Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | HALLMARK_UV_RESPONSE_DN |
| Enrichment Score (ES) | -0.27539703 |
| Normalized Enrichment Score (NES) | -1.1133742 |
| Nominal p-value | 0.2204301 |
| FDR q-value | 0.3011888 |
| FWER p-Value | 0.993 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | CYR61 | NA | CYR61 Entrez, Source | cysteine-rich, angiogenic inducer, 61 | 171 | 2.551 | 0.0207 | No |
| 2 | SERPINE1 | NA | SERPINE1 Entrez, Source | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 290 | 2.039 | 0.0384 | No |
| 3 | F3 | NA | F3 Entrez, Source | coagulation factor III (thromboplastin, tissue factor) | 301 | 1.981 | 0.0613 | No |
| 4 | LDLR | NA | LDLR Entrez, Source | low density lipoprotein receptor (familial hypercholesterolemia) | 945 | 1.147 | 0.0392 | No |
| 5 | PLCB4 | NA | PLCB4 Entrez, Source | phospholipase C, beta 4 | 1067 | 1.086 | 0.0454 | No |
| 6 | PRKCE | NA | PRKCE Entrez, Source | protein kinase C, epsilon | 1341 | 0.965 | 0.0417 | No |
| 7 | PDLIM5 | NA | PDLIM5 Entrez, Source | PDZ and LIM domain 5 | 1485 | 0.914 | 0.0446 | No |
| 8 | PIK3CD | NA | PIK3CD Entrez, Source | phosphoinositide-3-kinase, catalytic, delta polypeptide | 1572 | 0.890 | 0.0503 | No |
| 9 | RGS4 | NA | RGS4 Entrez, Source | regulator of G-protein signalling 4 | 1577 | 0.888 | 0.0606 | No |
| 10 | HAS2 | NA | HAS2 Entrez, Source | hyaluronan synthase 2 | 1718 | 0.846 | 0.0629 | No |
| 11 | NFKB1 | NA | NFKB1 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 1767 | 0.835 | 0.0701 | No |
| 12 | NRP1 | NA | NRP1 Entrez, Source | neuropilin 1 | 1787 | 0.832 | 0.0789 | No |
| 13 | GRK5 | NA | GRK5 Entrez, Source | G protein-coupled receptor kinase 5 | 1840 | 0.820 | 0.0858 | No |
| 14 | MT1E | NA | MT1E Entrez, Source | metallothionein 1E (functional) | 1844 | 0.819 | 0.0953 | No |
| 15 | INPP4B | NA | INPP4B Entrez, Source | inositol polyphosphate-4-phosphatase, type II, 105kDa | 1989 | 0.790 | 0.0967 | No |
| 16 | RND3 | NA | RND3 Entrez, Source | Rho family GTPase 3 | 2011 | 0.785 | 0.1048 | No |
| 17 | TGFBR3 | NA | TGFBR3 Entrez, Source | transforming growth factor, beta receptor III (betaglycan, 300kDa) | 2021 | 0.784 | 0.1136 | No |
| 18 | FZD2 | NA | FZD2 Entrez, Source | frizzled homolog 2 (Drosophila) | 2027 | 0.783 | 0.1226 | No |
| 19 | TGFBR2 | NA | TGFBR2 Entrez, Source | transforming growth factor, beta receptor II (70/80kDa) | 2057 | 0.776 | 0.1302 | No |
| 20 | NEK7 | NA | NEK7 Entrez, Source | NIMA (never in mitosis gene a)-related kinase 7 | 2058 | 0.775 | 0.1394 | No |
| 21 | NR3C1 | NA | NR3C1 Entrez, Source | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 2235 | 0.736 | 0.1383 | No |
| 22 | ANXA2 | NA | ANXA2 Entrez, Source | annexin A2 | 2236 | 0.736 | 0.1471 | No |
| 23 | ZMIZ1 | NA | 2242 | 0.736 | 0.1555 | No | ||
| 24 | APBB2 | NA | APBB2 Entrez, Source | amyloid beta (A4) precursor protein-binding, family B, member 2 (Fe65-like) | 2319 | 0.720 | 0.1598 | No |
| 25 | RUNX1 | NA | RUNX1 Entrez, Source | runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene) | 2323 | 0.718 | 0.1682 | No |
| 26 | VAV2 | NA | VAV2 Entrez, Source | vav 2 oncogene | 2382 | 0.706 | 0.1733 | No |
