Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | HALLMARK_PROTEIN_SECRETION |
| Enrichment Score (ES) | -0.31549498 |
| Normalized Enrichment Score (NES) | -1.2166508 |
| Nominal p-value | 0.113300495 |
| FDR q-value | 0.16243261 |
| FWER p-Value | 0.856 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | KRT18 | NA | KRT18 Entrez, Source | keratin 18 | 372 | 1.771 | 0.0305 | No |
| 2 | COPE | NA | COPE Entrez, Source | coatomer protein complex, subunit epsilon | 977 | 1.131 | 0.0297 | No |
| 3 | EGFR | NA | EGFR Entrez, Source | epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) | 1042 | 1.098 | 0.0578 | No |
| 4 | SEC24D | NA | SEC24D Entrez, Source | SEC24 related gene family, member D (S. cerevisiae) | 2748 | 0.640 | -0.0181 | No |
| 5 | M6PR | NA | M6PR Entrez, Source | mannose-6-phosphate receptor (cation dependent) | 3594 | 0.511 | -0.0501 | No |
| 6 | CD63 | NA | CD63 Entrez, Source | CD63 molecule | 3837 | 0.482 | -0.0496 | No |
| 7 | GOSR2 | NA | GOSR2 Entrez, Source | golgi SNAP receptor complex member 2 | 4137 | 0.442 | -0.0534 | No |
| 8 | DOPEY1 | NA | DOPEY1 Entrez, Source | dopey family member 1 | 4437 | 0.407 | -0.0582 | No |
| 9 | TMX1 | NA | 5028 | 0.348 | -0.0808 | No | ||
| 10 | SCAMP3 | NA | SCAMP3 Entrez, Source | secretory carrier membrane protein 3 | 5163 | 0.335 | -0.0786 | No |
| 11 | ZW10 | NA | ZW10 Entrez, Source | ZW10, kinetochore associated, homolog (Drosophila) | 5211 | 0.330 | -0.0716 | No |
| 12 | ATP7A | NA | ATP7A Entrez, Source | ATPase, Cu++ transporting, alpha polypeptide (Menkes syndrome) | 5248 | 0.327 | -0.0642 | No |
| 13 | ATP6V1H | NA | ATP6V1H Entrez, Source | ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H | 5266 | 0.326 | -0.0557 | No |
| 14 | TMED2 | NA | TMED2 Entrez, Source | transmembrane emp24 domain trafficking protein 2 | 5695 | 0.287 | -0.0711 | No |
| 15 | DNM1L | NA | DNM1L Entrez, Source | dynamin 1-like | 6205 | 0.245 | -0.0922 | No |
| 16 | ADAM10 | NA | ADAM10 Entrez, Source | ADAM metallopeptidase domain 10 | 6234 | 0.242 | -0.0868 | No |
| 17 | RPS6KA3 | NA | RPS6KA3 Entrez, Source | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 6490 | 0.222 | -0.0945 | No |
| 18 | STX12 | NA | STX12 Entrez, Source | syntaxin 12 | 6716 | 0.202 | -0.1011 | No |
| 19 | GBF1 | NA | GBF1 Entrez, Source | golgi-specific brefeldin A resistance factor 1 | 6736 | 0.201 | -0.0964 | No |
| 20 | CLTA | NA | CLTA Entrez, Source | clathrin, light chain (Lca) | 6862 | 0.191 | -0.0978 | No |
| 21 | SH3GL2 | NA | SH3GL2 Entrez, Source | SH3-domain GRB2-like 2 | 6905 | 0.188 | -0.0947 | No |
| 22 | ARFGEF1 | NA | ARFGEF1 Entrez, Source | ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited) | 7049 | 0.176 | -0.0976 | No |
