Datasetw1a_vs_wt_vs_wt.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp_repos
Phenotypew1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos
Upregulated in classago1w1a
GeneSetHALLMARK_P53_PATHWAY
Enrichment Score (ES)0.35138282
Normalized Enrichment Score (NES)1.3967719
Nominal p-value0.011730205
FDR q-value0.050121184
FWER p-Value0.532
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_P53_PATHWAY   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1KRT17NAKRT17
Entrez,  Source
keratin 17184.5720.0359Yes
2MXD1NAMXD1
Entrez,  Source
MAX dimerization protein 11153.0590.0552Yes
3KLF4NAKLF4
Entrez,  Source
Kruppel-like factor 4 (gut)1722.5500.0727Yes
4EPHA2NAEPHA2
Entrez,  Source
EPH receptor A22392.2300.0870Yes
5TAP1NATAP1
Entrez,  Source
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)3151.9210.0984Yes
6TCN2NATCN2
Entrez,  Source
transcobalamin II; macrocytic anemia3381.8560.1121Yes
7IER5NAIER5
Entrez,  Source
immediate early response 54641.5930.1180Yes
8ITGB4NAITGB4
Entrez,  Source
integrin, beta 44791.5720.1299Yes
9SFNNASFN
Entrez,  Source
stratifin5131.5240.1404Yes
10PHLDA3NAPHLDA3
Entrez,  Source
pleckstrin homology-like domain, family A, member 35171.5220.1525Yes
11AENNA5541.4780.1624Yes
12TGFB1NATGFB1
Entrez,  Source
transforming growth factor, beta 1 (Camurati-Engelmann disease)5931.4250.1718Yes
13RNF19BNA6371.3820.1806Yes
14IL1ANAIL1A
Entrez,  Source
interleukin 1, alpha6471.3710.1912Yes
15NOTCH1NANOTCH1
Entrez,  Source
Notch homolog 1, translocation-associated (Drosophila)7151.3130.1980Yes
16JUNNAJUN
Entrez,  Source
jun oncogene7181.3120.2085Yes
17SPHK1NASPHK1
Entrez,  Source
sphingosine kinase 17931.2530.2145Yes
18GADD45ANAGADD45A
Entrez,  Source
growth arrest and DNA-damage-inducible, alpha8281.2250.2225Yes
19DRAM1NA8551.2060.2308Yes
20PPP1R15ANAPPP1R15A
Entrez,  Source
protein phosphatase 1, regulatory (inhibitor) subunit 15A8741.1910.2394Yes
21CASP1NACASP1
Entrez,  Source
caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)8971.1780.2477Yes
22S100A10NAS100A10
Entrez,  Source
S100 calcium binding protein A109691.1340.2529Yes
23VDRNAVDR
Entrez,  Source
vitamin D (1,25- dihydroxyvitamin D3) receptor10301.1040.2584Yes
24PLK3NAPLK3
Entrez,  Source
polo-like kinase 3 (Drosophila)10571.0890.2658Yes
25PDGFANAPDGFA
Entrez,  Source
platelet-derived growth factor alpha polypeptide11461.0480.2693Yes
26CCND3NACCND3
Entrez,  Source
cyclin D313470.9640.2660Yes
27DGKANADGKA
Entrez,  Source
diacylglycerol kinase, alpha 80kDa14470.9300.2680Yes
28CTSDNACTSD
Entrez,  Source
cathepsin D (lysosomal aspartyl peptidase)15010.9100.2724Yes
29FASNAFAS
Entrez,  Source
Fas (TNF receptor superfamily, member 6)16000.8810.2741Yes
30BAIAP2NABAIAP2
Entrez,  Source
BAI1-associated protein 216300.8730.2795Yes
31IRAK1NAIRAK1
Entrez,  Source
interleukin-1 receptor-associated kinase 116760.8570.2839Yes
32NUPR1NANUPR1
Entrez,  Source
-17280.8440.2879Yes
33CDKN2AIPNA17330.8430.2945Yes
34HRASNAHRAS
Entrez,  Source
v-Ha-ras Harvey rat sarcoma viral oncogene homolog17990.8310.2975Yes
35SERTAD3NASERTAD3
Entrez,  Source
SERTA domain containing 320420.7800.2904Yes
36LIFNALIF
Entrez,  Source
leukemia inhibitory factor (cholinergic differentiation factor)21410.7550.2910Yes