| 27 | RXRA | NA | RXRA Entrez, Source | retinoid X receptor, alpha | 2835 | 0.626 | 0.1557 | No |
| 28 | SCAF8 | NA | 2876 | 0.619 | 0.1608 | No | ||
| 29 | SDC2 | NA | SDC2 Entrez, Source | syndecan 2 (heparan sulfate proteoglycan 1, cell surface-associated, fibroglycan) | 2885 | 0.617 | 0.1676 | No |
| 30 | ATP2B1 | NA | ATP2B1 Entrez, Source | ATPase, Ca++ transporting, plasma membrane 1 | 2896 | 0.614 | 0.1744 | No |
| 31 | MAP1B | NA | MAP1B Entrez, Source | microtubule-associated protein 1B | 2961 | 0.602 | 0.1779 | No |
| 32 | BHLHE40 | NA | 2973 | 0.601 | 0.1845 | No | ||
| 33 | SLC7A1 | NA | SLC7A1 Entrez, Source | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | 3487 | 0.524 | 0.1622 | No |
| 34 | CELF2 | NA | 3647 | 0.505 | 0.1594 | No | ||
| 35 | ERBB2 | NA | ERBB2 Entrez, Source | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) | 3754 | 0.491 | 0.1593 | No |
| 36 | CITED2 | NA | CITED2 Entrez, Source | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 3858 | 0.480 | 0.1593 | No |
| 37 | DYRK1A | NA | DYRK1A Entrez, Source | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 4051 | 0.455 | 0.1540 | No |
| 38 | CDK13 | NA | 4098 | 0.447 | 0.1568 | No | ||
| 39 | SPOP | NA | SPOP Entrez, Source | speckle-type POZ protein | 4179 | 0.437 | 0.1575 | No |
| 40 | KIT | NA | KIT Entrez, Source | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | 4261 | 0.427 | 0.1581 | No |
| 41 | PPARG | NA | PPARG Entrez, Source | peroxisome proliferative activated receptor, gamma | 4428 | 0.408 | 0.1537 | No |
| 42 | NR1D2 | NA | NR1D2 Entrez, Source | nuclear receptor subfamily 1, group D, member 2 | 4477 | 0.403 | 0.1558 | No |
| 43 | PTPN21 | NA | PTPN21 Entrez, Source | protein tyrosine phosphatase, non-receptor type 21 | 4479 | 0.402 | 0.1605 | No |
| 44 | AMPH | NA | AMPH Entrez, Source | amphiphysin (Stiff-Man syndrome with breast cancer 128kDa autoantigen) | 4505 | 0.400 | 0.1639 | No |
| 45 | BMPR1A | NA | BMPR1A Entrez, Source | bone morphogenetic protein receptor, type IA | 4588 | 0.394 | 0.1640 | No |
| 46 | IRS1 | NA | IRS1 Entrez, Source | insulin receptor substrate 1 | 4599 | 0.393 | 0.1681 | No |
| 47 | ADORA2B | NA | ADORA2B Entrez, Source | adenosine A2b receptor | 4707 | 0.382 | 0.1667 | No |
| 48 | ABCC1 | NA | ABCC1 Entrez, Source | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | 4778 | 0.374 | 0.1672 | No |
| 49 | DDAH1 | NA | DDAH1 Entrez, Source | dimethylarginine dimethylaminohydrolase 1 | 4803 | 0.372 | 0.1703 | No |
| 50 | PEX14 | NA | PEX14 Entrez, Source | peroxisomal biogenesis factor 14 | 4816 | 0.371 | 0.1741 | No |
| 51 | MRPS31 | NA | MRPS31 Entrez, Source | mitochondrial ribosomal protein S31 | 4885 | 0.364 | 0.1746 | No |
| 52 | MAGI2 | NA | MAGI2 Entrez, Source | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 5081 | 0.343 | 0.1678 | No |
| 53 | PIK3R3 | NA | PIK3R3 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma) | 5162 | 0.335 | 0.1674 | No |
| 54 | CAP2 | NA | CAP2 Entrez, Source | CAP, adenylate cyclase-associated protein, 2 (yeast) | 5319 | 0.321 | 0.1625 | No |
| 55 | RASA2 | NA | RASA2 Entrez, Source | RAS p21 protein activator 2 | 5333 | 0.319 | 0.1656 | No |
