Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | HALLMARK_SPERMATOGENESIS |
| Enrichment Score (ES) | -0.32420385 |
| Normalized Enrichment Score (NES) | -1.2864976 |
| Nominal p-value | 0.036931816 |
| FDR q-value | 0.11075079 |
| FWER p-Value | 0.645 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | TUBA3C | NA | 398 | 1.724 | 0.0094 | No | ||
| 2 | IL13RA2 | NA | IL13RA2 Entrez, Source | interleukin 13 receptor, alpha 2 | 1194 | 1.024 | -0.0160 | No |
| 3 | CAMK4 | NA | CAMK4 Entrez, Source | calcium/calmodulin-dependent protein kinase IV | 1235 | 1.005 | 0.0002 | No |
| 4 | SLC12A2 | NA | SLC12A2 Entrez, Source | solute carrier family 12 (sodium/potassium/chloride transporters), member 2 | 1376 | 0.953 | 0.0098 | No |
| 5 | TLE4 | NA | TLE4 Entrez, Source | transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) | 1412 | 0.943 | 0.0251 | No |
| 6 | CCNA1 | NA | CCNA1 Entrez, Source | cyclin A1 | 1571 | 0.891 | 0.0326 | No |
| 7 | TNNI3 | NA | TNNI3 Entrez, Source | troponin I type 3 (cardiac) | 1592 | 0.883 | 0.0476 | No |
| 8 | ACRBP | NA | ACRBP Entrez, Source | acrosin binding protein | 2298 | 0.724 | 0.0218 | No |
| 9 | GRM8 | NA | GRM8 Entrez, Source | glutamate receptor, metabotropic 8 | 2429 | 0.698 | 0.0273 | No |
| 10 | ACRV1 | NA | ACRV1 Entrez, Source | acrosomal vesicle protein 1 | 2638 | 0.659 | 0.0278 | No |
| 11 | MEP1B | NA | MEP1B Entrez, Source | meprin A, beta | 2678 | 0.651 | 0.0375 | No |
| 12 | STAM2 | NA | STAM2 Entrez, Source | signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 | 2920 | 0.610 | 0.0353 | No |
| 13 | PGS1 | NA | PGS1 Entrez, Source | phosphatidylglycerophosphate synthase 1 | 2934 | 0.607 | 0.0457 | No |
| 14 | GFI1 | NA | GFI1 Entrez, Source | growth factor independent 1 | 3069 | 0.586 | 0.0490 | No |
| 15 | PSMG1 | NA | 3129 | 0.578 | 0.0562 | No | ||
| 16 | MAST2 | NA | MAST2 Entrez, Source | microtubule associated serine/threonine kinase 2 | 3650 | 0.505 | 0.0366 | No |
| 17 | DCC | NA | DCC Entrez, Source | deleted in colorectal carcinoma | 3852 | 0.480 | 0.0343 | No |
| 18 | BRAF | NA | BRAF Entrez, Source | v-raf murine sarcoma viral oncogene homolog B1 | 4135 | 0.442 | 0.0267 | No |
| 19 | ALOX15 | NA | ALOX15 Entrez, Source | arachidonate 15-lipoxygenase | 4267 | 0.426 | 0.0272 | No |
| 20 | CSNK2A2 | NA | CSNK2A2 Entrez, Source | casein kinase 2, alpha prime polypeptide | 4324 | 0.419 | 0.0318 | No |
| 21 | TULP2 | NA | TULP2 Entrez, Source | tubby like protein 2 | 4463 | 0.404 | 0.0315 | No |
| 22 | EZH2 | NA | EZH2 Entrez, Source | enhancer of zeste homolog 2 (Drosophila) | 4537 | 0.399 | 0.0347 | No |
| 23 | PAPOLB | NA | PAPOLB Entrez, Source | poly(A) polymerase beta (testis specific) | 5249 | 0.327 | 0.0013 | No |
| 24 | IFT88 | NA | IFT88 Entrez, Source | intraflagellar transport 88 homolog (Chlamydomonas) | 5301 | 0.323 | 0.0043 | No |
