Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1w1a |
| GeneSet | KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION |
| Enrichment Score (ES) | 0.377454 |
| Normalized Enrichment Score (NES) | 1.3884529 |
| Nominal p-value | 0.022690438 |
| FDR q-value | 0.28059214 |
| FWER p-Value | 0.996 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | NCF2 | NA | NCF2 Entrez, Source | neutrophil cytosolic factor 2 (65kDa, chronic granulomatous disease, autosomal 2) | 2 | 4.823 | 0.0692 | Yes |
| 2 | CLDN4 | NA | CLDN4 Entrez, Source | claudin 4 | 72 | 3.639 | 0.1176 | Yes |
| 3 | PLCG2 | NA | PLCG2 Entrez, Source | phospholipase C, gamma 2 (phosphatidylinositol-specific) | 92 | 3.302 | 0.1640 | Yes |
| 4 | CDH5 | NA | CDH5 Entrez, Source | cadherin 5, type 2, VE-cadherin (vascular epithelium) | 125 | 2.910 | 0.2040 | Yes |
| 5 | BCAR1 | NA | BCAR1 Entrez, Source | breast cancer anti-estrogen resistance 1 | 318 | 1.914 | 0.2209 | Yes |
| 6 | PIK3R1 | NA | PIK3R1 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha) | 366 | 1.786 | 0.2439 | Yes |
| 7 | CLDN1 | NA | CLDN1 Entrez, Source | claudin 1 | 403 | 1.710 | 0.2665 | Yes |
| 8 | MYL5 | NA | MYL5 Entrez, Source | myosin, light chain 5, regulatory | 415 | 1.685 | 0.2901 | Yes |
| 9 | ICAM1 | NA | ICAM1 Entrez, Source | intercellular adhesion molecule 1 (CD54), human rhinovirus receptor | 453 | 1.600 | 0.3110 | Yes |
| 10 | TXK | NA | TXK Entrez, Source | TXK tyrosine kinase | 771 | 1.270 | 0.3117 | Yes |
| 11 | ACTG1 | NA | ACTG1 Entrez, Source | actin, gamma 1 | 887 | 1.181 | 0.3223 | Yes |
| 12 | ITGAM | NA | ITGAM Entrez, Source | integrin, alpha M (complement component 3 receptor 3 subunit) | 1318 | 0.978 | 0.3125 | Yes |
| 13 | PIK3CD | NA | PIK3CD Entrez, Source | phosphoinositide-3-kinase, catalytic, delta polypeptide | 1572 | 0.890 | 0.3113 | Yes |
| 14 | CYBB | NA | CYBB Entrez, Source | cytochrome b-245, beta polypeptide (chronic granulomatous disease) | 1738 | 0.841 | 0.3142 | Yes |
| 15 | RAC2 | NA | RAC2 Entrez, Source | ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) | 1748 | 0.839 | 0.3258 | Yes |
| 16 | ACTN1 | NA | ACTN1 Entrez, Source | actinin, alpha 1 | 1755 | 0.838 | 0.3375 | Yes |
| 17 | ACTB | NA | ACTB Entrez, Source | actin, beta | 1765 | 0.836 | 0.3490 | Yes |
| 18 | RAPGEF3 | NA | RAPGEF3 Entrez, Source | Rap guanine nucleotide exchange factor (GEF) 3 | 1878 | 0.813 | 0.3545 | Yes |
| 19 | ACTN4 | NA | ACTN4 Entrez, Source | actinin, alpha 4 | 2321 | 0.719 | 0.3403 | Yes |
| 20 | PRKCG | NA | PRKCG Entrez, Source | protein kinase C, gamma | 2351 | 0.711 | 0.3489 | Yes |
| 21 | VAV2 | NA | VAV2 Entrez, Source | vav 2 oncogene | 2382 | 0.706 | 0.3574 | Yes |
| 22 | PTK2B | NA | PTK2B Entrez, Source | PTK2B protein tyrosine kinase 2 beta | 2398 | 0.703 | 0.3667 | Yes |
| 23 | NCF4 | NA | NCF4 Entrez, Source | neutrophil cytosolic factor 4, 40kDa | 2512 | 0.682 | 0.3702 | Yes |
| 24 | MSN | NA | MSN Entrez, Source | moesin | 2557 | 0.675 | 0.3775 | Yes |
| 25 | CLDN23 | NA | CLDN23 Entrez, Source | claudin 23 | 3689 | 0.499 | 0.3220 | No |
| 26 | VASP | NA | VASP Entrez, Source | vasodilator-stimulated phosphoprotein | 3873 | 0.478 | 0.3187 | No |
