Datasetw1a_vs_wt_vs_wt.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp_repos
Phenotypew1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos
Upregulated in classago1w1a
GeneSetHALLMARK_UV_RESPONSE_UP
Enrichment Score (ES)0.3427962
Normalized Enrichment Score (NES)1.3126309
Nominal p-value0.04347826
FDR q-value0.10309174
FWER p-Value0.821
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_UV_RESPONSE_UP   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1IL6NAIL6
Entrez,  Source
interleukin 6 (interferon, beta 2)174.5960.0493Yes
2IRF1NAIRF1
Entrez,  Source
interferon regulatory factor 11123.0670.0777Yes
3CXCL2NACXCL2
Entrez,  Source
chemokine (C-X-C motif) ligand 21932.4230.0997Yes
4SOD2NASOD2
Entrez,  Source
superoxide dismutase 2, mitochondrial2632.1240.1191Yes
5TAP1NATAP1
Entrez,  Source
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)3151.9210.1373Yes
6JUNBNAJUNB
Entrez,  Source
jun B proto-oncogene4261.6630.1494Yes
7ICAM1NAICAM1
Entrez,  Source
intercellular adhesion molecule 1 (CD54), human rhinovirus receptor4531.6000.1655Yes
8NFKBIANANFKBIA
Entrez,  Source
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha4601.5950.1826Yes
9MGAT1NAMGAT1
Entrez,  Source
mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase6341.3860.1881Yes
10NAT1NANAT1
Entrez,  Source
N-acetyltransferase 1 (arylamine N-acetyltransferase)6681.3520.2011Yes
11GPX3NAGPX3
Entrez,  Source
glutathione peroxidase 3 (plasma)6881.3320.2146Yes
12MAPK8IP2NAMAPK8IP2
Entrez,  Source
mitogen-activated protein kinase 8 interacting protein 27281.3050.2267Yes
13SQSTM1NASQSTM1
Entrez,  Source
sequestosome 17871.2570.2372Yes
14ASNSNAASNS
Entrez,  Source
asparagine synthetase8271.2250.2485Yes
15SLC6A12NASLC6A12
Entrez,  Source
solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 129161.1620.2563Yes
16IL6STNAIL6ST
Entrez,  Source
interleukin 6 signal transducer (gp130, oncostatin M receptor)10011.1180.2639Yes
17GLSNAGLS
Entrez,  Source
glutaminase10901.0720.2707Yes
18CYB5R1NACYB5R1
Entrez,  Source
cytochrome b5 reductase 112670.9930.2718Yes
19CLTBNACLTB
Entrez,  Source
clathrin, light chain (Lcb)13090.9800.2802Yes
20CCND3NACCND3
Entrez,  Source
cyclin D313470.9640.2887Yes
21APOMNAAPOM
Entrez,  Source
apolipoprotein M16660.8610.2805Yes
22DNAJB1NADNAJB1
Entrez,  Source
DnaJ (Hsp40) homolog, subfamily B, member 117740.8340.2837Yes
23PPIFNAPPIF
Entrez,  Source
peptidylprolyl isomerase F (cyclophilin F)18360.8210.2893Yes
24TACR3NATACR3
Entrez,  Source
tachykinin receptor 319480.7990.2919Yes
25WIZNAWIZ
Entrez,  Source
-19640.7950.2997Yes
26GCH1NAGCH1
Entrez,  Source
GTP cyclohydrolase 1 (dopa-responsive dystonia)19760.7920.3078Yes
27DNAJA1NADNAJA1
Entrez,  Source
DnaJ (Hsp40) homolog, subfamily A, member 122150.7410.3027Yes
28ALAS1NAALAS1
Entrez,  Source
aminolevulinate, delta-, synthase 122880.7270.3066Yes
29BAK1NABAK1
Entrez,  Source
BCL2-antagonist/killer 123660.7090.3101Yes
30MARK2NAMARK2
Entrez,  Source
MAP/microtubule affinity-regulating kinase 223670.7080.3178Yes
31GRINANAGRINA
Entrez,  Source
glutamate receptor, ionotropic, N-methyl D-asparate-associated protein 1 (glutamate binding)25910.6670.3128Yes
32RPN1NARPN1
Entrez,  Source
ribophorin I27100.6480.3133Yes
33CDC34NACDC34
Entrez,  Source
cell division cycle 3428340.6260.3133Yes
34H2AFXNAH2AFX
Entrez,  Source
H2A histone family, member X28490.6230.3194Yes
35BCL2L11NABCL2L11
Entrez,  Source
BCL2-like 11 (apoptosis facilitator)28800.6170.3244Yes
36BSGNABSG
Entrez,  Source
