Datasetw1a_vs_wt_vs_wt.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp_repos
Phenotypew1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos
Upregulated in classago1w1a
GeneSetHALLMARK_KRAS_SIGNALING_UP
Enrichment Score (ES)0.36864272
Normalized Enrichment Score (NES)1.4677676
Nominal p-value0.0029717681
FDR q-value0.027881721
FWER p-Value0.318
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_KRAS_SIGNALING_UP   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1IL7RNAIL7R
Entrez,  Source
interleukin 7 receptor44.7850.0314Yes
2CXCL10NACXCL10
Entrez,  Source
chemokine (C-X-C motif) ligand 10164.6310.0615Yes
3PDCD1LG2NAPDCD1LG2
Entrez,  Source
programmed cell death 1 ligand 2444.1890.0877Yes
4IL2RGNAIL2RG
Entrez,  Source
interleukin 2 receptor, gamma (severe combined immunodeficiency)573.9550.1132Yes
5CFBNACFB
Entrez,  Source
complement factor B673.6690.1370Yes
6TRAF1NATRAF1
Entrez,  Source
TNF receptor-associated factor 1893.3230.1578Yes
7CTSSNACTSS
Entrez,  Source
cathepsin S1213.0030.1759Yes
8PLAURNAPLAUR
Entrez,  Source
plasminogen activator, urokinase receptor1402.7840.1934Yes
9ITGA2NAITGA2
Entrez,  Source
integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)1482.7200.2110Yes
10LAPTM5NALAPTM5
Entrez,  Source
lysosomal associated multispanning membrane protein 51532.6820.2285Yes
11KLF4NAKLF4
Entrez,  Source
Kruppel-like factor 4 (gut)1722.5500.2444Yes
12BIRC3NABIRC3
Entrez,  Source
baculoviral IAP repeat-containing 31822.4840.2603Yes
13GPRC5BNAGPRC5B
Entrez,  Source
G protein-coupled receptor, family C, group 5, member B1832.4780.2767Yes
14MAFBNAMAFB
Entrez,  Source
v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)2102.3650.2909Yes
15TNFAIP3NATNFAIP3
Entrez,  Source
tumor necrosis factor, alpha-induced protein 32712.0950.3014Yes
16ANO1NA3731.7680.3075Yes
17HKDC1NAHKDC1
Entrez,  Source
hexokinase domain containing 14071.7040.3169Yes
18CSF2RANACSF2RA
Entrez,  Source
colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)4311.6520.3266Yes
19EREGNAEREG
Entrez,  Source
epiregulin5531.4790.3297Yes
20SPON1NASPON1
Entrez,  Source
spondin 1, extracellular matrix protein5711.4570.3384Yes
21F2RL1NAF2RL1
Entrez,  Source
coagulation factor II (thrombin) receptor-like 17451.2880.3373Yes
22IL1BNAIL1B
Entrez,  Source
interleukin 1, beta7791.2620.3438Yes
23SPRY2NASPRY2
Entrez,  Source
sprouty homolog 2 (Drosophila)8101.2400.3503Yes
24PPP1R15ANAPPP1R15A
Entrez,  Source
protein phosphatase 1, regulatory (inhibitor) subunit 15A8741.1910.3547Yes
25TSPAN1NATSPAN1
Entrez,  Source
tetraspanin 18831.1850.3621Yes
26ETV4NAETV4
Entrez,  Source
ets variant gene 4 (E1A enhancer binding protein, E1AF)11081.0660.3567Yes
27LAT2NALAT2
Entrez,  Source
linker for activation of T cells family, member 211441.0480.3617Yes
28FBXO4NAFBXO4
Entrez,  Source
F-box protein 413330.9700.3576Yes
29MAP3K1NAMAP3K1
Entrez,  Source
mitogen-activated protein kinase kinase kinase 114060.9450.3599Yes
30GFPT2NAGFPT2
Entrez,  Source
glutamine-fructose-6-phosphate transaminase 214410.9320.3641Yes
31PTCD2NAPTCD2
Entrez,  Source
pentatricopeptide repeat domain 215590.8930.3635Yes
32FCER1GNAFCER1G
Entrez,  Source
Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide17490.8390.3586Yes
33NRP1NANRP1
Entrez,  Source
neuropilin 117870.8320.3620Yes
34ADAM17NAADAM17
Entrez,  Source
ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme)18260.8230.3654Yes
35CAB39LNACAB39L
Entrez,  Source
