Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1w1a |
| GeneSet | KEGG_APOPTOSIS |
| Enrichment Score (ES) | 0.50376004 |
| Normalized Enrichment Score (NES) | 1.7903172 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.013633599 |
| FWER p-Value | 0.103 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | BIRC3 | NA | BIRC3 Entrez, Source | baculoviral IAP repeat-containing 3 | 182 | 2.484 | 0.0349 | Yes |
| 2 | MAP3K14 | NA | MAP3K14 Entrez, Source | mitogen-activated protein kinase kinase kinase 14 | 206 | 2.374 | 0.0767 | Yes |
| 3 | PIK3R1 | NA | PIK3R1 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha) | 366 | 1.786 | 0.1002 | Yes |
| 4 | NFKBIA | NA | NFKBIA Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 460 | 1.595 | 0.1240 | Yes |
| 5 | BCL2L1 | NA | BCL2L1 Entrez, Source | BCL2-like 1 | 512 | 1.526 | 0.1488 | Yes |
| 6 | IL1A | NA | IL1A Entrez, Source | interleukin 1, alpha | 647 | 1.371 | 0.1663 | Yes |
| 7 | TNFRSF10A | NA | TNFRSF10A Entrez, Source | tumor necrosis factor receptor superfamily, member 10a | 660 | 1.356 | 0.1902 | Yes |
| 8 | IRAK2 | NA | IRAK2 Entrez, Source | interleukin-1 receptor-associated kinase 2 | 694 | 1.328 | 0.2124 | Yes |
| 9 | TNFRSF1A | NA | TNFRSF1A Entrez, Source | tumor necrosis factor receptor superfamily, member 1A | 755 | 1.279 | 0.2322 | Yes |
| 10 | IL1B | NA | IL1B Entrez, Source | interleukin 1, beta | 779 | 1.262 | 0.2538 | Yes |
| 11 | TNFRSF10B | NA | TNFRSF10B Entrez, Source | tumor necrosis factor receptor superfamily, member 10b | 1020 | 1.110 | 0.2607 | Yes |
| 12 | PRKAR1B | NA | PRKAR1B Entrez, Source | protein kinase, cAMP-dependent, regulatory, type I, beta | 1068 | 1.084 | 0.2777 | Yes |
| 13 | RELA | NA | RELA Entrez, Source | v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian) | 1150 | 1.047 | 0.2922 | Yes |
| 14 | TNF | NA | TNF Entrez, Source | tumor necrosis factor (TNF superfamily, member 2) | 1210 | 1.015 | 0.3073 | Yes |
| 15 | IRAK3 | NA | IRAK3 Entrez, Source | interleukin-1 receptor-associated kinase 3 | 1256 | 0.998 | 0.3229 | Yes |
| 16 | FADD | NA | FADD Entrez, Source | Fas (TNFRSF6)-associated via death domain | 1402 | 0.946 | 0.3320 | Yes |
| 17 | PIK3CD | NA | PIK3CD Entrez, Source | phosphoinositide-3-kinase, catalytic, delta polypeptide | 1572 | 0.890 | 0.3388 | Yes |
| 18 | IKBKG | NA | IKBKG Entrez, Source | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | 1587 | 0.884 | 0.3541 | Yes |
| 19 | FAS | NA | FAS Entrez, Source | Fas (TNF receptor superfamily, member 6) | 1600 | 0.881 | 0.3694 | Yes |
| 20 | IL1R1 | NA | IL1R1 Entrez, Source | interleukin 1 receptor, type I | 1602 | 0.880 | 0.3853 | Yes |
| 21 | RIPK1 | NA | RIPK1 Entrez, Source | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 1659 | 0.863 | 0.3978 | Yes |
| 22 | IRAK1 | NA | IRAK1 Entrez, Source | interleukin-1 receptor-associated kinase 1 | 1676 | 0.857 | 0.4125 | Yes |
| 23 | CAPN1 | NA | CAPN1 Entrez, Source | calpain 1, (mu/I) large subunit | 1682 | 0.857 | 0.4277 | Yes |
| 24 | TRADD | NA | TRADD Entrez, Source | TNFRSF1A-associated via death domain | 1709 | 0.848 | 0.4416 | Yes |
| 25 | NFKB1 | NA | NFKB1 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 1767 | 0.835 | 0.4536 | Yes |
| 26 | CAPN2 | NA | CAPN2 Entrez, Source | calpain 2, (m/II) large subunit | 2083 | 0.769 | 0.4501 | Yes |
| 27 | IRAK4 | NA | IRAK4 Entrez, Source | interleukin-1 receptor-associated kinase 4 | 2128 | 0.759 | 0.4614 | Yes |
