Datasetw1a_vs_wt_vs_wt.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp_repos
Phenotypew1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos
Upregulated in classago1w1a
GeneSetKEGG_FOCAL_ADHESION
Enrichment Score (ES)0.35451937
Normalized Enrichment Score (NES)1.4053378
Nominal p-value0.009063444
FDR q-value0.28114408
FWER p-Value0.994
Table: GSEA Results Summary



Fig 1: Enrichment plot: KEGG_FOCAL_ADHESION   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1LAMA4NALAMA4
Entrez,  Source
laminin, alpha 41242.9380.0163Yes
2ITGA2NAITGA2
Entrez,  Source
integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)1482.7200.0364Yes
3BIRC3NABIRC3
Entrez,  Source
baculoviral IAP repeat-containing 31822.4840.0542Yes
4TNXBNATNXB
Entrez,  Source
tenascin XB1862.4720.0735Yes
5PIP5K1CNAPIP5K1C
Entrez,  Source
phosphatidylinositol-4-phosphate 5-kinase, type I, gamma1922.4260.0923Yes
6BCAR1NABCAR1
Entrez,  Source
breast cancer anti-estrogen resistance 13181.9140.1005Yes
7ITGA10NAITGA10
Entrez,  Source
integrin, alpha 103331.8760.1145Yes
8ITGA5NAITGA5
Entrez,  Source
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)3421.8480.1286Yes
9LAMB3NALAMB3
Entrez,  Source
laminin, beta 33431.8460.1431Yes
10COL6A2NACOL6A2
Entrez,  Source
collagen, type VI, alpha 23501.8260.1572Yes
11PIK3R1NAPIK3R1
Entrez,  Source
phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha)3661.7860.1705Yes
12FLNANAFLNA
Entrez,  Source
filamin A, alpha (actin binding protein 280)4101.6950.1814Yes
13MYL5NAMYL5
Entrez,  Source
myosin, light chain 5, regulatory4151.6850.1945Yes
14ITGB4NAITGB4
Entrez,  Source
integrin, beta 44791.5720.2034Yes
15ZYXNAZYX
Entrez,  Source
zyxin5381.5010.2120Yes
16ITGB8NAITGB8
Entrez,  Source
integrin, beta 85571.4760.2226Yes
17PAK6NAPAK6
Entrez,  Source
p21(CDKN1A)-activated kinase 66071.4080.2310Yes
18VWFNAVWF
Entrez,  Source
von Willebrand factor6891.3320.2370Yes
19JUNNAJUN
Entrez,  Source
jun oncogene7181.3120.2458Yes
20COL4A2NACOL4A2
Entrez,  Source
collagen, type IV, alpha 27941.2520.2515Yes
21FN1NAFN1
Entrez,  Source
fibronectin 18031.2440.2608Yes
22THBS1NATHBS1
Entrez,  Source
thrombospondin 18601.2020.2672Yes
23ACTG1NAACTG1
Entrez,  Source
actin, gamma 18871.1810.2751Yes
24SRCNASRC
Entrez,  Source
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)9011.1760.2836Yes
25LAMC2NALAMC2
Entrez,  Source
laminin, gamma 29171.1600.2919Yes
26ITGA3NAITGA3
Entrez,  Source
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)9611.1380.2985Yes
27EGFRNAEGFR
Entrez,  Source
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)10421.0980.3027Yes
28COL6A1NACOL6A1
Entrez,  Source
collagen, type VI, alpha 110541.0910.3107Yes
29MYLK2NAMYLK2
Entrez,  Source
myosin light chain kinase 2, skeletal muscle11001.0690.3166Yes
30PDGFANAPDGFA
Entrez,  Source
platelet-derived growth factor alpha polypeptide11461.0480.3224Yes
31FLNBNAFLNB
Entrez,  Source
filamin B, beta (actin binding protein 278)12201.0110.3263Yes
32LAMA5NALAMA5
Entrez,  Source
laminin, alpha 513260.9750.3281Yes
33CCND3NACCND3
Entrez,  Source
cyclin D313470.9640.3346Yes
34PIK3CDNAPIK3CD
Entrez,  Source
phosphoinositide-3-kinase, catalytic, delta polypeptide15720.8900.3291Yes
35RAC2NARAC2
Entrez,  Source
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)17480.8390.3260Yes
36ACTN1NAACTN1
Entrez,  Source
actinin, alpha 117550.8380.3323Yes
37ACTBNAACTB
Entrez,  Source