calcium binding protein 39-like19520.7980.3637Yes
36ETV5NAETV5
Entrez,  Source
ets variant gene 5 (ets-related molecule)20030.7860.3661Yes
37ADAM8NAADAM8
Entrez,  Source
ADAM metallopeptidase domain 820700.7720.3675Yes
38LIFNALIF
Entrez,  Source
leukemia inhibitory factor (cholinergic differentiation factor)21410.7550.3686Yes
39TPH1NATPH1
Entrez,  Source
tryptophan hydroxylase 1 (tryptophan 5-monooxygenase)22600.7330.3669No
40WDR33NAWDR33
Entrez,  Source
WD repeat domain 3325100.6830.3576No
41DCBLD2NADCBLD2
Entrez,  Source
discoidin, CUB and LCCL domain containing 225290.6790.3611No
42GUCY1A3NAGUCY1A3
Entrez,  Source
guanylate cyclase 1, soluble, alpha 327780.6340.3515No
43ANGPTL4NAANGPTL4
Entrez,  Source
angiopoietin-like 431270.5780.3360No
44IL33NA31620.5720.3379No
45ETS1NAETS1
Entrez,  Source
v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)33600.5420.3305No
46TMEM158NATMEM158
Entrez,  Source
transmembrane protein 15834460.5300.3293No
47MPZL2NA34810.5240.3308No
48NR0B2NANR0B2
Entrez,  Source
nuclear receptor subfamily 0, group B, member 236960.4980.3222No
49PLEK2NAPLEK2
Entrez,  Source
pleckstrin 237240.4940.3240No
50YRDCNAYRDC
Entrez,  Source
yrdC domain containing (E. coli)37860.4870.3238No
51APODNAAPOD
Entrez,  Source
apolipoprotein D37920.4860.3268No
52CMKLR1NACMKLR1
Entrez,  Source
chemokine-like receptor 139750.4640.3197No
53ZNF277NAZNF277
Entrez,  Source
zinc finger protein 27739800.4640.3226No
54PECAM1NAPECAM1
Entrez,  Source
platelet/endothelial cell adhesion molecule (CD31 antigen)40610.4540.3211No
55TNFRSF1BNATNFRSF1B
Entrez,  Source
tumor necrosis factor receptor superfamily, member 1B41640.4390.3183No
56PLATNAPLAT
Entrez,  Source
plasminogen activator, tissue43780.4140.3092No
57ATG10NAATG10
Entrez,  Source
ATG10 autophagy related 10 homolog (S. cerevisiae)43820.4130.3118No
58MTMR10NAMTMR10
Entrez,  Source
myotubularin related protein 1044050.4110.3133No
59PTGS2NAPTGS2
Entrez,  Source
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)44060.4100.3160No
60TOR1AIP2NATOR1AIP2
Entrez,  Source
torsin A interacting protein 244530.4050.3161No
61KCNN4NAKCNN4
Entrez,  Source
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 445230.3990.3149No
62HSD11B1NAHSD11B1
Entrez,  Source
hydroxysteroid (11-beta) dehydrogenase 147970.3730.3022No
63TRIB1NATRIB1
Entrez,  Source
tribbles homolog 1 (Drosophila)50110.3500.2927No
64CDADC1NACDADC1
Entrez,  Source
cytidine and dCMP deaminase domain containing 151570.3360.2868No
65MAP4K1NAMAP4K1
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 151840.3330.2876No
66SDCCAG8NASDCCAG8
Entrez,  Source
serologically defined colon cancer antigen 852420.3280.2866No
67TNNT2NATNNT2
Entrez,  Source
troponin T type 2 (cardiac)55530.2990.2713No
68GNG11NAGNG11
Entrez,  Source
guanine nucleotide binding protein (G protein), gamma 1155690.2980.2725No
69ENGNAENG
Entrez,  Source
endoglin (Osler-Rendu-Weber syndrome 1)55860.2970.2735No
70RGS16NARGS16
Entrez,  Source
regulator of G-protein signalling 1656380.2930.2726No
71MALLNAMALL
Entrez,  Source
mal, T-cell differentiation protein-like57200.2840.2700No
72IKZF1NAIKZF1
Entrez,  Source
IKAROS family zinc finger 1 (Ikaros)57750.2800.2689No
73AVL9NA58610.2720.2659No
74BTCNABTC
Entrez,  Source
betacellulin60750.2560.2558No
75AKT2NAAKT2
Entrez,  Source
v-akt murine thymoma viral oncogene homolog 261440.2500.2537No
76PRRX1NAPRRX1
Entrez,  Source
paired related homeobox 163620.2320.2431No
