Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | HALLMARK_PEROXISOME |
| Enrichment Score (ES) | -0.28790572 |
| Normalized Enrichment Score (NES) | -1.1216623 |
| Nominal p-value | 0.23287672 |
| FDR q-value | 0.308308 |
| FWER p-Value | 0.989 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | SOD2 | NA | SOD2 Entrez, Source | superoxide dismutase 2, mitochondrial | 263 | 2.124 | 0.0247 | No |
| 2 | MVP | NA | MVP Entrez, Source | major vault protein | 337 | 1.863 | 0.0551 | No |
| 3 | STS | NA | STS Entrez, Source | steroid sulfatase (microsomal), arylsulfatase C, isozyme S | 356 | 1.817 | 0.0877 | No |
| 4 | CRABP2 | NA | CRABP2 Entrez, Source | cellular retinoic acid binding protein 2 | 380 | 1.758 | 0.1190 | No |
| 5 | RXRG | NA | RXRG Entrez, Source | retinoid X receptor, gamma | 894 | 1.179 | 0.1124 | No |
| 6 | SEMA3C | NA | SEMA3C Entrez, Source | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 939 | 1.149 | 0.1312 | No |
| 7 | BCL10 | NA | BCL10 Entrez, Source | B-cell CLL/lymphoma 10 | 1035 | 1.099 | 0.1463 | No |
| 8 | CLN6 | NA | CLN6 Entrez, Source | ceroid-lipofuscinosis, neuronal 6, late infantile, variant | 1061 | 1.088 | 0.1650 | No |
| 9 | DIO1 | NA | DIO1 Entrez, Source | deiodinase, iodothyronine, type I | 1227 | 1.009 | 0.1745 | No |
| 10 | HRAS | NA | HRAS Entrez, Source | v-Ha-ras Harvey rat sarcoma viral oncogene homolog | 1799 | 0.831 | 0.1583 | No |
| 11 | ABCD1 | NA | ABCD1 Entrez, Source | ATP-binding cassette, sub-family D (ALD), member 1 | 2274 | 0.729 | 0.1455 | No |
| 12 | RETSAT | NA | RETSAT Entrez, Source | retinol saturase (all-trans-retinol 13,14-reductase) | 2802 | 0.630 | 0.1280 | No |
| 13 | HSD11B2 | NA | HSD11B2 Entrez, Source | hydroxysteroid (11-beta) dehydrogenase 2 | 3245 | 0.560 | 0.1139 | No |
| 14 | CEL | NA | CEL Entrez, Source | carboxyl ester lipase (bile salt-stimulated lipase) | 3443 | 0.530 | 0.1128 | No |
| 15 | SLC27A2 | NA | SLC27A2 Entrez, Source | solute carrier family 27 (fatty acid transporter), member 2 | 3493 | 0.523 | 0.1198 | No |
| 16 | ALB | NA | ALB Entrez, Source | albumin | 3765 | 0.490 | 0.1138 | No |
| 17 | CNBP | NA | CNBP Entrez, Source | CCHC-type zinc finger, nucleic acid binding protein | 3831 | 0.482 | 0.1191 | No |
| 18 | MSH2 | NA | MSH2 Entrez, Source | mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) | 3945 | 0.468 | 0.1216 | No |
| 19 | ERCC1 | NA | ERCC1 Entrez, Source | excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence) | 3950 | 0.468 | 0.1300 | No |
| 20 | TSPO | NA | TSPO Entrez, Source | translocator protein (18kDa) | 4148 | 0.441 | 0.1272 | No |
| 21 | PEX14 | NA | PEX14 Entrez, Source | peroxisomal biogenesis factor 14 | 4816 | 0.371 | 0.0972 | No |
| 22 | CLN8 | NA | CLN8 Entrez, Source | ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation) | 4898 | 0.362 | 0.0994 | No |
| 23 | MLYCD | NA | MLYCD Entrez, Source | malonyl-CoA decarboxylase | 5093 | 0.342 | 0.0950 | No |
| 24 | LONP2 | NA | 5295 | 0.323 | 0.0898 | No | ||
