.1349 | Yes |
| 4 | ULBP2 | NA | ULBP2 Entrez, Source | UL16 binding protein 2 | 240 | 2.224 | 0.1553 | Yes |
| 5 | ICAM2 | NA | ICAM2 Entrez, Source | intercellular adhesion molecule 2 | 283 | 2.050 | 0.1793 | Yes |
| 6 | PIK3R1 | NA | PIK3R1 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha) | 366 | 1.786 | 0.1977 | Yes |
| 7 | ULBP3 | NA | ULBP3 Entrez, Source | UL16 binding protein 3 | 383 | 1.756 | 0.2193 | Yes |
| 8 | FCGR3A | NA | FCGR3A Entrez, Source | Fc fragment of IgG, low affinity IIIa, receptor (CD16a) | 413 | 1.686 | 0.2394 | Yes |
| 9 | ICAM1 | NA | ICAM1 Entrez, Source | intercellular adhesion molecule 1 (CD54), human rhinovirus receptor | 453 | 1.600 | 0.2577 | Yes |
| 10 | TNFRSF10A | NA | TNFRSF10A Entrez, Source | tumor necrosis factor receptor superfamily, member 10a | 660 | 1.356 | 0.2637 | Yes |
| 11 | MICB | NA | MICB Entrez, Source | MHC class I polypeptide-related sequence B | 798 | 1.246 | 0.2721 | Yes |
| 12 | HLA-C | NA | HLA-C Entrez, Source | major histocompatibility complex, class I, C | 910 | 1.168 | 0.2809 | Yes |
| 13 | ULBP1 | NA | ULBP1 Entrez, Source | UL16 binding protein 1 | 912 | 1.165 | 0.2958 | Yes |
| 14 | TNFRSF10B | NA | TNFRSF10B Entrez, Source | tumor necrosis factor receptor superfamily, member 10b | 1020 | 1.110 | 0.3042 | Yes |
| 15 | TNF | NA | TNF Entrez, Source | tumor necrosis factor (TNF superfamily, member 2) | 1210 | 1.015 | 0.3067 | Yes |
| 16 | NFAT5 | NA | NFAT5 Entrez, Source | nuclear factor of activated T-cells 5, tonicity-responsive | 1243 | 1.002 | 0.3178 | Yes |
| 17 | PIK3CD | NA | PIK3CD Entrez, Source | phosphoinositide-3-kinase, catalytic, delta polypeptide | 1572 | 0.890 | 0.3110 | Yes |
| 18 | FAS | NA | FAS Entrez, Source | Fas (TNF receptor superfamily, member 6) | 1600 | 0.881 | 0.3208 | Yes |
| 19 | RAC2 | NA | RAC2 Entrez, Source | ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) | 1748 | 0.839 | 0.3235 | Yes |
| 20 | FCER1G | NA | FCER1G Entrez, Source | Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide | 1749 | 0.839 | 0.3342 | Yes |
| 21 | HLA-G | NA | HLA-G Entrez, Source | HLA-G histocompatibility antigen, class I, G | 1786 | 0.832 | 0.3429 | Yes |
| 22 | HRAS | NA | HRAS Entrez, Source | v-Ha-ras Harvey rat sarcoma viral oncogene homolog | 1799 | 0.831 | 0.3529 | Yes |
| 23 | HLA-A | NA | HLA-A Entrez, Source | major histocompatibility complex, class I, A | 1869 | 0.815 | 0.3595 | Yes |
| 24 | HLA-E | NA | HLA-E Entrez, Source | major histocompatibility complex, class I, E | 1915 | 0.805 | 0.3674 | Yes |
| 25 | SYK | NA | SYK Entrez, Source | spleen tyrosine kinase | 1934 | 0.802 | 0.3767 | Yes |
| 26 | RAET1E | NA | RAET1E Entrez, Source | retinoic acid early transcript 1E | 1977 | 0.792 | 0.3845 | Yes |
| 27 | MICA | NA | MICA Entrez, Source | MHC class I polypeptide-related sequence A | 1993 | 0.789 | 0.3938 | Yes |