37TP63NA21840.7470.2947Yes
38RPL36NARPL36
Entrez,  Source
ribosomal protein L3622590.7330.2965Yes
39DDIT3NADDIT3
Entrez,  Source
DNA-damage-inducible transcript 322750.7290.3016Yes
40JAG2NAJAG2
Entrez,  Source
jagged 222930.7260.3065Yes
41TAX1BP3NATAX1BP3
Entrez,  Source
Tax1 (human T-cell leukemia virus type I) binding protein 323290.7170.3103Yes
42RAP2BNARAP2B
Entrez,  Source
RAP2B, member of RAS oncogene family23650.7090.3141Yes
43BAK1NABAK1
Entrez,  Source
BCL2-antagonist/killer 123660.7090.3198Yes
44PLK2NAPLK2
Entrez,  Source
polo-like kinase 2 (Drosophila)23960.7040.3239Yes
45STEAP3NASTEAP3
Entrez,  Source
STEAP family member 324260.6980.3279Yes
46SOCS1NASOCS1
Entrez,  Source
suppressor of cytokine signaling 124850.6860.3302Yes
47RAD9ANARAD9A
Entrez,  Source
RAD9 homolog A (S. pombe)25500.6760.3321Yes
48FBXW7NAFBXW7
Entrez,  Source
F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila)26810.6510.3301Yes
49SEC61A1NASEC61A1
Entrez,  Source
Sec61 alpha 1 subunit (S. cerevisiae)27540.6390.3313Yes
50RETSATNARETSAT
Entrez,  Source
retinol saturase (all-trans-retinol 13,14-reductase)28020.6300.3337Yes
51RXRANARXRA
Entrez,  Source
retinoid X receptor, alpha28350.6260.3370Yes
52CCNKNACCNK
Entrez,  Source
cyclin K28660.6210.3404Yes
53SLC7A11NASLC7A11
Entrez,  Source
solute carrier family 7, (cationic amino acid transporter, y+ system) member 1129680.6010.3396Yes
54WRAP73NA29770.6000.3440Yes
55ZFP36L1NAZFP36L1
Entrez,  Source
zinc finger protein 36, C3H type-like 130350.5910.3456Yes
56TGFANATGFA
Entrez,  Source
transforming growth factor, alpha30750.5850.3481Yes
57POM121NAPOM121
Entrez,  Source
POM121 membrane glycoprotein (rat)31020.5820.3514Yes
58SDC1NASDC1
Entrez,  Source
syndecan 134540.5290.3361No
59TPD52L1NATPD52L1
Entrez,  Source
tumor protein D52-like 136620.5020.3287No
60RAD51CNARAD51C
Entrez,  Source
RAD51 homolog C (S. cerevisiae)36630.5020.3327No
61BLCAPNABLCAP
Entrez,  Source
bladder cancer associated protein38170.4830.3281No
62INHBBNAINHBB
Entrez,  Source
inhibin, beta B (activin AB beta polypeptide)38380.4820.3309No
63DNTTIP2NADNTTIP2
Entrez,  Source
deoxynucleotidyltransferase, terminal, interacting protein 238540.4800.3339No
64RRP8NA39510.4680.3323No
65MAPKAPK3NAMAPKAPK3
Entrez,  Source
mitogen-activated protein kinase-activated protein kinase 339710.4650.3350No
66TRIB3NATRIB3
Entrez,  Source
tribbles homolog 3 (Drosophila)42380.4290.3237No
67RCHY1NARCHY1
Entrez,  Source
ring finger and CHY zinc finger domain containing 142690.4260.3255No
68NOL8NANOL8
Entrez,  Source
nucleolar protein 843410.4170.3249No
69NUDT15NANUDT15
Entrez,  Source
nudix (nucleoside diphosphate linked moiety X)-type motif 1543440.4170.3282No
70PRMT2NAPRMT2
Entrez,  Source
protein arginine methyltransferase 245270.3990.3213No
71CGRRF1NACGRRF1
Entrez,  Source
cell growth regulator with ring finger domain 145900.3940.3210No
72RHBDF2NARHBDF2
Entrez,  Source
rhomboid 5 homolog 2 (Drosophila)48910.3630.3072No
73CCP110NA50000.3520.3041No
74ZBTB16NAZBTB16
Entrez,  Source
zinc finger and BTB domain containing 1650560.3450.3038No
75HMOX1NAHMOX1
Entrez,  Source
heme oxygenase (decycling) 151180.3400.3031No
76CSRNP2NA51290.3390.3053No
77TSC22D1NATSC22D1
Entrez,  Source
TSC22 domain family, member 151950.3320.3044No
