Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | KEGG_CITRATE_CYCLE_TCA_CYCLE |
| Enrichment Score (ES) | -0.6297321 |
| Normalized Enrichment Score (NES) | -1.9137226 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.005622145 |
| FWER p-Value | 0.024 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | PCK2 | NA | PCK2 Entrez, Source | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | 3604 | 0.510 | -0.1709 | No |
| 2 | OGDH | NA | OGDH Entrez, Source | oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) | 5309 | 0.322 | -0.2473 | No |
| 3 | PDHA2 | NA | PDHA2 Entrez, Source | pyruvate dehydrogenase (lipoamide) alpha 2 | 6115 | 0.253 | -0.2779 | No |
| 4 | IDH3G | NA | IDH3G Entrez, Source | isocitrate dehydrogenase 3 (NAD+) gamma | 6746 | 0.199 | -0.3018 | No |
| 5 | CS | NA | CS Entrez, Source | citrate synthase | 6878 | 0.190 | -0.2987 | No |
| 6 | DLST | NA | DLST Entrez, Source | dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) | 8390 | 0.080 | -0.3776 | No |
| 7 | DLAT | NA | DLAT Entrez, Source | dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) | 11362 | -0.102 | -0.5358 | No |
| 8 | PCK1 | NA | PCK1 Entrez, Source | phosphoenolpyruvate carboxykinase 1 (soluble) | 11490 | -0.114 | -0.5366 | No |
| 9 | MDH2 | NA | MDH2 Entrez, Source | malate dehydrogenase 2, NAD (mitochondrial) | 11787 | -0.139 | -0.5453 | No |
| 10 | ACLY | NA | ACLY Entrez, Source | ATP citrate lyase | 12137 | -0.168 | -0.5555 | No |
| 11 | SUCLA2 | NA | SUCLA2 Entrez, Source | succinate-CoA ligase, ADP-forming, beta subunit | 12175 | -0.171 | -0.5482 | No |
| 12 | IDH3A | NA | IDH3A Entrez, Source | isocitrate dehydrogenase 3 (NAD+) alpha | 12987 | -0.244 | -0.5796 | No |
| 13 | SDHC | NA | SDHC Entrez, Source | succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa | 13605 | -0.301 | -0.5972 | No |
| 14 | ACO2 | NA | ACO2 Entrez, Source | aconitase 2, mitochondrial | 14158 | -0.364 | -0.6078 | Yes |
| 15 | SUCLG2 | NA | SUCLG2 Entrez, Source | succinate-CoA ligase, GDP-forming, beta subunit | 14250 | -0.373 | -0.5925 | Yes |
| 16 | SDHA | NA | SDHA Entrez, Source | succinate dehydrogenase complex, subunit A, flavoprotein (Fp) | 14927 | -0.465 | -0.6044 | Yes |
| 17 | FH | NA | FH Entrez, Source | fumarate hydratase | 15028 | -0.479 | -0.5838 | Yes |
| 18 | PDHA1 | NA | PDHA1 Entrez, Source | pyruvate dehydrogenase (lipoamide) alpha 1 | 15056 | -0.483 | -0.5589 | Yes |
| 19 | IDH1 | NA | IDH1 Entrez, Source | isocitrate dehydrogenase 1 (NADP+), soluble | 15361 | -0.527 | -0.5470 | Yes |
| 20 | DLD | NA | DLD Entrez, Source | dihydrolipoamide dehydrogenase | 15418 | -0.535 | -0.5210 | Yes |
| 21 | SDHB | NA | SDHB Entrez, Source | succinate dehydrogenase complex, subunit B, iron sulfur (Ip) | 15593 | -0.569 | -0.4995 | Yes |
| 22 | PDHB | NA | PDHB Entrez, Source | pyruvate dehydrogenase (lipoamide) beta | 16571 | -0.817 | -0.5089 | Yes |
| 23 | SUCLG1 | NA | SUCLG1 Entrez, Source | succinate-CoA ligase, GDP-forming, alpha subunit | 16597 | -0.825 | -0.4653 | Yes |
| 24 | SDHD | NA | SDHD Entrez, Source | succinate dehydrogenase complex, subunit D, integral membrane protein | 16792 | -0.886 | -0.4277 | Yes |
| 25 | MDH1 | NA | MDH1 Entrez, Source | malate dehydrogenase 1, NAD (soluble) | 17345 | -1.146 | -0.3957 | Yes |
| 26 | ACO1 | NA | ACO1 Entrez, Source | aconitase 1, soluble | 17583 | -1.325 | -0.3366 | Yes |
| 27 | PC | NA | PC Entrez, Source | pyruvate carboxylase | 17856 | -1.750 | -0.2562 | Yes |
| 28 | IDH2 | NA | IDH2 Entrez, Source | isocitrate dehydrogenase 2 (NADP+), mitochondrial | 17869 | -1.770 | -0.1604 | Yes |
| 29 | OGDHL | NA | OGDHL Entrez, Source | oxoglutarate dehydrogenase-like | 18114 | -3.245 | 0.0029 | Yes |