| 25 | ERCC3 | NA | ERCC3 Entrez, Source | excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing) | 5466 | 0.306 | 0.0861 | No |
| 26 | ABCC8 | NA | ABCC8 Entrez, Source | ATP-binding cassette, sub-family C (CFTR/MRP), member 8 | 6109 | 0.253 | 0.0552 | No |
| 27 | CTBP1 | NA | CTBP1 Entrez, Source | C-terminal binding protein 1 | 6266 | 0.239 | 0.0510 | No |
| 28 | ACSL4 | NA | ACSL4 Entrez, Source | acyl-CoA synthetase long-chain family member 4 | 6463 | 0.225 | 0.0443 | No |
| 29 | YWHAH | NA | YWHAH Entrez, Source | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide | 6580 | 0.213 | 0.0418 | No |
| 30 | SLC25A19 | NA | SLC25A19 Entrez, Source | solute carrier family 25 (mitochondrial deoxynucleotide carrier), member 19 | 6758 | 0.199 | 0.0357 | No |
| 31 | RDH11 | NA | RDH11 Entrez, Source | retinol dehydrogenase 11 (all-trans/9-cis/11-cis) | 6821 | 0.194 | 0.0359 | No |
| 32 | ACSL5 | NA | ACSL5 Entrez, Source | acyl-CoA synthetase long-chain family member 5 | 6933 | 0.185 | 0.0331 | No |
| 33 | SLC25A17 | NA | SLC25A17 Entrez, Source | solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17 | 7152 | 0.169 | 0.0242 | No |
| 34 | SCGB1A1 | NA | SCGB1A1 Entrez, Source | secretoglobin, family 1A, member 1 (uteroglobin) | 7225 | 0.165 | 0.0233 | No |
| 35 | ITGB1BP1 | NA | ITGB1BP1 Entrez, Source | integrin beta 1 binding protein 1 | 7332 | 0.157 | 0.0203 | No |
| 36 | HSD3B7 | NA | HSD3B7 Entrez, Source | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 | 7819 | 0.121 | -0.0044 | No |
| 37 | PEX6 | NA | PEX6 Entrez, Source | peroxisomal biogenesis factor 6 | 7887 | 0.116 | -0.0059 | No |
| 38 | GNPAT | NA | GNPAT Entrez, Source | glyceronephosphate O-acyltransferase | 8028 | 0.105 | -0.0117 | No |
| 39 | TTR | NA | TTR Entrez, Source | transthyretin (prealbumin, amyloidosis type I) | 8177 | 0.094 | -0.0182 | No |
| 40 | DHCR24 | NA | DHCR24 Entrez, Source | 24-dehydrocholesterol reductase | 8233 | 0.091 | -0.0195 | No |
| 41 | SLC23A2 | NA | SLC23A2 Entrez, Source | solute carrier family 23 (nucleobase transporters), member 2 | 8258 | 0.089 | -0.0192 | No |
| 42 | CACNA1B | NA | CACNA1B Entrez, Source | calcium channel, voltage-dependent, L type, alpha 1B subunit | 8297 | 0.086 | -0.0197 | No |
| 43 | GSTK1 | NA | GSTK1 Entrez, Source | glutathione S-transferase kappa 1 | 8511 | 0.071 | -0.0302 | No |
| 44 | ACAA1 | NA | ACAA1 Entrez, Source | acetyl-Coenzyme A acyltransferase 1 (peroxisomal 3-oxoacyl-Coenzyme A thiolase) | 8617 | 0.064 | -0.0349 | No |
| 45 | CDK7 | NA | CDK7 Entrez, Source | cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase) | 8644 | 0.061 | -0.0352 | No |
| 46 | ABCC5 | NA | ABCC5 Entrez, Source | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 8981 | 0.036 | -0.0531 | No |
| 47 | ABCD2 | NA | ABCD2 Entrez, Source | ATP-binding cassette, sub-family D (ALD), member 2 | 8992 | 0.035 | -0.0530 | No |
| 48 | SLC35B2 | NA | SLC35B2 Entrez, Source | solute carrier family 35, member B2 | 8997 | 0.035 | -0.0526 | No |
| 49 | PEX11A | NA | PEX11A Entrez, Source | peroxisomal biogenesis factor 11A | 9043 | 0.032 | -0.0545 | No |
