Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | KEGG_GLYCOLYSIS_GLUCONEOGENESIS |
| Enrichment Score (ES) | -0.47489917 |
| Normalized Enrichment Score (NES) | -1.6705325 |
| Nominal p-value | 0.0024813896 |
| FDR q-value | 0.033951066 |
| FWER p-Value | 0.329 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | FBP2 | NA | FBP2 Entrez, Source | fructose-1,6-bisphosphatase 2 | 3541 | 0.517 | -0.1762 | No |
| 2 | PCK2 | NA | PCK2 Entrez, Source | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | 3604 | 0.510 | -0.1605 | No |
| 3 | ALDOA | NA | ALDOA Entrez, Source | aldolase A, fructose-bisphosphate | 3679 | 0.499 | -0.1459 | No |
| 4 | LDHAL6B | NA | LDHAL6B Entrez, Source | lactate dehydrogenase A-like 6B | 3846 | 0.481 | -0.1371 | No |
| 5 | ADH1A | NA | ADH1A Entrez, Source | alcohol dehydrogenase 1A (class I), alpha polypeptide | 4183 | 0.436 | -0.1393 | No |
| 6 | PFKP | NA | PFKP Entrez, Source | phosphofructokinase, platelet | 5062 | 0.345 | -0.1749 | No |
| 7 | ALDH3A1 | NA | ALDH3A1 Entrez, Source | aldehyde dehydrogenase 3 family, memberA1 | 5434 | 0.309 | -0.1838 | No |
| 8 | HK2 | NA | HK2 Entrez, Source | hexokinase 2 | 5760 | 0.282 | -0.1912 | No |
| 9 | FBP1 | NA | FBP1 Entrez, Source | fructose-1,6-bisphosphatase 1 | 5809 | 0.278 | -0.1834 | No |
| 10 | GCK | NA | GCK Entrez, Source | glucokinase (hexokinase 4, maturity onset diabetes of the young 2) | 5924 | 0.268 | -0.1797 | No |
| 11 | PDHA2 | NA | PDHA2 Entrez, Source | pyruvate dehydrogenase (lipoamide) alpha 2 | 6115 | 0.253 | -0.1807 | No |
| 12 | HK3 | NA | HK3 Entrez, Source | hexokinase 3 (white cell) | 6682 | 0.205 | -0.2043 | No |
| 13 | ADH5 | NA | ADH5 Entrez, Source | alcohol dehydrogenase 5 (class III), chi polypeptide | 6816 | 0.195 | -0.2044 | No |
| 14 | LDHAL6A | NA | LDHAL6A Entrez, Source | lactate dehydrogenase A-like 6A | 6991 | 0.181 | -0.2072 | No |
| 15 | ACSS2 | NA | ACSS2 Entrez, Source | acyl-CoA synthetase short-chain family member 2 | 7022 | 0.178 | -0.2022 | No |
| 16 | PGM2 | NA | PGM2 Entrez, Source | phosphoglucomutase 2 | 7838 | 0.119 | -0.2427 | No |
| 17 | PGAM1 | NA | PGAM1 Entrez, Source | phosphoglycerate mutase 1 (brain) | 8385 | 0.080 | -0.2699 | No |
| 18 | ENO2 | NA | ENO2 Entrez, Source | enolase 2 (gamma, neuronal) | 8999 | 0.035 | -0.3024 | No |
| 19 | ENO1 | NA | ENO1 Entrez, Source | enolase 1, (alpha) | 9208 | 0.020 | -0.3132 | No |
| 20 | PGM1 | NA | PGM1 Entrez, Source | phosphoglucomutase 1 | 9960 | -0.017 | -0.3540 | No |
| 21 | GPI | NA | GPI Entrez, Source | glucose phosphate isomerase | 10110 | -0.027 | -0.3612 | No |
| 22 | GAPDH | NA | GAPDH Entrez, Source | glyceraldehyde-3-phosphate dehydrogenase | 10205 | -0.031 | -0.3653 | No |
| 23 | PKLR | NA | PKLR Entrez, Source | pyruvate kinase, liver and RBC | 10370 | -0.040 | -0.3728 | No |
| 24 | GALM | NA | GALM Entrez, Source | galactose mutarotase (aldose 1-epimerase) | 10428 | -0.044 | -0.3743 | No |
| 25 | ALDH3B2 | NA | ALDH3B2 Entrez, Source | aldehyde dehydrogenase 3 family, member B2 | 10497 | -0.047 | -0.3763 | No |
| 26 | ALDOB | NA | ALDOB Entrez, Source | aldolase B, fructose-bisphosphate | 10946 | -0.074 | -0.3983 | No |
| 27 | DLAT | NA | DLAT Entrez, Source | dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) | 11362 | -0.102 | -0.4174 | No |
| 28 | PCK1 | NA | PCK1 Entrez, Source | phosphoenolpyruvate carboxykinase 1 (soluble) | 11490 | -0.114 | -0.4201 | No |
| 29 | G6PC2 | NA | G6PC2 Entrez, Source | glucose-6-phosphatase, catalytic, 2 | 11708 | -0.133 | -0.4271 | No |
| 30 | ADH1B | NA | ADH1B Entrez, Source | alcohol dehydrogenase IB (class I), beta polypeptide | 11741 | -0.135 | -0.4238 | No |
