Datasetw1a_vs_wt_vs_wt.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp_repos
Phenotypew1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos
Upregulated in classago1w1a
GeneSetHALLMARK_TNFA_SIGNALING_VIA_NFKB
Enrichment Score (ES)0.65129465
Normalized Enrichment Score (NES)2.5951374
Nominal p-value0.0
FDR q-value0.0
FWER p-Value0.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_TNFA_SIGNALING_VIA_NFKB   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1CXCL11NACXCL11
Entrez,  Source
chemokine (C-X-C motif) ligand 1104.8720.0213Yes
2IL7RNAIL7R
Entrez,  Source
interleukin 7 receptor44.7850.0421Yes
3CCL5NACCL5
Entrez,  Source
chemokine (C-C motif) ligand 564.7680.0629Yes
4IFIT2NAIFIT2
Entrez,  Source
interferon-induced protein with tetratricopeptide repeats 2144.6750.0830Yes
5DDX58NADDX58
Entrez,  Source
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58154.6490.1033Yes
6CXCL10NACXCL10
Entrez,  Source
chemokine (C-X-C motif) ligand 10164.6310.1236Yes
7IL6NAIL6
Entrez,  Source
interleukin 6 (interferon, beta 2)174.5960.1437Yes
8IFIH1NAIFIH1
Entrez,  Source
interferon induced with helicase C domain 1603.9300.1585Yes
9TRAF1NATRAF1
Entrez,  Source
TNF receptor-associated factor 1893.3230.1715Yes
10AREGNAAREG
Entrez,  Source
amphiregulin (schwannoma-derived growth factor)973.2410.1853Yes
11PTGER4NAPTGER4
Entrez,  Source
prostaglandin E receptor 4 (subtype EP4)1013.2130.1992Yes
12SDC4NASDC4
Entrez,  Source
syndecan 4 (amphiglycan, ryudocan)1053.1890.2130Yes
13IRF1NAIRF1
Entrez,  Source
interferon regulatory factor 11123.0670.2261Yes
14MXD1NAMXD1
Entrez,  Source
MAX dimerization protein 11153.0590.2393Yes
15RELBNARELB
Entrez,  Source
v-rel reticuloendotheliosis viral oncogene homolog B, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 (avian)1163.0280.2526Yes
16OLR1NAOLR1
Entrez,  Source
oxidised low density lipoprotein (lectin-like) receptor 11302.8730.2644Yes
17NFKB2NANFKB2
Entrez,  Source
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)1382.8040.2763Yes
18PLAURNAPLAUR
Entrez,  Source
plasminogen activator, urokinase receptor1402.7840.2884Yes
19TNIP1NATNIP1
Entrez,  Source
TNFAIP3 interacting protein 11702.5520.2980Yes
20CYR61NACYR61
Entrez,  Source
cysteine-rich, angiogenic inducer, 611712.5510.3092Yes
21KLF4NAKLF4
Entrez,  Source
Kruppel-like factor 4 (gut)1722.5500.3203Yes
22BIRC3NABIRC3
Entrez,  Source
baculoviral IAP repeat-containing 31822.4840.3307Yes
23B4GALT5NAB4GALT5
Entrez,  Source
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 51852.4760.3414Yes
24CXCL2NACXCL2
Entrez,  Source
chemokine (C-X-C motif) ligand 21932.4230.3516Yes
25FOSL1NAFOSL1
Entrez,  Source
FOS-like antigen 11982.4080.3619Yes
26PHLDA1NAPHLDA1
Entrez,  Source
pleckstrin homology-like domain, family A, member 12212.3180.3709Yes
27DUSP5NADUSP5
Entrez,  Source
dual specificity phosphatase 52252.2820.3807Yes
28ZFP36NAZFP36
Entrez,  Source