| 23 | VAMP3 | NA | VAMP3 Entrez, Source | vesicle-associated membrane protein 3 (cellubrevin) | 7239 | 0.164 | -0.1033 | No |
| 24 | ARF1 | NA | ARF1 Entrez, Source | ADP-ribosylation factor 1 | 7554 | 0.140 | -0.1166 | No |
| 25 | YKT6 | NA | YKT6 Entrez, Source | YKT6 v-SNARE homolog (S. cerevisiae) | 7585 | 0.137 | -0.1143 | No |
| 26 | CLTC | NA | CLTC Entrez, Source | clathrin, heavy chain (Hc) | 7604 | 0.136 | -0.1114 | No |
| 27 | GLA | NA | GLA Entrez, Source | galactosidase, alpha | 8009 | 0.106 | -0.1307 | No |
| 28 | MON2 | NA | MON2 Entrez, Source | MON2 homolog (S. cerevisiae) | 8133 | 0.097 | -0.1347 | No |
| 29 | RAB9A | NA | 8206 | 0.093 | -0.1360 | No | ||
| 30 | USO1 | NA | 8416 | 0.078 | -0.1453 | No | ||
| 31 | AP3S1 | NA | AP3S1 Entrez, Source | adaptor-related protein complex 3, sigma 1 subunit | 8695 | 0.058 | -0.1590 | No |
| 32 | NAPG | NA | NAPG Entrez, Source | N-ethylmaleimide-sensitive factor attachment protein, gamma | 8703 | 0.057 | -0.1578 | No |
| 33 | RAB5A | NA | RAB5A Entrez, Source | RAB5A, member RAS oncogene family | 8837 | 0.048 | -0.1637 | No |
| 34 | YIPF6 | NA | YIPF6 Entrez, Source | Yip1 domain family, member 6 | 8969 | 0.037 | -0.1699 | No |
| 35 | AP2S1 | NA | AP2S1 Entrez, Source | adaptor-related protein complex 2, sigma 1 subunit | 9038 | 0.032 | -0.1727 | No |
| 36 | COPB2 | NA | COPB2 Entrez, Source | coatomer protein complex, subunit beta 2 (beta prime) | 9300 | 0.014 | -0.1868 | No |
| 37 | NAPA | NA | NAPA Entrez, Source | N-ethylmaleimide-sensitive factor attachment protein, alpha | 9909 | -0.013 | -0.2200 | No |
| 38 | RER1 | NA | RER1 Entrez, Source | RER1 retention in endoplasmic reticulum 1 homolog (S. cerevisiae) | 9976 | -0.018 | -0.2232 | No |
| 39 | RAB14 | NA | RAB14 Entrez, Source | RAB14, member RAS oncogene family | 10192 | -0.031 | -0.2342 | No |
| 40 | LMAN1 | NA | LMAN1 Entrez, Source | lectin, mannose-binding, 1 | 10289 | -0.038 | -0.2384 | No |
| 41 | SSPN | NA | SSPN Entrez, Source | sarcospan (Kras oncogene-associated gene) | 10648 | -0.057 | -0.2566 | No |
| 42 | AP3B1 | NA | AP3B1 Entrez, Source | adaptor-related protein complex 3, beta 1 subunit | 10689 | -0.060 | -0.2570 | No |
| 43 | COG2 | NA | COG2 Entrez, Source | component of oligomeric golgi complex 2 | 10779 | -0.064 | -0.2601 | No |
| 44 | VPS4B | NA | VPS4B Entrez, Source | vacuolar protein sorting 4 homolog B (S. cerevisiae) | 10962 | -0.075 | -0.2680 | No |
| 45 | AP1G1 | NA | AP1G1 Entrez, Source | adaptor-related protein complex 1, gamma 1 subunit | 11340 | -0.101 | -0.2860 | No |
| 46 | ATP1A1 | NA | ATP1A1 Entrez, Source | ATPase, Na+/K+ transporting, alpha 1 polypeptide | 11447 | -0.110 | -0.2887 | No |
