Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | KEGG_COMPLEMENT_AND_COAGULATION_CASCADES |
| Enrichment Score (ES) | -0.42365298 |
| Normalized Enrichment Score (NES) | -1.5146743 |
| Nominal p-value | 0.010362694 |
| FDR q-value | 0.09171749 |
| FWER p-Value | 0.791 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | CFB | NA | CFB Entrez, Source | complement factor B | 67 | 3.669 | 0.0564 | No |
| 2 | PLAUR | NA | PLAUR Entrez, Source | plasminogen activator, urokinase receptor | 140 | 2.784 | 0.0980 | No |
| 3 | SERPINE1 | NA | SERPINE1 Entrez, Source | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 290 | 2.039 | 0.1231 | No |
| 4 | F3 | NA | F3 Entrez, Source | coagulation factor III (thromboplastin, tissue factor) | 301 | 1.981 | 0.1550 | No |
| 5 | THBD | NA | THBD Entrez, Source | thrombomodulin | 429 | 1.656 | 0.1751 | No |
| 6 | VWF | NA | VWF Entrez, Source | von Willebrand factor | 689 | 1.332 | 0.1826 | No |
| 7 | SERPINC1 | NA | SERPINC1 Entrez, Source | serpin peptidase inhibitor, clade C (antithrombin), member 1 | 846 | 1.211 | 0.1938 | No |
| 8 | C5 | NA | C5 Entrez, Source | complement component 5 | 1122 | 1.055 | 0.1959 | No |
| 9 | C8G | NA | C8G Entrez, Source | complement component 8, gamma polypeptide | 1405 | 0.945 | 0.1957 | No |
| 10 | F12 | NA | F12 Entrez, Source | coagulation factor XII (Hageman factor) | 1541 | 0.899 | 0.2030 | No |
| 11 | FGA | NA | FGA Entrez, Source | fibrinogen alpha chain | 2283 | 0.727 | 0.1740 | No |
| 12 | F13B | NA | F13B Entrez, Source | coagulation factor XIII, B polypeptide | 2416 | 0.700 | 0.1781 | No |
| 13 | CD55 | NA | CD55 Entrez, Source | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 3246 | 0.560 | 0.1415 | No |
| 14 | PLAT | NA | PLAT Entrez, Source | plasminogen activator, tissue | 4378 | 0.414 | 0.0858 | No |
| 15 | C8A | NA | C8A Entrez, Source | complement component 8, alpha polypeptide | 4637 | 0.388 | 0.0779 | No |
| 16 | CFD | NA | CFD Entrez, Source | complement factor D (adipsin) | 4915 | 0.360 | 0.0685 | No |
| 17 | C2 | NA | C2 Entrez, Source | complement component 2 | 5139 | 0.338 | 0.0617 | No |
| 18 | C4BPB | NA | C4BPB Entrez, Source | complement component 4 binding protein, beta | 5408 | 0.312 | 0.0520 | No |
| 19 | C9 | NA | C9 Entrez, Source | complement component 9 | 5665 | 0.290 | 0.0426 | No |
| 20 | BDKRB1 | NA | BDKRB1 Entrez, Source | bradykinin receptor B1 | 5715 | 0.285 | 0.0446 | No |
| 21 | F13A1 | NA | F13A1 Entrez, Source | coagulation factor XIII, A1 polypeptide | 7831 | 0.120 | -0.0703 | No |
| 22 | C4A | NA | C4A Entrez, Source | complement component 4A (Rodgers blood group) | 8455 | 0.075 | -0.1035 | No |
| 23 | F5 | NA | F5 Entrez, Source | coagulation factor V (proaccelerin, labile factor) | 9077 | 0.029 | -0.1373 | No |
| 24 | F8 | NA | F8 Entrez, Source | coagulation factor VIII, procoagulant component (hemophilia A) | 9357 | 0.011 | -0.1526 | No |
| 25 | C1QC | NA | C1QC Entrez, Source | complement component 1, q subcomponent, C chain | 9437 | 0.004 | -0.1569 | No |
| 26 | C1QA | NA | C1QA Entrez, Source | complement component 1, q subcomponent, A chain | 9581 | 0.000 | -0.1648 | No |
| 27 | FGG | NA | FGG Entrez, Source | fibrinogen gamma chain | 10726 | -0.062 | -0.2270 | No |
| 28 | F9 | NA | F9 Entrez, Source | coagulation factor IX (plasma thromboplastic component, Christmas disease, hemophilia B) | 10764 | -0.063 | -0.2280 | No |
| 29 | C8B | NA | C8B Entrez, Source | complement component 8, beta polypeptide | 11187 | -0.090 | -0.2498 | No |
| 30 | F7 | NA | F7 Entrez, Source | coagulation factor VII (serum prothrombin conversion accelerator) | 12061 | -0.161 | -0.2954 | No |
| 31 | SERPIND1 | NA | SERPIND1 Entrez, Source | serpin peptidase inhibitor, clade D (heparin cofactor), member 1 | 12089 | -0.163 | -0.2942 | No |
| 32 | CR2 | NA | CR2 Entrez, Source | complement component (3d/Epstein Barr virus) receptor 2 | 12243 | -0.177 | -0.2998 | No |
| 33 | CPB2 | NA | CPB2 Entrez, Source | carboxypeptidase B2 (plasma, carboxypeptidase U) | 12825 | -0.228 | -0.3282 | No |
