Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1w1a |
| GeneSet | HALLMARK_UNFOLDED_PROTEIN_RESPONSE |
| Enrichment Score (ES) | 0.44004056 |
| Normalized Enrichment Score (NES) | 1.6178124 |
| Nominal p-value | 0.0015748031 |
| FDR q-value | 0.007041268 |
| FWER p-Value | 0.069 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | IFIT1 | NA | IFIT1 Entrez, Source | interferon-induced protein with tetratricopeptide repeats 1 | 38 | 4.327 | 0.0783 | Yes |
| 2 | HSP90B1 | NA | HSP90B1 Entrez, Source | heat shock protein 90kDa beta (Grp94), member 1 | 196 | 2.412 | 0.1145 | Yes |
| 3 | HYOU1 | NA | HYOU1 Entrez, Source | hypoxia up-regulated 1 | 316 | 1.919 | 0.1435 | Yes |
| 4 | CCL2 | NA | CCL2 Entrez, Source | chemokine (C-C motif) ligand 2 | 493 | 1.546 | 0.1626 | Yes |
| 5 | TUBB2A | NA | TUBB2A Entrez, Source | tubulin, beta 2A | 564 | 1.466 | 0.1859 | Yes |
| 6 | CEBPB | NA | CEBPB Entrez, Source | CCAAT/enhancer binding protein (C/EBP), beta | 619 | 1.396 | 0.2089 | Yes |
| 7 | HSPA5 | NA | HSPA5 Entrez, Source | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 777 | 1.263 | 0.2237 | Yes |
| 8 | PDIA6 | NA | PDIA6 Entrez, Source | protein disulfide isomerase family A, member 6 | 824 | 1.227 | 0.2439 | Yes |
| 9 | ASNS | NA | ASNS Entrez, Source | asparagine synthetase | 827 | 1.225 | 0.2666 | Yes |
| 10 | CALR | NA | CALR Entrez, Source | calreticulin | 1065 | 1.086 | 0.2737 | Yes |
| 11 | CXXC1 | NA | CXXC1 Entrez, Source | CXXC finger 1 (PHD domain) | 1070 | 1.083 | 0.2936 | Yes |
| 12 | WFS1 | NA | WFS1 Entrez, Source | Wolfram syndrome 1 (wolframin) | 1393 | 0.948 | 0.2934 | Yes |
| 13 | RRP9 | NA | 1735 | 0.842 | 0.2902 | Yes | ||
| 14 | ATP6V0D1 | NA | ATP6V0D1 Entrez, Source | ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 | 1966 | 0.794 | 0.2922 | Yes |
| 15 | CHAC1 | NA | CHAC1 Entrez, Source | ChaC, cation transport regulator homolog 1 (E. coli) | 2165 | 0.751 | 0.2952 | Yes |
| 16 | GEMIN4 | NA | GEMIN4 Entrez, Source | gem (nuclear organelle) associated protein 4 | 2297 | 0.725 | 0.3014 | Yes |
| 17 | ZBTB17 | NA | ZBTB17 Entrez, Source | zinc finger and BTB domain containing 17 | 2546 | 0.676 | 0.3002 | Yes |
| 18 | XBP1 | NA | XBP1 Entrez, Source | X-box binding protein 1 | 2846 | 0.624 | 0.2953 | Yes |
| 19 | NFYA | NA | NFYA Entrez, Source | nuclear transcription factor Y, alpha | 2847 | 0.623 | 0.3069 | Yes |
| 20 | H2AFX | NA | H2AFX Entrez, Source | H2A histone family, member X | 2849 | 0.623 | 0.3184 | Yes |
| 21 | DNAJA4 | NA | DNAJA4 Entrez, Source | DnaJ (Hsp40) homolog, subfamily A, member 4 | 2873 | 0.619 | 0.3286 | Yes |
| 22 | SLC1A4 | NA | SLC1A4 Entrez, Source | solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 | 2912 | 0.612 | 0.3379 | Yes |
| 23 | PDIA5 | NA | PDIA5 Entrez, Source | protein disulfide isomerase family A, member 5 | 2941 | 0.606 | 0.3476 | Yes |
| 24 | EXOSC4 | NA | EXOSC4 Entrez, Source | exosome component 4 | 3260 | 0.558 | 0.3404 | Yes |
| 25 | POP4 | NA | POP4 Entrez, Source | processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae) | 3275 | 0.556 | 0.3500 | Yes |