| 50 | PEX5 | NA | PEX5 Entrez, Source | peroxisomal biogenesis factor 5 | 9046 | 0.031 | -0.0540 | No |
| 51 | IDE | NA | IDE Entrez, Source | insulin-degrading enzyme | 9051 | 0.031 | -0.0536 | No |
| 52 | NUDT19 | NA | NUDT19 Entrez, Source | nudix (nucleoside diphosphate linked moiety X)-type motif 19 | 9063 | 0.030 | -0.0537 | No |
| 53 | PRDX5 | NA | PRDX5 Entrez, Source | peroxiredoxin 5 | 9470 | 0.003 | -0.0761 | No |
| 54 | CRABP1 | NA | CRABP1 Entrez, Source | cellular retinoic acid binding protein 1 | 9567 | 0.000 | -0.0814 | No |
| 55 | SERPINA6 | NA | SERPINA6 Entrez, Source | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 | 9983 | -0.018 | -0.1040 | No |
| 56 | HSD17B11 | NA | 10104 | -0.026 | -0.1102 | No | ||
| 57 | ABCB9 | NA | ABCB9 Entrez, Source | ATP-binding cassette, sub-family B (MDR/TAP), member 9 | 10629 | -0.056 | -0.1382 | No |
| 58 | SIAH1 | NA | SIAH1 Entrez, Source | seven in absentia homolog 1 (Drosophila) | 10795 | -0.065 | -0.1461 | No |
| 59 | HAO2 | NA | HAO2 Entrez, Source | hydroxyacid oxidase 2 (long chain) | 10859 | -0.069 | -0.1483 | No |
| 60 | PEX2 | NA | 10877 | -0.070 | -0.1480 | No | ||
| 61 | PEX11B | NA | PEX11B Entrez, Source | peroxisomal biogenesis factor 11B | 10934 | -0.073 | -0.1497 | No |
| 62 | VPS4B | NA | VPS4B Entrez, Source | vacuolar protein sorting 4 homolog B (S. cerevisiae) | 10962 | -0.075 | -0.1498 | No |
| 63 | ACOT8 | NA | ACOT8 Entrez, Source | acyl-CoA thioesterase 8 | 11947 | -0.151 | -0.2015 | No |
| 64 | ABCB4 | NA | ABCB4 Entrez, Source | ATP-binding cassette, sub-family B (MDR/TAP), member 4 | 11952 | -0.151 | -0.1989 | No |
| 65 | FIS1 | NA | FIS1 Entrez, Source | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | 11966 | -0.152 | -0.1968 | No |
| 66 | FADS1 | NA | FADS1 Entrez, Source | fatty acid desaturase 1 | 12002 | -0.156 | -0.1959 | No |
| 67 | ECI2 | NA | 12467 | -0.198 | -0.2179 | No | ||
| 68 | ALDH1A1 | NA | ALDH1A1 Entrez, Source | aldehyde dehydrogenase 1 family, member A1 | 12537 | -0.205 | -0.2179 | No |
| 69 | PABPC1 | NA | PABPC1 Entrez, Source | poly(A) binding protein, cytoplasmic 1 | 12740 | -0.222 | -0.2250 | No |
| 70 | ELOVL5 | NA | ELOVL5 Entrez, Source | ELOVL family member 5, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast) | 13047 | -0.249 | -0.2373 | No |
| 71 | HMGCL | NA | HMGCL Entrez, Source | 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (hydroxymethylglutaricaciduria) | 13133 | -0.256 | -0.2373 | No |
| 72 | PRDX1 | NA | PRDX1 Entrez, Source | peroxiredoxin 1 | 13418 | -0.284 | -0.2478 | No |
| 73 | SLC25A4 | NA | SLC25A4 Entrez, Source | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 | 13504 | -0.292 | -0.2471 | No |
| 74 | SMARCC1 | NA | SMARCC1 Entrez, Source | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | 13610 | -0.302 | -0.2473 | No |
| 75 | PEX13 | NA | PEX13 Entrez, Source | peroxisome biogenesis factor 13 | 13856 | -0.326 | -0.2549 | No |
| 76 | EPHX2 | NA | EPHX2 Entrez, Source | epoxide hydrolase 2, cytoplasmic | 13870 | -0.327 | -0.2495 | No |
