Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1w1a |
| GeneSet | KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY |
| Enrichment Score (ES) | 0.7608225 |
| Normalized Enrichment Score (NES) | 2.4169233 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0 |
| FWER p-Value | 0.0 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | CCL5 | NA | CCL5 Entrez, Source | chemokine (C-C motif) ligand 5 | 6 | 4.768 | 0.1063 | Yes |
| 2 | DDX58 | NA | DDX58 Entrez, Source | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 | 15 | 4.649 | 0.2098 | Yes |
| 3 | CXCL10 | NA | CXCL10 Entrez, Source | chemokine (C-X-C motif) ligand 10 | 16 | 4.631 | 0.3133 | Yes |
| 4 | IL6 | NA | IL6 Entrez, Source | interleukin 6 (interferon, beta 2) | 17 | 4.596 | 0.4161 | Yes |
| 5 | TMEM173 | NA | TMEM173 Entrez, Source | transmembrane protein 173 | 207 | 2.372 | 0.4587 | Yes |
| 6 | AIM2 | NA | AIM2 Entrez, Source | absent in melanoma 2 | 228 | 2.262 | 0.5081 | Yes |
| 7 | NFKBIA | NA | NFKBIA Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 460 | 1.595 | 0.5311 | Yes |
| 8 | IL1B | NA | IL1B Entrez, Source | interleukin 1, beta | 779 | 1.262 | 0.5417 | Yes |
| 9 | IKBKE | NA | IKBKE Entrez, Source | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 866 | 1.200 | 0.5638 | Yes |
| 10 | CASP1 | NA | CASP1 Entrez, Source | caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) | 897 | 1.178 | 0.5885 | Yes |
| 11 | RIPK3 | NA | RIPK3 Entrez, Source | receptor-interacting serine-threonine kinase 3 | 949 | 1.146 | 0.6113 | Yes |
| 12 | POLR3C | NA | POLR3C Entrez, Source | polymerase (RNA) III (DNA directed) polypeptide C (62kD) | 997 | 1.121 | 0.6337 | Yes |
| 13 | IRF3 | NA | IRF3 Entrez, Source | interferon regulatory factor 3 | 1012 | 1.113 | 0.6579 | Yes |
| 14 | RELA | NA | RELA Entrez, Source | v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian) | 1150 | 1.047 | 0.6737 | Yes |
| 15 | POLR3H | NA | POLR3H Entrez, Source | polymerase (RNA) III (DNA directed) polypeptide H (22.9kD) | 1384 | 0.951 | 0.6821 | Yes |
| 16 | POLR3G | NA | POLR3G Entrez, Source | polymerase (RNA) III (DNA directed) polypeptide G (32kD) | 1585 | 0.885 | 0.6909 | Yes |
| 17 | IKBKG | NA | IKBKG Entrez, Source | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | 1587 | 0.884 | 0.7106 | Yes |
| 18 | RIPK1 | NA | RIPK1 Entrez, Source | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 1659 | 0.863 | 0.7260 | Yes |
| 19 | NFKB1 | NA | NFKB1 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 1767 | 0.835 | 0.7387 | Yes |
| 20 | IL18 | NA | IL18 Entrez, Source | interleukin 18 (interferon-gamma-inducing factor) | 1911 | 0.805 | 0.7488 | Yes |
| 21 | ADAR | NA | ADAR Entrez, Source | adenosine deaminase, RNA-specific | 2013 | 0.785 | 0.7608 | Yes |
| 22 | TREX1 | NA | TREX1 Entrez, Source | three prime repair exonuclease 1 | 2814 | 0.629 | 0.7307 | No |
| 23 | CHUK | NA | CHUK Entrez, Source | conserved helix-loop-helix ubiquitous kinase | 3103 | 0.582 | 0.7278 | No |
| 24 | IL33 | NA | 3162 | 0.572 | 0.7374 | No | ||
| 25 | POLR3K | NA | POLR3K Entrez, Source | polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa | 3379 | 0.540 | 0.7376 | No |
| 26 | POLR1D | NA | POLR1D Entrez, Source | polymerase (RNA) I polypeptide D, 16kDa | 4280 | 0.425 | 0.6974 | No |
| 27 | IFNA21 | NA | IFNA21 Entrez, Source | interferon, alpha 21 | 5854 | 0.273 | 0.6167 | No |
| 28 | POLR3B | NA | POLR3B Entrez, Source | polymerase (RNA) III (DNA directed) polypeptide B | 5881 | 0.271 | 0.6213 | No |
| 29 | POLR1C | NA | POLR1C Entrez, Source | polymerase (RNA) I polypeptide C, 30kDa | 6200 | 0.245 | 0.6093 | No |
| 30 | POLR3F | NA | POLR3F Entrez, Source | polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa | 6543 | 0.216 | 0.5952 | No |
| 31 | POLR3D | NA | POLR3D Entrez, Source | polymerase (RNA) III (DNA directed) polypeptide D, 44kDa | 6892 | 0.189 | 0.5802 | No |
| 32 | IFNB1 | NA | IFNB1 Entrez, Source | interferon, beta 1, fibroblast | 7718 | 0.129 | 0.5376 | No |
| 33 | IFNA17 | NA | IFNA17 Entrez, Source | interferon, alpha 17 | 8248 | 0.090 | 0.5104 | No |
| 34 | POLR3A | NA | POLR3A Entrez, Source | polymerase (RNA) III (DNA directed) polypeptide A, 155kDa | 8857 | 0.047 | 0.4779 | No |
| 35 | IRF7 | NA | IRF7 Entrez, Source | interferon regulatory factor 7 | 9107 | 0.027 | 0.4647 | No |
| 36 | IFNA13 | NA | IFNA13 Entrez, Source | interferon, alpha 13 | 9539 | 0.000 | 0.4410 | No |
| 37 | PYCARD | NA | PYCARD Entrez, Source | PYD and CARD domain containing | 9666 | 0.000 | 0.4340 | No |
| 38 | ZBP1 | NA | ZBP1 Entrez, Source | Z-DNA binding protein 1 | 9799 | -0.006 | 0.4268 | No |
| 39 | IFNA8 | NA | IFNA8 Entrez, Source | interferon, alpha 8 | 9853 | -0.010 | 0.4241 | No |
| 40 | IKBKB | NA | IKBKB Entrez, Source | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | 10944 | -0.074 | 0.3656 | No |
| 41 | IFNA10 | NA | IFNA10 Entrez, Source | interferon, alpha 10 | 11188 | -0.090 | 0.3542 | No |
| 42 | IFNA16 | NA | IFNA16 Entrez, Source | interferon, alpha 16 | 11217 | -0.092 | 0.3548 | No |
| 43 | IFNA1 | NA | IFNA1 Entrez, Source | interferon, alpha 1 | 11267 | -0.096 | 0.3542 | No |
| 44 | IFNA6 | NA | IFNA6 Entrez, Source | interferon, alpha 6 | 11724 | -0.134 | 0.3320 | No |
| 45 | TBK1 | NA | TBK1 Entrez, Source | TANK-binding kinase 1 | 12301 | -0.183 | 0.3043 | No |
| 46 | MAVS | NA | 12412 | -0.192 | 0.3025 | No | ||
| 47 | IFNA2 | NA | IFNA2 Entrez, Source | interferon, alpha 2 | 13213 | -0.263 | 0.2643 | No |
| 48 | POLR3GL | NA | POLR3GL Entrez, Source | polymerase (RNA) III (DNA directed) polypeptide G (32kD) like | 14500 | -0.405 | 0.2024 | No |
