Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1w1a |
| GeneSet | KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION |
| Enrichment Score (ES) | 0.3988307 |
| Normalized Enrichment Score (NES) | 1.3454794 |
| Nominal p-value | 0.07180385 |
| FDR q-value | 0.34169206 |
| FWER p-Value | 1.0 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | CCL5 | NA | CCL5 Entrez, Source | chemokine (C-C motif) ligand 5 | 6 | 4.768 | 0.1162 | Yes |
| 2 | PLCG2 | NA | PLCG2 Entrez, Source | phospholipase C, gamma 2 (phosphatidylinositol-specific) | 92 | 3.302 | 0.1921 | Yes |
| 3 | MAP3K14 | NA | MAP3K14 Entrez, Source | mitogen-activated protein kinase kinase kinase 14 | 206 | 2.374 | 0.2439 | Yes |
| 4 | NFKBIA | NA | NFKBIA Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 460 | 1.595 | 0.2689 | Yes |
| 5 | JUN | NA | JUN Entrez, Source | jun oncogene | 718 | 1.312 | 0.2867 | Yes |
| 6 | SRC | NA | SRC Entrez, Source | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | 901 | 1.176 | 0.3054 | Yes |
| 7 | EGFR | NA | EGFR Entrez, Source | epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) | 1042 | 1.098 | 0.3245 | Yes |
| 8 | RELA | NA | RELA Entrez, Source | v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian) | 1150 | 1.047 | 0.3442 | Yes |
| 9 | IKBKG | NA | IKBKG Entrez, Source | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | 1587 | 0.884 | 0.3417 | Yes |
| 10 | NFKB1 | NA | NFKB1 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 1767 | 0.835 | 0.3522 | Yes |
| 11 | ADAM17 | NA | ADAM17 Entrez, Source | ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme) | 1826 | 0.823 | 0.3691 | Yes |
| 12 | ATP6V0D1 | NA | ATP6V0D1 Entrez, Source | ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 | 1966 | 0.794 | 0.3809 | Yes |
| 13 | CSK | NA | CSK Entrez, Source | c-src tyrosine kinase | 1991 | 0.790 | 0.3988 | Yes |
| 14 | CASP3 | NA | CASP3 Entrez, Source | caspase 3, apoptosis-related cysteine peptidase | 2903 | 0.613 | 0.3635 | No |
| 15 | NOD1 | NA | 3005 | 0.596 | 0.3725 | No | ||
| 16 | CHUK | NA | CHUK Entrez, Source | conserved helix-loop-helix ubiquitous kinase | 3103 | 0.582 | 0.3813 | No |
| 17 | ATP6V1C2 | NA | ATP6V1C2 Entrez, Source | ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2 | 3184 | 0.569 | 0.3908 | No |
| 18 | ATP6V0A2 | NA | ATP6V0A2 Entrez, Source | ATPase, H+ transporting, lysosomal V0 subunit a2 | 3508 | 0.521 | 0.3857 | No |
| 19 | GIT1 | NA | GIT1 Entrez, Source | G protein-coupled receptor kinase interactor 1 | 3665 | 0.501 | 0.3893 | No |
| 20 | ATP6V0C | NA | ATP6V0C Entrez, Source | ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c | 4013 | 0.460 | 0.3814 | No |
| 21 | LYN | NA | LYN Entrez, Source | v-yes-1 Yamaguchi sarcoma viral related oncogene homolog | 4244 | 0.428 | 0.3792 | No |
| 22 | MAPK11 | NA | MAPK11 Entrez, Source | mitogen-activated protein kinase 11 | 4342 | 0.417 | 0.3840 | No |
| 23 | ATP6V0B | NA | ATP6V0B Entrez, Source | ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b | 4369 | 0.414 | 0.3927 | No |
| 24 | ATP6V0E2 | NA | ATP6V0E2 Entrez, Source | ATPase, H+ transporting V0 subunit e2 | 4813 | 0.371 | 0.3773 | No |
| 25 | ATP6V1H | NA | ATP6V1H Entrez, Source | ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H | 5266 | 0.326 | 0.3603 | No |
| 26 | PAK1 | NA | PAK1 Entrez, Source | p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast) | 5493 | 0.303 | 0.3552 | No |
| 27 | ATP6V1G1 | NA | ATP6V1G1 Entrez, Source | ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 | 5872 | 0.272 | 0.3410 | No |
| 28 | JAM2 | NA | JAM2 Entrez, Source | junctional adhesion molecule 2 | 5980 | 0.265 | 0.3415 | No |
| 29 | MAPK12 | NA | MAPK12 Entrez, Source | mitogen-activated protein kinase 12 | 6059 | 0.258 | 0.3435 | No |
| 30 | ADAM10 | NA | ADAM10 Entrez, Source | ADAM metallopeptidase domain 10 | 6234 | 0.242 | 0.3398 | No |
| 31 | HBEGF | NA | HBEGF Entrez, Source | heparin-binding EGF-like growth factor | 6435 | 0.226 | 0.3343 | No |
| 32 | TJP1 | NA | TJP1 Entrez, Source | tight junction protein 1 (zona occludens 1) | 6982 | 0.181 | 0.3086 | No |
