Datasetw1a_vs_wt_vs_wt.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp_repos
Phenotypew1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos
Upregulated in classago1w1a
GeneSetHALLMARK_KRAS_SIGNALING_DN
Enrichment Score (ES)0.30639187
Normalized Enrichment Score (NES)1.2066855
Nominal p-value0.10339506
FDR q-value0.22563261
FWER p-Value0.985
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_KRAS_SIGNALING_DN   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1RSAD2NARSAD2
Entrez,  Source
radical S-adenosyl methionine domain containing 2294.4530.0337Yes
2KCNN1NAKCNN1
Entrez,  Source
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1593.9430.0634Yes
3TGM1NATGM1
Entrez,  Source
transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase)1193.0110.0840Yes
4IFI44LNAIFI44L
Entrez,  Source
interferon-induced protein 44-like1262.9040.1067Yes
5TCF7L1NATCF7L1
Entrez,  Source
transcription factor 7-like 1 (T-cell specific, HMG-box)1322.8490.1290Yes
6CNTFRNACNTFR
Entrez,  Source
ciliary neurotrophic factor receptor1632.6050.1480Yes
7PKP1NAPKP1
Entrez,  Source
plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)1992.4080.1652Yes
8LYPD3NALYPD3
Entrez,  Source
LY6/PLAUR domain containing 32242.2910.1820Yes
9EDN1NAEDN1
Entrez,  Source
endothelin 12702.0980.1961Yes
10RYR2NARYR2
Entrez,  Source
ryanodine receptor 2 (cardiac)2922.0240.2110Yes
11ENTPD7NAENTPD7
Entrez,  Source
ectonucleoside triphosphate diphosphohydrolase 74541.6000.2148Yes
12TGFB2NATGFB2
Entrez,  Source
transforming growth factor, beta 25891.4290.2187Yes
13TFF2NATFF2
Entrez,  Source
trefoil factor 2 (spasmolytic protein 1)6361.3820.2271Yes
14TLX1NATLX1
Entrez,  Source
T-cell leukemia homeobox 16381.3800.2380Yes
15SLC6A3NASLC6A3
Entrez,  Source
solute carrier family 6 (neurotransmitter transporter, dopamine), member 37601.2760.2413Yes
16HNF1ANA10441.0970.2343Yes
17FGGYNA10631.0870.2419Yes
18GPRC5CNAGPRC5C
Entrez,  Source
G protein-coupled receptor, family C, group 5, member C11201.0560.2472Yes
19C5NAC5
Entrez,  Source
complement component 511221.0550.2555Yes
20SPHK2NASPHK2
Entrez,  Source
sphingosine kinase 212141.0110.2585Yes
21GPR3NAGPR3
Entrez,  Source
G protein-coupled receptor 313990.9470.2558Yes
22COPZ2NACOPZ2
Entrez,  Source
coatomer protein complex, subunit zeta 214030.9460.2631Yes
23CDKAL1NACDKAL1
Entrez,  Source
CDK5 regulatory subunit associated protein 1-like 114300.9390.2691Yes
24CALCBNACALCB
Entrez,  Source
calcitonin-related polypeptide, beta14320.9390.2765Yes
25ALOX12BNAALOX12B
Entrez,  Source
arachidonate 12-lipoxygenase, 12R type14740.9180.2815Yes
26EFHD1NAEFHD1
Entrez,  Source
EF-hand domain family, member D114790.9160.2885Yes
27CCNA1NACCNA1
Entrez,  Source
cyclin A115710.8910.2905Yes
28TNNI3NATNNI3
Entrez,  Source
troponin I type 3 (cardiac)15920.8830.2964Yes
29IL12BNAIL12B
Entrez,  Source
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)16070.8800.3026Yes
30KRT5NAKRT5
Entrez,  Source
keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types)16690.8600.3061Yes
31KLHDC8ANAKLHDC8A
Entrez,  Source
kelch domain containing 8A17830.8330.3064Yes
32CLSTN3NACLSTN3
Entrez,  Source
calsyntenin 319330.8020.3045No
33SLC29A3NASLC29A3
Entrez,  Source
solute carrier family 29 (nucleoside transporters), member 324540.6930.2811No
34CDH16NACDH16
Entrez,  Source
cadherin 16, KSP-cadherin27720.6360.2685No