78ACVR1BNAACVR1B
Entrez,  Source
activin A receptor, type IB52070.3310.3064No
79ZNF365NAZNF365
Entrez,  Source
zinc finger protein 36552520.3270.3066No
80EPS8L2NAEPS8L2
Entrez,  Source
EPS8-like 252800.3240.3077No
81CDKN2BNACDKN2B
Entrez,  Source
cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)55380.3000.2959No
82APPNAAPP
Entrez,  Source
amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease)55770.2970.2961No
83ANKRA2NAANKRA2
Entrez,  Source
ankyrin repeat, family A (RFXANK-like), 256360.2930.2953No
84RGS16NARGS16
Entrez,  Source
regulator of G-protein signalling 1656380.2930.2976No
85RRADNARRAD
Entrez,  Source
Ras-related associated with diabetes57500.2820.2937No
86BAXNABAX
Entrez,  Source
BCL2-associated X protein57830.2800.2942No
87EI24NAEI24
Entrez,  Source
etoposide induced 2.4 mRNA58320.2750.2937No
88CD81NACD81
Entrez,  Source
CD81 molecule58790.2710.2934No
89PLXNB2NAPLXNB2
Entrez,  Source
plexin B258910.2700.2949No
90MKNK2NAMKNK2
Entrez,  Source
MAP kinase interacting serine/threonine kinase 260030.2630.2909No
91RPL18NARPL18
Entrez,  Source
ribosomal protein L1862080.2450.2815No
92TRAF4NATRAF4
Entrez,  Source
TNF receptor-associated factor 462820.2380.2794No
93PERPNAPERP
Entrez,  Source
PERP, TP53 apoptosis effector63660.2320.2766No
94HBEGFNAHBEGF
Entrez,  Source
heparin-binding EGF-like growth factor64350.2260.2746No
95TNNI1NATNNI1
Entrez,  Source
troponin I type 1 (skeletal, slow)65340.2170.2709No
96TOB1NATOB1
Entrez,  Source
transducer of ERBB2, 166030.2120.2689No
97XPCNAXPC
Entrez,  Source
xeroderma pigmentosum, complementation group C68660.1900.2558No
98HSPA4LNAHSPA4L
Entrez,  Source
heat shock 70kDa protein 4-like69930.1800.2503No
99CDK5R1NACDK5R1
Entrez,  Source
cyclin-dependent kinase 5, regulatory subunit 1 (p35)70140.1790.2506No
100SAT1NASAT1
Entrez,  Source
spermidine/spermine N1-acetyltransferase 170990.1740.2473No
101PITPNC1NAPITPNC1
Entrez,  Source
phosphatidylinositol transfer protein, cytoplasmic 171540.1690.2457No
102HIST3H2ANAHIST3H2A
Entrez,  Source
histone cluster 3, H2a72100.1660.2440No
103MDM2NAMDM2
Entrez,  Source
Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse)72890.1600.2409No
104CDKN1ANACDKN1A
Entrez,  Source
cyclin-dependent kinase inhibitor 1A (p21, Cip1)75230.1430.2291No
105SLC35D1NASLC35D1
Entrez,  Source
solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D177740.1240.2162No
106PRKAB1NAPRKAB1
Entrez,  Source
protein kinase, AMP-activated, beta 1 non-catalytic subunit78420.1190.2135No
107APAF1NAAPAF1
Entrez,  Source
apoptotic peptidase activating factor79270.1130.2097No
108SP1NASP1
Entrez,  Source
Sp1 transcription factor79610.1100.2088No
109EPHX1NAEPHX1
Entrez,  Source
epoxide hydrolase 1, microsomal (xenobiotic)82260.0910.1948No
110PPM1DNAPPM1D
Entrez,  Source
protein phosphatase 1D magnesium-dependent, delta isoform83070.0850.1911No
111PCNANAPCNA
Entrez,  Source
proliferating cell nuclear antigen84420.0760.1842No
112HDAC3NAHDAC3
Entrez,  Source
histone deacetylase 384880.0730.1823No
113GPX2NAGPX2
Entrez,  Source
glutathione peroxidase 2 (gastrointestinal)86060.0650.1763No
114ABCC5NAABCC5
Entrez,  Source
ATP-binding cassette, sub-family C (CFTR/MRP), member 589810.0360.1558No
115TSPYL2NATSPYL2
