Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1w1a |
| GeneSet | KEGG_JAK_STAT_SIGNALING_PATHWAY |
| Enrichment Score (ES) | 0.4700247 |
| Normalized Enrichment Score (NES) | 1.7951381 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.01768189 |
| FWER p-Value | 0.095 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | IL7R | NA | IL7R Entrez, Source | interleukin 7 receptor | 4 | 4.785 | 0.0499 | Yes |
| 2 | IL6 | NA | IL6 Entrez, Source | interleukin 6 (interferon, beta 2) | 17 | 4.596 | 0.0973 | Yes |
| 3 | CRLF2 | NA | CRLF2 Entrez, Source | cytokine receptor-like factor 2 | 30 | 4.450 | 0.1432 | Yes |
| 4 | IL2RG | NA | IL2RG Entrez, Source | interleukin 2 receptor, gamma (severe combined immunodeficiency) | 57 | 3.955 | 0.1831 | Yes |
| 5 | IL22RA1 | NA | IL22RA1 Entrez, Source | interleukin 22 receptor, alpha 1 | 88 | 3.325 | 0.2163 | Yes |
| 6 | CNTFR | NA | CNTFR Entrez, Source | ciliary neurotrophic factor receptor | 163 | 2.605 | 0.2394 | Yes |
| 7 | IL12RB1 | NA | IL12RB1 Entrez, Source | interleukin 12 receptor, beta 1 | 178 | 2.509 | 0.2649 | Yes |
| 8 | SPRY4 | NA | SPRY4 Entrez, Source | sprouty homolog 4 (Drosophila) | 208 | 2.371 | 0.2881 | Yes |
| 9 | CLCF1 | NA | CLCF1 Entrez, Source | cardiotrophin-like cytokine factor 1 | 281 | 2.060 | 0.3057 | Yes |
| 10 | JAK2 | NA | JAK2 Entrez, Source | Janus kinase 2 (a protein tyrosine kinase) | 306 | 1.958 | 0.3248 | Yes |
| 11 | PIK3R1 | NA | PIK3R1 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha) | 366 | 1.786 | 0.3402 | Yes |
| 12 | CSF2RA | NA | CSF2RA Entrez, Source | colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) | 431 | 1.652 | 0.3540 | Yes |
| 13 | IRF9 | NA | 502 | 1.537 | 0.3662 | Yes | ||
| 14 | BCL2L1 | NA | BCL2L1 Entrez, Source | BCL2-like 1 | 512 | 1.526 | 0.3816 | Yes |
| 15 | IL15RA | NA | IL15RA Entrez, Source | interleukin 15 receptor, alpha | 540 | 1.495 | 0.3958 | Yes |
| 16 | IL4R | NA | IL4R Entrez, Source | interleukin 4 receptor | 547 | 1.486 | 0.4110 | Yes |
| 17 | SPRY2 | NA | SPRY2 Entrez, Source | sprouty homolog 2 (Drosophila) | 810 | 1.240 | 0.4094 | Yes |
| 18 | IL7 | NA | IL7 Entrez, Source | interleukin 7 | 857 | 1.205 | 0.4195 | Yes |
| 19 | IL20RA | NA | IL20RA Entrez, Source | interleukin 20 receptor, alpha | 972 | 1.133 | 0.4250 | Yes |
| 20 | IL6ST | NA | IL6ST Entrez, Source | interleukin 6 signal transducer (gp130, oncostatin M receptor) | 1001 | 1.118 | 0.4352 | Yes |
| 21 | IL13RA2 | NA | IL13RA2 Entrez, Source | interleukin 13 receptor, alpha 2 | 1194 | 1.024 | 0.4352 | Yes |
| 22 | CCND3 | NA | CCND3 Entrez, Source | cyclin D3 | 1347 | 0.964 | 0.4369 | Yes |
| 23 | PIAS4 | NA | PIAS4 Entrez, Source | protein inhibitor of activated STAT, 4 | 1445 | 0.931 | 0.4413 | Yes |
| 24 | OSMR | NA | OSMR Entrez, Source | oncostatin M receptor | 1490 | 0.912 | 0.4484 | Yes |
| 25 | CREBBP | NA | CREBBP Entrez, Source | CREB binding protein (Rubinstein-Taybi syndrome) | 1528 | 0.903 | 0.4557 | Yes |
| 26 | PIK3CD | NA | PIK3CD Entrez, Source | phosphoinositide-3-kinase, catalytic, delta polypeptide | 1572 | 0.890 | 0.4627 | Yes |
| 27 | IL12B | NA | IL12B Entrez, Source | interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) | 1607 | 0.880 | 0.4700 | Yes |