| 56 | LAMC1 | NA | LAMC1 Entrez, Source | laminin, gamma 1 (formerly LAMB2) | 5595 | 0.296 | 0.1546 | No |
| 57 | COL1A2 | NA | COL1A2 Entrez, Source | collagen, type I, alpha 2 | 5608 | 0.295 | 0.1575 | No |
| 58 | SYNJ2 | NA | SYNJ2 Entrez, Source | synaptojanin 2 | 5766 | 0.281 | 0.1521 | No |
| 59 | MGMT | NA | MGMT Entrez, Source | O-6-methylguanine-DNA methyltransferase | 6410 | 0.228 | 0.1191 | No |
| 60 | PTPRM | NA | PTPRM Entrez, Source | protein tyrosine phosphatase, receptor type, M | 6455 | 0.225 | 0.1193 | No |
| 61 | ID1 | NA | ID1 Entrez, Source | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | 6530 | 0.218 | 0.1178 | No |
| 62 | CACNA1A | NA | CACNA1A Entrez, Source | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | 6755 | 0.199 | 0.1077 | No |
| 63 | MIOS | NA | 6873 | 0.190 | 0.1035 | No | ||
| 64 | TJP1 | NA | TJP1 Entrez, Source | tight junction protein 1 (zona occludens 1) | 6982 | 0.181 | 0.0997 | No |
| 65 | ACVR2A | NA | ACVR2A Entrez, Source | activin A receptor, type IIA | 7365 | 0.155 | 0.0803 | No |
| 66 | NIPBL | NA | NIPBL Entrez, Source | Nipped-B homolog (Drosophila) | 7454 | 0.147 | 0.0772 | No |
| 67 | PIAS3 | NA | PIAS3 Entrez, Source | protein inhibitor of activated STAT, 3 | 7532 | 0.142 | 0.0746 | No |
| 68 | MAP2K5 | NA | MAP2K5 Entrez, Source | mitogen-activated protein kinase kinase 5 | 7548 | 0.141 | 0.0754 | No |
| 69 | PRDM2 | NA | PRDM2 Entrez, Source | PR domain containing 2, with ZNF domain | 7884 | 0.116 | 0.0582 | No |
| 70 | SYNE1 | NA | SYNE1 Entrez, Source | spectrin repeat containing, nuclear envelope 1 | 8428 | 0.077 | 0.0290 | No |
| 71 | NOTCH2 | NA | NOTCH2 Entrez, Source | Notch homolog 2 (Drosophila) | 8565 | 0.067 | 0.0223 | No |
| 72 | ATP2C1 | NA | ATP2C1 Entrez, Source | ATPase, Ca++ transporting, type 2C, member 1 | 8578 | 0.066 | 0.0224 | No |
| 73 | KCNMA1 | NA | KCNMA1 Entrez, Source | potassium large conductance calcium-activated channel, subfamily M, alpha member 1 | 8580 | 0.066 | 0.0231 | No |
| 74 | PAPD7 | NA | 8629 | 0.062 | 0.0212 | No | ||
| 75 | CDC42BPA | NA | CDC42BPA Entrez, Source | CDC42 binding protein kinase alpha (DMPK-like) | 8681 | 0.059 | 0.0191 | No |
| 76 | BDNF | NA | BDNF Entrez, Source | brain-derived neurotrophic factor | 8706 | 0.057 | 0.0184 | No |
| 77 | YTHDC1 | NA | YTHDC1 Entrez, Source | YTH domain containing 1 | 8792 | 0.052 | 0.0143 | No |
| 78 | MAPK14 | NA | MAPK14 Entrez, Source | mitogen-activated protein kinase 14 | 8878 | 0.045 | 0.0101 | No |
| 79 | PHF3 | NA | PHF3 Entrez, Source | PHD finger protein 3 | 9226 | 0.019 | -0.0089 | No |
| 80 | ATRN | NA | ATRN Entrez, Source | attractin | 9500 | 0.001 | -0.0240 | No |
| 81 | GCNT1 | NA | GCNT1 Entrez, Source | glucosaminyl (N-acetyl) transferase 1, core 2 (beta-1,6-N-acetylglucosaminyltransferase) | 9958 | -0.017 | -0.0492 | No |
| 82 | IGF1R | NA | IGF1R Entrez, Source | insulin-like growth factor 1 receptor | 10119 | -0.027 | -0.0577 | No |
| 83 | WDR37 | NA | WDR37 Entrez, Source | WD repeat domain 37 | 10465 | -0.046 | -0.0763 | No |
| 84 | SCN8A | NA | SCN8A Entrez, Source | sodium channel, voltage gated, type VIII, alpha | 11576 | -0.121 | -0.1365 | No |
| 85 | AGGF1 | NA | AGGF1 Entrez, Source | angiogenic factor with G patch and FHA domains 1 | 12064 | -0.161 | -0.1616 | No |