| 25 | HSPA1L | NA | HSPA1L Entrez, Source | heat shock 70kDa protein 1-like | 5728 | 0.284 | -0.0141 | No |
| 26 | NPY5R | NA | NPY5R Entrez, Source | neuropeptide Y receptor Y5 | 5740 | 0.283 | -0.0095 | No |
| 27 | NOS1 | NA | NOS1 Entrez, Source | nitric oxide synthase 1 (neuronal) | 5884 | 0.271 | -0.0125 | No |
| 28 | PHF7 | NA | PHF7 Entrez, Source | PHD finger protein 7 | 5920 | 0.268 | -0.0096 | No |
| 29 | DPEP3 | NA | DPEP3 Entrez, Source | dipeptidase 3 | 5932 | 0.268 | -0.0053 | No |
| 30 | DBF4 | NA | DBF4 Entrez, Source | DBF4 homolog (S. cerevisiae) | 6068 | 0.257 | -0.0081 | No |
| 31 | PDHA2 | NA | PDHA2 Entrez, Source | pyruvate dehydrogenase (lipoamide) alpha 2 | 6115 | 0.253 | -0.0060 | No |
| 32 | CST8 | NA | CST8 Entrez, Source | cystatin 8 (cystatin-related epididymal specific) | 6273 | 0.239 | -0.0103 | No |
| 33 | ARL4A | NA | ARL4A Entrez, Source | ADP-ribosylation factor-like 4A | 6280 | 0.238 | -0.0063 | No |
| 34 | MTNR1A | NA | MTNR1A Entrez, Source | melatonin receptor 1A | 6370 | 0.231 | -0.0070 | No |
| 35 | GSG1 | NA | GSG1 Entrez, Source | germ cell associated 1 | 6413 | 0.228 | -0.0052 | No |
| 36 | ZC3H14 | NA | ZC3H14 Entrez, Source | zinc finger CCCH-type containing 14 | 6723 | 0.202 | -0.0186 | No |
| 37 | COIL | NA | COIL Entrez, Source | coilin | 6738 | 0.201 | -0.0157 | No |
| 38 | TEKT2 | NA | TEKT2 Entrez, Source | tektin 2 (testicular) | 6814 | 0.195 | -0.0164 | No |
| 39 | ZPBP | NA | ZPBP Entrez, Source | zona pellucida binding protein | 6847 | 0.191 | -0.0146 | No |
| 40 | HSPA4L | NA | HSPA4L Entrez, Source | heat shock 70kDa protein 4-like | 6993 | 0.180 | -0.0194 | No |
| 41 | CCT6B | NA | CCT6B Entrez, Source | chaperonin containing TCP1, subunit 6B (zeta 2) | 6999 | 0.180 | -0.0164 | No |
| 42 | IP6K1 | NA | 7214 | 0.166 | -0.0252 | No | ||
| 43 | ADAM2 | NA | ADAM2 Entrez, Source | ADAM metallopeptidase domain 2 (fertilin beta) | 7616 | 0.135 | -0.0450 | No |
| 44 | ART3 | NA | ART3 Entrez, Source | ADP-ribosyltransferase 3 | 7717 | 0.129 | -0.0482 | No |
| 45 | NF2 | NA | NF2 Entrez, Source | neurofibromin 2 (bilateral acoustic neuroma) | 7735 | 0.128 | -0.0468 | No |
| 46 | PARP2 | NA | PARP2 Entrez, Source | poly (ADP-ribose) polymerase family, member 2 | 7856 | 0.118 | -0.0513 | No |
| 47 | GMCL1 | NA | GMCL1 Entrez, Source | germ cell-less homolog 1 (Drosophila) | 8082 | 0.101 | -0.0619 | No |
| 48 | CRISP2 | NA | CRISP2 Entrez, Source | cysteine-rich secretory protein 2 | 8566 | 0.067 | -0.0875 | No |
| 49 | CLPB | NA | CLPB Entrez, Source | ClpB caseinolytic peptidase B homolog (E. coli) | 8670 | 0.060 | -0.0921 | No |
| 50 | CHFR | NA | CHFR Entrez, Source | checkpoint with forkhead and ring finger domains | 8709 | 0.057 | -0.0931 | No |
| 51 | NCAPH | NA | NCAPH Entrez, Source | non-SMC condensin I complex, subunit H | 8836 | 0.048 | -0.0992 | No |