| 28 | IL10RB | NA | IL10RB Entrez, Source | interleukin 10 receptor, beta | 1997 | 0.789 | 0.4567 | Yes |
| 29 | EPO | NA | EPO Entrez, Source | erythropoietin | 2054 | 0.776 | 0.4617 | Yes |
| 30 | LIF | NA | LIF Entrez, Source | leukemia inhibitory factor (cholinergic differentiation factor) | 2141 | 0.755 | 0.4648 | Yes |
| 31 | EP300 | NA | EP300 Entrez, Source | E1A binding protein p300 | 2210 | 0.742 | 0.4688 | Yes |
| 32 | SOCS1 | NA | SOCS1 Entrez, Source | suppressor of cytokine signaling 1 | 2485 | 0.686 | 0.4608 | Yes |
| 33 | IL2RA | NA | IL2RA Entrez, Source | interleukin 2 receptor, alpha | 2605 | 0.665 | 0.4612 | Yes |
| 34 | IL15 | NA | IL15 Entrez, Source | interleukin 15 | 2774 | 0.635 | 0.4585 | Yes |
| 35 | IFNAR1 | NA | IFNAR1 Entrez, Source | interferon (alpha, beta and omega) receptor 1 | 2807 | 0.630 | 0.4633 | Yes |
| 36 | STAT1 | NA | STAT1 Entrez, Source | signal transducer and activator of transcription 1, 91kDa | 2854 | 0.622 | 0.4673 | Yes |
| 37 | STAM2 | NA | STAM2 Entrez, Source | signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 | 2920 | 0.610 | 0.4700 | Yes |
| 38 | IFNAR2 | NA | IFNAR2 Entrez, Source | interferon (alpha, beta and omega) receptor 2 | 3113 | 0.580 | 0.4654 | No |
| 39 | IFNGR1 | NA | IFNGR1 Entrez, Source | interferon gamma receptor 1 | 3151 | 0.575 | 0.4694 | No |
| 40 | STAT3 | NA | STAT3 Entrez, Source | signal transducer and activator of transcription 3 (acute-phase response factor) | 3305 | 0.550 | 0.4667 | No |
| 41 | IL23A | NA | IL23A Entrez, Source | interleukin 23, alpha subunit p19 | 3416 | 0.534 | 0.4662 | No |
| 42 | CISH | NA | CISH Entrez, Source | cytokine inducible SH2-containing protein | 3602 | 0.510 | 0.4612 | No |
| 43 | STAT5A | NA | STAT5A Entrez, Source | signal transducer and activator of transcription 5A | 3875 | 0.478 | 0.4511 | No |
| 44 | IL11 | NA | IL11 Entrez, Source | interleukin 11 | 4400 | 0.411 | 0.4264 | No |
| 45 | CCND1 | NA | CCND1 Entrez, Source | cyclin D1 | 4440 | 0.407 | 0.4285 | No |
| 46 | IL20 | NA | IL20 Entrez, Source | interleukin 20 | 4747 | 0.378 | 0.4154 | No |
| 47 | STAT2 | NA | STAT2 Entrez, Source | signal transducer and activator of transcription 2, 113kDa | 5031 | 0.348 | 0.4034 | No |
| 48 | MPL | NA | MPL Entrez, Source | myeloproliferative leukemia virus oncogene | 5160 | 0.336 | 0.3998 | No |
| 49 | PIK3R3 | NA | PIK3R3 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma) | 5162 | 0.335 | 0.4032 | No |
| 50 | SOCS2 | NA | SOCS2 Entrez, Source | suppressor of cytokine signaling 2 | 5364 | 0.316 | 0.3954 | No |
| 51 | SOCS3 | NA | SOCS3 Entrez, Source | suppressor of cytokine signaling 3 | 5428 | 0.310 | 0.3951 | No |
| 52 | IL9R | NA | IL9R Entrez, Source | interleukin 9 receptor | 5468 | 0.306 | 0.3962 | No |
| 53 | JAK1 | NA | JAK1 Entrez, Source | Janus kinase 1 (a protein tyrosine kinase) | 5549 | 0.300 | 0.3949 | No |
| 54 | IFNA21 | NA | IFNA21 Entrez, Source | interferon, alpha 21 | 5854 | 0.273 | 0.3809 | No |
| 55 | SOCS5 | NA | SOCS5 Entrez, Source | suppressor of cytokine signaling 5 | 6031 | 0.261 | 0.3738 | No |
| 56 | IL21R | NA | IL21R Entrez, Source | interleukin 21 receptor | 6038 | 0.260 | 0.3762 | No |