| 28 | CASP7 | NA | CASP7 Entrez, Source | caspase 7, apoptosis-related cysteine peptidase | 2131 | 0.758 | 0.4751 | Yes |
| 29 | TNFSF10 | NA | TNFSF10 Entrez, Source | tumor necrosis factor (ligand) superfamily, member 10 | 2436 | 0.696 | 0.4709 | Yes |
| 30 | MYD88 | NA | MYD88 Entrez, Source | myeloid differentiation primary response gene (88) | 2759 | 0.638 | 0.4646 | Yes |
| 31 | BAD | NA | BAD Entrez, Source | BCL2-antagonist of cell death | 2764 | 0.637 | 0.4759 | Yes |
| 32 | CASP3 | NA | CASP3 Entrez, Source | caspase 3, apoptosis-related cysteine peptidase | 2903 | 0.613 | 0.4794 | Yes |
| 33 | CHUK | NA | CHUK Entrez, Source | conserved helix-loop-helix ubiquitous kinase | 3103 | 0.582 | 0.4790 | Yes |
| 34 | TRAF2 | NA | TRAF2 Entrez, Source | TNF receptor-associated factor 2 | 3221 | 0.564 | 0.4827 | Yes |
| 35 | PPP3CC | NA | PPP3CC Entrez, Source | protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform (calcineurin A gamma) | 3331 | 0.546 | 0.4866 | Yes |
| 36 | CASP10 | NA | CASP10 Entrez, Source | caspase 10, apoptosis-related cysteine peptidase | 3347 | 0.544 | 0.4956 | Yes |
| 37 | BIRC2 | NA | BIRC2 Entrez, Source | baculoviral IAP repeat-containing 2 | 3377 | 0.540 | 0.5038 | Yes |
| 38 | PPP3R2 | NA | PPP3R2 Entrez, Source | protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, beta isoform (calcineurin B, type II) | 4110 | 0.445 | 0.4713 | No |
| 39 | TNFRSF10C | NA | TNFRSF10C Entrez, Source | tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain | 4694 | 0.383 | 0.4461 | No |
| 40 | PIK3R3 | NA | PIK3R3 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma) | 5162 | 0.335 | 0.4263 | No |
| 41 | CASP8 | NA | CASP8 Entrez, Source | caspase 8, apoptosis-related cysteine peptidase | 5677 | 0.288 | 0.4031 | No |
| 42 | NTRK1 | NA | NTRK1 Entrez, Source | neurotrophic tyrosine kinase, receptor, type 1 | 5773 | 0.280 | 0.4029 | No |
| 43 | BAX | NA | BAX Entrez, Source | BCL2-associated X protein | 5783 | 0.280 | 0.4075 | No |
| 44 | ENDOD1 | NA | ENDOD1 Entrez, Source | endonuclease domain containing 1 | 5987 | 0.265 | 0.4011 | No |
| 45 | AKT2 | NA | AKT2 Entrez, Source | v-akt murine thymoma viral oncogene homolog 2 | 6144 | 0.250 | 0.3970 | No |
| 46 | CASP6 | NA | CASP6 Entrez, Source | caspase 6, apoptosis-related cysteine peptidase | 6428 | 0.227 | 0.3854 | No |
| 47 | IL3 | NA | IL3 Entrez, Source | interleukin 3 (colony-stimulating factor, multiple) | 6709 | 0.203 | 0.3736 | No |
| 48 | DFFA | NA | DFFA Entrez, Source | DNA fragmentation factor, 45kDa, alpha polypeptide | 6781 | 0.197 | 0.3733 | No |
| 49 | PPP3R1 | NA | PPP3R1 Entrez, Source | protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I) | 7244 | 0.164 | 0.3507 | No |
| 50 | EXOG | NA | 7355 | 0.155 | 0.3474 | No | ||
| 51 | AKT1 | NA | AKT1 Entrez, Source | v-akt murine thymoma viral oncogene homolog 1 | 7922 | 0.113 | 0.3181 | No |
| 52 | APAF1 | NA | APAF1 Entrez, Source | apoptotic peptidase activating factor | 7927 | 0.113 | 0.3200 | No |
| 53 | DFFB | NA | DFFB Entrez, Source | DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) | 7929 | 0.113 | 0.3220 | No |
| 54 | PRKACB | NA | PRKACB Entrez, Source | protein kinase, cAMP-dependent, catalytic, beta | 8188 | 0.094 | 0.3094 | No |
| 55 | NGF | NA | 8306 | 0.085 | 0.3045 | No | ||
| 56 | CSF2RB | NA | CSF2RB Entrez, Source | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) | 8457 | 0.075 | 0.2975 | No |