| 28 | MAP2K2 | NA | MAP2K2 Entrez, Source | mitogen-activated protein kinase kinase 2 | 2222 | 0.740 | 0.3907 | Yes |
| 29 | PRKCG | NA | PRKCG Entrez, Source | protein kinase C, gamma | 2351 | 0.711 | 0.3927 | Yes |
| 30 | VAV2 | NA | VAV2 Entrez, Source | vav 2 oncogene | 2382 | 0.706 | 0.4001 | Yes |
| 31 | PTK2B | NA | PTK2B Entrez, Source | PTK2B protein tyrosine kinase 2 beta | 2398 | 0.703 | 0.4083 | Yes |
| 32 | TNFSF10 | NA | TNFSF10 Entrez, Source | tumor necrosis factor (ligand) superfamily, member 10 | 2436 | 0.696 | 0.4152 | Yes |
| 33 | LAT | NA | LAT Entrez, Source | linker for activation of T cells | 2727 | 0.645 | 0.4074 | No |
| 34 | IFNAR1 | NA | IFNAR1 Entrez, Source | interferon (alpha, beta and omega) receptor 1 | 2807 | 0.630 | 0.4111 | No |
| 35 | CASP3 | NA | CASP3 Entrez, Source | caspase 3, apoptosis-related cysteine peptidase | 2903 | 0.613 | 0.4137 | No |
| 36 | IFNAR2 | NA | IFNAR2 Entrez, Source | interferon (alpha, beta and omega) receptor 2 | 3113 | 0.580 | 0.4095 | No |
| 37 | IFNGR1 | NA | IFNGR1 Entrez, Source | interferon gamma receptor 1 | 3151 | 0.575 | 0.4149 | No |
| 38 | PPP3CC | NA | PPP3CC Entrez, Source | protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform (calcineurin A gamma) | 3331 | 0.546 | 0.4120 | No |
| 39 | ARAF | NA | ARAF Entrez, Source | v-raf murine sarcoma 3611 viral oncogene homolog | 3865 | 0.479 | 0.3886 | No |
| 40 | SHC1 | NA | SHC1 Entrez, Source | SHC (Src homology 2 domain containing) transforming protein 1 | 4000 | 0.462 | 0.3871 | No |
| 41 | PPP3R2 | NA | PPP3R2 Entrez, Source | protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, beta isoform (calcineurin B, type II) | 4110 | 0.445 | 0.3867 | No |
| 42 | BRAF | NA | BRAF Entrez, Source | v-raf murine sarcoma viral oncogene homolog B1 | 4135 | 0.442 | 0.3911 | No |
| 43 | TNFRSF10C | NA | TNFRSF10C Entrez, Source | tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain | 4694 | 0.383 | 0.3651 | No |
| 44 | MAPK3 | NA | MAPK3 Entrez, Source | mitogen-activated protein kinase 3 | 4770 | 0.376 | 0.3657 | No |
| 45 | KIR2DL1 | NA | KIR2DL1 Entrez, Source | killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1 | 4793 | 0.373 | 0.3693 | No |
| 46 | VAV1 | NA | VAV1 Entrez, Source | vav 1 oncogene | 4895 | 0.363 | 0.3684 | No |
| 47 | PIK3R3 | NA | PIK3R3 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma) | 5162 | 0.335 | 0.3579 | No |
| 48 | NRAS | NA | NRAS Entrez, Source | neuroblastoma RAS viral (v-ras) oncogene homolog | 5250 | 0.327 | 0.3573 | No |
| 49 | PAK1 | NA | PAK1 Entrez, Source | p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast) | 5493 | 0.303 | 0.3478 | No |
| 50 | IFNA21 | NA | IFNA21 Entrez, Source | interferon, alpha 21 | 5854 | 0.273 | 0.3313 | No |
| 51 | SH2D1A | NA | SH2D1A Entrez, Source | SH2 domain protein 1A, Duncan's disease (lymphoproliferative syndrome) | 5986 | 0.265 | 0.3275 | No |