| 52 | ACE | NA | ACE Entrez, Source | angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 | 8941 | 0.040 | -0.1043 | No |
| 53 | MTOR | NA | 8951 | 0.039 | -0.1041 | No | ||
| 54 | CNIH2 | NA | CNIH2 Entrez, Source | cornichon homolog 2 (Drosophila) | 9045 | 0.031 | -0.1086 | No |
| 55 | IDE | NA | IDE Entrez, Source | insulin-degrading enzyme | 9051 | 0.031 | -0.1084 | No |
| 56 | OAZ3 | NA | OAZ3 Entrez, Source | ornithine decarboxylase antizyme 3 | 9187 | 0.022 | -0.1154 | No |
| 57 | MLLT10 | NA | MLLT10 Entrez, Source | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 9227 | 0.019 | -0.1172 | No |
| 58 | GAPDHS | NA | GAPDHS Entrez, Source | glyceraldehyde-3-phosphate dehydrogenase, spermatogenic | 9393 | 0.007 | -0.1263 | No |
| 59 | HIST1H1T | NA | HIST1H1T Entrez, Source | histone cluster 1, H1t | 9430 | 0.004 | -0.1282 | No |
| 60 | TSSK2 | NA | TSSK2 Entrez, Source | testis-specific serine kinase 2 | 9576 | 0.000 | -0.1362 | No |
| 61 | HOXB1 | NA | HOXB1 Entrez, Source | homeobox B1 | 9663 | 0.000 | -0.1410 | No |
| 62 | ZNRF4 | NA | ZNRF4 Entrez, Source | zinc and ring finger 4 | 9702 | 0.000 | -0.1431 | No |
| 63 | VDAC3 | NA | VDAC3 Entrez, Source | voltage-dependent anion channel 3 | 9739 | -0.001 | -0.1451 | No |
| 64 | GPR182 | NA | 9828 | -0.008 | -0.1498 | No | ||
| 65 | SPATA6 | NA | SPATA6 Entrez, Source | spermatogenesis associated 6 | 9858 | -0.010 | -0.1512 | No |
| 66 | GAD1 | NA | GAD1 Entrez, Source | glutamate decarboxylase 1 (brain, 67kDa) | 9933 | -0.015 | -0.1550 | No |
| 67 | RFC4 | NA | RFC4 Entrez, Source | replication factor C (activator 1) 4, 37kDa | 9957 | -0.017 | -0.1560 | No |
| 68 | DMRT1 | NA | DMRT1 Entrez, Source | doublesex and mab-3 related transcription factor 1 | 10371 | -0.040 | -0.1782 | No |
| 69 | TSN | NA | TSN Entrez, Source | translin | 10660 | -0.059 | -0.1931 | No |
| 70 | PHKG2 | NA | PHKG2 Entrez, Source | phosphorylase kinase, gamma 2 (testis) | 10832 | -0.067 | -0.2013 | No |
| 71 | PACRG | NA | PACRG Entrez, Source | PARK2 co-regulated | 10888 | -0.071 | -0.2031 | No |
| 72 | PRKAR2A | NA | PRKAR2A Entrez, Source | protein kinase, cAMP-dependent, regulatory, type II, alpha | 10915 | -0.072 | -0.2032 | No |
| 73 | DDX4 | NA | DDX4 Entrez, Source | DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 | 11285 | -0.097 | -0.2219 | No |
| 74 | YBX2 | NA | YBX2 Entrez, Source | Y box binding protein 2 | 11367 | -0.103 | -0.2245 | No |
| 75 | TOPBP1 | NA | TOPBP1 Entrez, Source | topoisomerase (DNA) II binding protein 1 | 12015 | -0.157 | -0.2575 | No |
| 76 | SYCP1 | NA | SYCP1 Entrez, Source | synaptonemal complex protein 1 | 12051 | -0.160 | -0.2565 | No |
| 77 | TNP1 | NA | TNP1 Entrez, Source | transition protein 1 (during histone to protamine replacement) | 12353 | -0.188 | -0.2698 | No |