| 27 | PECAM1 | NA | PECAM1 Entrez, Source | platelet/endothelial cell adhesion molecule (CD31 antigen) | 4061 | 0.454 | 0.3149 | No |
| 28 | VCL | NA | VCL Entrez, Source | vinculin | 4090 | 0.448 | 0.3197 | No |
| 29 | MAPK11 | NA | MAPK11 Entrez, Source | mitogen-activated protein kinase 11 | 4342 | 0.417 | 0.3118 | No |
| 30 | VAV1 | NA | VAV1 Entrez, Source | vav 1 oncogene | 4895 | 0.363 | 0.2865 | No |
| 31 | PIK3R3 | NA | PIK3R3 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma) | 5162 | 0.335 | 0.2765 | No |
| 32 | GNAI3 | NA | GNAI3 Entrez, Source | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 5414 | 0.311 | 0.2671 | No |
| 33 | CLDN19 | NA | CLDN19 Entrez, Source | claudin 19 | 5469 | 0.306 | 0.2685 | No |
| 34 | EZR | NA | 5855 | 0.273 | 0.2511 | No | ||
| 35 | CLDN10 | NA | CLDN10 Entrez, Source | claudin 10 | 5930 | 0.268 | 0.2508 | No |
| 36 | JAM2 | NA | JAM2 Entrez, Source | junctional adhesion molecule 2 | 5980 | 0.265 | 0.2519 | No |
| 37 | MAPK12 | NA | MAPK12 Entrez, Source | mitogen-activated protein kinase 12 | 6059 | 0.258 | 0.2513 | No |
| 38 | SIPA1 | NA | SIPA1 Entrez, Source | signal-induced proliferation-associated gene 1 | 6190 | 0.246 | 0.2477 | No |
| 39 | CLDN9 | NA | CLDN9 Entrez, Source | claudin 9 | 6326 | 0.234 | 0.2435 | No |
| 40 | PXN | NA | PXN Entrez, Source | paxillin | 6363 | 0.232 | 0.2449 | No |
| 41 | MMP2 | NA | MMP2 Entrez, Source | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | 6602 | 0.212 | 0.2347 | No |
| 42 | CLDN18 | NA | CLDN18 Entrez, Source | claudin 18 | 6775 | 0.198 | 0.2280 | No |
| 43 | CLDN14 | NA | CLDN14 Entrez, Source | claudin 14 | 7165 | 0.169 | 0.2089 | No |
| 44 | MYL2 | NA | MYL2 Entrez, Source | myosin, light chain 2, regulatory, cardiac, slow | 7327 | 0.157 | 0.2023 | No |
| 45 | MYL10 | NA | 7730 | 0.128 | 0.1818 | No | ||
| 46 | NOX3 | NA | NOX3 Entrez, Source | NADPH oxidase 3 | 7783 | 0.124 | 0.1807 | No |
| 47 | MYL12A | NA | 7897 | 0.115 | 0.1761 | No | ||
| 48 | CTNND1 | NA | CTNND1 Entrez, Source | catenin (cadherin-associated protein), delta 1 | 8232 | 0.091 | 0.1589 | No |
| 49 | CTNNA3 | NA | CTNNA3 Entrez, Source | catenin (cadherin-associated protein), alpha 3 | 8284 | 0.087 | 0.1573 | No |
| 50 | CYBA | NA | CYBA Entrez, Source | cytochrome b-245, alpha polypeptide | 8407 | 0.078 | 0.1517 | No |
| 51 | CLDN15 | NA | CLDN15 Entrez, Source | claudin 15 | 8414 | 0.078 | 0.1525 | No |
| 52 | ESAM | NA | ESAM Entrez, Source | endothelial cell adhesion molecule | 8611 | 0.064 | 0.1426 | No |
| 53 | ROCK1 | NA | ROCK1 Entrez, Source | Rho-associated, coiled-coil containing protein kinase 1 | 8743 | 0.055 | 0.1361 | No |
| 54 | PIK3CA | NA | PIK3CA Entrez, Source | phosphoinositide-3-kinase, catalytic, alpha polypeptide | 8784 | 0.052 | 0.1346 | No |
| 55 | MAPK14 | NA | MAPK14 Entrez, Source | mitogen-activated protein kinase 14 | 8878 | 0.045 | 0.1301 | No |
| 56 | CLDN20 | NA | CLDN20 Entrez, Source | claudin 20 | 9205 | 0.021 | 0.1124 | No |
| 57 | CLDN11 | NA | CLDN11 Entrez, Source | claudin 11 (oligodendrocyte transmembrane protein) | 9307 | 0.013 | 0.1070 | No |