actin, beta17650.8360.3384Yes
38HRASNAHRAS
Entrez,  Source
v-Ha-ras Harvey rat sarcoma viral oncogene homolog17990.8310.3431Yes
39COL4A1NACOL4A1
Entrez,  Source
collagen, type IV, alpha 118180.8250.3486Yes
40PAK4NAPAK4
Entrez,  Source
p21(CDKN1A)-activated kinase 418980.8080.3506Yes
41CAPN2NACAPN2
Entrez,  Source
calpain 2, (m/II) large subunit20830.7690.3464Yes
42COL5A1NACOL5A1
Entrez,  Source
collagen, type V, alpha 121450.7550.3490Yes
43ACTN4NAACTN4
Entrez,  Source
actinin, alpha 423210.7190.3449Yes
44PRKCGNAPRKCG
Entrez,  Source
protein kinase C, gamma23510.7110.3489Yes
45VAV2NAVAV2
Entrez,  Source
vav 2 oncogene23820.7060.3528Yes
46PAK3NAPAK3
Entrez,  Source
p21 (CDKN1A)-activated kinase 324500.6940.3545Yes
47BADNABAD
Entrez,  Source
BCL2-antagonist of cell death27640.6370.3421No
48ITGA6NAITGA6
Entrez,  Source
integrin, alpha 630330.5910.3319No
49COL5A3NACOL5A3
Entrez,  Source
collagen, type V, alpha 330480.5890.3357No
50MYLKNAMYLK
Entrez,  Source
myosin, light chain kinase31710.5710.3334No
51BIRC2NABIRC2
Entrez,  Source
baculoviral IAP repeat-containing 233770.5400.3263No
52ERBB2NAERBB2
Entrez,  Source
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)37540.4910.3092No
53VASPNAVASP
Entrez,  Source
vasodilator-stimulated phosphoprotein38730.4780.3064No
54SHC1NASHC1
Entrez,  Source
SHC (Src homology 2 domain containing) transforming protein 140000.4620.3031No
55TLN2NATLN2
Entrez,  Source
talin 240790.4500.3023No
56VCLNAVCL
Entrez,  Source
vinculin40900.4480.3053No
57FLNCNAFLNC
Entrez,  Source
filamin C, gamma (actin binding protein 280)41320.4420.3065No
58BRAFNABRAF
Entrez,  Source
v-raf murine sarcoma viral oncogene homolog B141350.4420.3098No
59COL2A1NACOL2A1
Entrez,  Source
collagen, type II, alpha 1 (primary osteoarthritis, spondyloepiphyseal dysplasia, congenital)41750.4380.3111No
60TNRNATNR
Entrez,  Source
tenascin R (restrictin, janusin)43580.4160.3043No
61ITGB6NAITGB6
Entrez,  Source
integrin, beta 643950.4120.3055No
62CCND1NACCND1
Entrez,  Source
cyclin D144400.4070.3063No
63ITGA1NAITGA1
Entrez,  Source
integrin, alpha 146890.3840.2955No
64MAPK3NAMAPK3
Entrez,  Source
mitogen-activated protein kinase 347700.3760.2940No
65VAV1NAVAV1
Entrez,  Source
vav 1 oncogene48950.3630.2900No
66CAV3NACAV3
Entrez,  Source
caveolin 349470.3560.2899No
67PIK3R3NAPIK3R3
Entrez,  Source
phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma)51620.3350.2807No
68PAK1NAPAK1
Entrez,  Source
p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)54930.3030.2647No
69COL6A3NACOL6A3
Entrez,  Source
collagen, type VI, alpha 355910.2960.2616No
70LAMC1NALAMC1
Entrez,  Source
laminin, gamma 1 (formerly LAMB2)55950.2960.2638No
71COL1A2NACOL1A2
Entrez,  Source
collagen, type I, alpha 256080.2950.2655No
72LAMB4NALAMB4
Entrez,  Source
laminin, beta 460800.2560.2413No
73AKT2NAAKT2
Entrez,  Source
v-akt murine thymoma viral oncogene homolog 261440.2500.2397No
74PXNNAPXN
Entrez,  Source
paxillin63630.2320.2294No
75DIAPH1NADIAPH1
Entrez,  Source
diaphanous homolog 1 (Drosophila)64200.2270.2281No
76RAPGEF1NARAPGEF1
Entrez,  Source
Rap guanine nucleotide exchange factor (GEF) 165150.2190.2246No
77PPP1CANAPPP1CA
Entrez,  Source
protein phosphatase 1, catalytic subunit, alpha isoform69120.1870.2040No
78CRKLNACRKL
Entrez,  Source
v-crk sarcoma virus CT10 oncogene homolog (avian)-like71190.1720.1939No
79ITGA8NAITGA8
Entrez,  Source
integrin, alpha 871800.1670.1919No
