Datasetw1a_vs_wt_vs_wt.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp_repos
Phenotypew1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos
Upregulated in classago1gfp
GeneSetKEGG_ALZHEIMERS_DISEASE
Enrichment Score (ES)-0.48318732
Normalized Enrichment Score (NES)-2.0023704
Nominal p-value0.0
FDR q-value0.002756788
FWER p-Value0.007
Table: GSEA Results Summary



Fig 1: Enrichment plot: KEGG_ALZHEIMERS_DISEASE   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1COX6B2NACOX6B2
Entrez,  Source
cytochrome c oxidase subunit VIb polypeptide 2 (testis)2732.0870.0057No
2GRIN2DNAGRIN2D
Entrez,  Source
glutamate receptor, ionotropic, N-methyl D-aspartate 2D7261.306-0.0064No
3TNFRSF1ANATNFRSF1A
Entrez,  Source
tumor necrosis factor receptor superfamily, member 1A7551.2790.0049No
4IL1BNAIL1B
Entrez,  Source
interleukin 1, beta7791.2620.0162No
5ITPR3NAITPR3
Entrez,  Source
inositol 1,4,5-triphosphate receptor, type 38041.2440.0273No
6PLCB4NAPLCB4
Entrez,  Source
phospholipase C, beta 410671.0860.0236No
7TNFNATNF
Entrez,  Source
tumor necrosis factor (TNF superfamily, member 2)12101.0150.0258No
8FADDNAFADD
Entrez,  Source
Fas (TNFRSF6)-associated via death domain14020.9460.0247No
9FASNAFAS
Entrez,  Source
Fas (TNF receptor superfamily, member 6)16000.8810.0225No
10CAPN1NACAPN1
Entrez,  Source
calpain 1, (mu/I) large subunit16820.8570.0266No
11ADAM17NAADAM17
Entrez,  Source
ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme)18260.8230.0269No
12ATP5DNAATP5D
Entrez,  Source
ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit18320.8220.0348No
13CAPN2NACAPN2
Entrez,  Source
calpain 2, (m/II) large subunit20830.7690.0286No
14CASP7NACASP7
Entrez,  Source
caspase 7, apoptosis-related cysteine peptidase21310.7580.0336No
15BADNABAD
Entrez,  Source
BCL2-antagonist of cell death27640.6370.0049No
16ITPR2NAITPR2
Entrez,  Source
inositol 1,4,5-triphosphate receptor, type 227660.6370.0112No
17APH1ANAAPH1A
Entrez,  Source
anterior pharynx defective 1 homolog A (C. elegans)27750.6350.0171No
18CASP3NACASP3
Entrez,  Source
caspase 3, apoptosis-related cysteine peptidase29030.6130.0162No
19NDUFB7NANDUFB7
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa32830.5540.0006No
20PPP3CCNAPPP3CC
Entrez,  Source
protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform (calcineurin A gamma)33310.5460.0035No
21PSENENNAPSENEN
Entrez,  Source
presenilin enhancer 2 homolog (C. elegans)35810.513-0.0052No
22PPP3R2NAPPP3R2
Entrez,  Source
protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, beta isoform (calcineurin B, type II)41100.445-0.0301No
23MAPTNAMAPT
Entrez,  Source
microtubule-associated protein tau41680.439-0.0289No
24PSEN1NAPSEN1
Entrez,  Source
presenilin 1 (Alzheimer disease 3)42030.434-0.0264No
25NDUFS8NANDUFS8
Entrez,  Source
NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)45810.395-0.0434No
26MAPK3NAMAPK3
Entrez,  Source
mitogen-activated protein kinase 347700.376-0.0501No
27APBB1NAAPBB1
Entrez,  Source
amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)49430.356-0.0561No
28CDK5NACDK5
Entrez,  Source
cyclin-dependent kinase 553600.316-0.0760No
29APPNAAPP
Entrez,  Source
amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease)55770.297-0.0850No
30CASP8NACASP8
Entrez,  Source
caspase 8, apoptosis-related cysteine peptidase56770.288-0.0876No
31COX7A1NACOX7A1
Entrez,  Source
cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)56810.288-0.0849No
32ERN1NAERN1
Entrez,  Source
endoplasmic reticulum to nucleus signalling 157170.285-0.0840No
33NDUFV3NANDUFV3
Entrez,  Source
NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa57510.282-0.0830No
34NOS1NANOS1
Entrez,  Source
nitric oxide synthase 1 (neuronal)58840.271-0.0877No
35NDUFB10NANDUFB10
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa59510.266-0.0887No
36ADAM10NAADAM10
Entrez,  Source