| 58 | CLDN17 | NA | CLDN17 Entrez, Source | claudin 17 | 9580 | 0.000 | 0.0919 | No |
| 59 | CLDN22 | NA | CLDN22 Entrez, Source | claudin 22 | 9844 | -0.009 | 0.0775 | No |
| 60 | RAC1 | NA | RAC1 Entrez, Source | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | 9857 | -0.010 | 0.0769 | No |
| 61 | CD99 | NA | CD99 Entrez, Source | CD99 molecule | 10071 | -0.023 | 0.0655 | No |
| 62 | MYLPF | NA | MYLPF Entrez, Source | - | 10088 | -0.024 | 0.0649 | No |
| 63 | GNAI2 | NA | GNAI2 Entrez, Source | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 | 10093 | -0.025 | 0.0651 | No |
| 64 | CLDN3 | NA | CLDN3 Entrez, Source | claudin 3 | 10142 | -0.029 | 0.0628 | No |
| 65 | ARHGAP5 | NA | ARHGAP5 Entrez, Source | Rho GTPase activating protein 5 | 10376 | -0.040 | 0.0505 | No |
| 66 | ITGA4 | NA | ITGA4 Entrez, Source | integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) | 10392 | -0.042 | 0.0503 | No |
| 67 | PLCG1 | NA | PLCG1 Entrez, Source | phospholipase C, gamma 1 | 10890 | -0.071 | 0.0238 | No |
| 68 | PIK3R5 | NA | PIK3R5 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 5, p101 | 11049 | -0.081 | 0.0162 | No |
| 69 | ACTN3 | NA | ACTN3 Entrez, Source | actinin, alpha 3 | 11241 | -0.094 | 0.0069 | No |
| 70 | ROCK2 | NA | ROCK2 Entrez, Source | Rho-associated, coiled-coil containing protein kinase 2 | 11260 | -0.095 | 0.0073 | No |
| 71 | CLDN8 | NA | CLDN8 Entrez, Source | claudin 8 | 11647 | -0.127 | -0.0123 | No |
| 72 | PIK3CB | NA | PIK3CB Entrez, Source | phosphoinositide-3-kinase, catalytic, beta polypeptide | 11650 | -0.127 | -0.0105 | No |
| 73 | PTK2 | NA | PTK2 Entrez, Source | PTK2 protein tyrosine kinase 2 | 11849 | -0.144 | -0.0194 | No |
| 74 | NOX1 | NA | NOX1 Entrez, Source | NADPH oxidase 1 | 11982 | -0.154 | -0.0245 | No |
| 75 | PIK3R2 | NA | PIK3R2 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta) | 12247 | -0.177 | -0.0366 | No |
| 76 | CDC42 | NA | CDC42 Entrez, Source | cell division cycle 42 (GTP binding protein, 25kDa) | 12435 | -0.196 | -0.0442 | No |
| 77 | CLDN6 | NA | CLDN6 Entrez, Source | claudin 6 | 12576 | -0.208 | -0.0489 | No |
| 78 | NCF1 | NA | NCF1 Entrez, Source | neutrophil cytosolic factor 1, (chronic granulomatous disease, autosomal 1) | 12615 | -0.211 | -0.0480 | No |
| 79 | CTNNB1 | NA | CTNNB1 Entrez, Source | catenin (cadherin-associated protein), beta 1, 88kDa | 12660 | -0.216 | -0.0473 | No |
| 80 | RHOA | NA | RHOA Entrez, Source | ras homolog gene family, member A | 12705 | -0.219 | -0.0466 | No |
| 81 | MYL12B | NA | 12935 | -0.238 | -0.0559 | No | ||
| 82 | MMP9 | NA | MMP9 Entrez, Source | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | 13001 | -0.245 | -0.0560 | No |
| 83 | RHOH | NA | RHOH Entrez, Source | ras homolog gene family, member H | 13145 | -0.257 | -0.0602 | No |
| 84 | CTNNA1 | NA | CTNNA1 Entrez, Source | catenin (cadherin-associated protein), alpha 1, 102kDa | 13267 | -0.269 | -0.0630 | No |
| 85 | CLDN16 | NA | CLDN16 Entrez, Source | claudin 16 | 13441 | -0.286 | -0.0685 | No |
| 86 | MYL7 | NA | MYL7 Entrez, Source | myosin, light chain 7, regulatory | 14008 | -0.346 | -0.0949 | No |