35KCNE2NAKCNE2
Entrez,  Source
potassium voltage-gated channel, Isk-related family, member 229090.6130.2658No
36CPA2NACPA2
Entrez,  Source
carboxypeptidase A2 (pancreatic)30120.5950.2648No
37ABCG4NAABCG4
Entrez,  Source
ATP-binding cassette, sub-family G (WHITE), member 430760.5850.2660No
38HSD11B2NAHSD11B2
Entrez,  Source
hydroxysteroid (11-beta) dehydrogenase 232450.5600.2611No
39IDUANAIDUA
Entrez,  Source
iduronidase, alpha-L-32550.5580.2650No
40MTHFRNAMTHFR
Entrez,  Source
5,10-methylenetetrahydrofolate reductase (NADPH)32670.5570.2688No
41SIDT1NASIDT1
Entrez,  Source
SID1 transmembrane family, member 137790.4870.2442No
42GTF3C5NAGTF3C5
Entrez,  Source
general transcription factor IIIC, polypeptide 5, 63kDa38200.4830.2459No
43DCCNADCC
Entrez,  Source
deleted in colorectal carcinoma38520.4800.2479No
44TGNATG
Entrez,  Source
thyroglobulin40200.4590.2423No
45PDE6BNAPDE6B
Entrez,  Source
phosphodiesterase 6B, cGMP-specific, rod, beta (congenital stationary night blindness 3, autosomal dominant)41570.4400.2382No
46COL2A1NACOL2A1
Entrez,  Source
collagen, type II, alpha 1 (primary osteoarthritis, spondyloepiphyseal dysplasia, congenital)41750.4380.2408No
47CPEB3NACPEB3
Entrez,  Source
cytoplasmic polyadenylation element binding protein 342530.4280.2399No
48NR6A1NANR6A1
Entrez,  Source
nuclear receptor subfamily 6, group A, member 143900.4120.2356No
49ATP4ANAATP4A
Entrez,  Source
ATPase, H+/K+ exchanging, alpha polypeptide44070.4100.2379No
50KRT4NAKRT4
Entrez,  Source
keratin 444220.4090.2404No
51SHOX2NASHOX2
Entrez,  Source
short stature homeobox 248930.3630.2171No
52INSL5NAINSL5
Entrez,  Source
insulin-like 549950.3520.2143No
53ZBTB16NAZBTB16
Entrez,  Source
zinc finger and BTB domain containing 1650560.3450.2137No
54BARD1NABARD1
Entrez,  Source
BRCA1 associated RING domain 150920.3420.2145No
55SLC5A5NASLC5A5
Entrez,  Source
solute carrier family 5 (sodium iodide symporter), member 551030.3420.2166No
56NR4A2NANR4A2
Entrez,  Source
nuclear receptor subfamily 4, group A, member 252830.3240.2093No
57CD40LGNACD40LG
Entrez,  Source
CD40 ligand (TNF superfamily, member 5, hyper-IgM syndrome)55450.3000.1971No
58SNNNASNN
Entrez,  Source
stannin57060.2850.1905No
59NOS1NANOS1
Entrez,  Source
nitric oxide synthase 1 (neuronal)58840.2710.1828No
60PAX3NAPAX3
Entrez,  Source
paired box gene 3 (Waardenburg syndrome 1)60690.2570.1746No
61ARPP21NA63350.2340.1617No
62NGBNANGB
Entrez,  Source
neuroglobin63360.2340.1636No
63EPHA5NAEPHA5
Entrez,  Source
EPH receptor A566650.2060.1470No
64KCND1NAKCND1
Entrez,  Source
potassium voltage-gated channel, Shal-related subfamily, member 168760.1900.1368No
65DTNBNADTNB
Entrez,  Source
dystrobrevin, beta70840.1750.1267No
66PNMTNAPNMT
Entrez,  Source
phenylethanolamine N-methyltransferase70970.1740.1274No
67AMBNNAAMBN
Entrez,  Source
ameloblastin (enamel matrix protein)71620.1690.1252No
68SCGB1A1NASCGB1A1
Entrez,  Source
secretoglobin, family 1A, member 1 (uteroglobin)72250.1650.1230No
69KRT1NAKRT1
Entrez,  Source
keratin 1 (epidermolytic hyperkeratosis)72320.1650.1240No
70SPRR3NASPRR3
Entrez,  Source
small proline-rich protein 373590.1550.1182No
71RGS11NARGS11
Entrez,  Source
regulator of G-protein signalling 1176470.1330.1033No
72MX1NAMX1
Entrez,  Source
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)76990.1300.1015No
73TSHBNATSHB
Entrez,  Source