77HBEGFNAHBEGF
Entrez,  Source
heparin-binding EGF-like growth factor64350.2260.2406No
78EVI5NAEVI5
Entrez,  Source
ecotropic viral integration site 565840.2120.2338No
79SERPINA3NASERPINA3
Entrez,  Source
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 366940.2040.2291No
80ZNF639NAZNF639
Entrez,  Source
zinc finger protein 63967970.1960.2247No
81IL10RANAIL10RA
Entrez,  Source
interleukin 10 receptor, alpha68370.1930.2238No
82CROTNACROT
Entrez,  Source
carnitine O-octanoyltransferase69030.1880.2214No
83HDAC9NAHDAC9
Entrez,  Source
histone deacetylase 969900.1810.2178No
84DNMBPNADNMBP
Entrez,  Source
dynamin binding protein70030.1800.2184No
85JUPNAJUP
Entrez,  Source
junction plakoglobin70790.1750.2154No
86GABRA3NAGABRA3
Entrez,  Source
gamma-aminobutyric acid (GABA) A receptor, alpha 372700.1620.2059No
87INHBANAINHBA
Entrez,  Source
inhibin, beta A (activin A, activin AB alpha polypeptide)73090.1590.2048No
88FGF9NAFGF9
Entrez,  Source
fibroblast growth factor 9 (glia-activating factor)74030.1510.2006No
89TMEM176ANATMEM176A
Entrez,  Source
transmembrane protein 176A74260.1490.2004No
90CBX8NACBX8
Entrez,  Source
chromobox homolog 8 (Pc class homolog, Drosophila)74690.1460.1990No
91SPARCL1NASPARCL1
Entrez,  Source
SPARC-like 1 (mast9, hevin)76140.1350.1919No
92IGF2NAIGF2
Entrez,  Source
insulin-like growth factor 2 (somatomedin A)77480.1270.1853No
93F13A1NAF13A1
Entrez,  Source
coagulation factor XIII, A1 polypeptide78310.1200.1816No
94ETV1NAETV1
Entrez,  Source
ets variant gene 182740.0870.1576No
95NGFNA83060.0850.1564No
96LCP1NALCP1
Entrez,  Source
lymphocyte cytosolic protein 1 (L-plastin)84310.0770.1500No
97FLT4NAFLT4
Entrez,  Source
fms-related tyrosine kinase 484430.0760.1499No
98TMEM100NATMEM100
Entrez,  Source
transmembrane protein 10084820.0730.1483No
99MMP11NAMMP11
Entrez,  Source
matrix metallopeptidase 11 (stromelysin 3)89260.0420.1239No
100ACENAACE
Entrez,  Source
angiotensin I converting enzyme (peptidyl-dipeptidase A) 189410.0400.1234No
101EMP1NAEMP1
Entrez,  Source
epithelial membrane protein 192560.0160.1060No
102PTBP2NAPTBP2
Entrez,  Source
polypyrimidine tract binding protein 293670.0100.1000No
103CA2NACA2
Entrez,  Source
carbonic anhydrase II95100.0000.0921No
104PLVAPNAPLVAP
Entrez,  Source
plasmalemma vesicle associated protein95550.0000.0896No
105CSF2NACSF2
Entrez,  Source
colony stimulating factor 2 (granulocyte-macrophage)95750.0000.0886No
106CIDEANACIDEA
Entrez,  Source
cell death-inducing DFFA-like effector a96700.0000.0834No
107TMEM176BNATMEM176B
Entrez,  Source
transmembrane protein 176B96760.0000.0831No
108GLRXNAGLRX
Entrez,  Source
glutaredoxin (thioltransferase)9744-0.0010.0794No
109CCND2NACCND2
Entrez,  Source
cyclin D210056-0.0230.0622No
110NAP1L2NANAP1L2
Entrez,  Source
nucleosome assembly protein 1-like 210070-0.0230.0616No
111MMP10NAMMP10
Entrez,  Source
matrix metallopeptidase 10 (stromelysin 2)10346-0.0400.0466No
112KIF5CNAKIF5C
Entrez,  Source
kinesin family member 5C10448-0.0450.0413No
113TSPAN7NATSPAN7
Entrez,  Source
tetraspanin 710626-0.0560.0318No
114PPBPNAPPBP
Entrez,  Source
pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)10865-0.0690.0190No
115WNT7ANAWNT7A
Entrez,  Source
wingless-type MMTV integration site family, member 7A11205-0.0920.0008No
116DUSP6NADUSP6
Entrez,  Source
dual specificity phosphatase 611523-0.116-0.0161No
117NINNANIN
Entrez,  Source
ninein (GSK3B interacting protein)11540-0.118-0.0162No
