Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | KEGG_CARDIAC_MUSCLE_CONTRACTION |
| Enrichment Score (ES) | -0.43451405 |
| Normalized Enrichment Score (NES) | -1.5941812 |
| Nominal p-value | 0.0050251256 |
| FDR q-value | 0.05492881 |
| FWER p-Value | 0.552 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | CACNB1 | NA | CACNB1 Entrez, Source | calcium channel, voltage-dependent, beta 1 subunit | 272 | 2.089 | 0.0324 | No |
| 2 | COX6B2 | NA | COX6B2 Entrez, Source | cytochrome c oxidase subunit VIb polypeptide 2 (testis) | 273 | 2.087 | 0.0799 | No |
| 3 | RYR2 | NA | RYR2 Entrez, Source | ryanodine receptor 2 (cardiac) | 292 | 2.024 | 0.1249 | No |
| 4 | SLC9A1 | NA | SLC9A1 Entrez, Source | solute carrier family 9 (sodium/hydrogen exchanger), member 1 (antiporter, Na+/H+, amiloride sensitive) | 499 | 1.540 | 0.1485 | No |
| 5 | TNNI3 | NA | TNNI3 Entrez, Source | troponin I type 3 (cardiac) | 1592 | 0.883 | 0.1082 | No |
| 6 | ATP1B1 | NA | ATP1B1 Entrez, Source | ATPase, Na+/K+ transporting, beta 1 polypeptide | 2080 | 0.770 | 0.0988 | No |
| 7 | CACNA2D1 | NA | CACNA2D1 Entrez, Source | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | 2707 | 0.648 | 0.0790 | No |
| 8 | CACNG6 | NA | CACNG6 Entrez, Source | calcium channel, voltage-dependent, gamma subunit 6 | 3964 | 0.466 | 0.0201 | No |
| 9 | TPM2 | NA | TPM2 Entrez, Source | tropomyosin 2 (beta) | 4827 | 0.370 | -0.0191 | No |
| 10 | SLC8A1 | NA | SLC8A1 Entrez, Source | solute carrier family 8 (sodium/calcium exchanger), member 1 | 5365 | 0.316 | -0.0416 | No |
| 11 | TNNT2 | NA | TNNT2 Entrez, Source | troponin T type 2 (cardiac) | 5553 | 0.299 | -0.0451 | No |
| 12 | COX7A1 | NA | COX7A1 Entrez, Source | cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) | 5681 | 0.288 | -0.0456 | No |
| 13 | TPM4 | NA | TPM4 Entrez, Source | tropomyosin 4 | 5712 | 0.285 | -0.0408 | No |
| 14 | TPM3 | NA | TPM3 Entrez, Source | tropomyosin 3 | 5767 | 0.281 | -0.0374 | No |
| 15 | ATP1A2 | NA | ATP1A2 Entrez, Source | ATPase, Na+/K+ transporting, alpha 2 (+) polypeptide | 5869 | 0.272 | -0.0368 | No |
| 16 | ATP1A4 | NA | ATP1A4 Entrez, Source | ATPase, Na+/K+ transporting, alpha 4 polypeptide | 7075 | 0.176 | -0.0994 | No |
| 17 | CACNB3 | NA | CACNB3 Entrez, Source | calcium channel, voltage-dependent, beta 3 subunit | 7115 | 0.172 | -0.0976 | No |
| 18 | MYL2 | NA | MYL2 Entrez, Source | myosin, light chain 2, regulatory, cardiac, slow | 7327 | 0.157 | -0.1057 | No |
| 19 | UQCR11 | NA | 7511 | 0.144 | -0.1125 | No | ||
| 20 | CACNG8 | NA | CACNG8 Entrez, Source | calcium channel, voltage-dependent, gamma subunit 8 | 8027 | 0.105 | -0.1386 | No |
| 21 | CACNA1C | NA | CACNA1C Entrez, Source | calcium channel, voltage-dependent, L type, alpha 1C subunit | 8216 | 0.092 | -0.1469 | No |
| 22 | SLC9A6 | NA | SLC9A6 Entrez, Source | solute carrier family 9 (sodium/hydrogen exchanger), member 6 | 8293 | 0.086 | -0.1491 | No |
| 23 | CACNA2D4 | NA | CACNA2D4 Entrez, Source | calcium channel, voltage-dependent, alpha 2/delta subunit 4 | 8604 | 0.065 | -0.1648 | No |
