Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | KEGG_LYSINE_DEGRADATION |
| Enrichment Score (ES) | -0.4986777 |
| Normalized Enrichment Score (NES) | -1.6139647 |
| Nominal p-value | 0.0023696683 |
| FDR q-value | 0.04882722 |
| FWER p-Value | 0.491 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | SETD1A | NA | SETD1A Entrez, Source | SET domain containing 1A | 2095 | 0.768 | -0.0755 | No |
| 2 | SUV39H1 | NA | SUV39H1 Entrez, Source | suppressor of variegation 3-9 homolog 1 (Drosophila) | 3143 | 0.576 | -0.1032 | No |
| 3 | EHMT2 | NA | EHMT2 Entrez, Source | euchromatic histone-lysine N-methyltransferase 2 | 4316 | 0.420 | -0.1460 | No |
| 4 | BBOX1 | NA | BBOX1 Entrez, Source | butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 | 4860 | 0.366 | -0.1568 | No |
| 5 | OGDH | NA | OGDH Entrez, Source | oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) | 5309 | 0.322 | -0.1648 | No |
| 6 | EHMT1 | NA | EHMT1 Entrez, Source | euchromatic histone-lysine N-methyltransferase 1 | 5403 | 0.313 | -0.1536 | No |
| 7 | AASDH | NA | AASDH Entrez, Source | - | 6072 | 0.257 | -0.1771 | No |
| 8 | SUV39H2 | NA | SUV39H2 Entrez, Source | suppressor of variegation 3-9 homolog 2 (Drosophila) | 6430 | 0.227 | -0.1849 | No |
| 9 | SETDB1 | NA | SETDB1 Entrez, Source | SET domain, bifurcated 1 | 7846 | 0.119 | -0.2568 | No |
| 10 | DLST | NA | DLST Entrez, Source | dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) | 8390 | 0.080 | -0.2826 | No |
| 11 | PLOD1 | NA | PLOD1 Entrez, Source | procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1 | 8570 | 0.067 | -0.2890 | No |
| 12 | NSD1 | NA | NSD1 Entrez, Source | nuclear receptor binding SET domain protein 1 | 8753 | 0.054 | -0.2962 | No |
| 13 | PLOD3 | NA | PLOD3 Entrez, Source | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 | 8840 | 0.048 | -0.2984 | No |
| 14 | SETMAR | NA | SETMAR Entrez, Source | SET domain and mariner transposase fusion gene | 9819 | -0.008 | -0.3520 | No |
| 15 | SETD1B | NA | SETD1B Entrez, Source | SET domain containing 1B | 10388 | -0.041 | -0.3812 | No |
| 16 | PLOD2 | NA | PLOD2 Entrez, Source | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 10798 | -0.065 | -0.4003 | No |
| 17 | DOT1L | NA | DOT1L Entrez, Source | DOT1-like, histone H3 methyltransferase (S. cerevisiae) | 11373 | -0.103 | -0.4266 | No |
| 18 | AASDHPPT | NA | AASDHPPT Entrez, Source | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 11763 | -0.136 | -0.4410 | No |
| 19 | ALDH1B1 | NA | ALDH1B1 Entrez, Source | aldehyde dehydrogenase 1 family, member B1 | 11847 | -0.144 | -0.4381 | No |
| 20 | SETDB2 | NA | SETDB2 Entrez, Source | SET domain, bifurcated 2 | 12415 | -0.194 | -0.4592 | No |
| 21 | AASS | NA | AASS Entrez, Source | aminoadipate-semialdehyde synthase | 13131 | -0.256 | -0.4853 | Yes |
| 22 | ALDH7A1 | NA | ALDH7A1 Entrez, Source | aldehyde dehydrogenase 7 family, member A1 | 13180 | -0.261 | -0.4744 | Yes |
| 23 | ECHS1 | NA | ECHS1 Entrez, Source | enoyl Coenzyme A hydratase, short chain, 1, mitochondrial | 13439 | -0.286 | -0.4737 | Yes |
| 24 | TMLHE | NA | TMLHE Entrez, Source | trimethyllysine hydroxylase, epsilon | 13695 | -0.311 | -0.4716 | Yes |
| 25 | ACAT2 | NA | ACAT2 Entrez, Source | acetyl-Coenzyme A acetyltransferase 2 (acetoacetyl Coenzyme A thiolase) | 13792 | -0.320 | -0.4602 | Yes |
| 26 | ALDH9A1 | NA | ALDH9A1 Entrez, Source | aldehyde dehydrogenase 9 family, member A1 | 13994 | -0.345 | -0.4533 | Yes |
| 27 | AADAT | NA | AADAT Entrez, Source | aminoadipate aminotransferase | 14053 | -0.352 | -0.4382 | Yes |
| 28 | ALDH3A2 | NA | ALDH3A2 Entrez, Source | aldehyde dehydrogenase 3 family, member A2 | 14517 | -0.407 | -0.4425 | Yes |
| 29 | HADH | NA | HADH Entrez, Source | hydroxyacyl-Coenzyme A dehydrogenase | 14585 | -0.417 | -0.4244 | Yes |
| 30 | GCDH | NA | GCDH Entrez, Source | glutaryl-Coenzyme A dehydrogenase | 15065 | -0.485 | -0.4256 | Yes |
| 31 | ASH1L | NA | ASH1L Entrez, Source | ash1 (absent, small, or homeotic)-like (Drosophila) | 15770 | -0.603 | -0.4330 | Yes |
| 32 | SETD2 | NA | SETD2 Entrez, Source | SET domain containing 2 | 16080 | -0.675 | -0.4148 | Yes |
| 33 | EHHADH | NA | EHHADH Entrez, Source | enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase | 16508 | -0.801 | -0.3966 | Yes |
| 34 | ALDH2 | NA | ALDH2 Entrez, Source | aldehyde dehydrogenase 2 family (mitochondrial) | 16658 | -0.842 | -0.3610 | Yes |
| 35 | HADHA | NA | HADHA Entrez, Source | hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit | 16783 | -0.880 | -0.3219 | Yes |
| 36 | SETD7 | NA | SETD7 Entrez, Source | SET domain containing (lysine methyltransferase) 7 | 17568 | -1.313 | -0.2967 | Yes |
| 37 | ACAT1 | NA | ACAT1 Entrez, Source | acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase) | 17713 | -1.484 | -0.2273 | Yes |
| 38 | PIPOX | NA | PIPOX Entrez, Source | pipecolic acid oxidase | 17785 | -1.592 | -0.1482 | Yes |
| 39 | OGDHL | NA | OGDHL Entrez, Source | oxoglutarate dehydrogenase-like | 18114 | -3.245 | 0.0029 | Yes |