| 57 | AKT2 | NA | AKT2 Entrez, Source | v-akt murine thymoma viral oncogene homolog 2 | 6144 | 0.250 | 0.3730 | No |
| 58 | STAT6 | NA | STAT6 Entrez, Source | signal transducer and activator of transcription 6, interleukin-4 induced | 6443 | 0.226 | 0.3588 | No |
| 59 | GH2 | NA | GH2 Entrez, Source | growth hormone 2 | 6485 | 0.222 | 0.3589 | No |
| 60 | LEP | NA | LEP Entrez, Source | leptin (obesity homolog, mouse) | 6610 | 0.211 | 0.3542 | No |
| 61 | IL3 | NA | IL3 Entrez, Source | interleukin 3 (colony-stimulating factor, multiple) | 6709 | 0.203 | 0.3509 | No |
| 62 | IL10RA | NA | IL10RA Entrez, Source | interleukin 10 receptor, alpha | 6837 | 0.193 | 0.3459 | No |
| 63 | OSM | NA | OSM Entrez, Source | oncostatin M | 7070 | 0.176 | 0.3348 | No |
| 64 | IFNGR2 | NA | IFNGR2 Entrez, Source | interferon gamma receptor 2 (interferon gamma transducer 1) | 7118 | 0.172 | 0.3340 | No |
| 65 | IL2 | NA | IL2 Entrez, Source | interleukin 2 | 7269 | 0.162 | 0.3274 | No |
| 66 | IL6R | NA | IL6R Entrez, Source | interleukin 6 receptor | 7349 | 0.156 | 0.3247 | No |
| 67 | STAT4 | NA | STAT4 Entrez, Source | signal transducer and activator of transcription 4 | 7424 | 0.150 | 0.3221 | No |
| 68 | PIAS3 | NA | PIAS3 Entrez, Source | protein inhibitor of activated STAT, 3 | 7532 | 0.142 | 0.3177 | No |
| 69 | IFNB1 | NA | IFNB1 Entrez, Source | interferon, beta 1, fibroblast | 7718 | 0.129 | 0.3087 | No |
| 70 | IL13 | NA | IL13 Entrez, Source | interleukin 13 | 7770 | 0.125 | 0.3072 | No |
| 71 | AKT1 | NA | AKT1 Entrez, Source | v-akt murine thymoma viral oncogene homolog 1 | 7922 | 0.113 | 0.3000 | No |
| 72 | IL5 | NA | IL5 Entrez, Source | interleukin 5 (colony-stimulating factor, eosinophil) | 8004 | 0.107 | 0.2967 | No |
| 73 | CSH1 | NA | CSH1 Entrez, Source | chorionic somatomammotropin hormone 1 (placental lactogen) | 8166 | 0.095 | 0.2887 | No |
| 74 | IFNA17 | NA | IFNA17 Entrez, Source | interferon, alpha 17 | 8248 | 0.090 | 0.2852 | No |
| 75 | GH1 | NA | GH1 Entrez, Source | growth hormone 1 | 8254 | 0.090 | 0.2858 | No |
| 76 | CNTF | NA | CNTF Entrez, Source | ciliary neurotrophic factor | 8335 | 0.083 | 0.2823 | No |
| 77 | CSF2RB | NA | CSF2RB Entrez, Source | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) | 8457 | 0.075 | 0.2763 | No |
| 78 | PIK3CA | NA | PIK3CA Entrez, Source | phosphoinositide-3-kinase, catalytic, alpha polypeptide | 8784 | 0.052 | 0.2588 | No |
| 79 | LIFR | NA | LIFR Entrez, Source | leukemia inhibitory factor receptor alpha | 8967 | 0.038 | 0.2491 | No |
| 80 | SPRED1 | NA | SPRED1 Entrez, Source | sprouty-related, EVH1 domain containing 1 | 9121 | 0.026 | 0.2409 | No |
| 81 | PIAS1 | NA | PIAS1 Entrez, Source | protein inhibitor of activated STAT, 1 | 9451 | 0.004 | 0.2227 | No |
| 82 | SOCS7 | NA | SOCS7 Entrez, Source | suppressor of cytokine signaling 7 | 9501 | 0.001 | 0.2199 | No |
| 83 | IL4 | NA | IL4 Entrez, Source | interleukin 4 | 9534 | 0.000 | 0.2182 | No |
| 84 | IFNA13 | NA | IFNA13 Entrez, Source | interferon, alpha 13 | 9539 | 0.000 | 0.2179 | No |
| 85 | CSF2 | NA | CSF2 Entrez, Source | colony stimulating factor 2 (granulocyte-macrophage) | 9575 | 0.000 | 0.2160 | No |