80MYL2NAMYL2
Entrez,  Source
myosin, light chain 2, regulatory, cardiac, slow73270.1570.1850No
81ITGB7NAITGB7
Entrez,  Source
integrin, beta 776280.1340.1694No
82MYL10NA77300.1280.1648No
83MYL12ANA78970.1150.1565No
84VEGFANA79030.1150.1571No
85AKT1NAAKT1
Entrez,  Source
v-akt murine thymoma viral oncogene homolog 179220.1130.1570No
86ILKNAILK
Entrez,  Source
integrin-linked kinase81670.0950.1441No
87HGFNAHGF
Entrez,  Source
hepatocyte growth factor (hepapoietin A; scatter factor)81930.0930.1435No
88SHC3NASHC3
Entrez,  Source
SHC (Src homology 2 domain containing) transforming protein 382450.0900.1414No
89ELK1NAELK1
Entrez,  Source
ELK1, member of ETS oncogene family83460.0820.1364No
90FLT4NAFLT4
Entrez,  Source
fms-related tyrosine kinase 484430.0760.1317No
91TLN1NATLN1
Entrez,  Source
talin 187290.0560.1163No
92ROCK1NAROCK1
Entrez,  Source
Rho-associated, coiled-coil containing protein kinase 187430.0550.1160No
93PIK3CANAPIK3CA
Entrez,  Source
phosphoinositide-3-kinase, catalytic, alpha polypeptide87840.0520.1142No
94COL4A6NACOL4A6
Entrez,  Source
collagen, type IV, alpha 688530.0470.1108No
95PAK2NAPAK2
Entrez,  Source
p21 (CDKN1A)-activated kinase 289150.0420.1077No
96IGF1NAIGF1
Entrez,  Source
insulin-like growth factor 1 (somatomedin C)93060.0140.0861No
97COMPNACOMP
Entrez,  Source
cartilage oligomeric matrix protein93480.0110.0839No
98THBS2NATHBS2
Entrez,  Source
thrombospondin 294830.0020.0765No
99SHC2NASHC2
Entrez,  Source
SHC (Src homology 2 domain containing) transforming protein 296470.0000.0674No
100MAP2K1NAMAP2K1
Entrez,  Source
mitogen-activated protein kinase kinase 19745-0.0010.0620No
101PDGFBNAPDGFB
Entrez,  Source
platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)9832-0.0080.0573No
102RAC1NARAC1
Entrez,  Source
ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)9857-0.0100.0560No
103CCND2NACCND2
Entrez,  Source
cyclin D210056-0.0230.0452No
104MYLPFNAMYLPF
Entrez,  Source
-10088-0.0240.0437No
105IGF1RNAIGF1R
Entrez,  Source
insulin-like growth factor 1 receptor10119-0.0270.0422No
106ITGA9NAITGA9
Entrez,  Source
integrin, alpha 910122-0.0270.0423No
107MAPK8NAMAPK8
Entrez,  Source
mitogen-activated protein kinase 810132-0.0280.0420No
108CRKNACRK
Entrez,  Source
v-crk sarcoma virus CT10 oncogene homolog (avian)10244-0.0340.0361No
109ARHGAP5NAARHGAP5
Entrez,  Source
Rho GTPase activating protein 510376-0.0400.0292No
110ITGA4NAITGA4
Entrez,  Source
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)10392-0.0420.0287No
111XIAPNA10443-0.0450.0262No
112IBSPNAIBSP
Entrez,  Source
integrin-binding sialoprotein (bone sialoprotein, bone sialoprotein II)10657-0.0580.0148No
113PARVANAPARVA
Entrez,  Source
parvin, alpha10887-0.0700.0026No
114LAMA2NALAMA2
Entrez,  Source
laminin, alpha 2 (merosin, congenital muscular dystrophy)10978-0.076-0.0018No
115PIK3R5NAPIK3R5
Entrez,  Source
phosphoinositide-3-kinase, regulatory subunit 5, p10111049-0.081-0.0050No
116ACTN3NAACTN3
Entrez,  Source
actinin, alpha 311241-0.094-0.0149No
117ROCK2NAROCK2
Entrez,  Source
Rho-associated, coiled-coil containing protein kinase 211260-0.095-0.0152No
118DOCK1NADOCK1
Entrez,  Source
dedicator of cytokinesis 111266-0.096-0.0147No
119PDGFRANAPDGFRA
Entrez,  Source
platelet-derived growth factor receptor, alpha polypeptide11392-0.105-0.0208No
120PDPK1NAPDPK1
Entrez,  Source
3-phosphoinositide dependent protein kinase-111449-0.110-0.0231No