basigin (Ok blood group)28870.6160.3309Yes
37CASP3NACASP3
Entrez,  Source
caspase 3, apoptosis-related cysteine peptidase29030.6130.3367Yes
38HSPA13NA29150.6110.3428Yes
39MSX1NAMSX1
Entrez,  Source
msh homeobox homolog 1 (Drosophila)33510.5430.3246No
40NR4A1NANR4A1
Entrez,  Source
nuclear receptor subfamily 4, group A, member 134150.5340.3269No
41PRPF3NAPRPF3
Entrez,  Source
PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae)34860.5240.3288No
42STARD3NASTARD3
Entrez,  Source
START domain containing 335480.5160.3310No
43CNPNACNP
Entrez,  Source
2',3'-cyclic nucleotide 3' phosphodiesterase35520.5160.3365No
44ALDOANAALDOA
Entrez,  Source
aldolase A, fructose-bisphosphate36790.4990.3350No
45PSMC3NAPSMC3
Entrez,  Source
proteasome (prosome, macropain) 26S subunit, ATPase, 338110.4840.3330No
46TUBA4ANA41230.4430.3206No
47COL2A1NACOL2A1
Entrez,  Source
collagen, type II, alpha 1 (primary osteoarthritis, spondyloepiphyseal dysplasia, congenital)41750.4380.3225No
48NXF1NANXF1
Entrez,  Source
nuclear RNA export factor 141770.4380.3273No
49LYNNALYN
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog42440.4280.3283No
50FKBP4NAFKBP4
Entrez,  Source
FK506 binding protein 4, 59kDa42850.4240.3307No
51HYAL2NAHYAL2
Entrez,  Source
hyaluronoglucosaminidase 242880.4230.3352No
52EIF5NAEIF5
Entrez,  Source
eukaryotic translation initiation factor 543170.4200.3383No
53DDX21NADDX21
Entrez,  Source
DEAD (Asp-Glu-Ala-Asp) box polypeptide 2144730.4030.3341No
54SHOX2NASHOX2
Entrez,  Source
short stature homeobox 248930.3630.3148No
55HMOX1NAHMOX1
Entrez,  Source
heme oxygenase (decycling) 151180.3400.3061No
56FEN1NAFEN1
Entrez,  Source
flap structure-specific endonuclease 151640.3350.3072No
57C4BPBNAC4BPB
Entrez,  Source
complement component 4 binding protein, beta54080.3120.2972No
58CDKN2BNACDKN2B
Entrez,  Source
cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)55380.3000.2933No
59MRPL23NAMRPL23
Entrez,  Source
mitochondrial ribosomal protein L2357380.2840.2853No
60RRADNARRAD
Entrez,  Source
Ras-related associated with diabetes57500.2820.2878No
61CHRNA5NACHRNA5
Entrez,  Source
cholinergic receptor, nicotinic, alpha 559040.2690.2823No
62POLE3NAPOLE3
Entrez,  Source
polymerase (DNA directed), epsilon 3 (p17 subunit)65120.2200.2510No
63MAOANAMAOA
Entrez,  Source
monoamine oxidase A65500.2150.2513No
64CLCN2NACLCN2
Entrez,  Source
chloride channel 266460.2070.2483No
65CCNE1NACCNE1
Entrez,  Source
cyclin E167720.1980.2435No
66PDAP1NAPDAP1
Entrez,  Source
PDGFA associated protein 168970.1880.2387No
67EPCAMNA69730.1820.2365No
68CCKNACCK
Entrez,  Source
cholecystokinin70770.1750.2327No
69CYB5BNACYB5B
Entrez,  Source
cytochrome b5 type B (outer mitochondrial membrane)71640.1690.2298No
70STIP1NASTIP1
Entrez,  Source
stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing protein)72170.1660.2287No
71PLCL1NAPLCL1
Entrez,  Source
phospholipase C-like 175410.1410.2123No
72YKT6NAYKT6
Entrez,  Source
YKT6 v-SNARE homolog (S. cerevisiae)75850.1370.2114No
73PARP2NAPARP2
Entrez,  Source
poly (ADP-ribose) polymerase family, member 278560.1180.1977No
74EIF2S3NAEIF2S3
Entrez,  Source
eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa81010.0990.1853No
75EPHX1NAEPHX1
Entrez,  Source
epoxide hydrolase 1, microsomal (xenobiotic)82260.0910.1794No
76TGFBRAP1NATGFBRAP1
Entrez,  Source
transforming growth factor, beta receptor associated protein 183220.0840.1750No
77AMD1NAAMD1
Entrez,  Source
adenosylmethionine decarboxylase 184360.0760.1696No
