Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | KEGG_BUTANOATE_METABOLISM |
| Enrichment Score (ES) | -0.4972607 |
| Normalized Enrichment Score (NES) | -1.5582582 |
| Nominal p-value | 0.016786572 |
| FDR q-value | 0.06611972 |
| FWER p-Value | 0.659 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | ACSM1 | NA | ACSM1 Entrez, Source | acyl-CoA synthetase medium-chain family member 1 | 1014 | 1.111 | 0.0027 | No |
| 2 | HMGCS1 | NA | HMGCS1 Entrez, Source | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) | 1289 | 0.985 | 0.0395 | No |
| 3 | ACSM5 | NA | 2136 | 0.757 | 0.0328 | No | ||
| 4 | ALDH5A1 | NA | ALDH5A1 Entrez, Source | aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase) | 3952 | 0.467 | -0.0426 | No |
| 5 | PDHA2 | NA | PDHA2 Entrez, Source | pyruvate dehydrogenase (lipoamide) alpha 2 | 6115 | 0.253 | -0.1485 | No |
| 6 | GAD1 | NA | GAD1 Entrez, Source | glutamate decarboxylase 1 (brain, 67kDa) | 9933 | -0.015 | -0.3582 | No |
| 7 | ACSM4 | NA | 10731 | -0.062 | -0.3988 | No | ||
| 8 | BDH1 | NA | BDH1 Entrez, Source | 3-hydroxybutyrate dehydrogenase, type 1 | 11785 | -0.139 | -0.4496 | No |
| 9 | ALDH1B1 | NA | ALDH1B1 Entrez, Source | aldehyde dehydrogenase 1 family, member B1 | 11847 | -0.144 | -0.4454 | No |
| 10 | L2HGDH | NA | L2HGDH Entrez, Source | L-2-hydroxyglutarate dehydrogenase | 11907 | -0.148 | -0.4408 | No |
| 11 | AACS | NA | AACS Entrez, Source | acetoacetyl-CoA synthetase | 12595 | -0.209 | -0.4676 | No |
| 12 | HMGCL | NA | HMGCL Entrez, Source | 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (hydroxymethylglutaricaciduria) | 13133 | -0.256 | -0.4838 | Yes |
| 13 | HMGCS2 | NA | HMGCS2 Entrez, Source | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial) | 13152 | -0.258 | -0.4712 | Yes |
| 14 | ALDH7A1 | NA | ALDH7A1 Entrez, Source | aldehyde dehydrogenase 7 family, member A1 | 13180 | -0.261 | -0.4589 | Yes |
| 15 | ECHS1 | NA | ECHS1 Entrez, Source | enoyl Coenzyme A hydratase, short chain, 1, mitochondrial | 13439 | -0.286 | -0.4580 | Yes |
| 16 | ACAT2 | NA | ACAT2 Entrez, Source | acetyl-Coenzyme A acetyltransferase 2 (acetoacetyl Coenzyme A thiolase) | 13792 | -0.320 | -0.4606 | Yes |
| 17 | ALDH9A1 | NA | ALDH9A1 Entrez, Source | aldehyde dehydrogenase 9 family, member A1 | 13994 | -0.345 | -0.4535 | Yes |
| 18 | ALDH3A2 | NA | ALDH3A2 Entrez, Source | aldehyde dehydrogenase 3 family, member A2 | 14517 | -0.407 | -0.4608 | Yes |
| 19 | HADH | NA | HADH Entrez, Source | hydroxyacyl-Coenzyme A dehydrogenase | 14585 | -0.417 | -0.4425 | Yes |
| 20 | GAD2 | NA | GAD2 Entrez, Source | glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) | 14709 | -0.430 | -0.4266 | Yes |
| 21 | ACADS | NA | ACADS Entrez, Source | acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain | 14739 | -0.435 | -0.4052 | Yes |
| 22 | PDHA1 | NA | PDHA1 Entrez, Source | pyruvate dehydrogenase (lipoamide) alpha 1 | 15056 | -0.483 | -0.3971 | Yes |
| 23 | OXCT1 | NA | OXCT1 Entrez, Source | 3-oxoacid CoA transferase 1 | 15398 | -0.531 | -0.3879 | Yes |
| 24 | OXCT2 | NA | OXCT2 Entrez, Source | 3-oxoacid CoA transferase 2 | 15598 | -0.569 | -0.3688 | Yes |
| 25 | BDH2 | NA | BDH2 Entrez, Source | 3-hydroxybutyrate dehydrogenase, type 2 | 16480 | -0.791 | -0.3757 | Yes |
| 26 | EHHADH | NA | EHHADH Entrez, Source | enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase | 16508 | -0.801 | -0.3349 | Yes |
| 27 | PDHB | NA | PDHB Entrez, Source | pyruvate dehydrogenase (lipoamide) beta | 16571 | -0.817 | -0.2952 | Yes |
| 28 | ALDH2 | NA | ALDH2 Entrez, Source | aldehyde dehydrogenase 2 family (mitochondrial) | 16658 | -0.842 | -0.2556 | Yes |
| 29 | HADHA | NA | HADHA Entrez, Source | hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit | 16783 | -0.880 | -0.2159 | Yes |
| 30 | ABAT | NA | ABAT Entrez, Source | 4-aminobutyrate aminotransferase | 17441 | -1.211 | -0.1883 | Yes |
| 31 | AKR1B10 | NA | AKR1B10 Entrez, Source | aldo-keto reductase family 1, member B10 (aldose reductase) | 17532 | -1.280 | -0.1257 | Yes |
| 32 | ACAT1 | NA | ACAT1 Entrez, Source | acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase) | 17713 | -1.484 | -0.0574 | Yes |
| 33 | ACSM3 | NA | ACSM3 Entrez, Source | acyl-CoA synthetase medium-chain family member 3 | 17767 | -1.561 | 0.0221 | Yes |