121ITGB5NAITGB5
Entrez,  Source
integrin, beta 511562-0.120-0.0283No
122PIK3CBNAPIK3CB
Entrez,  Source
phosphoinositide-3-kinase, catalytic, beta polypeptide11650-0.127-0.0322No
123LAMA1NALAMA1
Entrez,  Source
laminin, alpha 111699-0.132-0.0338No
124PTK2NAPTK2
Entrez,  Source
PTK2 protein tyrosine kinase 211849-0.144-0.0410No
125PTENNAPTEN
Entrez,  Source
phosphatase and tensin homolog (mutated in multiple advanced cancers 1)12081-0.162-0.0525No
126PPP1R12ANAPPP1R12A
Entrez,  Source
protein phosphatase 1, regulatory (inhibitor) subunit 12A12216-0.174-0.0586No
127PIK3R2NAPIK3R2
Entrez,  Source
phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta)12247-0.177-0.0589No
128PGFNAPGF
Entrez,  Source
placental growth factor, vascular endothelial growth factor-related protein12272-0.179-0.0588No
129PARVGNAPARVG
Entrez,  Source
parvin, gamma12284-0.181-0.0580No
130SOS1NASOS1
Entrez,  Source
son of sevenless homolog 1 (Drosophila)12302-0.183-0.0575No
131CDC42NACDC42
Entrez,  Source
cell division cycle 42 (GTP binding protein, 25kDa)12435-0.196-0.0633No
132KDRNAKDR
Entrez,  Source
kinase insert domain receptor (a type III receptor tyrosine kinase)12490-0.200-0.0648No
133CTNNB1NACTNNB1
Entrez,  Source
catenin (cadherin-associated protein), beta 1, 88kDa12660-0.216-0.0725No
134RHOANARHOA
Entrez,  Source
ras homolog gene family, member A12705-0.219-0.0732No
135FLT1NAFLT1
Entrez,  Source
fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)12790-0.227-0.0761No
136PPP1CBNAPPP1CB
Entrez,  Source
protein phosphatase 1, catalytic subunit, beta isoform12856-0.230-0.0779No
137CAV2NACAV2
Entrez,  Source
caveolin 212910-0.236-0.0789No
138MYL12BNA12935-0.238-0.0784No
139VEGFBNAVEGFB
Entrez,  Source
vascular endothelial growth factor B12945-0.240-0.0770No
140LAMC3NALAMC3
Entrez,  Source
laminin, gamma 312947-0.240-0.0752No
141PARVBNAPARVB
Entrez,  Source
parvin, beta13164-0.259-0.0852No
142SHC4NASHC4
Entrez,  Source
SHC (Src homology 2 domain containing) family, member 413233-0.266-0.0868No
143TNNNATNN
Entrez,  Source
tenascin N13301-0.272-0.0884No
144LAMB2NALAMB2
Entrez,  Source
laminin, beta 2 (laminin S)13505-0.292-0.0974No
145MAPK9NAMAPK9
Entrez,  Source
mitogen-activated protein kinase 913521-0.294-0.0959No
146FYNNAFYN
Entrez,  Source
FYN oncogene related to SRC, FGR, YES13562-0.297-0.0958No
147RAC3NARAC3
Entrez,  Source
ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)13740-0.315-0.1032No
148CHADNACHAD
Entrez,  Source
chondroadherin13827-0.323-0.1054No
149RELNNARELN
Entrez,  Source
reelin13877-0.328-0.1056No
150RAF1NARAF1
Entrez,  Source
v-raf-1 murine leukemia viral oncogene homolog 113934-0.335-0.1060No
151CAV1NACAV1
Entrez,  Source
caveolin 1, caveolae protein, 22kDa13996-0.345-0.1067No
152GRB2NAGRB2
Entrez,  Source
growth factor receptor-bound protein 214005-0.345-0.1044No
153MYL7NAMYL7
Entrez,  Source
myosin, light chain 7, regulatory14008-0.346-0.1018No
154ITGAVNAITGAV
Entrez,  Source
integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)14332-0.383-0.1168No
155MAPK10NAMAPK10
Entrez,  Source
mitogen-activated protein kinase 1014334-0.383-0.1138No
156RAP1ANARAP1A
Entrez,  Source
RAP1A, member of RAS oncogene family14381-0.389-0.1133No
157BCL2NABCL2
Entrez,  Source
B-cell CLL/lymphoma 214397-0.390-0.1111No
158MYL9NAMYL9
Entrez,  Source
myosin, light chain 9, regulatory14544-0.412-0.1159No
159VEGFCNAVEGFC
Entrez,  Source