78TMBIM6NA85390.0690.1647No
79ACAA1NAACAA1
Entrez,  Source
acetyl-Coenzyme A acyltransferase 1 (peroxisomal 3-oxoacyl-Coenzyme A thiolase)86170.0640.1611No
80HLA-FNAHLA-F
Entrez,  Source
major histocompatibility complex, class I, F87100.0570.1566No
81IGFBP2NAIGFBP2
Entrez,  Source
insulin-like growth factor binding protein 2, 36kDa87130.0570.1571No
82PRKCDNAPRKCD
Entrez,  Source
protein kinase C, delta89170.0420.1463No
83ENO2NAENO2
Entrez,  Source
enolase 2 (gamma, neuronal)89990.0350.1422No
84AP2S1NAAP2S1
Entrez,  Source
adaptor-related protein complex 2, sigma 1 subunit90380.0320.1405No
85HNRNPUNA91490.0240.1346No
86FOSBNAFOSB
Entrez,  Source
FBJ murine osteosarcoma viral oncogene homolog B92410.0180.1297No
87SPRNASPR
Entrez,  Source
sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)92850.0150.1275No
88ATP6V1FNAATP6V1F
Entrez,  Source
ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F92930.0150.1273No
89NTRK3NANTRK3
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 394080.0070.1210No
90NPTX2NANPTX2
Entrez,  Source
neuronal pentraxin II94450.0040.1191No
91LHX2NALHX2
Entrez,  Source
LIM homeobox 294640.0030.1181No
92CA2NACA2
Entrez,  Source
carbonic anhydrase II95100.0000.1156No
93RFC4NARFC4
Entrez,  Source
replication factor C (activator 1) 4, 37kDa9957-0.0170.0911No
94ATP6V1C1NAATP6V1C1
Entrez,  Source
ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C110089-0.0250.0841No
95PDLIM3NAPDLIM3
Entrez,  Source
PDZ and LIM domain 310224-0.0330.0770No
96MMP14NAMMP14
Entrez,  Source
matrix metallopeptidase 14 (membrane-inserted)10281-0.0370.0743No
97TARSNATARS
Entrez,  Source
threonyl-tRNA synthetase10452-0.0450.0653No
98URODNAUROD
Entrez,  Source
uroporphyrinogen decarboxylase10572-0.0520.0593No
99HTR7NAHTR7
Entrez,  Source
5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)10592-0.0540.0588No
100RETNARET
Entrez,  Source
ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)10661-0.0590.0557No
101GRPEL1NAGRPEL1
Entrez,  Source
GrpE-like 1, mitochondrial (E. coli)10668-0.0590.0560No
102CDC5LNACDC5L
Entrez,  Source
CDC5 cell division cycle 5-like (S. pombe)11395-0.1050.0169No
103TSTNATST
Entrez,  Source
thiosulfate sulfurtransferase (rhodanese)11432-0.1090.0160No
104AQP3NAAQP3
Entrez,  Source
aquaporin 3 (Gill blood group)11508-0.1160.0131No
105BIDNABID
Entrez,  Source
BH3 interacting domain death agonist11556-0.1190.0118No
106POLR2HNAPOLR2H
Entrez,  Source
polymerase (RNA) II (DNA directed) polypeptide H11856-0.145-0.0032No
107CYP1A1NACYP1A1
Entrez,  Source
cytochrome P450, family 1, subfamily A, polypeptide 111891-0.147-0.0035No
108E2F5NAE2F5
Entrez,  Source
E2F transcription factor 5, p130-binding12259-0.178-0.0219No
109RHOBNARHOB
Entrez,  Source
ras homolog gene family, member B12525-0.204-0.0344No
110STK25NASTK25
Entrez,  Source
serine/threonine kinase 25 (STE20 homolog, yeast)12894-0.235-0.0522No
111CDO1NACDO1
Entrez,  Source
cysteine dioxygenase, type I12911-0.237-0.0505No
112KCNH2NAKCNH2
Entrez,  Source
potassium voltage-gated channel, subfamily H (eag-related), member 213020-0.246-0.0538No
113CHKANACHKA
Entrez,  Source
choline kinase alpha13111-0.254-0.0561No
114TCHHNATCHH
Entrez,  Source
trichohyalin13204-0.263-0.0583No
115CEBPGNACEBPG
Entrez,  Source
CCAAT/enhancer binding protein (C/EBP), gamma13472-0.290-0.0699No
116SLC25A4NASLC25A4
Entrez,  Source
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 413504-0.292-0.0685No
117BTG1NABTG1
Entrez,  Source
B-cell translocation gene 1, anti-proliferative13694-0.311-0.0756No