| 86 | PTEN | NA | PTEN Entrez, Source | phosphatase and tensin homolog (mutated in multiple advanced cancers 1) | 12081 | -0.162 | -0.1605 | No |
| 87 | ATRX | NA | ATRX Entrez, Source | alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae) | 12122 | -0.167 | -0.1608 | No |
| 88 | SMAD7 | NA | SMAD7 Entrez, Source | SMAD, mothers against DPP homolog 7 (Drosophila) | 12163 | -0.170 | -0.1610 | No |
| 89 | MGLL | NA | MGLL Entrez, Source | monoglyceride lipase | 12767 | -0.225 | -0.1918 | No |
| 90 | FHL2 | NA | FHL2 Entrez, Source | four and a half LIM domains 2 | 12840 | -0.229 | -0.1930 | No |
| 91 | ATP2B4 | NA | ATP2B4 Entrez, Source | ATPase, Ca++ transporting, plasma membrane 4 | 12998 | -0.245 | -0.1988 | No |
| 92 | EFEMP1 | NA | EFEMP1 Entrez, Source | EGF-containing fibulin-like extracellular matrix protein 1 | 13012 | -0.246 | -0.1967 | No |
| 93 | MTA1 | NA | MTA1 Entrez, Source | metastasis associated 1 | 13086 | -0.252 | -0.1977 | No |
| 94 | ICA1 | NA | ICA1 Entrez, Source | islet cell autoantigen 1, 69kDa | 13531 | -0.294 | -0.2189 | No |
| 95 | FYN | NA | FYN Entrez, Source | FYN oncogene related to SRC, FGR, YES | 13562 | -0.297 | -0.2170 | No |
| 96 | GJA1 | NA | GJA1 Entrez, Source | gap junction protein, alpha 1, 43kDa (connexin 43) | 13672 | -0.309 | -0.2194 | No |
| 97 | SMAD3 | NA | SMAD3 Entrez, Source | SMAD, mothers against DPP homolog 3 (Drosophila) | 13718 | -0.312 | -0.2182 | No |
| 98 | RBPMS | NA | RBPMS Entrez, Source | RNA binding protein with multiple splicing | 13724 | -0.313 | -0.2148 | No |
| 99 | MYC | NA | MYC Entrez, Source | v-myc myelocytomatosis viral oncogene homolog (avian) | 13741 | -0.315 | -0.2119 | No |
| 100 | DUSP1 | NA | DUSP1 Entrez, Source | dual specificity phosphatase 1 | 13763 | -0.317 | -0.2093 | No |
| 101 | PTGFR | NA | PTGFR Entrez, Source | prostaglandin F receptor (FP) | 13977 | -0.342 | -0.2171 | No |
| 102 | CAV1 | NA | CAV1 Entrez, Source | caveolin 1, caveolae protein, 22kDa | 13996 | -0.345 | -0.2140 | No |
| 103 | PRKAR2B | NA | PRKAR2B Entrez, Source | protein kinase, cAMP-dependent, regulatory, type II, beta | 14232 | -0.370 | -0.2226 | No |
| 104 | SLC22A18 | NA | SLC22A18 Entrez, Source | solute carrier family 22 (organic cation transporter), member 18 | 14235 | -0.370 | -0.2184 | No |
| 105 | PMP22 | NA | PMP22 Entrez, Source | peripheral myelin protein 22 | 14389 | -0.389 | -0.2222 | No |
| 106 | ANXA4 | NA | ANXA4 Entrez, Source | annexin A4 | 14557 | -0.414 | -0.2266 | No |
| 107 | LPAR1 | NA | 14734 | -0.434 | -0.2312 | No | ||
| 108 | ITGB3 | NA | ITGB3 Entrez, Source | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | 14763 | -0.438 | -0.2276 | No |
| 109 | SRI | NA | SRI Entrez, Source | sorcin | 14847 | -0.455 | -0.2268 | No |
| 110 | SNAI2 | NA | SNAI2 Entrez, Source | snail homolog 2 (Drosophila) | 14951 | -0.469 | -0.2269 | No |
| 111 | KALRN | NA | KALRN Entrez, Source | kalirin, RhoGEF kinase | 15282 | -0.513 | -0.2392 | No |
| 112 | ARHGEF9 | NA | ARHGEF9 Entrez, Source | Cdc42 guanine nucleotide exchange factor (GEF) 9 | 15453 | -0.543 | -0.2422 | No |
