Datasetw1a_vs_wt_vs_wt.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp_repos
Phenotypew1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos
Upregulated in classago1w1a
GeneSetHALLMARK_INTERFERON_GAMMA_RESPONSE
Enrichment Score (ES)0.67556036
Normalized Enrichment Score (NES)2.6887965
Nominal p-value0.0
FDR q-value0.0
FWER p-Value0.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_INTERFERON_GAMMA_RESPONSE   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1CXCL11NACXCL11
Entrez,  Source
chemokine (C-X-C motif) ligand 1104.8720.0210Yes
2OAS2NAOAS2
Entrez,  Source
2'-5'-oligoadenylate synthetase 2, 69/71kDa14.8350.0419Yes
3ISG15NAISG15
Entrez,  Source
ISG15 ubiquitin-like modifier54.7840.0624Yes
4CCL5NACCL5
Entrez,  Source
chemokine (C-C motif) ligand 564.7680.0830Yes
5OASLNAOASL
Entrez,  Source
2'-5'-oligoadenylate synthetase-like74.7640.1035Yes
6IFIT3NAIFIT3
Entrez,  Source
interferon-induced protein with tetratricopeptide repeats 384.7500.1241Yes
7IFIT2NAIFIT2
Entrez,  Source
interferon-induced protein with tetratricopeptide repeats 2144.6750.1440Yes
8DDX58NADDX58
Entrez,  Source
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58154.6490.1640Yes
9CXCL10NACXCL10
Entrez,  Source
chemokine (C-X-C motif) ligand 10164.6310.1840Yes
10IL6NAIL6
Entrez,  Source
interleukin 6 (interferon, beta 2)174.5960.2039Yes
11ISG20NAISG20
Entrez,  Source
interferon stimulated exonuclease gene 20kDa194.5610.2235Yes
12IFI44NAIFI44
Entrez,  Source
interferon-induced protein 44214.5370.2430Yes
13RTP4NARTP4
Entrez,  Source
receptor transporter protein 4284.4780.2620Yes
14RSAD2NARSAD2
Entrez,  Source
radical S-adenosyl methionine domain containing 2294.4530.2813Yes
15TDRD7NATDRD7
Entrez,  Source
tudor domain containing 7354.3680.2998Yes
16IFIT1NAIFIT1
Entrez,  Source
interferon-induced protein with tetratricopeptide repeats 1384.3270.3184Yes
17DHX58NA404.2310.3366Yes
18DDX60NA474.1550.3542Yes
19WARSNAWARS
Entrez,  Source
tryptophanyl-tRNA synthetase494.1080.3719Yes
20IFIH1NAIFIH1
Entrez,  Source
interferon induced with helicase C domain 1603.9300.3883Yes
21CFBNACFB
Entrez,  Source
complement factor B673.6690.4038Yes
22HERC6NAHERC6
Entrez,  Source
hect domain and RLD 6713.6410.4194Yes
23SAMD9LNASAMD9L
Entrez,  Source
sterile alpha motif domain containing 9-like763.5600.4345Yes
24SECTM1NASECTM1
Entrez,  Source
secreted and transmembrane 1823.4230.4490Yes
25IFI27NAIFI27
Entrez,  Source
interferon, alpha-inducible protein 27843.3970.4636Yes
26APOL6NAAPOL6
Entrez,  Source
apolipoprotein L, 61003.2200.4767Yes
27IRF1NAIRF1
Entrez,  Source
interferon regulatory factor 11123.0670.4893Yes
28IFI44LNAIFI44L
Entrez,  Source
interferon-induced protein 44-like1262.9040.5011Yes
29ZNFX1NAZNFX1
Entrez,  Source
zinc finger, NFX1-type containing 11312.8590.5132Yes
30PSMB9NAPSMB9
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)1472.7210.5242Yes
31TRIM26NATRIM26
Entrez,  Source
tripartite motif-containing 261972.4100.5318Yes
32TRIM21NATRIM21
Entrez,  Source
tripartite motif-containing 212022.3880.5419Yes
33OAS3NAOAS3
Entrez,  Source
2'-5'-oligoadenylate synthetase 3, 100kDa2412.2170.5494Yes
34USP18NAUSP18
Entrez,  Source
ubiquitin specific peptidase 182582.1380.5577Yes
35SOD2NASOD2
Entrez,  Source
superoxide dismutase 2, mitochondrial2632.1240.5667Yes
36TNFAIP3NATNFAIP3
Entrez,  Source
tumor necrosis factor, alpha-induced protein 32712.0950.5753Yes
37MT2ANAMT2A
Entrez,  Source
metallothionein 2A2742.0860.5842Yes
38JAK2NAJAK2
Entrez,  Source
Janus kinase 2 (a protein tyrosine kinase)3061.9580.5910Yes
39PMLNAPML
Entrez,  Source
promyelocytic leukemia3071.9560.5994Yes
40TAP1NATAP1
Entrez,  Source
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)3151.9210.6073Yes
41MVPNAMVP
Entrez,  Source
major vault protein3371.8630.6142Yes
42ICAM1NAICAM1
Entrez,  Source
intercellular adhesion molecule 1 (CD54), human rhinovirus receptor4531.6000.6147Yes
43NFKBIANANFKBIA