118PPATNAPPAT
Entrez,  Source
phosphoribosyl pyrophosphate amidotransferase13804-0.320-0.0781No
119FURINNAFURIN
Entrez,  Source
furin (paired basic amino acid cleaving enzyme)13866-0.327-0.0779No
120ABCB1NAABCB1
Entrez,  Source
ATP-binding cassette, sub-family B (MDR/TAP), member 113944-0.338-0.0785No
121RASGRP1NARASGRP1
Entrez,  Source
RAS guanyl releasing protein 1 (calcium and DAG-regulated)14367-0.387-0.0977No
122DGAT1NADGAT1
Entrez,  Source
diacylglycerol O-acyltransferase homolog 1 (mouse)14394-0.390-0.0949No
123FOSNAFOS
Entrez,  Source
v-fos FBJ murine osteosarcoma viral oncogene homolog14425-0.395-0.0922No
124GALNAGAL
Entrez,  Source
galanin14439-0.397-0.0886No
125CDK2NACDK2
Entrez,  Source
cyclin-dependent kinase 214672-0.427-0.0968No
126TYRO3NATYRO3
Entrez,  Source
TYRO3 protein tyrosine kinase14706-0.430-0.0939No
127SIGMAR1NA14713-0.431-0.0895No
128PRKACANAPRKACA
Entrez,  Source
protein kinase, cAMP-dependent, catalytic, alpha14764-0.438-0.0875No
129BTG3NABTG3
Entrez,  Source
BTG family, member 314860-0.457-0.0878No
130FGF18NAFGF18
Entrez,  Source
fibroblast growth factor 1814949-0.468-0.0876No
131POLG2NAPOLG2
Entrez,  Source
polymerase (DNA directed), gamma 2, accessory subunit15007-0.476-0.0855No
132SULT1A1NASULT1A1
Entrez,  Source
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 115215-0.505-0.0915No
133NPTXRNANPTXR
Entrez,  Source
neuronal pentraxin receptor15308-0.517-0.0909No
134NKX2-5NANKX2-5
Entrez,  Source
NK2 transcription factor related, locus 5 (Drosophila)15443-0.541-0.0925No
135DLG4NADLG4
Entrez,  Source
discs, large homolog 4 (Drosophila)15451-0.543-0.0869No
136ARRB2NAARRB2
Entrez,  Source
arrestin, beta 215472-0.546-0.0820No
137RXRBNARXRB
Entrez,  Source
retinoid X receptor, beta15636-0.578-0.0848No
138CREG1NACREG1
Entrez,  Source
cellular repressor of E1A-stimulated genes 115755-0.599-0.0848No
139KLHDC3NAKLHDC3
Entrez,  Source
kelch domain containing 315981-0.652-0.0901No
140ONECUT1NAONECUT1
Entrez,  Source
one cut domain, family member 116126-0.687-0.0906No
141PPT1NAPPT1
Entrez,  Source
palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile)16196-0.705-0.0867No
142SLC6A8NASLC6A8
Entrez,  Source
solute carrier family 6 (neurotransmitter transporter, creatine), member 816278-0.728-0.0833No
143BMP2NABMP2
Entrez,  Source
bone morphogenetic protein 216401-0.765-0.0817No
144RAB27ANARAB27A
Entrez,  Source
RAB27A, member RAS oncogene family16433-0.774-0.0749No
145PTPRDNAPTPRD
Entrez,  Source
protein tyrosine phosphatase, receptor type, D16562-0.815-0.0731No
146PPP1R2NAPPP1R2
Entrez,  Source
protein phosphatase 1, regulatory (inhibitor) subunit 216736-0.868-0.0732No
147GGHNAGGH
Entrez,  Source
gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)16840-0.902-0.0691No
148FMO1NAFMO1
Entrez,  Source
flavin containing monooxygenase 117142-1.029-0.0745No
149TFRCNATFRC
Entrez,  Source
transferrin receptor (p90, CD71)17504-1.261-0.0808No
150CDKN1CNACDKN1C
Entrez,  Source
cyclin-dependent kinase inhibitor 1C (p57, Kip2)17588-1.334-0.0708No
151BTG2NABTG2
Entrez,  Source
BTG family, member 217959-2.061-0.0688No
152HSPA2NAHSPA2
Entrez,  Source
heat shock 70kDa protein 218042-2.509-0.0459No
153OLFM1NAOLFM1
Entrez,  Source
olfactomedin 118165-4.8240.0001No
Table: GSEA details [plain text format]



Fig 2: HALLMARK_UV_RESPONSE_UP   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_UV_RESPONSE_UP: Random ES distribution   
Gene set null distribution of ES for HALLMARK_UV_RESPONSE_UP