| 26 | BAG3 | NA | BAG3 Entrez, Source | BCL2-associated athanogene 3 | 3325 | 0.547 | 0.3574 | Yes |
| 27 | SSR1 | NA | SSR1 Entrez, Source | signal sequence receptor, alpha (translocon-associated protein alpha) | 3543 | 0.517 | 0.3550 | Yes |
| 28 | EIF4G1 | NA | EIF4G1 Entrez, Source | eukaryotic translation initiation factor 4 gamma, 1 | 3633 | 0.507 | 0.3595 | Yes |
| 29 | KHSRP | NA | KHSRP Entrez, Source | KH-type splicing regulatory protein (FUSE binding protein 2) | 3636 | 0.506 | 0.3688 | Yes |
| 30 | DNAJC3 | NA | DNAJC3 Entrez, Source | DnaJ (Hsp40) homolog, subfamily C, member 3 | 3652 | 0.504 | 0.3774 | Yes |
| 31 | YIF1A | NA | YIF1A Entrez, Source | Yip1 interacting factor homolog A (S. cerevisiae) | 3763 | 0.490 | 0.3804 | Yes |
| 32 | SHC1 | NA | SHC1 Entrez, Source | SHC (Src homology 2 domain containing) transforming protein 1 | 4000 | 0.462 | 0.3759 | Yes |
| 33 | NOP56 | NA | 4024 | 0.459 | 0.3831 | Yes | ||
| 34 | TATDN2 | NA | TATDN2 Entrez, Source | TatD DNase domain containing 2 | 4071 | 0.452 | 0.3890 | Yes |
| 35 | PARN | NA | PARN Entrez, Source | poly(A)-specific ribonuclease (deadenylation nuclease) | 4134 | 0.442 | 0.3938 | Yes |
| 36 | GOSR2 | NA | GOSR2 Entrez, Source | golgi SNAP receptor complex member 2 | 4137 | 0.442 | 0.4019 | Yes |
| 37 | EIF4EBP1 | NA | EIF4EBP1 Entrez, Source | eukaryotic translation initiation factor 4E binding protein 1 | 4188 | 0.436 | 0.4072 | Yes |
| 38 | ARFGAP1 | NA | ARFGAP1 Entrez, Source | ADP-ribosylation factor GTPase activating protein 1 | 4232 | 0.431 | 0.4129 | Yes |
| 39 | SRPRB | NA | SRPRB Entrez, Source | signal recognition particle receptor, B subunit | 4260 | 0.427 | 0.4193 | Yes |
| 40 | EIF4A1 | NA | EIF4A1 Entrez, Source | eukaryotic translation initiation factor 4A, isoform 1 | 4268 | 0.426 | 0.4268 | Yes |
| 41 | PREB | NA | PREB Entrez, Source | prolactin regulatory element binding | 4363 | 0.415 | 0.4293 | Yes |
| 42 | NOLC1 | NA | NOLC1 Entrez, Source | nucleolar and coiled-body phosphoprotein 1 | 4488 | 0.402 | 0.4299 | Yes |
| 43 | EIF4A3 | NA | 4765 | 0.376 | 0.4217 | Yes | ||
| 44 | LSM1 | NA | LSM1 Entrez, Source | LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 5046 | 0.346 | 0.4126 | Yes |
| 45 | NOP14 | NA | 5061 | 0.345 | 0.4182 | Yes | ||
| 46 | SDAD1 | NA | SDAD1 Entrez, Source | SDA1 domain containing 1 | 5086 | 0.343 | 0.4233 | Yes |
| 47 | IGFBP1 | NA | IGFBP1 Entrez, Source | insulin-like growth factor binding protein 1 | 5128 | 0.339 | 0.4273 | Yes |
| 48 | EIF2S1 | NA | EIF2S1 Entrez, Source | eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa | 5155 | 0.336 | 0.4321 | Yes |
| 49 | SLC30A5 | NA | SLC30A5 Entrez, Source | solute carrier family 30 (zinc transporter), member 5 | 5222 | 0.330 | 0.4346 | Yes |
| 50 | CNOT4 | NA | CNOT4 Entrez, Source | CCR4-NOT transcription complex, subunit 4 | 5235 | 0.329 | 0.4400 | Yes |
| 51 | PAIP1 | NA | PAIP1 Entrez, Source | poly(A) binding protein interacting protein 1 | 5593 | 0.296 | 0.4258 | No |
