Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 |
| Enrichment Score (ES) | -0.47071975 |
| Normalized Enrichment Score (NES) | -1.6954533 |
| Nominal p-value | 0.0024271845 |
| FDR q-value | 0.030669449 |
| FWER p-Value | 0.264 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | CYP3A7 | NA | CYP3A7 Entrez, Source | cytochrome P450, family 3, subfamily A, polypeptide 7 | 416 | 1.684 | 0.0262 | No |
| 2 | CYP1B1 | NA | CYP1B1 Entrez, Source | cytochrome P450, family 1, subfamily B, polypeptide 1 | 490 | 1.553 | 0.0676 | No |
| 3 | UGT1A7 | NA | UGT1A7 Entrez, Source | UDP glucuronosyltransferase 1 family, polypeptide A7 | 921 | 1.159 | 0.0777 | No |
| 4 | GSTM5 | NA | GSTM5 Entrez, Source | glutathione S-transferase M5 | 2032 | 0.782 | 0.0393 | No |
| 5 | UGT2B10 | NA | UGT2B10 Entrez, Source | UDP glucuronosyltransferase 2 family, polypeptide B10 | 2393 | 0.704 | 0.0400 | No |
| 6 | AKR1C1 | NA | AKR1C1 Entrez, Source | aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase) | 2767 | 0.636 | 0.0380 | No |
| 7 | ADH1A | NA | ADH1A Entrez, Source | alcohol dehydrogenase 1A (class I), alpha polypeptide | 4183 | 0.436 | -0.0274 | No |
| 8 | ALDH3A1 | NA | ALDH3A1 Entrez, Source | aldehyde dehydrogenase 3 family, memberA1 | 5434 | 0.309 | -0.0874 | No |
| 9 | CYP2C8 | NA | CYP2C8 Entrez, Source | cytochrome P450, family 2, subfamily C, polypeptide 8 | 6088 | 0.255 | -0.1160 | No |
| 10 | DHDH | NA | DHDH Entrez, Source | dihydrodiol dehydrogenase (dimeric) | 6388 | 0.230 | -0.1258 | No |
| 11 | ADH5 | NA | ADH5 Entrez, Source | alcohol dehydrogenase 5 (class III), chi polypeptide | 6816 | 0.195 | -0.1437 | No |
| 12 | CYP2B6 | NA | CYP2B6 Entrez, Source | cytochrome P450, family 2, subfamily B, polypeptide 6 | 8209 | 0.093 | -0.2179 | No |
| 13 | EPHX1 | NA | EPHX1 Entrez, Source | epoxide hydrolase 1, microsomal (xenobiotic) | 8226 | 0.091 | -0.2161 | No |
| 14 | CYP2S1 | NA | CYP2S1 Entrez, Source | cytochrome P450, family 2, subfamily S, polypeptide 1 | 8369 | 0.081 | -0.2216 | No |
| 15 | AKR1C2 | NA | AKR1C2 Entrez, Source | aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III) | 8399 | 0.079 | -0.2209 | No |
| 16 | GSTK1 | NA | GSTK1 Entrez, Source | glutathione S-transferase kappa 1 | 8511 | 0.071 | -0.2249 | No |
| 17 | UGT2A1 | NA | UGT2A1 Entrez, Source | UDP glucuronosyltransferase 2 family, polypeptide A1 | 8517 | 0.071 | -0.2231 | No |
| 18 | UGT2B28 | NA | UGT2B28 Entrez, Source | UDP glucuronosyltransferase 2 family, polypeptide B28 | 8783 | 0.052 | -0.2362 | No |
| 19 | MGST1 | NA | MGST1 Entrez, Source | microsomal glutathione S-transferase 1 | 9009 | 0.035 | -0.2477 | No |
| 20 | GSTO1 | NA | GSTO1 Entrez, Source | glutathione S-transferase omega 1 | 9224 | 0.019 | -0.2589 | No |