Entrez,  Source
TSPY-like 292890.0150.1388No
116HEXIM1NAHEXIM1
Entrez,  Source
hexamethylene bis-acetamide inducible 19784-0.0040.1114No
117CDKN2ANACDKN2A
Entrez,  Source
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)9855-0.0100.1076No
118RAB40CNARAB40C
Entrez,  Source
RAB40C, member RAS oncogene family9904-0.0120.1050No
119ERCC5NAERCC5
Entrez,  Source
me))9979-0.0180.1010No
120KLK8NAKLK8
Entrez,  Source
kallikrein 8 (neuropsin/ovasin)9984-0.0180.1010No
121RPS12NARPS12
Entrez,  Source
ribosomal protein S1210011-0.0190.0997No
122LRMPNALRMP
Entrez,  Source
lymphoid-restricted membrane protein10014-0.0190.0997No
123CCND2NACCND2
Entrez,  Source
cyclin D210056-0.0230.0976No
124FDXRNAFDXR
Entrez,  Source
ferredoxin reductase10185-0.0300.0907No
125AK1NAAK1
Entrez,  Source
adenylate kinase 110669-0.0590.0644No
126NHLH2NANHLH2
Entrez,  Source
nescient helix loop helix 210990-0.0770.0472No
127NINJ1NANINJ1
Entrez,  Source
ninjurin 111130-0.0860.0401No
128PMM1NAPMM1
Entrez,  Source
phosphomannomutase 111351-0.1020.0287No
129FOXO3NA11405-0.1060.0266No
130HINT1NAHINT1
Entrez,  Source
histidine triad nucleotide binding protein 111890-0.1470.0009No
131TNFSF9NATNFSF9
Entrez,  Source
tumor necrosis factor (ligand) superfamily, member 911926-0.1500.0002No
132DCXRNADCXR
Entrez,  Source
dicarbonyl/L-xylulose reductase12071-0.161-0.0066No
133PTPRENAPTPRE
Entrez,  Source
protein tyrosine phosphatase, receptor type, E12152-0.169-0.0096No
134POLHNAPOLH
Entrez,  Source
polymerase (DNA directed), eta12180-0.172-0.0098No
135VWA5ANA12220-0.175-0.0105No
136GLS2NAGLS2
Entrez,  Source
glutaminase 2 (liver, mitochondrial)12286-0.182-0.0127No
137TPRKBNATPRKB
Entrez,  Source
TP53RK binding protein12633-0.213-0.0302No
138RALGDSNARALGDS
Entrez,  Source
ral guanine nucleotide dissociation stimulator12778-0.226-0.0364No
139ISCUNA13050-0.249-0.0494No
140TCHHNATCHH
Entrez,  Source
trichohyalin13204-0.263-0.0558No
141IER3NAIER3
Entrez,  Source
immediate early response 313360-0.277-0.0622No
142STOMNASTOM
Entrez,  Source
stomatin13438-0.286-0.0642No
143RB1NARB1
Entrez,  Source
retinoblastoma 1 (including osteosarcoma)13520-0.294-0.0663No
144H2AFJNAH2AFJ
Entrez,  Source
H2A histone family, member J13544-0.295-0.0652No
145IP6K2NA13637-0.306-0.0679No
146BTG1NABTG1
Entrez,  Source
B-cell translocation gene 1, anti-proliferative13694-0.311-0.0685No
147KIF13BNAKIF13B
Entrez,  Source
kinesin family member 13B13893-0.330-0.0768No
148CDH13NACDH13
Entrez,  Source
cadherin 13, H-cadherin (heart)14418-0.393-0.1028No
149FOSNAFOS
Entrez,  Source
v-fos FBJ murine osteosarcoma viral oncogene homolog14425-0.395-0.1000No
150IFI30NAIFI30
Entrez,  Source
interferon, gamma-inducible protein 3014483-0.404-0.0999No
151F2RNAF2R
Entrez,  Source
coagulation factor II (thrombin) receptor14494-0.404-0.0972No
152FGF13NAFGF13
Entrez,  Source
fibroblast growth factor 1314593-0.418-0.0992No
153RPS27LNARPS27L
Entrez,  Source
ribosomal protein S27-like14922-0.464-0.1137No
154TXNIPNATXNIP
Entrez,  Source
thioredoxin interacting protein14955-0.469-0.1117No
155ALOX15BNAALOX15B
Entrez,  Source
arachidonate 15-lipoxygenase, type B14956-0.469-0.1080No
156SLC19A2NASLC19A2
Entrez,  Source
solute carrier family 19 (thiamine transporter), member 215063-0.484-0.1099No
