Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1w1a |
| GeneSet | KEGG_ECM_RECEPTOR_INTERACTION |
| Enrichment Score (ES) | 0.41228926 |
| Normalized Enrichment Score (NES) | 1.4721159 |
| Nominal p-value | 0.014827018 |
| FDR q-value | 0.19081746 |
| FWER p-Value | 0.95 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | SDC4 | NA | SDC4 Entrez, Source | syndecan 4 (amphiglycan, ryudocan) | 105 | 3.189 | 0.0394 | Yes |
| 2 | LAMA4 | NA | LAMA4 Entrez, Source | laminin, alpha 4 | 124 | 2.938 | 0.0800 | Yes |
| 3 | ITGA2 | NA | ITGA2 Entrez, Source | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 148 | 2.720 | 0.1173 | Yes |
| 4 | TNXB | NA | TNXB Entrez, Source | tenascin XB | 186 | 2.472 | 0.1503 | Yes |
| 5 | ITGA10 | NA | ITGA10 Entrez, Source | integrin, alpha 10 | 333 | 1.876 | 0.1688 | Yes |
| 6 | ITGA5 | NA | ITGA5 Entrez, Source | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 342 | 1.848 | 0.1946 | Yes |
| 7 | LAMB3 | NA | LAMB3 Entrez, Source | laminin, beta 3 | 343 | 1.846 | 0.2208 | Yes |
| 8 | COL6A2 | NA | COL6A2 Entrez, Source | collagen, type VI, alpha 2 | 350 | 1.826 | 0.2463 | Yes |
| 9 | ITGB4 | NA | ITGB4 Entrez, Source | integrin, beta 4 | 479 | 1.572 | 0.2615 | Yes |
| 10 | CD44 | NA | CD44 Entrez, Source | CD44 molecule (Indian blood group) | 515 | 1.523 | 0.2812 | Yes |
| 11 | ITGB8 | NA | ITGB8 Entrez, Source | integrin, beta 8 | 557 | 1.476 | 0.2998 | Yes |
| 12 | AGRN | NA | 596 | 1.422 | 0.3179 | Yes | ||
| 13 | VWF | NA | VWF Entrez, Source | von Willebrand factor | 689 | 1.332 | 0.3317 | Yes |
| 14 | COL4A2 | NA | COL4A2 Entrez, Source | collagen, type IV, alpha 2 | 794 | 1.252 | 0.3437 | Yes |
| 15 | FN1 | NA | FN1 Entrez, Source | fibronectin 1 | 803 | 1.244 | 0.3609 | Yes |
| 16 | THBS1 | NA | THBS1 Entrez, Source | thrombospondin 1 | 860 | 1.202 | 0.3748 | Yes |
| 17 | LAMC2 | NA | LAMC2 Entrez, Source | laminin, gamma 2 | 917 | 1.160 | 0.3882 | Yes |
| 18 | ITGA3 | NA | ITGA3 Entrez, Source | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 961 | 1.138 | 0.4019 | Yes |
| 19 | COL6A1 | NA | COL6A1 Entrez, Source | collagen, type VI, alpha 1 | 1054 | 1.091 | 0.4123 | Yes |
| 20 | LAMA5 | NA | LAMA5 Entrez, Source | laminin, alpha 5 | 1326 | 0.975 | 0.4111 | No |
| 21 | COL4A1 | NA | COL4A1 Entrez, Source | collagen, type IV, alpha 1 | 1818 | 0.825 | 0.3957 | No |
| 22 | COL5A1 | NA | COL5A1 Entrez, Source | collagen, type V, alpha 1 | 2145 | 0.755 | 0.3883 | No |
| 23 | CD47 | NA | CD47 Entrez, Source | CD47 molecule | 2166 | 0.751 | 0.3979 | No |
| 24 | SDC2 | NA | SDC2 Entrez, Source | syndecan 2 (heparan sulfate proteoglycan 1, cell surface-associated, fibroglycan) | 2885 | 0.617 | 0.3669 | No |
| 25 | ITGA6 | NA | ITGA6 Entrez, Source | integrin, alpha 6 | 3033 | 0.591 | 0.3672 | No |
| 26 | COL5A3 | NA | COL5A3 Entrez, Source | collagen, type V, alpha 3 | 3048 | 0.589 | 0.3747 | No |
| 27 | SDC1 | NA | SDC1 Entrez, Source | syndecan 1 | 3454 | 0.529 | 0.3598 | No |