zinc finger protein 36, C3H type, homolog (mouse)2372.2360.3899Yes
29SOD2NASOD2
Entrez,  Source
superoxide dismutase 2, mitochondrial2632.1240.3978Yes
30EDN1NAEDN1
Entrez,  Source
endothelin 12702.0980.4066Yes
31TNFAIP3NATNFAIP3
Entrez,  Source
tumor necrosis factor, alpha-induced protein 32712.0950.4158Yes
32CLCF1NACLCF1
Entrez,  Source
cardiotrophin-like cytokine factor 12812.0600.4243Yes
33SERPINE1NASERPINE1
Entrez,  Source
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 12902.0390.4328Yes
34NFKBIENANFKBIE
Entrez,  Source
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon2982.0070.4411Yes
35F3NAF3
Entrez,  Source
coagulation factor III (thromboplastin, tissue factor)3011.9810.4497Yes
36TAP1NATAP1
Entrez,  Source
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)3151.9210.4574Yes
37LAMB3NALAMB3
Entrez,  Source
laminin, beta 33431.8460.4640Yes
38FUT4NAFUT4
Entrez,  Source
fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)3441.8410.4720Yes
39PANX1NAPANX1
Entrez,  Source
pannexin 13631.7940.4789Yes
40JUNBNAJUNB
Entrez,  Source
jun B proto-oncogene4261.6630.4827Yes
41ICAM1NAICAM1
Entrez,  Source
intercellular adhesion molecule 1 (CD54), human rhinovirus receptor4531.6000.4882Yes
42NFKBIANANFKBIA
Entrez,  Source
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha4601.5950.4949Yes
43IER5NAIER5
Entrez,  Source
immediate early response 54641.5930.5017Yes
44CCL2NACCL2
Entrez,  Source
chemokine (C-C motif) ligand 24931.5460.5069Yes
45SERPINB8NASERPINB8
Entrez,  Source
serpin peptidase inhibitor, clade B (ovalbumin), member 84951.5410.5136Yes
46ETS2NAETS2
Entrez,  Source
v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)5081.5340.5196Yes
47CD44NACD44
Entrez,  Source
CD44 molecule (Indian blood group)5151.5230.5260Yes
48JAG1NAJAG1
Entrez,  Source
jagged 1 (Alagille syndrome)5161.5230.5326Yes
49IL15RANAIL15RA
Entrez,  Source
interleukin 15 receptor, alpha5401.4950.5379Yes
50MCL1NAMCL1
Entrez,  Source
myeloid cell leukemia sequence 1 (BCL2-related)5611.4710.5432Yes
51TUBB2ANATUBB2A
Entrez,  Source
tubulin, beta 2A5641.4660.5495Yes
52CEBPBNACEBPB
Entrez,  Source
CCAAT/enhancer binding protein (C/EBP), beta6191.3960.5526Yes
53RNF19BNA6371.3820.5577Yes
54IL1ANAIL1A
Entrez,  Source
interleukin 1, alpha6471.3710.5632Yes
55PHLDA2NAPHLDA2
Entrez,  Source
pleckstrin homology-like domain, family A, member 26921.3290.5666Yes
56ZC3H12ANAZC3H12A
Entrez,  Source
zinc finger CCCH-type containing 12A6971.3260.5722Yes
57JUNNAJUN
Entrez,  Source
jun oncogene7181.3120.5768Yes
58RCAN1NA7201.3090.5825Yes
59F2RL1NAF2RL1
Entrez,  Source
coagulation factor II (thrombin) receptor-like 17451.2880.5868Yes
60IL1BNAIL1B
Entrez,  Source
interleukin 1, beta7791.2620.5905Yes
61SQSTM1NASQSTM1
Entrez,  Source
sequestosome 17871.2570.5956Yes
62SPHK1NASPHK1
Entrez,  Source
sphingosine kinase 17931.2530.6008Yes
63GADD45ANAGADD45A
Entrez,  Source