vascular endothelial growth factor C14653-0.425-0.1186No
160VAV3NAVAV3
Entrez,  Source
vav 3 oncogene14722-0.432-0.1190No
161ITGB3NAITGB3
Entrez,  Source
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)14763-0.438-0.1178No
162MAPK1NAMAPK1
Entrez,  Source
mitogen-activated protein kinase 114765-0.439-0.1144No
163PDGFCNAPDGFC
Entrez,  Source
platelet derived growth factor C14827-0.451-0.1142No
164RAP1BNARAP1B
Entrez,  Source
RAP1B, member of RAS oncogene family14943-0.467-0.1169No
165PPP1CCNAPPP1CC
Entrez,  Source
protein phosphatase 1, catalytic subunit, gamma isoform15049-0.482-0.1190No
166SPP1NASPP1
Entrez,  Source
secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)15059-0.484-0.1156No
167TNCNATNC
Entrez,  Source
tenascin C (hexabrachion)15273-0.513-0.1234No
168PRKCBNA15489-0.550-0.1311No
169ACTN2NAACTN2
Entrez,  Source
actinin, alpha 215627-0.577-0.1342No
170GSK3BNAGSK3B
Entrez,  Source
glycogen synthase kinase 3 beta15693-0.588-0.1331No
171COL11A1NACOL11A1
Entrez,  Source
collagen, type XI, alpha 115884-0.631-0.1387No
172ITGA11NAITGA11
Entrez,  Source
integrin, alpha 1115895-0.632-0.1343No
173COL11A2NACOL11A2
Entrez,  Source
collagen, type XI, alpha 215998-0.656-0.1348No
174RASGRF1NARASGRF1
Entrez,  Source
Ras protein-specific guanine nucleotide-releasing factor 116065-0.671-0.1332No
175COL4A4NACOL4A4
Entrez,  Source
collagen, type IV, alpha 416105-0.682-0.1300No
176THBS3NATHBS3
Entrez,  Source
thrombospondin 316137-0.689-0.1263No
177SOS2NASOS2
Entrez,  Source
son of sevenless homolog 2 (Drosophila)16328-0.741-0.1310No
178ARHGAP35NA16487-0.793-0.1336No
179PDGFDNAPDGFD
Entrez,  Source
platelet derived growth factor D16772-0.877-0.1424No
180ITGB1NAITGB1
Entrez,  Source
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)16942-0.944-0.1444No
181LAMA3NALAMA3
Entrez,  Source
laminin, alpha 316986-0.962-0.1392No
182ITGA7NAITGA7
Entrez,  Source
integrin, alpha 717088-1.007-0.1369No
183METNAMET
Entrez,  Source
met proto-oncogene (hepatocyte growth factor receptor)17207-1.062-0.1351No
184THBS4NATHBS4
Entrez,  Source
thrombospondin 417229-1.076-0.1278No
185LAMB1NALAMB1
Entrez,  Source
laminin, beta 117257-1.095-0.1206No
186COL6A6NA17427-1.205-0.1206No
187COL5A2NACOL5A2
Entrez,  Source
collagen, type V, alpha 217557-1.302-0.1175No
188COL3A1NACOL3A1
Entrez,  Source
collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant)17611-1.363-0.1097No
189PIK3CGNAPIK3CG
Entrez,  Source
phosphoinositide-3-kinase, catalytic, gamma polypeptide17630-1.385-0.0998No
190EGFNAEGF
Entrez,  Source
epidermal growth factor (beta-urogastrone)17704-1.472-0.0922No
191AKT3NAAKT3
Entrez,  Source
v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)17766-1.559-0.0833No
192COL1A1NACOL1A1
Entrez,  Source
collagen, type I, alpha 117830-1.690-0.0735No
193PRKCANAPRKCA
Entrez,  Source
protein kinase C, alpha17892-1.832-0.0625No
194PDGFRBNAPDGFRB
Entrez,  Source
platelet-derived growth factor receptor, beta polypeptide17904-1.866-0.0484No
195ITGA2BNAITGA2B
Entrez,  Source
integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)18009-2.323-0.0358No
196VTNNAVTN
Entrez,  Source
vitronectin18023-2.397-0.0177No
197MYLK3NA18115-3.2490.0029No
Table: GSEA details [plain text format]



Fig 2: KEGG_FOCAL_ADHESION   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: KEGG_FOCAL_ADHESION: Random ES distribution   
Gene set null distribution of ES for KEGG_FOCAL_ADHESION