| 24 | ATP2A2 | NA | ATP2A2 Entrez, Source | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | 8661 | 0.060 | -0.1665 | No |
| 25 | COX8C | NA | COX8C Entrez, Source | cytochrome c oxidase subunit 8C | 9478 | 0.003 | -0.2115 | No |
| 26 | FXYD2 | NA | FXYD2 Entrez, Source | FXYD domain containing ion transport regulator 2 | 9614 | 0.000 | -0.2190 | No |
| 27 | COX4I2 | NA | COX4I2 Entrez, Source | cytochrome c oxidase subunit IV isoform 2 (lung) | 9626 | 0.000 | -0.2196 | No |
| 28 | CACNB4 | NA | CACNB4 Entrez, Source | calcium channel, voltage-dependent, beta 4 subunit | 9754 | -0.002 | -0.2266 | No |
| 29 | CACNG7 | NA | CACNG7 Entrez, Source | calcium channel, voltage-dependent, gamma subunit 7 | 9788 | -0.005 | -0.2283 | No |
| 30 | MYH6 | NA | MYH6 Entrez, Source | myosin, heavy chain 6, cardiac muscle, alpha (cardiomyopathy, hypertrophic 1) | 10193 | -0.031 | -0.2499 | No |
| 31 | MYH7 | NA | MYH7 Entrez, Source | myosin, heavy chain 7, cardiac muscle, beta | 10534 | -0.050 | -0.2676 | No |
| 32 | CACNG2 | NA | CACNG2 Entrez, Source | calcium channel, voltage-dependent, gamma subunit 2 | 10610 | -0.055 | -0.2705 | No |
| 33 | CACNG1 | NA | CACNG1 Entrez, Source | calcium channel, voltage-dependent, gamma subunit 1 | 10744 | -0.062 | -0.2764 | No |
| 34 | ATP1B2 | NA | ATP1B2 Entrez, Source | ATPase, Na+/K+ transporting, beta 2 polypeptide | 10904 | -0.072 | -0.2836 | No |
| 35 | MYL3 | NA | MYL3 Entrez, Source | myosin, light chain 3, alkali; ventricular, skeletal, slow | 11228 | -0.093 | -0.2993 | No |
| 36 | CACNG5 | NA | CACNG5 Entrez, Source | calcium channel, voltage-dependent, gamma subunit 5 | 11320 | -0.100 | -0.3021 | No |
| 37 | ATP1A1 | NA | ATP1A1 Entrez, Source | ATPase, Na+/K+ transporting, alpha 1 polypeptide | 11447 | -0.110 | -0.3065 | No |
| 38 | CACNA1S | NA | CACNA1S Entrez, Source | calcium channel, voltage-dependent, L type, alpha 1S subunit | 12552 | -0.206 | -0.3629 | No |
| 39 | TPM1 | NA | TPM1 Entrez, Source | tropomyosin 1 (alpha) | 12684 | -0.218 | -0.3651 | No |
| 40 | CYC1 | NA | CYC1 Entrez, Source | cytochrome c-1 | 12899 | -0.235 | -0.3716 | No |
| 41 | COX7A2L | NA | COX7A2L Entrez, Source | cytochrome c oxidase subunit VIIa polypeptide 2 like | 13373 | -0.279 | -0.3914 | No |
| 42 | COX7B2 | NA | COX7B2 Entrez, Source | cytochrome c oxidase subunit VIIb2 | 13956 | -0.340 | -0.4159 | No |
| 43 | UQCRC1 | NA | UQCRC1 Entrez, Source | ubiquinol-cytochrome c reductase core protein I | 14122 | -0.360 | -0.4168 | No |
| 44 | CACNA1F | NA | CACNA1F Entrez, Source | calcium channel, voltage-dependent, alpha 1F subunit | 14354 | -0.386 | -0.4208 | No |
| 45 | COX6A1 | NA | COX6A1 Entrez, Source | cytochrome c oxidase subunit VIa polypeptide 1 | 14365 | -0.387 | -0.4126 | No |
| 46 | COX5A | NA | COX5A Entrez, Source | cytochrome c oxidase subunit Va | 14438 | -0.397 | -0.4075 | No |
| 47 | UQCRQ | NA | UQCRQ Entrez, Source | ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa | 14817 | -0.449 | -0.4182 | No |