thyroid stimulating hormone, beta77100.1300.1020No
74P2RY4NAP2RY4
Entrez,  Source
pyrimidinergic receptor P2Y, G-protein coupled, 477690.1250.0998No
75IL5NAIL5
Entrez,  Source
interleukin 5 (colony-stimulating factor, eosinophil)80040.1070.0876No
76HTR1BNAHTR1B
Entrez,  Source
5-hydroxytryptamine (serotonin) receptor 1B81350.0970.0811No
77IGFBP2NAIGFBP2
Entrez,  Source
insulin-like growth factor binding protein 2, 36kDa87130.0570.0495No
78CD207NACD207
Entrez,  Source
CD207 molecule, langerin87800.0520.0462No
79SCN10ANASCN10A
Entrez,  Source
sodium channel, voltage-gated, type X, alpha89060.0430.0396No
80SKILNASKIL
Entrez,  Source
SKI-like89130.0430.0396No
81THNSL2NA89190.0420.0397No
82WNT16NAWNT16
Entrez,  Source
wingless-type MMTV integration site family, member 1689390.0400.0389No
83LFNGNALFNG
Entrez,  Source
lunatic fringe homolog (Drosophila)89940.0350.0362No
84SPTBN2NASPTBN2
Entrez,  Source
spectrin, beta, non-erythrocytic 290760.0290.0320No
85H2AFY2NAH2AFY2
Entrez,  Source
H2A histone family, member Y291460.0240.0283No
86PLAG1NAPLAG1
Entrez,  Source
pleiomorphic adenoma gene 193250.0120.0185No
87CLPSNACLPS
Entrez,  Source
colipase, pancreatic95350.0000.0069No
88RIBC2NARIBC2
Entrez,  Source
RIB43A domain with coiled-coils 295740.0000.0048No
89VPREB1NAVPREB1
Entrez,  Source
pre-B lymphocyte gene 197070.000-0.0026No
90SERPINB2NASERPINB2
Entrez,  Source
serpin peptidase inhibitor, clade B (ovalbumin), member 29790-0.005-0.0071No
91KRT15NAKRT15
Entrez,  Source
keratin 159953-0.017-0.0160No
92KLK8NAKLK8
Entrez,  Source
kallikrein 8 (neuropsin/ovasin)9984-0.018-0.0175No
93CPB1NACPB1
Entrez,  Source
carboxypeptidase B1 (tissue)10001-0.018-0.0182No
94OXTNAOXT
Entrez,  Source
oxytocin, prepro- (neurophysin I)10066-0.023-0.0216No
95CCDC106NACCDC106
Entrez,  Source
coiled-coil domain containing 10610285-0.037-0.0334No
96NPHS1NANPHS1
Entrez,  Source
nephrosis 1, congenital, Finnish type (nephrin)10394-0.042-0.0391No
97CHRNGNACHRNG
Entrez,  Source
cholinergic receptor, nicotinic, gamma10436-0.045-0.0410No
98GRID2NAGRID2
Entrez,  Source
glutamate receptor, ionotropic, delta 210441-0.045-0.0409No
99NTF3NANTF3
Entrez,  Source
neurotrophin 310471-0.046-0.0421No
100MYH7NAMYH7
Entrez,  Source
myosin, heavy chain 7, cardiac muscle, beta10534-0.050-0.0452No
101CACNG1NACACNG1
Entrez,  Source
calcium channel, voltage-dependent, gamma subunit 110744-0.062-0.0563No
102KCNMB1NAKCNMB1
Entrez,  Source
potassium large conductance calcium-activated channel, subfamily M, beta member 110775-0.064-0.0575No
103IRS4NAIRS4
Entrez,  Source
insulin receptor substrate 410864-0.069-0.0618No
104SLC16A7NASLC16A7
Entrez,  Source
solute carrier family 16, member 7 (monocarboxylic acid transporter 2)11060-0.081-0.0720No
105GP2NAGP2
Entrez,  Source
glycoprotein 2 (zymogen granule membrane)11206-0.092-0.0794No
106CYP11B2NACYP11B2
Entrez,  Source
cytochrome P450, family 11, subfamily B, polypeptide 211230-0.093-0.0799No
107HTR1DNAHTR1D
Entrez,  Source
5-hydroxytryptamine (serotonin) receptor 1D11342-0.101-0.0853No
108TAS2R4NATAS2R4
Entrez,  Source
taste receptor, type 2, member 411365-0.103-0.0857No
109YBX2NAYBX2
Entrez,  Source
Y box binding protein 211367-0.103-0.0849No
110CALML5NACALML5
Entrez,  Source
calmodulin-like 511385-0.104-0.0850No
111CLDN8NACLDN8
Entrez,  Source
claudin 811647-0.127-0.0986No
112PROP1NAPROP1