| 57 | PIK3CA | NA | PIK3CA Entrez, Source | phosphoinositide-3-kinase, catalytic, alpha polypeptide | 8784 | 0.052 | 0.2804 | No |
| 58 | XIAP | NA | 10443 | -0.045 | 0.1896 | No | ||
| 59 | PRKACG | NA | PRKACG Entrez, Source | protein kinase, cAMP-dependent, catalytic, gamma | 10762 | -0.063 | 0.1731 | No |
| 60 | CFLAR | NA | CFLAR Entrez, Source | CASP8 and FADD-like apoptosis regulator | 10825 | -0.067 | 0.1709 | No |
| 61 | PRKAR2A | NA | PRKAR2A Entrez, Source | protein kinase, cAMP-dependent, regulatory, type II, alpha | 10915 | -0.072 | 0.1673 | No |
| 62 | IKBKB | NA | IKBKB Entrez, Source | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | 10944 | -0.074 | 0.1671 | No |
| 63 | PIK3R5 | NA | PIK3R5 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 5, p101 | 11049 | -0.081 | 0.1628 | No |
| 64 | BID | NA | BID Entrez, Source | BH3 interacting domain death agonist | 11556 | -0.119 | 0.1370 | No |
| 65 | PIK3CB | NA | PIK3CB Entrez, Source | phosphoinositide-3-kinase, catalytic, beta polypeptide | 11650 | -0.127 | 0.1341 | No |
| 66 | PIK3R2 | NA | PIK3R2 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta) | 12247 | -0.177 | 0.1044 | No |
| 67 | ATM | NA | ATM Entrez, Source | ataxia telangiectasia mutated (includes complementation groups A, C and D) | 12852 | -0.230 | 0.0751 | No |
| 68 | ENDOG | NA | ENDOG Entrez, Source | endonuclease G | 12949 | -0.241 | 0.0742 | No |
| 69 | PRKAR1A | NA | PRKAR1A Entrez, Source | protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) | 13249 | -0.267 | 0.0625 | No |
| 70 | AIFM1 | NA | 13591 | -0.300 | 0.0491 | No | ||
| 71 | CYCS | NA | CYCS Entrez, Source | cytochrome c, somatic | 13663 | -0.308 | 0.0507 | No |
| 72 | IL3RA | NA | IL3RA Entrez, Source | interleukin 3 receptor, alpha (low affinity) | 13810 | -0.322 | 0.0485 | No |
| 73 | FASLG | NA | FASLG Entrez, Source | Fas ligand (TNF superfamily, member 6) | 13862 | -0.326 | 0.0516 | No |
| 74 | PRKAR2B | NA | PRKAR2B Entrez, Source | protein kinase, cAMP-dependent, regulatory, type II, beta | 14232 | -0.370 | 0.0379 | No |
| 75 | BCL2 | NA | BCL2 Entrez, Source | B-cell CLL/lymphoma 2 | 14397 | -0.390 | 0.0359 | No |
| 76 | PPP3CA | NA | PPP3CA Entrez, Source | protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform (calcineurin A alpha) | 14469 | -0.401 | 0.0392 | No |
| 77 | PRKACA | NA | PRKACA Entrez, Source | protein kinase, cAMP-dependent, catalytic, alpha | 14764 | -0.438 | 0.0309 | No |
| 78 | PRKX | NA | PRKX Entrez, Source | protein kinase, X-linked | 15462 | -0.544 | 0.0022 | No |
| 79 | IL1RAP | NA | IL1RAP Entrez, Source | interleukin 1 receptor accessory protein | 15684 | -0.587 | 0.0006 | No |
| 80 | TP53 | NA | TP53 Entrez, Source | tumor protein p53 (Li-Fraumeni syndrome) | 15988 | -0.654 | -0.0043 | No |
| 81 | CHP2 | NA | 16192 | -0.704 | -0.0028 | No | ||
| 82 | PPP3CB | NA | PPP3CB Entrez, Source | protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform (calcineurin A beta) | 16406 | -0.766 | -0.0007 | No |
| 83 | TNFRSF10D | NA | TNFRSF10D Entrez, Source | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | 17112 | -1.020 | -0.0212 | No |
| 84 | PIK3CG | NA | PIK3CG Entrez, Source | phosphoinositide-3-kinase, catalytic, gamma polypeptide | 17630 | -1.385 | -0.0247 | No |
| 85 | CASP9 | NA | CASP9 Entrez, Source | caspase 9, apoptosis-related cysteine peptidase | 17671 | -1.437 | -0.0009 | No |
| 86 | AKT3 | NA | AKT3 Entrez, Source | v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) | 17766 | -1.559 | 0.0222 | No |