| 86 | IL22 | NA | IL22 Entrez, Source | interleukin 22 | 9649 | 0.000 | 0.2119 | No |
| 87 | IFNA8 | NA | IFNA8 Entrez, Source | interferon, alpha 8 | 9853 | -0.010 | 0.2008 | No |
| 88 | TSLP | NA | TSLP Entrez, Source | - | 9939 | -0.015 | 0.1962 | No |
| 89 | CCND2 | NA | CCND2 Entrez, Source | cyclin D2 | 10056 | -0.023 | 0.1900 | No |
| 90 | CBLC | NA | CBLC Entrez, Source | Cas-Br-M (murine) ecotropic retroviral transforming sequence c | 10474 | -0.046 | 0.1674 | No |
| 91 | CSF3 | NA | CSF3 Entrez, Source | colony stimulating factor 3 (granulocyte) | 10639 | -0.057 | 0.1589 | No |
| 92 | CBLB | NA | CBLB Entrez, Source | Cas-Br-M (murine) ecotropic retroviral transforming sequence b | 10677 | -0.059 | 0.1574 | No |
| 93 | IL12A | NA | IL12A Entrez, Source | interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) | 10711 | -0.061 | 0.1563 | No |
| 94 | PIK3R5 | NA | PIK3R5 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 5, p101 | 11049 | -0.081 | 0.1384 | No |
| 95 | IFNA10 | NA | IFNA10 Entrez, Source | interferon, alpha 10 | 11188 | -0.090 | 0.1317 | No |
| 96 | IFNA16 | NA | IFNA16 Entrez, Source | interferon, alpha 16 | 11217 | -0.092 | 0.1311 | No |
| 97 | IFNA1 | NA | IFNA1 Entrez, Source | interferon, alpha 1 | 11267 | -0.096 | 0.1294 | No |
| 98 | PIK3CB | NA | PIK3CB Entrez, Source | phosphoinositide-3-kinase, catalytic, beta polypeptide | 11650 | -0.127 | 0.1095 | No |
| 99 | GHR | NA | GHR Entrez, Source | growth hormone receptor | 11671 | -0.129 | 0.1098 | No |
| 100 | IFNA6 | NA | IFNA6 Entrez, Source | interferon, alpha 6 | 11724 | -0.134 | 0.1083 | No |
| 101 | IL5RA | NA | IL5RA Entrez, Source | interleukin 5 receptor, alpha | 11812 | -0.141 | 0.1049 | No |
| 102 | CSF3R | NA | CSF3R Entrez, Source | colony stimulating factor 3 receptor (granulocyte) | 11935 | -0.150 | 0.0997 | No |
| 103 | IL13RA1 | NA | IL13RA1 Entrez, Source | interleukin 13 receptor, alpha 1 | 11942 | -0.151 | 0.1010 | No |
| 104 | PIK3R2 | NA | PIK3R2 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta) | 12247 | -0.177 | 0.0860 | No |
| 105 | TYK2 | NA | TYK2 Entrez, Source | tyrosine kinase 2 | 12261 | -0.178 | 0.0871 | No |
| 106 | SOS1 | NA | SOS1 Entrez, Source | son of sevenless homolog 1 (Drosophila) | 12302 | -0.183 | 0.0868 | No |
| 107 | IL2RB | NA | IL2RB Entrez, Source | interleukin 2 receptor, beta | 12478 | -0.199 | 0.0792 | No |
| 108 | IFNK | NA | IFNK Entrez, Source | interferon, kappa | 12516 | -0.203 | 0.0792 | No |
| 109 | STAM | NA | STAM Entrez, Source | signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 | 12618 | -0.212 | 0.0758 | No |
| 110 | PIAS2 | NA | PIAS2 Entrez, Source | protein inhibitor of activated STAT, 2 | 12701 | -0.219 | 0.0736 | No |
| 111 | CBL | NA | CBL Entrez, Source | Cas-Br-M (murine) ecotropic retroviral transforming sequence | 12715 | -0.220 | 0.0752 | No |
| 112 | IFNA2 | NA | IFNA2 Entrez, Source | interferon, alpha 2 | 13213 | -0.263 | 0.0504 | No |
| 113 | IL19 | NA | IL19 Entrez, Source | interleukin 19 | 13337 | -0.274 | 0.0464 | No |
| 114 | IL21 | NA | IL21 Entrez, Source | interleukin 21 | 13578 | -0.299 | 0.0362 | No |
| 115 | PRLR | NA | PRLR Entrez, Source | prolactin receptor | 13664 | -0.308 | 0.0347 | No |