118PCP4NAPCP4
Entrez,  Source
Purkinje cell protein 411762-0.136-0.0276No
119G0S2NAG0S2
Entrez,  Source
G0/G1switch 211959-0.152-0.0375No
120USP12NAUSP12
Entrez,  Source
ubiquitin specific peptidase 1212110-0.165-0.0447No
121GALNT3NAGALNT3
Entrez,  Source
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)12130-0.167-0.0447No
122VWA5ANA12220-0.175-0.0485No
123ARG1NAARG1
Entrez,  Source
arginase, liver12300-0.183-0.0517No
124GYPCNAGYPC
Entrez,  Source
glycophorin C (Gerbich blood group)12549-0.206-0.0641No
125TLR8NATLR8
Entrez,  Source
toll-like receptor 812696-0.219-0.0708No
126CBLNACBL
Entrez,  Source
Cas-Br-M (murine) ecotropic retroviral transforming sequence12715-0.220-0.0703No
127MMP9NAMMP9
Entrez,  Source
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)13001-0.245-0.0846No
128RABGAP1LNARABGAP1L
Entrez,  Source
RAB GTPase activating protein 1-like13191-0.262-0.0933No
129GADD45GNAGADD45G
Entrez,  Source
growth arrest and DNA-damage-inducible, gamma13229-0.265-0.0936No
130RBM4NARBM4
Entrez,  Source
RNA binding motif protein 413381-0.279-0.1002No
131BPGMNABPGM
Entrez,  Source
2,3-bisphosphoglycerate mutase13410-0.283-0.0999No
132AKAP12NAAKAP12
Entrez,  Source
A kinase (PRKA) anchor protein (gravin) 1213511-0.293-0.1035No
133STRNNASTRN
Entrez,  Source
striatin, calmodulin binding protein13688-0.310-0.1112No
134C3AR1NAC3AR1
Entrez,  Source
complement component 3a receptor 113822-0.322-0.1165No
135RELNNARELN
Entrez,  Source
reelin13877-0.328-0.1173No
136NR1H4NANR1H4
Entrez,  Source
nuclear receptor subfamily 1, group H, member 413880-0.328-0.1153No
137SNAP91NASNAP91
Entrez,  Source
synaptosomal-associated protein, 91kDa homolog (mouse)13882-0.329-0.1132No
138ABCB1NAABCB1
Entrez,  Source
ATP-binding cassette, sub-family B (MDR/TAP), member 113944-0.338-0.1143No
139CXCR4NACXCR4
Entrez,  Source
chemokine (C-X-C motif) receptor 414131-0.361-0.1223No
140IL1RL2NAIL1RL2
Entrez,  Source
interleukin 1 receptor-like 214139-0.362-0.1203No
141CLEC4ANACLEC4A
Entrez,  Source
C-type lectin domain family 4, member A14190-0.366-0.1206No
142SLPINASLPI
Entrez,  Source
secretory leukocyte peptidase inhibitor14196-0.367-0.1185No
143IRF8NAIRF8
Entrez,  Source
interferon regulatory factor 814315-0.381-0.1225No
144CCL20NACCL20
Entrez,  Source
chemokine (C-C motif) ligand 2014330-0.383-0.1208No
145BTBD3NABTBD3
Entrez,  Source
BTB (POZ) domain containing 314375-0.388-0.1206No
146SNAP25NASNAP25
Entrez,  Source
synaptosomal-associated protein, 25kDa14411-0.392-0.1200No
147PSMB8NAPSMB8
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)14436-0.397-0.1187No
148ADAMDEC1NAADAMDEC1
Entrez,  Source
ADAM-like, decysin 114475-0.402-0.1182No
149HIST1H2BBNAHIST1H2BB
Entrez,  Source
histone cluster 1, H2bb14687-0.429-0.1271No
150SOX9NASOX9
Entrez,  Source
SRY (sex determining region Y)-box 9 (campomelic dysplasia, autosomal sex-reversal)14717-0.432-0.1258No
151HOXD11NAHOXD11
Entrez,  Source
homeobox D1114810-0.448-0.1280No
152DOCK2NADOCK2
Entrez,  Source
dedicator of cytokinesis 214846-0.454-0.1269No
153SCN1BNASCN1B
Entrez,  Source
sodium channel, voltage-gated, type I, beta14862-0.457-0.1247No
154SPP1NASPP1
Entrez,  Source
secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)15059-0.484-0.1324No
155MYCNNAMYCN
Entrez,  Source
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)15106-0.490-0.1317No
156EPB41L3NAEPB41L3
Entrez,  Source