| 52 | ERN1 | NA | ERN1 Entrez, Source | endoplasmic reticulum to nucleus signalling 1 | 5717 | 0.285 | 0.4243 | No |
| 53 | EXOSC10 | NA | EXOSC10 Entrez, Source | exosome component 10 | 5820 | 0.276 | 0.4237 | No |
| 54 | EXOSC9 | NA | EXOSC9 Entrez, Source | exosome component 9 | 5970 | 0.265 | 0.4204 | No |
| 55 | DKC1 | NA | DKC1 Entrez, Source | dyskeratosis congenita 1, dyskerin | 6285 | 0.237 | 0.4075 | No |
| 56 | EDC4 | NA | EDC4 Entrez, Source | enhancer of mRNA decapping 4 | 6427 | 0.227 | 0.4039 | No |
| 57 | EXOSC2 | NA | EXOSC2 Entrez, Source | exosome component 2 | 7018 | 0.179 | 0.3745 | No |
| 58 | EIF4E | NA | EIF4E Entrez, Source | eukaryotic translation initiation factor 4E | 7293 | 0.160 | 0.3623 | No |
| 59 | EDEM1 | NA | EDEM1 Entrez, Source | ER degradation enhancer, mannosidase alpha-like 1 | 7611 | 0.135 | 0.3473 | No |
| 60 | EXOC2 | NA | EXOC2 Entrez, Source | exocyst complex component 2 | 7633 | 0.134 | 0.3486 | No |
| 61 | KDELR3 | NA | KDELR3 Entrez, Source | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 | 7802 | 0.122 | 0.3416 | No |
| 62 | VEGFA | NA | 7903 | 0.115 | 0.3382 | No | ||
| 63 | EXOSC5 | NA | EXOSC5 Entrez, Source | exosome component 5 | 7951 | 0.111 | 0.3377 | No |
| 64 | EEF2 | NA | EEF2 Entrez, Source | eukaryotic translation elongation factor 2 | 8098 | 0.099 | 0.3314 | No |
| 65 | DNAJB9 | NA | DNAJB9 Entrez, Source | DnaJ (Hsp40) homolog, subfamily B, member 9 | 8229 | 0.091 | 0.3259 | No |
| 66 | YWHAZ | NA | YWHAZ Entrez, Source | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide | 8392 | 0.080 | 0.3184 | No |
| 67 | SPCS3 | NA | SPCS3 Entrez, Source | signal peptidase complex subunit 3 homolog (S. cerevisiae) | 8510 | 0.071 | 0.3133 | No |
| 68 | DCP1A | NA | DCP1A Entrez, Source | DCP1 decapping enzyme homolog A (S. cerevisiae) | 8653 | 0.061 | 0.3065 | No |
| 69 | ATF6 | NA | ATF6 Entrez, Source | activating transcription factor 6 | 8839 | 0.048 | 0.2972 | No |
| 70 | HSPA9 | NA | 9108 | 0.026 | 0.2828 | No | ||
| 71 | EXOSC1 | NA | EXOSC1 Entrez, Source | exosome component 1 | 9145 | 0.024 | 0.2813 | No |
| 72 | TSPYL2 | NA | TSPYL2 Entrez, Source | TSPY-like 2 | 9289 | 0.015 | 0.2737 | No |
| 73 | PSAT1 | NA | PSAT1 Entrez, Source | phosphoserine aminotransferase 1 | 9309 | 0.013 | 0.2729 | No |
| 74 | FUS | NA | FUS Entrez, Source | fusion (involved in t(12;16) in malignant liposarcoma) | 9448 | 0.004 | 0.2653 | No |
| 75 | CKS1B | NA | CKS1B Entrez, Source | CDC28 protein kinase regulatory subunit 1B | 9735 | -0.001 | 0.2495 | No |
| 76 | BANF1 | NA | BANF1 Entrez, Source | barrier to autointegration factor 1 | 10029 | -0.020 | 0.2336 | No |
| 77 | MTHFD2 | NA | MTHFD2 Entrez, Source | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 10233 | -0.033 | 0.2230 | No |
| 78 | DCTN1 | NA | DCTN1 Entrez, Source | dynactin 1 (p150, glued homolog, Drosophila) | 10245 | -0.034 | 0.2230 | No |
| 79 | TARS | NA | TARS Entrez, Source | threonyl-tRNA synthetase | 10452 | -0.045 | 0.2125 | No |
| 80 | ALDH18A1 | NA | ALDH18A1 Entrez, Source | aldehyde dehydrogenase 18 family, member A1 | 11560 | -0.120 | 0.1534 | No |