| 21 | UGT1A1 | NA | UGT1A1 Entrez, Source | UDP glucuronosyltransferase 1 family, polypeptide A1 | 9443 | 0.004 | -0.2708 | No |
| 22 | CYP3A43 | NA | CYP3A43 Entrez, Source | cytochrome P450, family 3, subfamily A, polypeptide 43 | 9550 | 0.000 | -0.2767 | No |
| 23 | UGT1A6 | NA | UGT1A6 Entrez, Source | UDP glucuronosyltransferase 1 family, polypeptide A6 | 9965 | -0.017 | -0.2990 | No |
| 24 | UGT1A4 | NA | UGT1A4 Entrez, Source | UDP glucuronosyltransferase 1 family, polypeptide A4 | 9999 | -0.018 | -0.3003 | No |
| 25 | GSTA3 | NA | GSTA3 Entrez, Source | glutathione S-transferase A3 | 10169 | -0.029 | -0.3088 | No |
| 26 | UGT1A3 | NA | UGT1A3 Entrez, Source | UDP glucuronosyltransferase 1 family, polypeptide A3 | 10381 | -0.041 | -0.3193 | No |
| 27 | ALDH3B2 | NA | ALDH3B2 Entrez, Source | aldehyde dehydrogenase 3 family, member B2 | 10497 | -0.047 | -0.3243 | No |
| 28 | GSTM1 | NA | GSTM1 Entrez, Source | glutathione S-transferase M1 | 10630 | -0.056 | -0.3299 | No |
| 29 | GSTA2 | NA | GSTA2 Entrez, Source | glutathione S-transferase A2 | 10863 | -0.069 | -0.3407 | No |
| 30 | GSTT2 | NA | GSTT2 Entrez, Source | glutathione S-transferase theta 2 | 10988 | -0.077 | -0.3453 | No |
| 31 | UGT2B4 | NA | UGT2B4 Entrez, Source | UDP glucuronosyltransferase 2 family, polypeptide B4 | 11238 | -0.094 | -0.3563 | No |
| 32 | ADH1B | NA | ADH1B Entrez, Source | alcohol dehydrogenase IB (class I), beta polypeptide | 11741 | -0.135 | -0.3801 | No |
| 33 | CYP2F1 | NA | CYP2F1 Entrez, Source | cytochrome P450, family 2, subfamily F, polypeptide 1 | 11875 | -0.146 | -0.3832 | No |
| 34 | CYP1A1 | NA | CYP1A1 Entrez, Source | cytochrome P450, family 1, subfamily A, polypeptide 1 | 11891 | -0.147 | -0.3797 | No |
| 35 | AKR1C4 | NA | AKR1C4 Entrez, Source | aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4) | 12614 | -0.211 | -0.4134 | No |
| 36 | CYP3A4 | NA | CYP3A4 Entrez, Source | cytochrome P450, family 3, subfamily A, polypeptide 4 | 12914 | -0.237 | -0.4230 | No |
| 37 | UGT2B11 | NA | UGT2B11 Entrez, Source | UDP glucuronosyltransferase 2 family, polypeptide B11 | 13085 | -0.251 | -0.4250 | No |
| 38 | UGT1A9 | NA | UGT1A9 Entrez, Source | UDP glucuronosyltransferase 1 family, polypeptide A9 | 13491 | -0.291 | -0.4389 | No |
| 39 | ADH4 | NA | ADH4 Entrez, Source | alcohol dehydrogenase 4 (class II), pi polypeptide | 13607 | -0.301 | -0.4364 | No |
| 40 | UGT2B15 | NA | UGT2B15 Entrez, Source | UDP glucuronosyltransferase 2 family, polypeptide B15 | 14032 | -0.349 | -0.4497 | No |
| 41 | UGT2B7 | NA | UGT2B7 Entrez, Source | UDP glucuronosyltransferase 2 family, polypeptide B7 | 14101 | -0.357 | -0.4430 | No |
| 42 | UGT1A10 | NA | UGT1A10 Entrez, Source | UDP glucuronosyltransferase 1 family, polypeptide A10 | 14604 | -0.419 | -0.4585 | Yes |