| 33 | ATP6V0A1 | NA | ATP6V0A1 Entrez, Source | ATPase, H+ transporting, lysosomal V0 subunit a1 | 8034 | 0.105 | 0.2531 | No |
| 34 | MAP2K4 | NA | MAP2K4 Entrez, Source | mitogen-activated protein kinase kinase 4 | 8148 | 0.096 | 0.2492 | No |
| 35 | ATP6V0A4 | NA | ATP6V0A4 Entrez, Source | ATPase, H+ transporting, lysosomal V0 subunit a4 | 8309 | 0.085 | 0.2424 | No |
| 36 | ATP6V0D2 | NA | ATP6V0D2 Entrez, Source | ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 | 8341 | 0.083 | 0.2427 | No |
| 37 | MAPK14 | NA | MAPK14 Entrez, Source | mitogen-activated protein kinase 14 | 8878 | 0.045 | 0.2142 | No |
| 38 | ATP6V1F | NA | ATP6V1F Entrez, Source | ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F | 9293 | 0.015 | 0.1917 | No |
| 39 | CXCR1 | NA | 9439 | 0.004 | 0.1838 | No | ||
| 40 | RAC1 | NA | RAC1 Entrez, Source | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | 9857 | -0.010 | 0.1610 | No |
| 41 | ATP6V1C1 | NA | ATP6V1C1 Entrez, Source | ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 | 10089 | -0.025 | 0.1488 | No |
| 42 | MAPK8 | NA | MAPK8 Entrez, Source | mitogen-activated protein kinase 8 | 10132 | -0.028 | 0.1472 | No |
| 43 | ATP6V0E1 | NA | ATP6V0E1 Entrez, Source | ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 | 10451 | -0.045 | 0.1307 | No |
| 44 | PLCG1 | NA | PLCG1 Entrez, Source | phospholipase C, gamma 1 | 10890 | -0.071 | 0.1083 | No |
| 45 | IKBKB | NA | IKBKB Entrez, Source | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | 10944 | -0.074 | 0.1071 | No |
| 46 | CXCL1 | NA | CXCL1 Entrez, Source | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 11070 | -0.082 | 0.1022 | No |
| 47 | ATP6V1E1 | NA | ATP6V1E1 Entrez, Source | ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 | 11672 | -0.129 | 0.0722 | No |
| 48 | CDC42 | NA | CDC42 Entrez, Source | cell division cycle 42 (GTP binding protein, 25kDa) | 12435 | -0.196 | 0.0349 | No |
| 49 | ATP6V1D | NA | ATP6V1D Entrez, Source | ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D | 12946 | -0.240 | 0.0126 | No |
| 50 | ATP6V1A | NA | ATP6V1A Entrez, Source | ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A | 13230 | -0.265 | 0.0034 | No |
| 51 | MAPK9 | NA | MAPK9 Entrez, Source | mitogen-activated protein kinase 9 | 13521 | -0.294 | -0.0054 | No |
| 52 | PTPRZ1 | NA | PTPRZ1 Entrez, Source | protein tyrosine phosphatase, receptor-type, Z polypeptide 1 | 13553 | -0.296 | 0.0001 | No |
| 53 | MAPK10 | NA | MAPK10 Entrez, Source | mitogen-activated protein kinase 10 | 14334 | -0.383 | -0.0336 | No |
| 54 | PTPN11 | NA | PTPN11 Entrez, Source | protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) | 14759 | -0.438 | -0.0463 | No |
| 55 | ATP6V1B2 | NA | ATP6V1B2 Entrez, Source | ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 | 14796 | -0.445 | -0.0375 | No |
| 56 | MAPK13 | NA | MAPK13 Entrez, Source | mitogen-activated protein kinase 13 | 14840 | -0.454 | -0.0288 | No |
| 57 | ATP6V1G3 | NA | ATP6V1G3 Entrez, Source | ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3 | 15088 | -0.487 | -0.0305 | No |
| 58 | TCIRG1 | NA | TCIRG1 Entrez, Source | T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 | 15138 | -0.493 | -0.0212 | No |
| 59 | ATP6AP1 | NA | ATP6AP1 Entrez, Source | ATPase, H+ transporting, lysosomal accessory protein 1 | 15484 | -0.549 | -0.0268 | No |
| 60 | JAM3 | NA | JAM3 Entrez, Source | junctional adhesion molecule 3 | 15734 | -0.595 | -0.0260 | No |
| 61 | ATP6V1B1 | NA | ATP6V1B1 Entrez, Source | ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 (Renal tubular acidosis with deafness) | 15794 | -0.609 | -0.0144 | No |
| 62 | ATP6V1G2 | NA | ATP6V1G2 Entrez, Source | ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 | 16993 | -0.965 | -0.0570 | No |
| 63 | IGSF5 | NA | IGSF5 Entrez, Source | immunoglobulin superfamily, member 5 | 17121 | -1.025 | -0.0390 | No |
| 64 | MET | NA | MET Entrez, Source | met proto-oncogene (hepatocyte growth factor receptor) | 17207 | -1.062 | -0.0177 | No |
| 65 | F11R | NA | F11R Entrez, Source | F11 receptor | 17580 | -1.322 | -0.0060 | No |
| 66 | CXCR2 | NA | 17773 | -1.569 | 0.0218 | No |