| 47 | GOLGA4 | NA | GOLGA4 Entrez, Source | golgi autoantigen, golgin subfamily a, 4 | 11528 | -0.117 | -0.2897 | No |
| 48 | RAB22A | NA | RAB22A Entrez, Source | RAB22A, member RAS oncogene family | 11667 | -0.128 | -0.2937 | No |
| 49 | ARFGEF2 | NA | ARFGEF2 Entrez, Source | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | 11710 | -0.133 | -0.2922 | No |
| 50 | STX16 | NA | STX16 Entrez, Source | syntaxin 16 | 11768 | -0.137 | -0.2914 | No |
| 51 | ARCN1 | NA | ARCN1 Entrez, Source | archain 1 | 11780 | -0.138 | -0.2880 | No |
| 52 | TPD52 | NA | TPD52 Entrez, Source | tumor protein D52 | 11937 | -0.150 | -0.2923 | No |
| 53 | ERGIC3 | NA | ERGIC3 Entrez, Source | ERGIC and golgi 3 | 12150 | -0.169 | -0.2992 | No |
| 54 | CLN5 | NA | CLN5 Entrez, Source | ceroid-lipofuscinosis, neuronal 5 | 12241 | -0.177 | -0.2991 | No |
| 55 | ANP32E | NA | ANP32E Entrez, Source | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | 12539 | -0.205 | -0.3096 | Yes |
| 56 | STAM | NA | STAM Entrez, Source | signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 | 12618 | -0.212 | -0.3078 | Yes |
| 57 | AP2M1 | NA | AP2M1 Entrez, Source | adaptor-related protein complex 2, mu 1 subunit | 12694 | -0.219 | -0.3056 | Yes |
| 58 | AP2B1 | NA | AP2B1 Entrez, Source | adaptor-related protein complex 2, beta 1 subunit | 12771 | -0.225 | -0.3034 | Yes |
| 59 | VAMP4 | NA | VAMP4 Entrez, Source | vesicle-associated membrane protein 4 | 12865 | -0.232 | -0.3018 | Yes |
| 60 | CAV2 | NA | CAV2 Entrez, Source | caveolin 2 | 12910 | -0.236 | -0.2974 | Yes |
| 61 | COPB1 | NA | COPB1 Entrez, Source | coatomer protein complex, subunit beta 1 | 12964 | -0.242 | -0.2934 | Yes |
| 62 | SCRN1 | NA | SCRN1 Entrez, Source | secernin 1 | 13264 | -0.269 | -0.3022 | Yes |
| 63 | RAB2A | NA | 13350 | -0.276 | -0.2989 | Yes | ||
| 64 | BET1 | NA | BET1 Entrez, Source | BET1 homolog (S. cerevisiae) | 13417 | -0.284 | -0.2944 | Yes |
| 65 | IGF2R | NA | IGF2R Entrez, Source | insulin-like growth factor 2 receptor | 13479 | -0.290 | -0.2894 | Yes |
| 66 | ICA1 | NA | ICA1 Entrez, Source | islet cell autoantigen 1, 69kDa | 13531 | -0.294 | -0.2837 | Yes |
| 67 | TOM1L1 | NA | TOM1L1 Entrez, Source | target of myb1-like 1 (chicken) | 13588 | -0.300 | -0.2782 | Yes |
| 68 | OCRL | NA | OCRL Entrez, Source | oculocerebrorenal syndrome of Lowe | 13606 | -0.301 | -0.2705 | Yes |
| 69 | CTSC | NA | CTSC Entrez, Source | cathepsin C | 13770 | -0.317 | -0.2703 | Yes |
| 70 | SGMS1 | NA | 13865 | -0.327 | -0.2661 | Yes | ||
| 71 | SOD1 | NA | SOD1 Entrez, Source | superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) | 13992 | -0.344 | -0.2632 | Yes |