| 31 | LDHA | NA | LDHA Entrez, Source | lactate dehydrogenase A | 11836 | -0.143 | -0.4237 | No |
| 32 | ALDH1B1 | NA | ALDH1B1 Entrez, Source | aldehyde dehydrogenase 1 family, member B1 | 11847 | -0.144 | -0.4189 | No |
| 33 | ACSS1 | NA | ACSS1 Entrez, Source | acyl-CoA synthetase short-chain family member 1 | 12088 | -0.163 | -0.4260 | No |
| 34 | LDHC | NA | LDHC Entrez, Source | lactate dehydrogenase C | 12974 | -0.243 | -0.4658 | Yes |
| 35 | G6PC | NA | G6PC Entrez, Source | glucose-6-phosphatase, catalytic subunit | 13037 | -0.247 | -0.4600 | Yes |
| 36 | ALDH7A1 | NA | ALDH7A1 Entrez, Source | aldehyde dehydrogenase 7 family, member A1 | 13180 | -0.261 | -0.4581 | Yes |
| 37 | BPGM | NA | BPGM Entrez, Source | 2,3-bisphosphoglycerate mutase | 13410 | -0.283 | -0.4601 | Yes |
| 38 | ADH4 | NA | ADH4 Entrez, Source | alcohol dehydrogenase 4 (class II), pi polypeptide | 13607 | -0.301 | -0.4596 | Yes |
| 39 | PFKM | NA | PFKM Entrez, Source | phosphofructokinase, muscle | 13622 | -0.305 | -0.4490 | Yes |
| 40 | PGAM4 | NA | PGAM4 Entrez, Source | phosphoglycerate mutase family member 4 | 13881 | -0.328 | -0.4509 | Yes |
| 41 | TPI1 | NA | TPI1 Entrez, Source | triosephosphate isomerase 1 | 13969 | -0.341 | -0.4430 | Yes |
| 42 | ALDH9A1 | NA | ALDH9A1 Entrez, Source | aldehyde dehydrogenase 9 family, member A1 | 13994 | -0.345 | -0.4314 | Yes |
| 43 | AKR1A1 | NA | AKR1A1 Entrez, Source | aldo-keto reductase family 1, member A1 (aldehyde reductase) | 14488 | -0.404 | -0.4435 | Yes |
| 44 | ALDH3A2 | NA | ALDH3A2 Entrez, Source | aldehyde dehydrogenase 3 family, member A2 | 14517 | -0.407 | -0.4298 | Yes |
| 45 | PDHA1 | NA | PDHA1 Entrez, Source | pyruvate dehydrogenase (lipoamide) alpha 1 | 15056 | -0.483 | -0.4414 | Yes |
| 46 | PFKL | NA | PFKL Entrez, Source | phosphofructokinase, liver | 15122 | -0.492 | -0.4266 | Yes |
| 47 | ADH7 | NA | ADH7 Entrez, Source | alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide | 15198 | -0.502 | -0.4119 | Yes |
| 48 | ADH1C | NA | ADH1C Entrez, Source | alcohol dehydrogenase 1C (class I), gamma polypeptide | 15278 | -0.513 | -0.3970 | Yes |
| 49 | PGK1 | NA | PGK1 Entrez, Source | phosphoglycerate kinase 1 | 15295 | -0.515 | -0.3787 | Yes |
| 50 | DLD | NA | DLD Entrez, Source | dihydrolipoamide dehydrogenase | 15418 | -0.535 | -0.3654 | Yes |
| 51 | LDHB | NA | LDHB Entrez, Source | lactate dehydrogenase B | 15651 | -0.581 | -0.3564 | Yes |
| 52 | ALDH3B1 | NA | ALDH3B1 Entrez, Source | aldehyde dehydrogenase 3 family, member B1 | 16343 | -0.746 | -0.3667 | Yes |
| 53 | PDHB | NA | PDHB Entrez, Source | pyruvate dehydrogenase (lipoamide) beta | 16571 | -0.817 | -0.3486 | Yes |
| 54 | ALDH2 | NA | ALDH2 Entrez, Source | aldehyde dehydrogenase 2 family (mitochondrial) | 16658 | -0.842 | -0.3218 | Yes |
| 55 | PGK2 | NA | PGK2 Entrez, Source | phosphoglycerate kinase 2 | 16766 | -0.876 | -0.2949 | Yes |
| 56 | PGAM2 | NA | PGAM2 Entrez, Source | phosphoglycerate mutase 2 (muscle) | 17299 | -1.118 | -0.2824 | Yes |
| 57 | ADH6 | NA | ADH6 Entrez, Source | alcohol dehydrogenase 6 (class V) | 17315 | -1.127 | -0.2411 | Yes |
| 58 | ALDH1A3 | NA | ALDH1A3 Entrez, Source | aldehyde dehydrogenase 1 family, member A3 | 17486 | -1.245 | -0.2038 | Yes |
| 59 | ALDOC | NA | ALDOC Entrez, Source | aldolase C, fructose-bisphosphate | 17829 | -1.686 | -0.1596 | Yes |
| 60 | HK1 | NA | HK1 Entrez, Source | hexokinase 1 | 17874 | -1.787 | -0.0951 | Yes |
| 61 | ENO3 | NA | ENO3 Entrez, Source | enolase 3 (beta, muscle) | 18098 | -2.969 | 0.0038 | Yes |