erythrocyte membrane protein band 4.1-like 315114-0.491-0.1289No
157FUCA1NAFUCA1
Entrez,  Source
fucosidase, alpha-L- 1, tissue15450-0.542-0.1439No
158PEG3NAPEG3
Entrez,  Source
paternally expressed 315477-0.548-0.1417No
159AMMECR1NAAMMECR1
Entrez,  Source
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region, gene 115524-0.556-0.1406No
160PRKG2NAPRKG2
Entrez,  Source
protein kinase, cGMP-dependent, type II15578-0.567-0.1398No
161ANXA10NAANXA10
Entrez,  Source
annexin A1015751-0.599-0.1454No
162SCG5NASCG5
Entrez,  Source
secretogranin V (7B2 protein)15831-0.616-0.1457No
163SEMA3BNASEMA3B
Entrez,  Source
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B15844-0.620-0.1423No
164GPNMBNAGPNMB
Entrez,  Source
glycoprotein (transmembrane) nmb15883-0.630-0.1403No
165PIGRNAPIGR
Entrez,  Source
polymeric immunoglobulin receptor15984-0.653-0.1415No
166IGFBP3NAIGFBP3
Entrez,  Source
insulin-like growth factor binding protein 316100-0.681-0.1434No
167PLAUNAPLAU
Entrez,  Source
plasminogen activator, urokinase16140-0.690-0.1410No
168CPENACPE
Entrez,  Source
carboxypeptidase E16214-0.709-0.1404No
169MAP7NAMAP7
Entrez,  Source
microtubule-associated protein 716361-0.751-0.1435No
170BMP2NABMP2
Entrez,  Source
bone morphogenetic protein 216401-0.765-0.1406No
171MMDNAMMD
Entrez,  Source
monocyte to macrophage differentiation-associated16453-0.780-0.1383No
172TFPINATFPI
Entrez,  Source
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)16492-0.795-0.1352No
173SATB1NASATB1
Entrez,  Source
special AT-rich sequence binding protein 1 (binds to nuclear matrix/scaffold-associating DNA's)16579-0.821-0.1345No
174ST6GAL1NAST6GAL1
Entrez,  Source
ST6 beta-galactosamide alpha-2,6-sialyltranferase 116626-0.832-0.1315No
175TRIB2NATRIB2
Entrez,  Source
tribbles homolog 2 (Drosophila)16645-0.837-0.1270No
176SCG3NASCG3
Entrez,  Source
secretogranin III16654-0.840-0.1219No
177ITGB2NAITGB2
Entrez,  Source
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)16810-0.892-0.1246No
178ITGBL1NAITGBL1
Entrez,  Source
integrin, beta-like 1 (with EGF-like repeat domains)16834-0.900-0.1199No
179PRDM1NAPRDM1
Entrez,  Source
PR domain containing 1, with ZNF domain16924-0.937-0.1187No
180TSPAN13NATSPAN13
Entrez,  Source
tetraspanin 1317092-1.009-0.1213No
181CD37NACD37
Entrez,  Source
CD37 molecule17190-1.052-0.1197No
182CBR4NACBR4
Entrez,  Source
carbonyl reductase 417376-1.169-0.1223No
183ALDH1A3NAALDH1A3
Entrez,  Source
aldehyde dehydrogenase 1 family, member A317486-1.245-0.1201No
184ANKHNAANKH
Entrez,  Source
ankylosis, progressive homolog (mouse)17759-1.546-0.1250No
185LY96NALY96
Entrez,  Source
lymphocyte antigen 9617781-1.580-0.1157No
186ID2NAID2
Entrez,  Source
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein17991-2.214-0.1127No
187EPHB2NAEPHB2
Entrez,  Source
EPH receptor B218076-2.789-0.0989No
188CFHNACFH
Entrez,  Source
complement factor H18095-2.940-0.0805No
189USH1CNAUSH1C
Entrez,  Source
Usher syndrome 1C (autosomal recessive, severe)18153-4.149-0.0562No
190PTPRRNAPTPRR
Entrez,  Source
protein tyrosine phosphatase, receptor type, R18155-4.285-0.0279No
191ALDH1A2NAALDH1A2
Entrez,  Source
aldehyde dehydrogenase 1 family, member A218157-4.3080.0006No
Table: GSEA details [plain text format]



Fig 2: HALLMARK_KRAS_SIGNALING_UP   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_KRAS_SIGNALING_UP: Random ES distribution   
Gene set null distribution of ES for HALLMARK_KRAS_SIGNALING_UP