growth arrest and DNA-damage-inducible, alpha8281.2250.6042Yes
64DRAM1NA8551.2060.6081Yes
65PPP1R15ANAPPP1R15A
Entrez,  Source
protein phosphatase 1, regulatory (inhibitor) subunit 15A8741.1910.6123Yes
66TGIF1NA8931.1790.6164Yes
67LDLRNALDLR
Entrez,  Source
low density lipoprotein receptor (familial hypercholesterolemia)9451.1470.6186Yes
68IL6STNAIL6ST
Entrez,  Source
interleukin 6 signal transducer (gp130, oncostatin M receptor)10011.1180.6205Yes
69EGR2NAEGR2
Entrez,  Source
early growth response 2 (Krox-20 homolog, Drosophila)10161.1100.6245Yes
70HES1NAHES1
Entrez,  Source
hairy and enhancer of split 1, (Drosophila)10721.0820.6262Yes
71RELANARELA
Entrez,  Source
v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian)11501.0470.6265Yes
72TNFNATNF
Entrez,  Source
tumor necrosis factor (TNF superfamily, member 2)12101.0150.6277Yes
73MAFFNAMAFF
Entrez,  Source
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)12371.0040.6306Yes
74NFAT5NANFAT5
Entrez,  Source
nuclear factor of activated T-cells 5, tonicity-responsive12431.0020.6347Yes
75BCL3NABCL3
Entrez,  Source
B-cell CLL/lymphoma 313000.9820.6359Yes
76TNIP2NATNIP2
Entrez,  Source
TNFAIP3 interacting protein 213720.9550.6361Yes
77MAP2K3NAMAP2K3
Entrez,  Source
mitogen-activated protein kinase kinase 313730.9550.6403Yes
78GFPT2NAGFPT2
Entrez,  Source
glutamine-fructose-6-phosphate transaminase 214410.9320.6407Yes
79PDE4BNAPDE4B
Entrez,  Source
phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)14460.9300.6445Yes
80PDLIM5NAPDLIM5
Entrez,  Source
PDZ and LIM domain 514850.9140.6464Yes
81EHD1NAEHD1
Entrez,  Source
EH-domain containing 115760.8890.6453Yes
82IL12BNAIL12B
Entrez,  Source
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)16070.8800.6474Yes
83CSF1NACSF1
Entrez,  Source
colony stimulating factor 1 (macrophage)16080.8800.6513Yes
84NFKB1NANFKB1
Entrez,  Source
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)17670.8350.6462No
85ICOSLGNAICOSLG
Entrez,  Source
inducible T-cell co-stimulator ligand19030.8080.6422No
86IER2NAIER2
Entrez,  Source
immediate early response 219040.8080.6457No
87IL18NAIL18
Entrez,  Source
interleukin 18 (interferon-gamma-inducing factor)19110.8050.6489No
88GCH1NAGCH1
Entrez,  Source
GTP cyclohydrolase 1 (dopa-responsive dystonia)19760.7920.6488No
89KLF2NAKLF2
Entrez,  Source
Kruppel-like factor 2 (lung)20240.7840.6496No
90LIFNALIF
Entrez,  Source
leukemia inhibitory factor (cholinergic differentiation factor)21410.7550.6465No
91FOSL2NAFOSL2
Entrez,  Source
FOS-like antigen 222810.7280.6419No
92KLF10NAKLF10
Entrez,  Source
Kruppel-like factor 1023500.7110.6413No
93PLK2NAPLK2
Entrez,  Source
polo-like kinase 2 (Drosophila)23960.7040.6418No
94NAMPTNA25410.6770.6368No
95CCRL2NACCRL2
Entrez,  Source
chemokine (C-C motif) receptor-like 227300.6440.6291No
96ATP2B1NAATP2B1
Entrez,  Source
ATPase, Ca++ transporting, plasma membrane 128960.6140.6226No
97BHLHE40NA29730.6010.6210No