| 77 | ABCB1 | NA | ABCB1 Entrez, Source | ATP-binding cassette, sub-family B (MDR/TAP), member 1 | 13944 | -0.338 | -0.2473 | No |
| 78 | SOD1 | NA | SOD1 Entrez, Source | superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) | 13992 | -0.344 | -0.2436 | No |
| 79 | ALDH9A1 | NA | ALDH9A1 Entrez, Source | aldehyde dehydrogenase 9 family, member A1 | 13994 | -0.345 | -0.2372 | No |
| 80 | HSD17B4 | NA | HSD17B4 Entrez, Source | hydroxysteroid (17-beta) dehydrogenase 4 | 14216 | -0.369 | -0.2427 | No |
| 81 | ISOC1 | NA | ISOC1 Entrez, Source | isochorismatase domain containing 1 | 14630 | -0.422 | -0.2577 | No |
| 82 | CRAT | NA | CRAT Entrez, Source | carnitine acetyltransferase | 14842 | -0.454 | -0.2610 | No |
| 83 | ACOX1 | NA | ACOX1 Entrez, Source | acyl-Coenzyme A oxidase 1, palmitoyl | 14870 | -0.458 | -0.2540 | No |
| 84 | SCP2 | NA | SCP2 Entrez, Source | sterol carrier protein 2 | 15228 | -0.506 | -0.2644 | No |
| 85 | IDH1 | NA | IDH1 Entrez, Source | isocitrate dehydrogenase 1 (NADP+), soluble | 15361 | -0.527 | -0.2620 | No |
| 86 | NR1I2 | NA | NR1I2 Entrez, Source | nuclear receptor subfamily 1, group I, member 2 | 15389 | -0.531 | -0.2537 | No |
| 87 | DLG4 | NA | DLG4 Entrez, Source | discs, large homolog 4 (Drosophila) | 15451 | -0.543 | -0.2470 | No |
| 88 | ABCD3 | NA | ABCD3 Entrez, Source | ATP-binding cassette, sub-family D (ALD), member 3 | 16108 | -0.682 | -0.2707 | Yes |
| 89 | TOP2A | NA | TOP2A Entrez, Source | topoisomerase (DNA) II alpha 170kDa | 16265 | -0.724 | -0.2660 | Yes |
| 90 | EHHADH | NA | EHHADH Entrez, Source | enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase | 16508 | -0.801 | -0.2645 | Yes |
| 91 | FDPS | NA | FDPS Entrez, Source | farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) | 16931 | -0.940 | -0.2705 | Yes |
| 92 | IDI1 | NA | IDI1 Entrez, Source | isopentenyl-diphosphate delta isomerase 1 | 17064 | -0.996 | -0.2594 | Yes |
| 93 | CADM1 | NA | 17132 | -1.026 | -0.2441 | Yes | ||
| 94 | ECH1 | NA | ECH1 Entrez, Source | enoyl Coenzyme A hydratase 1, peroxisomal | 17135 | -1.027 | -0.2252 | Yes |
| 95 | CAT | NA | CAT Entrez, Source | catalase | 17167 | -1.043 | -0.2077 | Yes |
| 96 | ATXN1 | NA | ATXN1 Entrez, Source | ataxin 1 | 17686 | -1.455 | -0.2095 | Yes |
| 97 | SULT2B1 | NA | SULT2B1 Entrez, Source | sulfotransferase family, cytosolic, 2B, member 1 | 17782 | -1.584 | -0.1854 | Yes |
| 98 | ACSL1 | NA | ACSL1 Entrez, Source | acyl-CoA synthetase long-chain family member 1 | 17864 | -1.764 | -0.1573 | Yes |
| 99 | IDH2 | NA | IDH2 Entrez, Source | isocitrate dehydrogenase 2 (NADP+), mitochondrial | 17869 | -1.770 | -0.1248 | Yes |
| 100 | DHRS3 | NA | DHRS3 Entrez, Source | dehydrogenase/reductase (SDR family) member 3 | 17931 | -1.939 | -0.0923 | Yes |
| 101 | UGT2B17 | NA | UGT2B17 Entrez, Source | UDP glucuronosyltransferase 2 family, polypeptide B17 | 18075 | -2.762 | -0.0492 | Yes |
| 102 | FABP6 | NA | FABP6 Entrez, Source | fatty acid binding protein 6, ileal (gastrotropin) | 18092 | -2.931 | 0.0042 | Yes |