| 34 | C6 | NA | C6 Entrez, Source | complement component 6 | 13182 | -0.261 | -0.3436 | No |
| 35 | C4B | NA | C4B Entrez, Source | complement component 4B (Childo blood group) | 13661 | -0.308 | -0.3649 | No |
| 36 | C3AR1 | NA | C3AR1 Entrez, Source | complement component 3a receptor 1 | 13822 | -0.322 | -0.3685 | No |
| 37 | SERPING1 | NA | SERPING1 Entrez, Source | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary) | 13833 | -0.324 | -0.3637 | No |
| 38 | SERPINA1 | NA | SERPINA1 Entrez, Source | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 13846 | -0.325 | -0.3591 | No |
| 39 | PROC | NA | PROC Entrez, Source | protein C (inactivator of coagulation factors Va and VIIIa) | 13938 | -0.336 | -0.3586 | No |
| 40 | F11 | NA | F11 Entrez, Source | coagulation factor XI (plasma thromboplastin antecedent) | 14109 | -0.358 | -0.3621 | No |
| 41 | F2R | NA | F2R Entrez, Source | coagulation factor II (thrombin) receptor | 14494 | -0.404 | -0.3767 | No |
| 42 | F2 | NA | F2 Entrez, Source | coagulation factor II (thrombin) | 14879 | -0.459 | -0.3904 | No |
| 43 | C7 | NA | C7 Entrez, Source | complement component 7 | 15400 | -0.532 | -0.4105 | No |
| 44 | SERPINA5 | NA | SERPINA5 Entrez, Source | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 | 15468 | -0.545 | -0.4052 | No |
| 45 | MBL2 | NA | MBL2 Entrez, Source | mannose-binding lectin (protein C) 2, soluble (opsonic defect) | 15678 | -0.586 | -0.4072 | No |
| 46 | CR1 | NA | CR1 Entrez, Source | complement component (3b/4b) receptor 1 (Knops blood group) | 15977 | -0.651 | -0.4130 | Yes |
| 47 | KLKB1 | NA | KLKB1 Entrez, Source | kallikrein B, plasma (Fletcher factor) 1 | 16098 | -0.680 | -0.4085 | Yes |
| 48 | PLAU | NA | PLAU Entrez, Source | plasminogen activator, urokinase | 16140 | -0.690 | -0.3995 | Yes |
| 49 | FGB | NA | FGB Entrez, Source | fibrinogen beta chain | 16255 | -0.721 | -0.3940 | Yes |
| 50 | C3 | NA | C3 Entrez, Source | complement component 3 | 16387 | -0.761 | -0.3887 | Yes |
| 51 | TFPI | NA | TFPI Entrez, Source | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 16492 | -0.795 | -0.3815 | Yes |
| 52 | C4BPA | NA | C4BPA Entrez, Source | complement component 4 binding protein, alpha | 16609 | -0.830 | -0.3743 | Yes |
| 53 | KNG1 | NA | KNG1 Entrez, Source | kininogen 1 | 16622 | -0.832 | -0.3613 | Yes |
| 54 | CD46 | NA | CD46 Entrez, Source | CD46 molecule, complement regulatory protein | 16711 | -0.856 | -0.3522 | Yes |
| 55 | PLG | NA | PLG Entrez, Source | plasminogen | 16761 | -0.873 | -0.3406 | Yes |
| 56 | MASP2 | NA | MASP2 Entrez, Source | mannan-binding lectin serine peptidase 2 | 17100 | -1.016 | -0.3426 | Yes |
| 57 | SERPINF2 | NA | SERPINF2 Entrez, Source | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 | 17159 | -1.037 | -0.3289 | Yes |
| 58 | C1S | NA | C1S Entrez, Source | complement component 1, s subcomponent | 17205 | -1.061 | -0.3140 | Yes |
| 59 | CD59 | NA | CD59 Entrez, Source | CD59 molecule, complement regulatory protein | 17237 | -1.080 | -0.2980 | Yes |
| 60 | C5AR1 | NA | C5AR1 Entrez, Source | complement component 5a receptor 1 | 17488 | -1.249 | -0.2914 | Yes |
| 61 | F10 | NA | F10 Entrez, Source | coagulation factor X | 17562 | -1.308 | -0.2740 | Yes |
| 62 | MASP1 | NA | MASP1 Entrez, Source | mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) | 17818 | -1.663 | -0.2609 | Yes |
| 63 | BDKRB2 | NA | BDKRB2 Entrez, Source | bradykinin receptor B2 | 17880 | -1.800 | -0.2348 | Yes |
| 64 | C1R | NA | C1R Entrez, Source | complement component 1, r subcomponent | 17902 | -1.865 | -0.2054 | Yes |
| 65 | A2M | NA | A2M Entrez, Source | alpha-2-macroglobulin | 18074 | -2.760 | -0.1697 | Yes |
| 66 | CFH | NA | CFH Entrez, Source | complement factor H | 18095 | -2.940 | -0.1227 | Yes |
| 67 | PROS1 | NA | PROS1 Entrez, Source | protein S (alpha) | 18136 | -3.580 | -0.0663 | Yes |
| 68 | CFI | NA | CFI Entrez, Source | complement factor I | 18152 | -4.148 | 0.0008 | Yes |