Entrez,  Source
prophet of Pit1, paired-like homeodomain transcription factor11681-0.130-0.0994No
113MAST3NAMAST3
Entrez,  Source
microtubule associated serine/threonine kinase 311750-0.135-0.1021No
114TCL1ANATCL1A
Entrez,  Source
T-cell leukemia/lymphoma 1A11754-0.136-0.1012No
115ITIH3NAITIH3
Entrez,  Source
inter-alpha (globulin) inhibitor H311814-0.141-0.1033No
116ADRA2CNAADRA2C
Entrez,  Source
adrenergic, alpha-2C-, receptor12304-0.183-0.1291No
117ABCB11NAABCB11
Entrez,  Source
ATP-binding cassette, sub-family B (MDR/TAP), member 1112378-0.189-0.1316No
118FGF16NAFGF16
Entrez,  Source
fibroblast growth factor 1612426-0.195-0.1327No
119GAMTNAGAMT
Entrez,  Source
guanidinoacetate N-methyltransferase12440-0.196-0.1319No
120PDCD1NAPDCD1
Entrez,  Source
programmed cell death 112448-0.197-0.1307No
121CHST2NACHST2
Entrez,  Source
carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 212453-0.197-0.1293No
122SNCBNASNCB
Entrez,  Source
synuclein, beta12567-0.207-0.1340No
123SLC30A3NASLC30A3
Entrez,  Source
solute carrier family 30 (zinc transporter), member 312584-0.209-0.1332No
124BMPR1BNABMPR1B
Entrez,  Source
bone morphogenetic protein receptor, type IB12634-0.213-0.1343No
125TFCP2L1NATFCP2L1
Entrez,  Source
transcription factor CP2-like 112640-0.214-0.1328No
126PAX4NAPAX4
Entrez,  Source
paired box gene 412796-0.227-0.1397No
127ASB7NAASB7
Entrez,  Source
ankyrin repeat and SOCS box-containing 712866-0.232-0.1417No
128MEFVNAMEFV
Entrez,  Source
Mediterranean fever13269-0.269-0.1619No
129KLK7NAKLK7
Entrez,  Source
kallikrein 7 (chymotryptic, stratum corneum)13280-0.270-0.1603No
130CLDN16NACLDN16
Entrez,  Source
claudin 1613441-0.286-0.1669No
131CKMNACKM
Entrez,  Source
creatine kinase, muscle13869-0.327-0.1881No
132PTGFRNAPTGFR
Entrez,  Source
prostaglandin F receptor (FP)13977-0.342-0.1913No
133TFAP2BNATFAP2B
Entrez,  Source
transcription factor AP-2 beta (activating enhancer binding protein 2 beta)14047-0.351-0.1924No
134ITGB1BP2NAITGB1BP2
Entrez,  Source
integrin beta 1 binding protein (melusin) 214194-0.367-0.1976No
135CACNA1FNACACNA1F
Entrez,  Source
calcium channel, voltage-dependent, alpha 1F subunit14354-0.386-0.2033No
136TEX15NATEX15
Entrez,  Source
testis expressed sequence 1514435-0.397-0.2046No
137SLC38A3NASLC38A3
Entrez,  Source
solute carrier family 38, member 314467-0.401-0.2032No
138PRODHNAPRODH
Entrez,  Source
proline dehydrogenase (oxidase) 114498-0.405-0.2016No
139PTPRJNAPTPRJ
Entrez,  Source
protein tyrosine phosphatase, receptor type, J14570-0.415-0.2023No
140IFNGNAIFNG
Entrez,  Source
interferon, gamma14617-0.420-0.2015No
141SLC25A23NASLC25A23
Entrez,  Source
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 2314754-0.437-0.2056No
142DLK2NA14802-0.446-0.2047No
143SOX10NASOX10
Entrez,  Source
SRY (sex determining region Y)-box 1014881-0.459-0.2054No
144SERPINA10NASERPINA10
Entrez,  Source
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1014894-0.461-0.2024No
145GPR19NAGPR19
Entrez,  Source
G protein-coupled receptor 1915044-0.482-0.2069No
146CCR8NACCR8
Entrez,  Source
chemokine (C-C motif) receptor 815111-0.490-0.2066No
147MFSD6NA15382-0.530-0.2175No
148STAG3NASTAG3
Entrez,  Source
stromal antigen 315386-0.531-0.2134No
149EDN2NAEDN2
Entrez,  Source
endothelin 215438-0.539-0.2120No
150ATP6V1B1NAATP6V1B1
Entrez,  Source
ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 (Renal tubular acidosis with deafness)15794-0.609-0.2269No
151PDK2NAPDK2
Entrez,  Source
pyruvate dehydrogenase kinase, isozyme 215800-0.611-0.2223No
152MSH5NAMSH5
Entrez,  Source
mutS homolog 5 (E. coli)15808-0.612-0.2178No
153SGK1NA15983-0.652-0.2223No
154CELSR2NACELSR2
Entrez,  Source
cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)15994-0.655-0.2177No
155FAM46CNAFAM46C
Entrez,  Source
family with sequence similarity 46, member C15997-0.656-0.2126No
156MYOTNAMYOT
Entrez,  Source
myotilin16199-0.707-0.2182No
157SLC6A14NASLC6A14
Entrez,  Source
solute carrier family 6 (amino acid transporter), member 1416416-0.769-0.2241No
158YPEL1NAYPEL1
Entrez,  Source
yippee-like 1 (Drosophila)16511-0.801-0.2230No
159CD80NACD80
Entrez,  Source
CD80 molecule16598-0.825-0.2212No
160RYR1NARYR1
Entrez,  Source
ryanodine receptor 1 (skeletal)16607-0.828-0.2151No
161P2RX6NA16632-0.833-0.2098No
162FSHBNAFSHB
Entrez,  Source
follicle stimulating hormone, beta polypeptide16659-0.842-0.2046No
163GDNFNAGDNF
Entrez,  Source
glial cell derived neurotrophic factor16732-0.867-0.2017No
164KCNQ2NAKCNQ2
Entrez,  Source
potassium voltage-gated channel, KQT-like subfamily, member 216768-0.876-0.1967No
165UPK3BNAUPK3B
Entrez,  Source
uroplakin 3B16770-0.877-0.1898No
166GP1BANAGP1BA
Entrez,  Source
glycoprotein Ib (platelet), alpha polypeptide16892-0.922-0.1892No
167SYNPONASYNPO
Entrez,  Source
synaptopodin16949-0.946-0.1848No
168THRBNATHRB
Entrez,  Source
thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)17028-0.984-0.1813No
169CAPN9NACAPN9
Entrez,  Source
calpain 917038-0.988-0.1740No
170NRIP2NANRIP2
Entrez,  Source
nuclear receptor interacting protein 217046-0.990-0.1665No
171CAMK1DNACAMK1D
Entrez,  Source
calcium/calmodulin-dependent protein kinase ID17065-0.996-0.1596No
172NUDT11NANUDT11
Entrez,  Source
nudix (nucleoside diphosphate linked moiety X)-type motif 1117173-1.046-0.1573No
173CYP39A1NACYP39A1
Entrez,  Source
cytochrome P450, family 39, subfamily A, polypeptide 117404-1.192-0.1606No
174MYO15ANAMYO15A
Entrez,  Source
myosin XVA17424-1.204-0.1521No
175BRDTNABRDT
Entrez,  Source
bromodomain, testis-specific17478-1.241-0.1452No
176AKR1B10NAAKR1B10
Entrez,  Source
aldo-keto reductase family 1, member B10 (aldose reductase)17532-1.280-0.1380No
177EGFNAEGF
Entrez,  Source
epidermal growth factor (beta-urogastrone)17704-1.472-0.1358No
178ACTC1NAACTC1
Entrez,  Source
actin, alpha, cardiac muscle 117885-1.811-0.1315No
179FGFR3NAFGFR3
Entrez,  Source
fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism)17891-1.831-0.1172No
180BTG2NABTG2
Entrez,  Source
BTG family, member 217959-2.061-0.1046No
181SMPXNASMPX
Entrez,  Source
small muscle protein, X-linked18010-2.335-0.0889No
182EDARNAEDAR
Entrez,  Source
ectodysplasin A receptor18057-2.620-0.0707No
183UGT2B17NAUGT2B17
Entrez,  Source
UDP glucuronosyltransferase 2 family, polypeptide B1718075-2.762-0.0497No
184SLC12A3NASLC12A3
Entrez,  Source
solute carrier family 12 (sodium/chloride transporters), member 318117-3.265-0.0261No
185KRT13NAKRT13
Entrez,  Source
keratin 1318137-3.6300.0017No
Table: GSEA details [plain text format]



Fig 2: HALLMARK_KRAS_SIGNALING_DN   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_KRAS_SIGNALING_DN: Random ES distribution   
Gene set null distribution of ES for HALLMARK_KRAS_SIGNALING_DN