ADAM metallopeptidase domain 1062340.242-0.1019No
37NDUFS7NANDUFS7
Entrez,  Source
NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase)62790.238-0.1020No
38PSEN2NAPSEN2
Entrez,  Source
presenilin 2 (Alzheimer disease 4)64780.223-0.1107No
39NCSTNNANCSTN
Entrez,  Source
nicastrin65140.220-0.1105No
40CDK5R1NACDK5R1
Entrez,  Source
cyclin-dependent kinase 5, regulatory subunit 1 (p35)70140.179-0.1364No
41PPP3R1NAPPP3R1
Entrez,  Source
protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I)72440.164-0.1475No
42NAE1NA73640.155-0.1525No
43UQCR11NA75110.144-0.1592No
44GRIN1NAGRIN1
Entrez,  Source
glutamate receptor, ionotropic, N-methyl D-aspartate 178340.120-0.1759No
45APAF1NAAPAF1
Entrez,  Source
apoptotic peptidase activating factor79270.113-0.1798No
46CACNA1CNACACNA1C
Entrez,  Source
calcium channel, voltage-dependent, L type, alpha 1C subunit82160.092-0.1949No
47ATP2A2NAATP2A2
Entrez,  Source
ATPase, Ca++ transporting, cardiac muscle, slow twitch 286610.060-0.2189No
48ATF6NAATF6
Entrez,  Source
activating transcription factor 688390.048-0.2283No
49IDENAIDE
Entrez,  Source
insulin-degrading enzyme90510.031-0.2397No
50APOENAAPOE
Entrez,  Source
apolipoprotein E91960.021-0.2475No
51COX8CNACOX8C
Entrez,  Source
cytochrome c oxidase subunit 8C94780.003-0.2630No
52COX4I2NACOX4I2
Entrez,  Source
cytochrome c oxidase subunit IV isoform 2 (lung)96260.000-0.2712No
53NDUFS6NANDUFS6
Entrez,  Source
NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase)9787-0.005-0.2800No
54HSD17B10NA10055-0.023-0.2946No
55GAPDHNAGAPDH
Entrez,  Source
glyceraldehyde-3-phosphate dehydrogenase10205-0.031-0.3026No
56CALM1NACALM1
Entrez,  Source
calmodulin 1 (phosphorylase kinase, delta)10458-0.045-0.3161No
57CALM3NACALM3
Entrez,  Source
calmodulin 3 (phosphorylase kinase, delta)10866-0.069-0.3380No
58CALML5NACALML5
Entrez,  Source
calmodulin-like 511385-0.104-0.3657No
59BIDNABID
Entrez,  Source
BH3 interacting domain death agonist11556-0.119-0.3740No
60NDUFB9NANDUFB9
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa11657-0.128-0.3783No
61PLCB2NAPLCB2
Entrez,  Source
phospholipase C, beta 211908-0.148-0.3907No
62CACNA1SNACACNA1S
Entrez,  Source
calcium channel, voltage-dependent, L type, alpha 1S subunit12552-0.206-0.4243No
63NDUFV2NANDUFV2
Entrez,  Source
NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa12646-0.214-0.4273No
64CYC1NACYC1
Entrez,  Source
cytochrome c-112899-0.235-0.4390No
65PLCB3NAPLCB3
Entrez,  Source
phospholipase C, beta 3 (phosphatidylinositol-specific)12969-0.242-0.4404No
66NDUFB2NANDUFB2
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa13224-0.265-0.4518No
67COX7A2LNACOX7A2L
Entrez,  Source
cytochrome c oxidase subunit VIIa polypeptide 2 like13373-0.279-0.4572No
68RYR3NARYR3
Entrez,  Source
ryanodine receptor 313478-0.290-0.4601No
69SDHCNASDHC
Entrez,  Source
succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa13605-0.301-0.4641No
70GRIN2CNAGRIN2C
Entrez,  Source
glutamate receptor, ionotropic, N-methyl D-aspartate 2C13660-0.308-0.4640No
71CYCSNACYCS
Entrez,  Source
cytochrome c, somatic13663-0.308-0.4611No
72ATP5G2NAATP5G2
Entrez,  Source
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C2 (subunit 9)13780-0.318-0.4643No
73NDUFA6NANDUFA6
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa13931-0.335-0.4693No
74ATP5HNAATP5H
Entrez,  Source
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d13940-0.337-0.4664No
75COX7B2NACOX7B2
Entrez,  Source
cytochrome c oxidase subunit VIIb213956-0.340-0.4638No
76UQCRC1NAUQCRC1
Entrez,  Source
ubiquinol-cytochrome c reductase core protein I14122-0.360-0.4694No
77CACNA1FNACACNA1F
Entrez,  Source
calcium channel, voltage-dependent, alpha 1F subunit14354-0.386-0.4784No
78COX6A1NACOX6A1
Entrez,  Source
cytochrome c oxidase subunit VIa polypeptide 114365-0.387-0.4750No
79NDUFA8NANDUFA8