| 87 | GNAI1 | NA | GNAI1 Entrez, Source | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 14113 | -0.358 | -0.0955 | No |
| 88 | CXCR4 | NA | CXCR4 Entrez, Source | chemokine (C-X-C motif) receptor 4 | 14131 | -0.361 | -0.0913 | No |
| 89 | RAP1A | NA | RAP1A Entrez, Source | RAP1A, member of RAS oncogene family | 14381 | -0.389 | -0.0995 | No |
| 90 | MYL9 | NA | MYL9 Entrez, Source | myosin, light chain 9, regulatory | 14544 | -0.412 | -0.1025 | No |
| 91 | ITK | NA | ITK Entrez, Source | IL2-inducible T-cell kinase | 14581 | -0.416 | -0.0986 | No |
| 92 | VAV3 | NA | VAV3 Entrez, Source | vav 3 oncogene | 14722 | -0.432 | -0.1001 | No |
| 93 | CLDN2 | NA | CLDN2 Entrez, Source | claudin 2 | 14728 | -0.433 | -0.0942 | No |
| 94 | PTPN11 | NA | PTPN11 Entrez, Source | protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) | 14759 | -0.438 | -0.0895 | No |
| 95 | MAPK13 | NA | MAPK13 Entrez, Source | mitogen-activated protein kinase 13 | 14840 | -0.454 | -0.0874 | No |
| 96 | RASSF5 | NA | RASSF5 Entrez, Source | Ras association (RalGDS/AF-6) domain family 5 | 14890 | -0.460 | -0.0836 | No |
| 97 | RAP1B | NA | RAP1B Entrez, Source | RAP1B, member of RAS oncogene family | 14943 | -0.467 | -0.0797 | No |
| 98 | CXCL12 | NA | CXCL12 Entrez, Source | chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) | 15002 | -0.475 | -0.0761 | No |
| 99 | CLDN5 | NA | CLDN5 Entrez, Source | claudin 5 (transmembrane protein deleted in velocardiofacial syndrome) | 15336 | -0.521 | -0.0871 | No |
| 100 | VCAM1 | NA | VCAM1 Entrez, Source | vascular cell adhesion molecule 1 | 15433 | -0.538 | -0.0847 | No |
| 101 | ITGAL | NA | ITGAL Entrez, Source | integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) | 15441 | -0.540 | -0.0773 | No |
| 102 | PRKCB | NA | 15489 | -0.550 | -0.0720 | No | ||
| 103 | THY1 | NA | THY1 Entrez, Source | Thy-1 cell surface antigen | 15540 | -0.559 | -0.0667 | No |
| 104 | ACTN2 | NA | ACTN2 Entrez, Source | actinin, alpha 2 | 15627 | -0.577 | -0.0632 | No |
| 105 | JAM3 | NA | JAM3 Entrez, Source | junctional adhesion molecule 3 | 15734 | -0.595 | -0.0606 | No |
| 106 | OCLN | NA | OCLN Entrez, Source | occludin | 16178 | -0.699 | -0.0750 | No |
| 107 | ARHGAP35 | NA | 16487 | -0.793 | -0.0807 | No | ||
| 108 | ITGB2 | NA | ITGB2 Entrez, Source | integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) | 16810 | -0.892 | -0.0857 | No |
| 109 | ITGB1 | NA | ITGB1 Entrez, Source | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 16942 | -0.944 | -0.0794 | No |
| 110 | CTNNA2 | NA | CTNNA2 Entrez, Source | catenin (cadherin-associated protein), alpha 2 | 17310 | -1.125 | -0.0836 | No |
| 111 | F11R | NA | F11R Entrez, Source | F11 receptor | 17580 | -1.322 | -0.0795 | No |
| 112 | PIK3CG | NA | PIK3CG Entrez, Source | phosphoinositide-3-kinase, catalytic, gamma polypeptide | 17630 | -1.385 | -0.0623 | No |
| 113 | PRKCA | NA | PRKCA Entrez, Source | protein kinase C, alpha | 17892 | -1.832 | -0.0505 | No |
| 114 | CLDN7 | NA | CLDN7 Entrez, Source | claudin 7 | 17954 | -2.035 | -0.0246 | No |
| 115 | RAPGEF4 | NA | RAPGEF4 Entrez, Source | Rap guanine nucleotide exchange factor (GEF) 4 | 18045 | -2.533 | 0.0068 | No |