| 81 | SPCS1 | NA | SPCS1 Entrez, Source | signal peptidase complex subunit 1 homolog (S. cerevisiae) | 11582 | -0.121 | 0.1545 | No |
| 82 | XPOT | NA | XPOT Entrez, Source | exportin, tRNA (nuclear export receptor for tRNAs) | 11845 | -0.143 | 0.1426 | No |
| 83 | DDX10 | NA | DDX10 Entrez, Source | DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 | 11855 | -0.145 | 0.1448 | No |
| 84 | IMP3 | NA | IMP3 Entrez, Source | IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast) | 11911 | -0.148 | 0.1445 | No |
| 85 | ATF4 | NA | ATF4 Entrez, Source | activating transcription factor 4 (tax-responsive enhancer element B67) | 12333 | -0.186 | 0.1247 | No |
| 86 | SERP1 | NA | SERP1 Entrez, Source | - | 12345 | -0.187 | 0.1276 | No |
| 87 | NHP2 | NA | 12624 | -0.212 | 0.1161 | No | ||
| 88 | WIPI1 | NA | WIPI1 Entrez, Source | WD repeat domain, phosphoinositide interacting 1 | 12628 | -0.213 | 0.1199 | No |
| 89 | SKIV2L2 | NA | SKIV2L2 Entrez, Source | superkiller viralicidic activity 2-like 2 (S. cerevisiae) | 12708 | -0.220 | 0.1196 | No |
| 90 | FKBP14 | NA | FKBP14 Entrez, Source | FK506 binding protein 14, 22 kDa | 12734 | -0.222 | 0.1223 | No |
| 91 | NPM1 | NA | NPM1 Entrez, Source | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 12872 | -0.232 | 0.1191 | No |
| 92 | CNOT2 | NA | CNOT2 Entrez, Source | CCR4-NOT transcription complex, subunit 2 | 12972 | -0.242 | 0.1181 | No |
| 93 | STC2 | NA | STC2 Entrez, Source | stanniocalcin 2 | 12988 | -0.244 | 0.1218 | No |
| 94 | CEBPG | NA | CEBPG Entrez, Source | CCAAT/enhancer binding protein (C/EBP), gamma | 13472 | -0.290 | 0.1005 | No |
| 95 | IARS | NA | IARS Entrez, Source | isoleucine-tRNA synthetase | 13983 | -0.342 | 0.0786 | No |
| 96 | LSM4 | NA | LSM4 Entrez, Source | LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 14057 | -0.352 | 0.0811 | No |
| 97 | SEC11A | NA | 14371 | -0.388 | 0.0710 | No | ||
| 98 | RPS14 | NA | RPS14 Entrez, Source | ribosomal protein S14 | 14490 | -0.404 | 0.0719 | No |
| 99 | DCP2 | NA | DCP2 Entrez, Source | DCP2 decapping enzyme homolog (S. cerevisiae) | 15160 | -0.497 | 0.0441 | No |
| 100 | TTC37 | NA | 15258 | -0.511 | 0.0483 | No | ||
| 101 | EIF2AK3 | NA | EIF2AK3 Entrez, Source | eukaryotic translation initiation factor 2-alpha kinase 3 | 15965 | -0.647 | 0.0212 | No |
| 102 | NFYB | NA | NFYB Entrez, Source | nuclear transcription factor Y, beta | 16009 | -0.657 | 0.0310 | No |
| 103 | HERPUD1 | NA | HERPUD1 Entrez, Source | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 16023 | -0.661 | 0.0426 | No |
| 104 | KIF5B | NA | KIF5B Entrez, Source | kinesin family member 5B | 16346 | -0.747 | 0.0387 | No |
| 105 | EIF4A2 | NA | EIF4A2 Entrez, Source | eukaryotic translation initiation factor 4A, isoform 2 | 16543 | -0.810 | 0.0429 | No |
| 106 | DDIT4 | NA | DDIT4 Entrez, Source | DNA-damage-inducible transcript 4 | 17443 | -1.212 | 0.0156 | No |
| 107 | SLC7A5 | NA | SLC7A5 Entrez, Source | solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 | 17569 | -1.313 | 0.0331 | No |