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa14368-0.388-0.4713No
80COX5ANACOX5A
Entrez,  Source
cytochrome c oxidase subunit Va14438-0.397-0.4711No
81PPP3CANAPPP3CA
Entrez,  Source
protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform (calcineurin A alpha)14469-0.401-0.4688No
82NDUFS4NANDUFS4
Entrez,  Source
NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)14729-0.433-0.4789Yes
83MAPK1NAMAPK1
Entrez,  Source
mitogen-activated protein kinase 114765-0.439-0.4764Yes
84UQCRQNAUQCRQ
Entrez,  Source
ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa14817-0.449-0.4748Yes
85CALM2NACALM2
Entrez,  Source
calmodulin 2 (phosphorylase kinase, delta)14904-0.462-0.4749Yes
86NDUFV1NANDUFV1
Entrez,  Source
NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa14914-0.463-0.4708Yes
87SDHANASDHA
Entrez,  Source
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)14927-0.465-0.4668Yes
88NDUFS3NANDUFS3
Entrez,  Source
NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase)15047-0.482-0.4686Yes
89CALML6NACALML6
Entrez,  Source
calmodulin-like 615119-0.491-0.4676Yes
90NDUFS2NANDUFS2
Entrez,  Source
NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)15173-0.499-0.4656Yes
91UQCRFS1NAUQCRFS1
Entrez,  Source
ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 115206-0.503-0.4624Yes
92ATP5ONAATP5O
Entrez,  Source
ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit (oligomycin sensitivity conferring protein)15213-0.505-0.4577Yes
93NDUFA3NANDUFA3
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa15224-0.505-0.4532Yes
94ATP5G3NAATP5G3
Entrez,  Source
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9)15229-0.506-0.4483Yes
95GRIN2ANAGRIN2A
Entrez,  Source
glutamate receptor, ionotropic, N-methyl D-aspartate 2A15241-0.508-0.4439Yes
96ATP5G1NAATP5G1
Entrez,  Source
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C1 (subunit 9)15261-0.511-0.4398Yes
97COX4I1NACOX4I1
Entrez,  Source
cytochrome c oxidase subunit IV isoform 115269-0.512-0.4351Yes
98ATP5C1NAATP5C1
Entrez,  Source
ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 115544-0.560-0.4447Yes
99NDUFA10NANDUFA10
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa15560-0.563-0.4399Yes
100ATP5JNAATP5J
Entrez,  Source
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F615585-0.568-0.4356Yes
101NDUFAB1NANDUFAB1
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa15592-0.569-0.4302Yes
102SDHBNASDHB
Entrez,  Source
succinate dehydrogenase complex, subunit B, iron sulfur (Ip)15593-0.569-0.4245Yes
103GRIN2BNAGRIN2B
Entrez,  Source
glutamate receptor, ionotropic, N-methyl D-aspartate 2B15610-0.573-0.4197Yes
104GSK3BNAGSK3B
Entrez,  Source
glycogen synthase kinase 3 beta15693-0.588-0.4184Yes
105NDUFA7NANDUFA7
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa15694-0.588-0.4125Yes
106NDUFB6NANDUFB6
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa15771-0.603-0.4107Yes
107NDUFB8NANDUFB8
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa15852-0.621-0.4089Yes
108COX8ANACOX8A
Entrez,  Source
cytochrome c oxidase subunit 8A (ubiquitous)15949-0.642-0.4078Yes
109COX5BNACOX5B
Entrez,  Source
cytochrome c oxidase subunit Vb15956-0.644-0.4018Yes
110EIF2AK3NAEIF2AK3
Entrez,  Source
eukaryotic translation initiation factor 2-alpha kinase 315965-0.647-0.3957Yes
111NDUFC2NANDUFC2
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa16000-0.656-0.3911Yes
112UQCRHLNA16025-0.661-0.3858Yes
113COX6B1NACOX6B1
Entrez,  Source
cytochrome c oxidase subunit Vib polypeptide 1 (ubiquitous)16035-0.665-0.3797Yes
114BACE1NABACE1
Entrez,  Source
beta-site APP-cleaving enzyme 116092-0.679-0.3760Yes
115NDUFB4NANDUFB4
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa16185-0.702-0.3741Yes
116CHP2NA16192-0.704-0.3674Yes
117NDUFA1NANDUFA1
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa16223-0.711-0.3619Yes
118NDUFA9NANDUFA9