98TRIP10NATRIP10
Entrez,  Source
thyroid hormone receptor interactor 1030990.5820.6166No
99BIRC2NABIRC2
Entrez,  Source
baculoviral IAP repeat-containing 233770.5400.6036No
100NR4A1NANR4A1
Entrez,  Source
nuclear receptor subfamily 4, group A, member 134150.5340.6039No
101IL23ANAIL23A
Entrez,  Source
interleukin 23, alpha subunit p1934160.5340.6062No
102EIF1NAEIF1
Entrez,  Source
eukaryotic translation initiation factor 134980.5220.6040No
103TANKNATANK
Entrez,  Source
TRAF family member-associated NFKB activator36300.5070.5989No
104FJX1NAFJX1
Entrez,  Source
four jointed box 1 (Drosophila)37390.4930.5951No
105YRDCNAYRDC
Entrez,  Source
yrdC domain containing (E. coli)37860.4870.5946No
106STAT5ANASTAT5A
Entrez,  Source
signal transducer and activator of transcription 5A38750.4780.5918No
107DENND5ANA39240.4710.5912No
108KDM6BNA41300.4430.5817No
109PER1NAPER1
Entrez,  Source
period homolog 1 (Drosophila)41950.4350.5801No
110TNFAIP8NATNFAIP8
Entrez,  Source
tumor necrosis factor, alpha-induced protein 843150.4200.5753No
111PTGS2NAPTGS2
Entrez,  Source
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)44060.4100.5721No
112CCND1NACCND1
Entrez,  Source
cyclin D144400.4070.5720No
113SPSB1NASPSB1
Entrez,  Source
splA/ryanodine receptor domain and SOCS box containing 144650.4030.5725No
114TLR2NATLR2
Entrez,  Source
toll-like receptor 246770.3850.5624No
115MAP3K8NAMAP3K8
Entrez,  Source
mitogen-activated protein kinase kinase kinase 847640.3760.5593No
116TRIB1NATRIB1
Entrez,  Source
tribbles homolog 1 (Drosophila)50110.3500.5471No
117DNAJB4NADNAJB4
Entrez,  Source
DnaJ (Hsp40) homolog, subfamily B, member 450600.3450.5459No
118TSC22D1NATSC22D1
Entrez,  Source
TSC22 domain family, member 151950.3320.5399No
119NR4A2NANR4A2
Entrez,  Source
nuclear receptor subfamily 4, group A, member 252830.3240.5365No
120PFKFB3NAPFKFB3
Entrez,  Source
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 354260.3100.5300No
121SOCS3NASOCS3
Entrez,  Source
suppressor of cytokine signaling 354280.3100.5313No
122TIPARPNATIPARP
Entrez,  Source
TCDD-inducible poly(ADP-ribose) polymerase54780.3050.5299No
123SNNNASNN
Entrez,  Source
stannin57060.2850.5185No
124TNFRSF9NATNFRSF9
Entrez,  Source
tumor necrosis factor receptor superfamily, member 963500.2320.4837No
125HBEGFNAHBEGF
Entrez,  Source
heparin-binding EGF-like growth factor64350.2260.4801No
126RIPK2NARIPK2
Entrez,  Source
receptor-interacting serine-threonine kinase 268040.1960.4604No
127SIK1NA69220.1860.4547No
128SAT1NASAT1
Entrez,  Source
spermidine/spermine N1-acetyltransferase 170990.1740.4457No
129IFNGR2NAIFNGR2
Entrez,  Source
interferon gamma receptor 2 (interferon gamma transducer 1)71180.1720.4455No
130INHBANAINHBA
Entrez,  Source
inhibin, beta A (activin A, activin AB alpha polypeptide)73090.1590.4356No
131CDKN1ANACDKN1A
Entrez,  Source
cyclin-dependent kinase inhibitor 1A (p21, Cip1)75230.1430.4244No
132SLC2A6NASLC2A6