| 48 | CACNA2D2 | NA | CACNA2D2 Entrez, Source | calcium channel, voltage-dependent, alpha 2/delta subunit 2 | 15113 | -0.490 | -0.4234 | Yes |
| 49 | UQCRFS1 | NA | UQCRFS1 Entrez, Source | ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 | 15206 | -0.503 | -0.4170 | Yes |
| 50 | COX4I1 | NA | COX4I1 Entrez, Source | cytochrome c oxidase subunit IV isoform 1 | 15269 | -0.512 | -0.4088 | Yes |
| 51 | ATP1B3 | NA | ATP1B3 Entrez, Source | ATPase, Na+/K+ transporting, beta 3 polypeptide | 15637 | -0.579 | -0.4159 | Yes |
| 52 | ATP1B4 | NA | ATP1B4 Entrez, Source | ATPase, (Na+)/K+ transporting, beta 4 polypeptide | 15847 | -0.620 | -0.4134 | Yes |
| 53 | COX8A | NA | COX8A Entrez, Source | cytochrome c oxidase subunit 8A (ubiquitous) | 15949 | -0.642 | -0.4044 | Yes |
| 54 | COX5B | NA | COX5B Entrez, Source | cytochrome c oxidase subunit Vb | 15956 | -0.644 | -0.3901 | Yes |
| 55 | UQCRHL | NA | 16025 | -0.661 | -0.3788 | Yes | ||
| 56 | COX6B1 | NA | COX6B1 Entrez, Source | cytochrome c oxidase subunit Vib polypeptide 1 (ubiquitous) | 16035 | -0.665 | -0.3642 | Yes |
| 57 | CACNG4 | NA | CACNG4 Entrez, Source | calcium channel, voltage-dependent, gamma subunit 4 | 16270 | -0.725 | -0.3606 | Yes |
| 58 | UQCR10 | NA | 16475 | -0.787 | -0.3540 | Yes | ||
| 59 | COX7A2 | NA | COX7A2 Entrez, Source | cytochrome c oxidase subunit VIIa polypeptide 2 (liver) | 16640 | -0.835 | -0.3441 | Yes |
| 60 | UQCRH | NA | UQCRH Entrez, Source | ubiquinol-cytochrome c reductase hinge protein | 16759 | -0.873 | -0.3308 | Yes |
| 61 | COX6C | NA | COX6C Entrez, Source | cytochrome c oxidase subunit VIc | 16973 | -0.957 | -0.3208 | Yes |
| 62 | COX7B | NA | COX7B Entrez, Source | cytochrome c oxidase subunit VIIb | 17181 | -1.049 | -0.3084 | Yes |
| 63 | UQCRB | NA | UQCRB Entrez, Source | ubiquinol-cytochrome c reductase binding protein | 17309 | -1.123 | -0.2899 | Yes |
| 64 | COX7C | NA | COX7C Entrez, Source | cytochrome c oxidase subunit VIIc | 17459 | -1.227 | -0.2702 | Yes |
| 65 | UQCRC2 | NA | UQCRC2 Entrez, Source | ubiquinol-cytochrome c reductase core protein II | 17465 | -1.232 | -0.2425 | Yes |
| 66 | ATP1A3 | NA | ATP1A3 Entrez, Source | ATPase, Na+/K+ transporting, alpha 3 polypeptide | 17617 | -1.370 | -0.2197 | Yes |
| 67 | CACNB2 | NA | CACNB2 Entrez, Source | calcium channel, voltage-dependent, beta 2 subunit | 17676 | -1.438 | -0.1902 | Yes |
| 68 | CACNA1D | NA | CACNA1D Entrez, Source | calcium channel, voltage-dependent, L type, alpha 1D subunit | 17718 | -1.492 | -0.1586 | Yes |
| 69 | CACNA2D3 | NA | CACNA2D3 Entrez, Source | calcium channel, voltage-dependent, alpha 2/delta 3 subunit | 17871 | -1.777 | -0.1266 | Yes |
| 70 | ACTC1 | NA | ACTC1 Entrez, Source | actin, alpha, cardiac muscle 1 | 17885 | -1.811 | -0.0862 | Yes |
| 71 | CACNG3 | NA | CACNG3 Entrez, Source | calcium channel, voltage-dependent, gamma subunit 3 | 17919 | -1.903 | -0.0447 | Yes |
| 72 | TNNC1 | NA | TNNC1 Entrez, Source | troponin C type 1 (slow) | 18050 | -2.569 | 0.0065 | Yes |