| 52 | NFATC1 | NA | NFATC1 Entrez, Source | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 | 6023 | 0.262 | 0.3288 | No |
| 53 | LCK | NA | LCK Entrez, Source | lymphocyte-specific protein tyrosine kinase | 6635 | 0.208 | 0.2977 | No |
| 54 | HCST | NA | HCST Entrez, Source | hematopoietic cell signal transducer | 6895 | 0.189 | 0.2857 | No |
| 55 | IFNGR2 | NA | IFNGR2 Entrez, Source | interferon gamma receptor 2 (interferon gamma transducer 1) | 7118 | 0.172 | 0.2756 | No |
| 56 | PPP3R1 | NA | PPP3R1 Entrez, Source | protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I) | 7244 | 0.164 | 0.2708 | No |
| 57 | HLA-B | NA | HLA-B Entrez, Source | major histocompatibility complex, class I, B | 7547 | 0.141 | 0.2559 | No |
| 58 | IFNB1 | NA | IFNB1 Entrez, Source | interferon, beta 1, fibroblast | 7718 | 0.129 | 0.2481 | No |
| 59 | FCGR3B | NA | FCGR3B Entrez, Source | Fc fragment of IgG, low affinity IIIb, receptor (CD16b) | 7861 | 0.118 | 0.2417 | No |
| 60 | SHC3 | NA | SHC3 Entrez, Source | SHC (Src homology 2 domain containing) transforming protein 3 | 8245 | 0.090 | 0.2217 | No |
| 61 | IFNA17 | NA | IFNA17 Entrez, Source | interferon, alpha 17 | 8248 | 0.090 | 0.2227 | No |
| 62 | PIK3CA | NA | PIK3CA Entrez, Source | phosphoinositide-3-kinase, catalytic, alpha polypeptide | 8784 | 0.052 | 0.1937 | No |
| 63 | KLRK1 | NA | KLRK1 Entrez, Source | killer cell lectin-like receptor subfamily K, member 1 | 8796 | 0.051 | 0.1938 | No |
| 64 | KLRD1 | NA | KLRD1 Entrez, Source | killer cell lectin-like receptor subfamily D, member 1 | 8851 | 0.047 | 0.1914 | No |
| 65 | CD244 | NA | CD244 Entrez, Source | CD244 molecule, natural killer cell receptor 2B4 | 9104 | 0.027 | 0.1778 | No |
| 66 | RAET1G | NA | RAET1G Entrez, Source | retinoic acid early transcript 1G | 9158 | 0.023 | 0.1751 | No |
| 67 | IFNA13 | NA | IFNA13 Entrez, Source | interferon, alpha 13 | 9539 | 0.000 | 0.1541 | No |
| 68 | CSF2 | NA | CSF2 Entrez, Source | colony stimulating factor 2 (granulocyte-macrophage) | 9575 | 0.000 | 0.1521 | No |
| 69 | SHC2 | NA | SHC2 Entrez, Source | SHC (Src homology 2 domain containing) transforming protein 2 | 9647 | 0.000 | 0.1482 | No |
| 70 | KIR3DL2 | NA | KIR3DL2 Entrez, Source | killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2 | 9673 | 0.000 | 0.1468 | No |
| 71 | KIR2DS4 | NA | KIR2DS4 Entrez, Source | killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4 | 9690 | 0.000 | 0.1459 | No |
| 72 | MAP2K1 | NA | MAP2K1 Entrez, Source | mitogen-activated protein kinase kinase 1 | 9745 | -0.001 | 0.1430 | No |
| 73 | NFATC3 | NA | NFATC3 Entrez, Source | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 | 9791 | -0.005 | 0.1405 | No |
| 74 | IFNA8 | NA | IFNA8 Entrez, Source | interferon, alpha 8 | 9853 | -0.010 | 0.1373 | No |