Entrez,  Source
solute carrier family 2 (facilitated glucose transporter), member 678220.1210.4083No
133VEGFANA79030.1150.4044No
134CEBPDNACEBPD
Entrez,  Source
CCAAT/enhancer binding protein (C/EBP), delta86630.0600.3624No
135KLF6NAKLF6
Entrez,  Source
Kruppel-like factor 687570.0540.3574No
136MSCNAMSC
Entrez,  Source
musculin (activated B-cell factor-1)88560.0470.3522No
137FOSBNAFOSB
Entrez,  Source
FBJ murine osteosarcoma viral oncogene homolog B92410.0180.3309No
138CXCL6NACXCL6
Entrez,  Source
chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)95630.0000.3130No
139CSF2NACSF2
Entrez,  Source
colony stimulating factor 2 (granulocyte-macrophage)95750.0000.3124No
140BCL2A1NABCL2A1
Entrez,  Source
BCL2-related protein A195990.0000.3112No
141SERPINB2NASERPINB2
Entrez,  Source
serpin peptidase inhibitor, clade B (ovalbumin), member 29790-0.0050.3006No
142TNFAIP2NATNFAIP2
Entrez,  Source
tumor necrosis factor, alpha-induced protein 210588-0.0530.2565No
143CFLARNACFLAR
Entrez,  Source
CASP8 and FADD-like apoptosis regulator10825-0.0670.2436No
144CXCL3NACXCL3
Entrez,  Source
chemokine (C-X-C motif) ligand 310925-0.0730.2385No
145CXCL1NACXCL1
Entrez,  Source
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)11070-0.0820.2308No
146NINJ1NANINJ1
Entrez,  Source
ninjurin 111130-0.0860.2279No
147BCL6NABCL6
Entrez,  Source
B-cell CLL/lymphoma 6 (zinc finger protein 51)11376-0.1040.2147No
148B4GALT1NAB4GALT1
Entrez,  Source
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 111658-0.1280.1996No
149LITAFNALITAF
Entrez,  Source
lipopolysaccharide-induced TNF factor11705-0.1330.1977No
150TNFSF9NATNFSF9
Entrez,  Source
tumor necrosis factor (ligand) superfamily, member 911926-0.1500.1861No
151G0S2NAG0S2
Entrez,  Source
G0/G1switch 211959-0.1520.1850No
152GADD45BNAGADD45B
Entrez,  Source
growth arrest and DNA-damage-inducible, beta11970-0.1530.1851No
153PTPRENAPTPRE
Entrez,  Source
protein tyrosine phosphatase, receptor type, E12152-0.1690.1757No
154DUSP4NADUSP4
Entrez,  Source
dual specificity phosphatase 412317-0.1840.1674No
155TNFAIP6NATNFAIP6
Entrez,  Source
tumor necrosis factor, alpha-induced protein 612429-0.1950.1621No
156RHOBNARHOB
Entrez,  Source
ras homolog gene family, member B12525-0.2040.1577No
157CCNL1NACCNL1
Entrez,  Source
cyclin L112562-0.2070.1566No
158IER3NAIER3
Entrez,  Source
immediate early response 313360-0.2770.1135No
159BTG1NABTG1
Entrez,  Source
B-cell translocation gene 1, anti-proliferative13694-0.3110.0963No
160SMAD3NASMAD3
Entrez,  Source
SMAD, mothers against DPP homolog 3 (Drosophila)13718-0.3120.0964No
161EFNA1NAEFNA1
Entrez,  Source
ephrin-A113734-0.3140.0969No
162MYCNAMYC
Entrez,  Source
v-myc myelocytomatosis viral oncogene homolog (avian)13741-0.3150.0980No
163DUSP1NADUSP1
Entrez,  Source
dual specificity phosphatase 113763-0.3170.0982No
164KYNUNAKYNU
Entrez,  Source
kynureninase (L-kynurenine hydrolase)14108-0.3580.0806No