| 78 | TALDO1 | NA | TALDO1 Entrez, Source | transaldolase 1 | 12656 | -0.216 | -0.2826 | No |
| 79 | PIAS2 | NA | PIAS2 Entrez, Source | protein inhibitor of activated STAT, 2 | 12701 | -0.219 | -0.2810 | No |
| 80 | SIRT1 | NA | SIRT1 Entrez, Source | sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae) | 12830 | -0.228 | -0.2839 | No |
| 81 | STRBP | NA | STRBP Entrez, Source | spermatid perinuclear RNA binding protein | 12919 | -0.237 | -0.2845 | No |
| 82 | AGFG1 | NA | 12948 | -0.240 | -0.2817 | No | ||
| 83 | PCSK4 | NA | PCSK4 Entrez, Source | proprotein convertase subtilisin/kexin type 4 | 12955 | -0.241 | -0.2776 | No |
| 84 | LDHC | NA | LDHC Entrez, Source | lactate dehydrogenase C | 12974 | -0.243 | -0.2741 | No |
| 85 | AKAP4 | NA | AKAP4 Entrez, Source | A kinase (PRKA) anchor protein 4 | 13084 | -0.251 | -0.2756 | No |
| 86 | BUB1 | NA | BUB1 Entrez, Source | BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) | 13719 | -0.312 | -0.3050 | No |
| 87 | SNAP91 | NA | SNAP91 Entrez, Source | synaptosomal-associated protein, 91kDa homolog (mouse) | 13882 | -0.329 | -0.3080 | No |
| 88 | ACTL7B | NA | ACTL7B Entrez, Source | actin-like 7B | 14175 | -0.365 | -0.3175 | Yes |
| 89 | IL12RB2 | NA | IL12RB2 Entrez, Source | interleukin 12 receptor, beta 2 | 14277 | -0.377 | -0.3163 | Yes |
| 90 | CDK1 | NA | 14384 | -0.389 | -0.3150 | Yes | ||
| 91 | KIF2C | NA | KIF2C Entrez, Source | kinesin family member 2C | 14496 | -0.404 | -0.3138 | Yes |
| 92 | ADAD1 | NA | 14603 | -0.419 | -0.3120 | Yes | ||
| 93 | THEG | NA | THEG Entrez, Source | Theg homolog (mouse) | 14662 | -0.426 | -0.3075 | Yes |
| 94 | TKTL1 | NA | TKTL1 Entrez, Source | transketolase-like 1 | 14700 | -0.429 | -0.3017 | Yes |
| 95 | DMC1 | NA | DMC1 Entrez, Source | DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast) | 14732 | -0.434 | -0.2955 | Yes |
| 96 | RAD17 | NA | RAD17 Entrez, Source | RAD17 homolog (S. pombe) | 14735 | -0.435 | -0.2876 | Yes |
| 97 | RPL39L | NA | RPL39L Entrez, Source | ribosomal protein L39-like | 14746 | -0.436 | -0.2802 | Yes |
| 98 | TTK | NA | TTK Entrez, Source | TTK protein kinase | 14952 | -0.469 | -0.2830 | Yes |
| 99 | DNAJB8 | NA | DNAJB8 Entrez, Source | DnaJ (Hsp40) homolog, subfamily B, member 8 | 14959 | -0.470 | -0.2748 | Yes |
| 100 | CLGN | NA | CLGN Entrez, Source | calmegin | 15014 | -0.477 | -0.2691 | Yes |
| 101 | POMC | NA | POMC Entrez, Source | proopiomelanocortin (adrenocorticotropin/ beta-lipotropin/ alpha-melanocyte stimulating hormone/ beta-melanocyte stimulating hormone/ beta-endorphin) | 15077 | -0.486 | -0.2637 | Yes |
| 102 | GSTM3 | NA | GSTM3 Entrez, Source | glutathione S-transferase M3 (brain) | 15376 | -0.529 | -0.2705 | Yes |
| 103 | CHRM4 | NA | CHRM4 Entrez, Source | cholinergic receptor, muscarinic 4 | 15506 | -0.553 | -0.2676 | Yes |