| 28 | COL2A1 | NA | COL2A1 Entrez, Source | collagen, type II, alpha 1 (primary osteoarthritis, spondyloepiphyseal dysplasia, congenital) | 4175 | 0.438 | 0.3262 | No |
| 29 | TNR | NA | TNR Entrez, Source | tenascin R (restrictin, janusin) | 4358 | 0.416 | 0.3221 | No |
| 30 | ITGB6 | NA | ITGB6 Entrez, Source | integrin, beta 6 | 4395 | 0.412 | 0.3259 | No |
| 31 | ITGA1 | NA | ITGA1 Entrez, Source | integrin, alpha 1 | 4689 | 0.384 | 0.3151 | No |
| 32 | COL6A3 | NA | COL6A3 Entrez, Source | collagen, type VI, alpha 3 | 5591 | 0.296 | 0.2695 | No |
| 33 | LAMC1 | NA | LAMC1 Entrez, Source | laminin, gamma 1 (formerly LAMB2) | 5595 | 0.296 | 0.2736 | No |
| 34 | COL1A2 | NA | COL1A2 Entrez, Source | collagen, type I, alpha 2 | 5608 | 0.295 | 0.2771 | No |
| 35 | LAMB4 | NA | LAMB4 Entrez, Source | laminin, beta 4 | 6080 | 0.256 | 0.2547 | No |
| 36 | SV2A | NA | SV2A Entrez, Source | synaptic vesicle glycoprotein 2A | 6652 | 0.206 | 0.2260 | No |
| 37 | ITGA8 | NA | ITGA8 Entrez, Source | integrin, alpha 8 | 7180 | 0.167 | 0.1992 | No |
| 38 | ITGB7 | NA | ITGB7 Entrez, Source | integrin, beta 7 | 7628 | 0.134 | 0.1764 | No |
| 39 | COL4A6 | NA | COL4A6 Entrez, Source | collagen, type IV, alpha 6 | 8853 | 0.047 | 0.1094 | No |
| 40 | COMP | NA | COMP Entrez, Source | cartilage oligomeric matrix protein | 9348 | 0.011 | 0.0822 | No |
| 41 | DAG1 | NA | DAG1 Entrez, Source | dystroglycan 1 (dystrophin-associated glycoprotein 1) | 9368 | 0.010 | 0.0813 | No |
| 42 | THBS2 | NA | THBS2 Entrez, Source | thrombospondin 2 | 9483 | 0.002 | 0.0751 | No |
| 43 | ITGA9 | NA | ITGA9 Entrez, Source | integrin, alpha 9 | 10122 | -0.027 | 0.0402 | No |
| 44 | ITGA4 | NA | ITGA4 Entrez, Source | integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) | 10392 | -0.042 | 0.0259 | No |
| 45 | HSPG2 | NA | HSPG2 Entrez, Source | heparan sulfate proteoglycan 2 (perlecan) | 10642 | -0.057 | 0.0129 | No |
| 46 | IBSP | NA | IBSP Entrez, Source | integrin-binding sialoprotein (bone sialoprotein, bone sialoprotein II) | 10657 | -0.058 | 0.0130 | No |
| 47 | LAMA2 | NA | LAMA2 Entrez, Source | laminin, alpha 2 (merosin, congenital muscular dystrophy) | 10978 | -0.076 | -0.0036 | No |
| 48 | ITGB5 | NA | ITGB5 Entrez, Source | integrin, beta 5 | 11562 | -0.120 | -0.0342 | No |
| 49 | LAMA1 | NA | LAMA1 Entrez, Source | laminin, alpha 1 | 11699 | -0.132 | -0.0398 | No |
| 50 | SV2B | NA | SV2B Entrez, Source | synaptic vesicle glycoprotein 2B | 11721 | -0.133 | -0.0391 | No |
| 51 | GP5 | NA | GP5 Entrez, Source | glycoprotein V (platelet) | 12392 | -0.190 | -0.0735 | No |
| 52 | GP1BB | NA | GP1BB Entrez, Source | glycoprotein Ib (platelet), beta polypeptide | 12396 | -0.190 | -0.0709 | No |
| 53 | LAMC3 | NA | LAMC3 Entrez, Source | laminin, gamma 3 | 12947 | -0.240 | -0.0979 | No |
| 54 | TNN | NA | TNN Entrez, Source | tenascin N | 13301 | -0.272 | -0.1136 | No |
| 55 | LAMB2 | NA | LAMB2 Entrez, Source | laminin, beta 2 (laminin S) | 13505 | -0.292 | -0.1207 | No |
| 56 | CHAD | NA | CHAD Entrez, Source | chondroadherin | 13827 | -0.323 | -0.1339 | No |