| 75 | RAC1 | NA | RAC1 Entrez, Source | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | 9857 | -0.010 | 0.1372 | No |
| 76 | CD48 | NA | CD48 Entrez, Source | CD48 molecule | 10024 | -0.020 | 0.1283 | No |
| 77 | PRF1 | NA | PRF1 Entrez, Source | perforin 1 (pore forming protein) | 10618 | -0.055 | 0.0961 | No |
| 78 | PLCG1 | NA | PLCG1 Entrez, Source | phospholipase C, gamma 1 | 10890 | -0.071 | 0.0820 | No |
| 79 | NCR1 | NA | NCR1 Entrez, Source | natural cytotoxicity triggering receptor 1 | 10956 | -0.075 | 0.0794 | No |
| 80 | NCR3 | NA | NCR3 Entrez, Source | natural cytotoxicity triggering receptor 3 | 11043 | -0.080 | 0.0757 | No |
| 81 | PIK3R5 | NA | PIK3R5 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 5, p101 | 11049 | -0.081 | 0.0764 | No |
| 82 | NCR2 | NA | NCR2 Entrez, Source | natural cytotoxicity triggering receptor 2 | 11065 | -0.082 | 0.0766 | No |
| 83 | IFNA10 | NA | IFNA10 Entrez, Source | interferon, alpha 10 | 11188 | -0.090 | 0.0710 | No |
| 84 | IFNA16 | NA | IFNA16 Entrez, Source | interferon, alpha 16 | 11217 | -0.092 | 0.0707 | No |
| 85 | IFNA1 | NA | IFNA1 Entrez, Source | interferon, alpha 1 | 11267 | -0.096 | 0.0692 | No |
| 86 | BID | NA | BID Entrez, Source | BH3 interacting domain death agonist | 11556 | -0.119 | 0.0547 | No |
| 87 | PIK3CB | NA | PIK3CB Entrez, Source | phosphoinositide-3-kinase, catalytic, beta polypeptide | 11650 | -0.127 | 0.0512 | No |
| 88 | IFNA6 | NA | IFNA6 Entrez, Source | interferon, alpha 6 | 11724 | -0.134 | 0.0489 | No |
| 89 | TYROBP | NA | TYROBP Entrez, Source | TYRO protein tyrosine kinase binding protein | 11727 | -0.134 | 0.0505 | No |
| 90 | LCP2 | NA | LCP2 Entrez, Source | lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) | 11815 | -0.141 | 0.0475 | No |
| 91 | PIK3R2 | NA | PIK3R2 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta) | 12247 | -0.177 | 0.0259 | No |
| 92 | SOS1 | NA | SOS1 Entrez, Source | son of sevenless homolog 1 (Drosophila) | 12302 | -0.183 | 0.0252 | No |
| 93 | IFNA2 | NA | IFNA2 Entrez, Source | interferon, alpha 2 | 13213 | -0.263 | -0.0218 | No |
| 94 | SHC4 | NA | SHC4 Entrez, Source | SHC (Src homology 2 domain containing) family, member 4 | 13233 | -0.266 | -0.0195 | No |
| 95 | FYN | NA | FYN Entrez, Source | FYN oncogene related to SRC, FGR, YES | 13562 | -0.297 | -0.0338 | No |
| 96 | RAC3 | NA | RAC3 Entrez, Source | ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) | 13740 | -0.315 | -0.0396 | No |
| 97 | FASLG | NA | FASLG Entrez, Source | Fas ligand (TNF superfamily, member 6) | 13862 | -0.326 | -0.0421 | No |
| 98 | SH3BP2 | NA | SH3BP2 Entrez, Source | SH3-domain binding protein 2 | 13923 | -0.333 | -0.0412 | No |
| 99 | RAF1 | NA | RAF1 Entrez, Source | v-raf-1 murine leukemia viral oncogene homolog 1 | 13934 | -0.335 | -0.0374 | No |