| 104 | SLC2A5 | NA | SLC2A5 Entrez, Source | solute carrier family 2 (facilitated glucose/fructose transporter), member 5 | 15641 | -0.580 | -0.2644 | Yes |
| 105 | JAM3 | NA | JAM3 Entrez, Source | junctional adhesion molecule 3 | 15734 | -0.595 | -0.2587 | Yes |
| 106 | SCG5 | NA | SCG5 Entrez, Source | secretogranin V (7B2 protein) | 15831 | -0.616 | -0.2527 | Yes |
| 107 | NEFH | NA | NEFH Entrez, Source | neurofilament, heavy polypeptide 200kDa | 15853 | -0.622 | -0.2425 | Yes |
| 108 | CFTR | NA | CFTR Entrez, Source | cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) | 15890 | -0.631 | -0.2330 | Yes |
| 109 | MLF1 | NA | MLF1 Entrez, Source | myeloid leukemia factor 1 | 15955 | -0.644 | -0.2248 | Yes |
| 110 | SHE | NA | SHE Entrez, Source | Src homology 2 domain containing E | 16031 | -0.663 | -0.2169 | Yes |
| 111 | HTR5A | NA | HTR5A Entrez, Source | 5-hydroxytryptamine (serotonin) receptor 5A | 16102 | -0.681 | -0.2083 | Yes |
| 112 | AURKA | NA | AURKA Entrez, Source | aurora kinase A | 16121 | -0.685 | -0.1968 | Yes |
| 113 | ELOVL3 | NA | ELOVL3 Entrez, Source | elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3 | 16139 | -0.689 | -0.1851 | Yes |
| 114 | TCP11 | NA | TCP11 Entrez, Source | t-complex 11 (mouse) | 16161 | -0.695 | -0.1736 | Yes |
| 115 | NEK2 | NA | NEK2 Entrez, Source | NIMA (never in mitosis gene a)-related kinase 2 | 16344 | -0.746 | -0.1701 | Yes |
| 116 | MAP7 | NA | MAP7 Entrez, Source | microtubule-associated protein 7 | 16361 | -0.751 | -0.1572 | Yes |
| 117 | NPHP1 | NA | NPHP1 Entrez, Source | nephronophthisis 1 (juvenile) | 16445 | -0.777 | -0.1477 | Yes |
| 118 | PEBP1 | NA | PEBP1 Entrez, Source | phosphatidylethanolamine binding protein 1 | 16552 | -0.812 | -0.1387 | Yes |
| 119 | DDX25 | NA | DDX25 Entrez, Source | DEAD (Asp-Glu-Ala-Asp) box polypeptide 25 | 16570 | -0.817 | -0.1247 | Yes |
| 120 | SCG3 | NA | SCG3 Entrez, Source | secretogranin III | 16654 | -0.840 | -0.1140 | Yes |
| 121 | CLVS1 | NA | 16696 | -0.852 | -0.1007 | Yes | ||
| 122 | SEPT4 | NA | SEPT4 Entrez, Source | septin 4 | 16728 | -0.866 | -0.0866 | Yes |
| 123 | PGK2 | NA | PGK2 Entrez, Source | phosphoglycerate kinase 2 | 16766 | -0.876 | -0.0727 | Yes |
| 124 | NAA11 | NA | 16793 | -0.886 | -0.0579 | Yes | ||
| 125 | CCNB2 | NA | CCNB2 Entrez, Source | cyclin B2 | 17059 | -0.994 | -0.0545 | Yes |
| 126 | ADCYAP1 | NA | ADCYAP1 Entrez, Source | adenylate cyclase activating polypeptide 1 (pituitary) | 17076 | -1.002 | -0.0371 | Yes |
| 127 | CDKN3 | NA | CDKN3 Entrez, Source | cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity phosphatase) | 17564 | -1.309 | -0.0402 | Yes |
| 128 | LPIN1 | NA | LPIN1 Entrez, Source | lipin 1 | 17741 | -1.516 | -0.0222 | Yes |
| 129 | HSPA2 | NA | HSPA2 Entrez, Source | heat shock 70kDa protein 2 | 18042 | -2.509 | 0.0069 | Yes |