| 57 | RELN | NA | RELN Entrez, Source | reelin | 13877 | -0.328 | -0.1319 | No |
| 58 | SV2C | NA | SV2C Entrez, Source | synaptic vesicle glycoprotein 2C | 14267 | -0.375 | -0.1481 | No |
| 59 | ITGAV | NA | ITGAV Entrez, Source | integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) | 14332 | -0.383 | -0.1462 | No |
| 60 | ITGB3 | NA | ITGB3 Entrez, Source | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | 14763 | -0.438 | -0.1638 | No |
| 61 | SPP1 | NA | SPP1 Entrez, Source | secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1) | 15059 | -0.484 | -0.1732 | No |
| 62 | TNC | NA | TNC Entrez, Source | tenascin C (hexabrachion) | 15273 | -0.513 | -0.1778 | No |
| 63 | GP9 | NA | GP9 Entrez, Source | glycoprotein IX (platelet) | 15458 | -0.543 | -0.1802 | No |
| 64 | COL11A1 | NA | COL11A1 Entrez, Source | collagen, type XI, alpha 1 | 15884 | -0.631 | -0.1948 | No |
| 65 | ITGA11 | NA | ITGA11 Entrez, Source | integrin, alpha 11 | 15895 | -0.632 | -0.1864 | No |
| 66 | COL11A2 | NA | COL11A2 Entrez, Source | collagen, type XI, alpha 2 | 15998 | -0.656 | -0.1827 | No |
| 67 | COL4A4 | NA | COL4A4 Entrez, Source | collagen, type IV, alpha 4 | 16105 | -0.682 | -0.1789 | No |
| 68 | THBS3 | NA | THBS3 Entrez, Source | thrombospondin 3 | 16137 | -0.689 | -0.1709 | No |
| 69 | HMMR | NA | HMMR Entrez, Source | hyaluronan-mediated motility receptor (RHAMM) | 16504 | -0.799 | -0.1798 | No |
| 70 | SDC3 | NA | SDC3 Entrez, Source | syndecan 3 (N-syndecan) | 16691 | -0.851 | -0.1780 | No |
| 71 | GP1BA | NA | GP1BA Entrez, Source | glycoprotein Ib (platelet), alpha polypeptide | 16892 | -0.922 | -0.1760 | No |
| 72 | ITGB1 | NA | ITGB1 Entrez, Source | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 16942 | -0.944 | -0.1653 | No |
| 73 | LAMA3 | NA | LAMA3 Entrez, Source | laminin, alpha 3 | 16986 | -0.962 | -0.1541 | No |
| 74 | GP6 | NA | GP6 Entrez, Source | glycoprotein VI (platelet) | 17002 | -0.968 | -0.1412 | No |
| 75 | CD36 | NA | CD36 Entrez, Source | CD36 molecule (thrombospondin receptor) | 17086 | -1.007 | -0.1315 | No |
| 76 | ITGA7 | NA | ITGA7 Entrez, Source | integrin, alpha 7 | 17088 | -1.007 | -0.1173 | No |
| 77 | THBS4 | NA | THBS4 Entrez, Source | thrombospondin 4 | 17229 | -1.076 | -0.1098 | No |
| 78 | LAMB1 | NA | LAMB1 Entrez, Source | laminin, beta 1 | 17257 | -1.095 | -0.0957 | No |
| 79 | COL6A6 | NA | 17427 | -1.205 | -0.0880 | No | ||
| 80 | COL5A2 | NA | COL5A2 Entrez, Source | collagen, type V, alpha 2 | 17557 | -1.302 | -0.0767 | No |
| 81 | COL3A1 | NA | COL3A1 Entrez, Source | collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant) | 17611 | -1.363 | -0.0603 | No |
| 82 | COL1A1 | NA | COL1A1 Entrez, Source | collagen, type I, alpha 1 | 17830 | -1.690 | -0.0484 | No |
| 83 | ITGA2B | NA | ITGA2B Entrez, Source | integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) | 18009 | -2.323 | -0.0253 | No |
| 84 | VTN | NA | VTN Entrez, Source | vitronectin | 18023 | -2.397 | 0.0080 | No |