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa16239-0.717-0.3556Yes
119ATP2A3NAATP2A3
Entrez,  Source
ATPase, Ca++ transporting, ubiquitous16345-0.747-0.3540Yes
120PPP3CBNAPPP3CB
Entrez,  Source
protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform (calcineurin A beta)16406-0.766-0.3497Yes
121NDUFS1NANDUFS1
Entrez,  Source
NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)16420-0.771-0.3427Yes
122UQCR10NA16475-0.787-0.3378Yes
123NDUFS5NANDUFS5
Entrez,  Source
NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase)16478-0.790-0.3300Yes
124NDUFA2NANDUFA2
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa16488-0.793-0.3226Yes
125GNAQNAGNAQ
Entrez,  Source
guanine nucleotide binding protein (G protein), q polypeptide16547-0.811-0.3177Yes
126COX7A2NACOX7A2
Entrez,  Source
cytochrome c oxidase subunit VIIa polypeptide 2 (liver)16640-0.835-0.3145Yes
127NDUFC1NANDUFC1
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa16657-0.841-0.3070Yes
128NDUFA4NANDUFA4
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa16700-0.853-0.3008Yes
129UQCRHNAUQCRH
Entrez,  Source
ubiquinol-cytochrome c reductase hinge protein16759-0.873-0.2953Yes
130SDHDNASDHD
Entrez,  Source
succinate dehydrogenase complex, subunit D, integral membrane protein16792-0.886-0.2882Yes
131LRP1NALRP1
Entrez,  Source
low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)16858-0.907-0.2828Yes
132COX6CNACOX6C
Entrez,  Source
cytochrome c oxidase subunit VIc16973-0.957-0.2795Yes
133ATP5A1NAATP5A1
Entrez,  Source
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle17098-1.012-0.2763Yes
134NDUFB5NANDUFB5
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa17105-1.017-0.2665Yes
135ATP5BNAATP5B
Entrez,  Source
ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide17107-1.018-0.2564Yes
136ATP5F1NAATP5F1
Entrez,  Source
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B117165-1.039-0.2492Yes
137COX7BNACOX7B
Entrez,  Source
cytochrome c oxidase subunit VIIb17181-1.049-0.2395Yes
138BACE2NABACE2
Entrez,  Source
beta-site APP-cleaving enzyme 217214-1.067-0.2306Yes
139NDUFB3NANDUFB3
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa17222-1.073-0.2203Yes
140NDUFB1NANDUFB1
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa17262-1.097-0.2115Yes
141UQCRBNAUQCRB
Entrez,  Source
ubiquinol-cytochrome c reductase binding protein17309-1.123-0.2028Yes
142ATP2A1NAATP2A1
Entrez,  Source
ATPase, Ca++ transporting, cardiac muscle, fast twitch 117421-1.201-0.1970Yes
143COX7CNACOX7C
Entrez,  Source
cytochrome c oxidase subunit VIIc17459-1.227-0.1868Yes
144UQCRC2NAUQCRC2
Entrez,  Source
ubiquinol-cytochrome c reductase core protein II17465-1.232-0.1748Yes
145NDUFA5NANDUFA5
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5, 13kDa17656-1.422-0.1711Yes
146CASP9NACASP9
Entrez,  Source
caspase 9, apoptosis-related cysteine peptidase17671-1.437-0.1575Yes
147CACNA1DNACACNA1D
Entrez,  Source
calcium channel, voltage-dependent, L type, alpha 1D subunit17718-1.492-0.1452Yes
148NDUFA4L2NANDUFA4L2
Entrez,  Source
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 217899-1.860-0.1366Yes
149ITPR1NAITPR1
Entrez,  Source
inositol 1,4,5-triphosphate receptor, type 117960-2.065-0.1193Yes
150SNCANASNCA
Entrez,  Source
synuclein, alpha (non A4 component of amyloid precursor)18027-2.421-0.0988Yes
151MMENAMME
Entrez,  Source
membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase)18035-2.458-0.0746Yes
152PLCB1NAPLCB1
Entrez,  Source
phospholipase C, beta 1 (phosphoinositide-specific)18128-3.450-0.0453Yes
153LPLNALPL
Entrez,  Source
lipoprotein lipase18162-4.7450.0003Yes
Table: GSEA details [plain text format]



Fig 2: KEGG_ALZHEIMERS_DISEASE   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: KEGG_ALZHEIMERS_DISEASE: Random ES distribution   
Gene set null distribution of ES for KEGG_ALZHEIMERS_DISEASE