| 100 | GRB2 | NA | GRB2 Entrez, Source | growth factor receptor-bound protein 2 | 14005 | -0.345 | -0.0369 | No |
| 101 | CD247 | NA | CD247 Entrez, Source | CD247 molecule | 14094 | -0.357 | -0.0372 | No |
| 102 | PPP3CA | NA | PPP3CA Entrez, Source | protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform (calcineurin A alpha) | 14469 | -0.401 | -0.0527 | No |
| 103 | NFATC2 | NA | NFATC2 Entrez, Source | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 14514 | -0.407 | -0.0500 | No |
| 104 | IFNG | NA | IFNG Entrez, Source | interferon, gamma | 14617 | -0.420 | -0.0502 | No |
| 105 | VAV3 | NA | VAV3 Entrez, Source | vav 3 oncogene | 14722 | -0.432 | -0.0504 | No |
| 106 | PTPN11 | NA | PTPN11 Entrez, Source | protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) | 14759 | -0.438 | -0.0468 | No |
| 107 | MAPK1 | NA | MAPK1 Entrez, Source | mitogen-activated protein kinase 1 | 14765 | -0.439 | -0.0415 | No |
| 108 | ZAP70 | NA | ZAP70 Entrez, Source | zeta-chain (TCR) associated protein kinase 70kDa | 15272 | -0.513 | -0.0629 | No |
| 109 | KRAS | NA | KRAS Entrez, Source | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog | 15437 | -0.539 | -0.0651 | No |
| 110 | ITGAL | NA | ITGAL Entrez, Source | integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) | 15441 | -0.540 | -0.0583 | No |
| 111 | PRKCB | NA | 15489 | -0.550 | -0.0539 | No | ||
| 112 | CHP2 | NA | 16192 | -0.704 | -0.0837 | No | ||
| 113 | KLRC1 | NA | KLRC1 Entrez, Source | killer cell lectin-like receptor subfamily C, member 1 | 16234 | -0.716 | -0.0768 | No |
| 114 | SOS2 | NA | SOS2 Entrez, Source | son of sevenless homolog 2 (Drosophila) | 16328 | -0.741 | -0.0725 | No |
| 115 | PPP3CB | NA | PPP3CB Entrez, Source | protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform (calcineurin A beta) | 16406 | -0.766 | -0.0669 | No |
| 116 | ITGB2 | NA | ITGB2 Entrez, Source | integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) | 16810 | -0.892 | -0.0778 | No |
| 117 | TNFRSF10D | NA | TNFRSF10D Entrez, Source | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | 17112 | -1.020 | -0.0814 | No |
| 118 | PTPN6 | NA | PTPN6 Entrez, Source | protein tyrosine phosphatase, non-receptor type 6 | 17170 | -1.045 | -0.0712 | No |
| 119 | NFATC4 | NA | NFATC4 Entrez, Source | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 | 17476 | -1.240 | -0.0721 | No |
| 120 | PIK3CG | NA | PIK3CG Entrez, Source | phosphoinositide-3-kinase, catalytic, gamma polypeptide | 17630 | -1.385 | -0.0628 | No |
| 121 | PRKCA | NA | PRKCA Entrez, Source | protein kinase C, alpha | 17892 | -1.832 | -0.0538 | No |
| 122 | KLRC2 | NA | KLRC2 Entrez, Source | killer cell lectin-like receptor subfamily C, member 2 | 18032 | -2.440 | -0.0302 | No |
| 123 | KLRC3 | NA | KLRC3 Entrez, Source | killer cell lectin-like receptor subfamily C, member 3 | 18094 | -2.932 | 0.0040 | No |