| 113 | ATP5S | NA | ATP5S Entrez, Source | ATP synthase, H+ transporting, mitochondrial F0 complex, subunit s (factor B) | 15753 | -0.599 | -0.2516 | No |
| 114 | COL11A1 | NA | COL11A1 Entrez, Source | collagen, type XI, alpha 1 | 15884 | -0.631 | -0.2514 | No |
| 115 | IGFBP5 | NA | IGFBP5 Entrez, Source | insulin-like growth factor binding protein 5 | 16318 | -0.739 | -0.2666 | Yes |
| 116 | ADD3 | NA | ADD3 Entrez, Source | adducin 3 (gamma) | 16366 | -0.753 | -0.2603 | Yes |
| 117 | NFIB | NA | NFIB Entrez, Source | nuclear factor I/B | 16430 | -0.773 | -0.2547 | Yes |
| 118 | TFPI | NA | TFPI Entrez, Source | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 16492 | -0.795 | -0.2486 | Yes |
| 119 | DLG1 | NA | DLG1 Entrez, Source | discs, large homolog 1 (Drosophila) | 16683 | -0.848 | -0.2491 | Yes |
| 120 | FBLN5 | NA | FBLN5 Entrez, Source | fibulin 5 | 16695 | -0.852 | -0.2396 | Yes |
| 121 | CDKN1B | NA | CDKN1B Entrez, Source | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | 16862 | -0.909 | -0.2381 | Yes |
| 122 | DAB2 | NA | DAB2 Entrez, Source | disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) | 16929 | -0.939 | -0.2306 | Yes |
| 123 | DBP | NA | DBP Entrez, Source | D site of albumin promoter (albumin D-box) binding protein | 16950 | -0.946 | -0.2205 | Yes |
| 124 | SIPA1L1 | NA | SIPA1L1 Entrez, Source | signal-induced proliferation-associated 1 like 1 | 17171 | -1.045 | -0.2203 | Yes |
| 125 | MET | NA | MET Entrez, Source | met proto-oncogene (hepatocyte growth factor receptor) | 17207 | -1.062 | -0.2097 | Yes |
| 126 | CDON | NA | CDON Entrez, Source | Cdon homolog (mouse) | 17232 | -1.079 | -0.1982 | Yes |
| 127 | VLDLR | NA | VLDLR Entrez, Source | very low density lipoprotein receptor | 17333 | -1.141 | -0.1902 | Yes |
| 128 | MMP16 | NA | MMP16 Entrez, Source | matrix metallopeptidase 16 (membrane-inserted) | 17418 | -1.199 | -0.1807 | Yes |
| 129 | INSIG1 | NA | INSIG1 Entrez, Source | insulin induced gene 1 | 17447 | -1.215 | -0.1679 | Yes |
| 130 | BCKDHB | NA | BCKDHB Entrez, Source | branched chain keto acid dehydrogenase E1, beta polypeptide (maple syrup urine disease) | 17499 | -1.258 | -0.1558 | Yes |
| 131 | COL5A2 | NA | COL5A2 Entrez, Source | collagen, type V, alpha 2 | 17557 | -1.302 | -0.1435 | Yes |
| 132 | COL3A1 | NA | COL3A1 Entrez, Source | collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant) | 17611 | -1.363 | -0.1303 | Yes |
| 133 | ATXN1 | NA | ATXN1 Entrez, Source | ataxin 1 | 17686 | -1.455 | -0.1172 | Yes |
| 134 | AKT3 | NA | AKT3 Entrez, Source | v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) | 17766 | -1.559 | -0.1031 | Yes |
| 135 | COL1A1 | NA | COL1A1 Entrez, Source | collagen, type I, alpha 1 | 17830 | -1.690 | -0.0865 | Yes |
| 136 | DLC1 | NA | DLC1 Entrez, Source | deleted in liver cancer 1 | 17838 | -1.704 | -0.0667 | Yes |
| 137 | PRKCA | NA | PRKCA Entrez, Source | protein kinase C, alpha | 17892 | -1.832 | -0.0480 | Yes |
| 138 | PDGFRB | NA | PDGFRB Entrez, Source | platelet-derived growth factor receptor, beta polypeptide | 17904 | -1.866 | -0.0265 | Yes |
| 139 | LTBP1 | NA | LTBP1 Entrez, Source | latent transforming growth factor beta binding protein 1 | 18129 | -3.461 | 0.0021 | Yes |