| 116 | MYC | NA | MYC Entrez, Source | v-myc myelocytomatosis viral oncogene homolog (avian) | 13741 | -0.315 | 0.0338 | No |
| 117 | IL3RA | NA | IL3RA Entrez, Source | interleukin 3 receptor, alpha (low affinity) | 13810 | -0.322 | 0.0334 | No |
| 118 | SPRED2 | NA | SPRED2 Entrez, Source | sprouty-related, EVH1 domain containing 2 | 13836 | -0.324 | 0.0354 | No |
| 119 | GRB2 | NA | GRB2 Entrez, Source | growth factor receptor-bound protein 2 | 14005 | -0.345 | 0.0297 | No |
| 120 | IFNE | NA | 14107 | -0.358 | 0.0278 | No | ||
| 121 | IL12RB2 | NA | IL12RB2 Entrez, Source | interleukin 12 receptor, beta 2 | 14277 | -0.377 | 0.0224 | No |
| 122 | IL23R | NA | IL23R Entrez, Source | interleukin 23 receptor | 14535 | -0.410 | 0.0124 | No |
| 123 | IFNG | NA | IFNG Entrez, Source | interferon, gamma | 14617 | -0.420 | 0.0123 | No |
| 124 | PTPN11 | NA | PTPN11 Entrez, Source | protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) | 14759 | -0.438 | 0.0091 | No |
| 125 | SPRY3 | NA | SPRY3 Entrez, Source | sprouty homolog 3 (Drosophila) | 14766 | -0.439 | 0.0134 | No |
| 126 | EPOR | NA | EPOR Entrez, Source | erythropoietin receptor | 14902 | -0.462 | 0.0107 | No |
| 127 | SOCS4 | NA | SOCS4 Entrez, Source | suppressor of cytokine signaling 4 | 14915 | -0.464 | 0.0149 | No |
| 128 | STAT5B | NA | STAT5B Entrez, Source | signal transducer and activator of transcription 5B | 15023 | -0.478 | 0.0140 | No |
| 129 | PRL | NA | PRL Entrez, Source | prolactin | 15211 | -0.504 | 0.0089 | No |
| 130 | TPO | NA | TPO Entrez, Source | thyroid peroxidase | 15426 | -0.536 | 0.0026 | No |
| 131 | IL10 | NA | IL10 Entrez, Source | interleukin 10 | 15556 | -0.562 | 0.0013 | No |
| 132 | IL22RA2 | NA | IL22RA2 Entrez, Source | interleukin 22 receptor, alpha 2 | 16113 | -0.684 | -0.0224 | No |
| 133 | SOS2 | NA | SOS2 Entrez, Source | son of sevenless homolog 2 (Drosophila) | 16328 | -0.741 | -0.0265 | No |
| 134 | LEPR | NA | LEPR Entrez, Source | leptin receptor | 16372 | -0.755 | -0.0210 | No |
| 135 | CTF1 | NA | CTF1 Entrez, Source | cardiotrophin 1 | 16377 | -0.756 | -0.0133 | No |
| 136 | IL24 | NA | IL24 Entrez, Source | interleukin 24 | 16444 | -0.776 | -0.0088 | No |
| 137 | SPRY1 | NA | SPRY1 Entrez, Source | sprouty homolog 1, antagonist of FGF signaling (Drosophila) | 16877 | -0.916 | -0.0232 | No |
| 138 | PIM1 | NA | PIM1 Entrez, Source | pim-1 oncogene | 17087 | -1.007 | -0.0242 | No |
| 139 | PTPN6 | NA | PTPN6 Entrez, Source | protein tyrosine phosphatase, non-receptor type 6 | 17170 | -1.045 | -0.0179 | No |
| 140 | IL20RB | NA | IL20RB Entrez, Source | interleukin 20 receptor beta | 17522 | -1.274 | -0.0240 | No |
| 141 | JAK3 | NA | JAK3 Entrez, Source | Janus kinase 3 (a protein tyrosine kinase, leukocyte) | 17614 | -1.365 | -0.0148 | No |
| 142 | IFNW1 | NA | IFNW1 Entrez, Source | interferon, omega 1 | 17627 | -1.383 | -0.0010 | No |
| 143 | PIK3CG | NA | PIK3CG Entrez, Source | phosphoinositide-3-kinase, catalytic, gamma polypeptide | 17630 | -1.385 | 0.0134 | No |
| 144 | AKT3 | NA | AKT3 Entrez, Source | v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) | 17766 | -1.559 | 0.0222 | No |