157FAM162ANA15085-0.486-0.1072No
158ABHD4NAABHD4
Entrez,  Source
abhydrolase domain containing 415117-0.491-0.1049No
159ADANAADA
Entrez,  Source
adenosine deaminase15162-0.497-0.1034No
160TRAFD1NATRAFD1
Entrez,  Source
TRAF-type zinc finger domain containing 115172-0.499-0.0999No
161TM4SF1NATM4SF1
Entrez,  Source
transmembrane 4 L six family member 115193-0.502-0.0969No
162VAMP8NAVAMP8
Entrez,  Source
vesicle-associated membrane protein 8 (endobrevin)15341-0.522-0.1009No
163FUCA1NAFUCA1
Entrez,  Source
fucosidase, alpha-L- 1, tissue15450-0.542-0.1025No
164LDHBNALDHB
Entrez,  Source
lactate dehydrogenase B15651-0.581-0.1090No
165DEF6NADEF6
Entrez,  Source
differentially expressed in FDCP 6 homolog (mouse)15692-0.588-0.1064No
166S100A4NAS100A4
Entrez,  Source
S100 calcium binding protein A415715-0.591-0.1029No
167SERPINB5NASERPINB5
Entrez,  Source
serpin peptidase inhibitor, clade B (ovalbumin), member 515827-0.615-0.1041No
168TRIAP1NATRIAP1
Entrez,  Source
TP53 regulated inhibitor of apoptosis 115913-0.634-0.1037No
169TM7SF3NATM7SF3
Entrez,  Source
transmembrane 7 superfamily member 315918-0.635-0.0988No
170TP53NATP53
Entrez,  Source
tumor protein p53 (Li-Fraumeni syndrome)15988-0.654-0.0974No
171BMP2NABMP2
Entrez,  Source
bone morphogenetic protein 216401-0.765-0.1141No
172CD82NACD82
Entrez,  Source
CD82 molecule16677-0.847-0.1226No
173PTPN14NAPTPN14
Entrez,  Source
protein tyrosine phosphatase, non-receptor type 1416682-0.848-0.1159No
174WWP1NAWWP1
Entrez,  Source
WW domain containing E3 ubiquitin protein ligase 116763-0.875-0.1133No
175ST14NAST14
Entrez,  Source
suppression of tumorigenicity 14 (colon carcinoma)16797-0.889-0.1080No
176DDB2NADDB2
Entrez,  Source
damage-specific DNA binding protein 2, 48kDa16967-0.955-0.1097No
177GM2ANAGM2A
Entrez,  Source
GM2 ganglioside activator17091-1.009-0.1084No
178HIST1H1CNAHIST1H1C
Entrez,  Source
histone cluster 1, H1c17302-1.119-0.1110No
179MXD4NAMXD4
Entrez,  Source
MAX dimerization protein 417326-1.133-0.1032No
180SLC3A2NASLC3A2
Entrez,  Source
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 217347-1.148-0.0950No
181PROCRNAPROCR
Entrez,  Source
protein C receptor, endothelial (EPCR)17377-1.170-0.0872No
182ABATNAABAT
Entrez,  Source
4-aminobutyrate aminotransferase17441-1.211-0.0809No
183DDIT4NADDIT4
Entrez,  Source
DNA-damage-inducible transcript 417443-1.212-0.0712No
184SESN1NASESN1
Entrez,  Source
sestrin 117500-1.259-0.0642No
185CCNG1NACCNG1
Entrez,  Source
cyclin G117512-1.267-0.0546No
186CEBPANACEBPA
Entrez,  Source
CCAAT/enhancer binding protein (C/EBP), alpha17537-1.286-0.0455No
187NDRG1NANDRG1
Entrez,  Source
N-myc downstream regulated gene 117599-1.346-0.0380No
188CTSFNACTSF
Entrez,  Source
cathepsin F17723-1.497-0.0328No
189BTG2NABTG2
Entrez,  Source
BTG family, member 217959-2.061-0.0292No
190CLCA2NACLCA2
Entrez,  Source
chloride channel, calcium activated, family member 217964-2.071-0.0128No
191ZMAT3NAZMAT3
Entrez,  Source
zinc finger, matrin type 318099-2.9730.0038No
Table: GSEA details [plain text format]



Fig 2: HALLMARK_P53_PATHWAY   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_P53_PATHWAY: Random ES distribution   
Gene set null distribution of ES for HALLMARK_P53_PATHWAY