165RELNAREL
Entrez,  Source
v-rel reticuloendotheliosis viral oncogene homolog (avian)14156-0.3640.0796No
166CCL20NACCL20
Entrez,  Source
chemokine (C-C motif) ligand 2014330-0.3830.0716No
167NFE2L2NANFE2L2
Entrez,  Source
nuclear factor (erythroid-derived 2)-like 214372-0.3880.0711No
168FOSNAFOS
Entrez,  Source
v-fos FBJ murine osteosarcoma viral oncogene homolog14425-0.3950.0699No
169CD69NACD69
Entrez,  Source
CD69 molecule14577-0.4160.0633No
170GPR183NA14643-0.4240.0616No
171BTG3NABTG3
Entrez,  Source
BTG family, member 314860-0.4570.0515No
172TNCNATNC
Entrez,  Source
tenascin C (hexabrachion)15273-0.5130.0309No
173SLC2A3NASLC2A3
Entrez,  Source
solute carrier family 2 (facilitated glucose transporter), member 315473-0.5470.0222No
174MARCKSNAMARCKS
Entrez,  Source
myristoylated alanine-rich protein kinase C substrate15669-0.5840.0139No
175PTX3NAPTX3
Entrez,  Source
pentraxin-related gene, rapidly induced by IL-1 beta15670-0.5850.0164No
176SGK1NA15983-0.6520.0019No
177EGR1NAEGR1
Entrez,  Source
early growth response 116089-0.678-0.0009No
178PLEKNAPLEK
Entrez,  Source
pleckstrin16096-0.6800.0017No
179PLAUNAPLAU
Entrez,  Source
plasminogen activator, urokinase16140-0.6900.0023No
180BMP2NABMP2
Entrez,  Source
bone morphogenetic protein 216401-0.765-0.0088No
181NFIL3NANFIL3
Entrez,  Source
nuclear factor, interleukin 3 regulated16520-0.802-0.0119No
182CD80NACD80
Entrez,  Source
CD80 molecule16598-0.825-0.0125No
183NR4A3NANR4A3
Entrez,  Source
nuclear receptor subfamily 4, group A, member 316928-0.939-0.0267No
184PMEPA1NA16965-0.954-0.0246No
185KLF9NAKLF9
Entrez,  Source
Kruppel-like factor 917180-1.048-0.0319No
186PNRC1NAPNRC1
Entrez,  Source
proline-rich nuclear receptor coactivator 117226-1.076-0.0297No
187EGR3NAEGR3
Entrez,  Source
early growth response 317235-1.079-0.0254No
188SLC16A6NASLC16A6
Entrez,  Source
solute carrier family 16, member 6 (monocarboxylic acid transporter 7)17442-1.212-0.0316No
189DUSP2NADUSP2
Entrez,  Source
dual specificity phosphatase 217607-1.360-0.0347No
190IRS2NAIRS2
Entrez,  Source
insulin receptor substrate 217690-1.460-0.0329No
191ZBTB10NAZBTB10
Entrez,  Source
zinc finger and BTB domain containing 1017697-1.467-0.0268No
192BTG2NABTG2
Entrez,  Source
BTG family, member 217959-2.061-0.0323No
193ID2NAID2
Entrez,  Source
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein17991-2.214-0.0244No
194CD83NACD83
Entrez,  Source
CD83 molecule18007-2.314-0.0151No
195ABCA1NAABCA1
Entrez,  Source
ATP-binding cassette, sub-family A (ABC1), member 118056-2.602-0.0064No
196GEMNAGEM
Entrez,  Source
GTP binding protein overexpressed in skeletal muscle18086-2.8530.0045No
Table: GSEA details [plain text format]



Fig 2: HALLMARK_TNFA_SIGNALING_VIA_NFKB   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_TNFA_SIGNALING_VIA_NFKB: Random ES distribution   
Gene set null distribution of ES for HALLMARK_TNFA_SIGNALING_VIA_NFKB