| 72 | GALC | NA | GALC Entrez, Source | galactosylceramidase | 14088 | -0.357 | -0.2581 | Yes |
| 73 | SEC22B | NA | SEC22B Entrez, Source | SEC22 vesicle trafficking protein homolog B (S. cerevisiae) | 14413 | -0.392 | -0.2647 | Yes |
| 74 | VPS45 | NA | 14491 | -0.404 | -0.2573 | Yes | ||
| 75 | ARFIP1 | NA | ARFIP1 Entrez, Source | ADP-ribosylation factor interacting protein 1 (arfaptin 1) | 14493 | -0.404 | -0.2457 | Yes |
| 76 | TSG101 | NA | TSG101 Entrez, Source | tumor susceptibility gene 101 | 14724 | -0.433 | -0.2460 | Yes |
| 77 | MAPK1 | NA | MAPK1 Entrez, Source | mitogen-activated protein kinase 1 | 14765 | -0.439 | -0.2356 | Yes |
| 78 | ARFGAP3 | NA | ARFGAP3 Entrez, Source | ADP-ribosylation factor GTPase activating protein 3 | 14921 | -0.464 | -0.2307 | Yes |
| 79 | VAMP7 | NA | 15130 | -0.493 | -0.2281 | Yes | ||
| 80 | SNX2 | NA | SNX2 Entrez, Source | sorting nexin 2 | 15317 | -0.519 | -0.2234 | Yes |
| 81 | STX7 | NA | STX7 Entrez, Source | syntaxin 7 | 15342 | -0.522 | -0.2097 | Yes |
| 82 | LAMP2 | NA | LAMP2 Entrez, Source | lysosomal-associated membrane protein 2 | 15452 | -0.543 | -0.2000 | Yes |
| 83 | TMED10 | NA | TMED10 Entrez, Source | transmembrane emp24-like trafficking protein 10 (yeast) | 15508 | -0.553 | -0.1871 | Yes |
| 84 | ATP6V1B1 | NA | ATP6V1B1 Entrez, Source | ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 (Renal tubular acidosis with deafness) | 15794 | -0.609 | -0.1853 | Yes |
| 85 | DST | NA | DST Entrez, Source | dystonin | 15838 | -0.619 | -0.1699 | Yes |
| 86 | KIF1B | NA | KIF1B Entrez, Source | kinesin family member 1B | 15954 | -0.643 | -0.1577 | Yes |
| 87 | CLCN3 | NA | CLCN3 Entrez, Source | chloride channel 3 | 16143 | -0.691 | -0.1482 | Yes |
| 88 | PPT1 | NA | PPT1 Entrez, Source | palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile) | 16196 | -0.705 | -0.1307 | Yes |
| 89 | GNAS | NA | GNAS Entrez, Source | GNAS complex locus | 16263 | -0.724 | -0.1135 | Yes |
| 90 | BNIP3 | NA | BNIP3 Entrez, Source | BCL2/adenovirus E1B 19kDa interacting protein 3 | 16611 | -0.831 | -0.1088 | Yes |
| 91 | PAM | NA | PAM Entrez, Source | peptidylglycine alpha-amidating monooxygenase | 16641 | -0.835 | -0.0863 | Yes |
| 92 | SNAP23 | NA | SNAP23 Entrez, Source | synaptosomal-associated protein, 23kDa | 16999 | -0.966 | -0.0782 | Yes |
| 93 | SCAMP1 | NA | SCAMP1 Entrez, Source | secretory carrier membrane protein 1 | 17266 | -1.099 | -0.0612 | Yes |
| 94 | TSPAN8 | NA | TSPAN8 Entrez, Source | tetraspanin 8 | 17484 | -1.245 | -0.0373 | Yes |
| 95 | ABCA1 | NA | ABCA1 Entrez, Source | ATP-binding cassette, sub-family A (ABC1), member 1 | 18056 | -2.602 | 0.0061 | Yes |