| 43 | MGST2 | NA | MGST2 Entrez, Source | microsomal glutathione S-transferase 2 | 14678 | -0.428 | -0.4500 | Yes |
| 44 | UGT2A3 | NA | UGT2A3 Entrez, Source | UDP glucuronosyltransferase 2 family, polypeptide A3 | 14723 | -0.432 | -0.4398 | Yes |
| 45 | CYP2C9 | NA | CYP2C9 Entrez, Source | cytochrome P450, family 2, subfamily C, polypeptide 9 | 14837 | -0.453 | -0.4328 | Yes |
| 46 | ADH7 | NA | ADH7 Entrez, Source | alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide | 15198 | -0.502 | -0.4380 | Yes |
| 47 | ADH1C | NA | ADH1C Entrez, Source | alcohol dehydrogenase 1C (class I), gamma polypeptide | 15278 | -0.513 | -0.4274 | Yes |
| 48 | GSTM3 | NA | GSTM3 Entrez, Source | glutathione S-transferase M3 (brain) | 15376 | -0.529 | -0.4173 | Yes |
| 49 | CYP1A2 | NA | CYP1A2 Entrez, Source | cytochrome P450, family 1, subfamily A, polypeptide 2 | 15535 | -0.558 | -0.4097 | Yes |
| 50 | ALDH3B1 | NA | ALDH3B1 Entrez, Source | aldehyde dehydrogenase 3 family, member B1 | 16343 | -0.746 | -0.4324 | Yes |
| 51 | CYP2C19 | NA | CYP2C19 Entrez, Source | cytochrome P450, family 2, subfamily C, polypeptide 19 | 16630 | -0.833 | -0.4239 | Yes |
| 52 | CYP2E1 | NA | CYP2E1 Entrez, Source | cytochrome P450, family 2, subfamily E, polypeptide 1 | 16791 | -0.886 | -0.4068 | Yes |
| 53 | GSTM4 | NA | GSTM4 Entrez, Source | glutathione S-transferase M4 | 17003 | -0.968 | -0.3902 | Yes |
| 54 | GSTO2 | NA | GSTO2 Entrez, Source | glutathione S-transferase omega 2 | 17090 | -1.008 | -0.3654 | Yes |
| 55 | AKR1C3 | NA | AKR1C3 Entrez, Source | aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) | 17106 | -1.018 | -0.3365 | Yes |
| 56 | GSTA4 | NA | GSTA4 Entrez, Source | glutathione S-transferase A4 | 17164 | -1.038 | -0.3093 | Yes |
| 57 | ADH6 | NA | ADH6 Entrez, Source | alcohol dehydrogenase 6 (class V) | 17315 | -1.127 | -0.2846 | Yes |
| 58 | GSTT1 | NA | GSTT1 Entrez, Source | glutathione S-transferase theta 1 | 17453 | -1.221 | -0.2565 | Yes |
| 59 | GSTM2 | NA | GSTM2 Entrez, Source | glutathione S-transferase M2 (muscle) | 17471 | -1.236 | -0.2213 | Yes |
| 60 | ALDH1A3 | NA | ALDH1A3 Entrez, Source | aldehyde dehydrogenase 1 family, member A3 | 17486 | -1.245 | -0.1857 | Yes |
| 61 | CYP3A5 | NA | CYP3A5 Entrez, Source | cytochrome P450, family 3, subfamily A, polypeptide 5 | 17729 | -1.504 | -0.1551 | Yes |
| 62 | MGST3 | NA | MGST3 Entrez, Source | microsomal glutathione S-transferase 3 | 17763 | -1.551 | -0.1115 | Yes |
| 63 | CYP2C18 | NA | CYP2C18 Entrez, Source | cytochrome P450, family 2, subfamily C, polypeptide 18 | 17886 | -1.812 | -0.0653 | Yes |
| 64 | UGT2B17 | NA | UGT2B17 Entrez, Source | UDP glucuronosyltransferase 2 family, polypeptide B17 | 18075 | -2.762 | 0.0051 | Yes |