Entrez,  Source
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha4601.5950.6212Yes
44PSMB10NAPSMB10
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 104801.5690.6270Yes
45CCL2NACCL2
Entrez,  Source
chemokine (C-C motif) ligand 24931.5460.6330Yes
46IRF9NA5021.5370.6392Yes
47PARP12NAPARP12
Entrez,  Source
poly (ADP-ribose) polymerase family, member 125251.5140.6445Yes
48IL15RANAIL15RA
Entrez,  Source
interleukin 15 receptor, alpha5401.4950.6501Yes
49IL4RNAIL4R
Entrez,  Source
interleukin 4 receptor5471.4860.6562Yes
50NMINANMI
Entrez,  Source
N-myc (and STAT) interactor5801.4410.6607Yes
51TAPBPNATAPBP
Entrez,  Source
TAP binding protein (tapasin)7171.3130.6588Yes
52IL7NAIL7
Entrez,  Source
interleukin 78571.2050.6562Yes
53CASP1NACASP1
Entrez,  Source
caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)8971.1780.6592Yes
54CASP4NACASP4
Entrez,  Source
caspase 4, apoptosis-related cysteine peptidase9461.1470.6614Yes
55SP110NASP110
Entrez,  Source
SP110 nuclear body protein10381.0980.6611Yes
56PSME1NAPSME1
Entrez,  Source
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)10491.0960.6653Yes
57PLSCR1NAPLSCR1
Entrez,  Source
phospholipid scramblase 110711.0830.6688Yes
58IFITM3NAIFITM3
Entrez,  Source
interferon induced transmembrane protein 3 (1-8U)13610.9590.6569Yes
59PDE4BNAPDE4B
Entrez,  Source
phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)14460.9300.6562Yes
60FASNAFAS
Entrez,  Source
Fas (TNF receptor superfamily, member 6)16000.8810.6515Yes
61PSME2NAPSME2
Entrez,  Source
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)16130.8780.6546Yes
62RIPK1NARIPK1
Entrez,  Source
receptor (TNFRSF)-interacting serine-threonine kinase 116590.8630.6558Yes
63NUP93NANUP93
Entrez,  Source
nucleoporin 93kDa17080.8480.6568Yes
64NFKB1NANFKB1
Entrez,  Source
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)17670.8350.6572Yes
65HLA-GNAHLA-G
Entrez,  Source
HLA-G histocompatibility antigen, class I, G17860.8320.6598Yes
66CMPK2NA17920.8320.6631Yes
67TRIM14NATRIM14
Entrez,  Source
tripartite motif-containing 1417970.8310.6665Yes
68HLA-ANAHLA-A
Entrez,  Source
major histocompatibility complex, class I, A18690.8150.6660Yes
69B2MNAB2M
Entrez,  Source
beta-2-microglobulin19170.8050.6669Yes
70GBP6NAGBP6
Entrez,  Source
guanylate binding protein family, member 619400.8000.6691Yes
71GCH1NAGCH1
Entrez,  Source
GTP cyclohydrolase 1 (dopa-responsive dystonia)19760.7920.6706Yes
72ADARNAADAR
Entrez,  Source
adenosine deaminase, RNA-specific20130.7850.6720Yes
73RNF31NARNF31
Entrez,  Source
ring finger protein 3120180.7850.6751Yes
74OGFRNAOGFR
Entrez,  Source
opioid growth factor receptor20910.7680.6745Yes
75CASP7NACASP7
Entrez,  Source
caspase 7, apoptosis-related cysteine peptidase21310.7580.6756Yes
76IRF2NAIRF2
Entrez,  Source
interferon regulatory factor 223860.7050.6645No
77TNFSF10NATNFSF10
Entrez,  Source
tumor necrosis factor (ligand) superfamily, member 1024360.6960.6648No
78SOCS1NASOCS1
Entrez,  Source
suppressor of cytokine signaling 124850.6860.6650No
79NAMPTNA25410.6770.6649No
80MYD88NAMYD88
Entrez,  Source
myeloid differentiation primary response gene (88)27590.6380.6556No
81IL15NAIL15
Entrez,  Source
interleukin 1527740.6350.6575No
82STAT1NASTAT1
Entrez,  Source
signal transducer and activator of transcription 1, 91kDa28540.6220.6558No
83CASP3NACASP3
Entrez,  Source
caspase 3, apoptosis-related cysteine peptidase29030.6130.6558No
84NOD1NA30050.5960.6528No
85PNPNA30250.5920.6543No
86SLC25A28NASLC25A28
Entrez,  Source
solute carrier family 25, member 2830300.5920.6566No
87IFNAR2NAIFNAR2
Entrez,  Source
interferon (alpha, beta and omega) receptor 231130.5800.6545No
88EIF2AK2NAEIF2AK2
Entrez,  Source
eukaryotic translation initiation factor 2-alpha kinase 231480.5760.6551No
89STAT3NASTAT3
Entrez,  Source
signal transducer and activator of transcription 3 (acute-phase response factor)33050.5500.6488No
90PTPN1NAPTPN1
Entrez,  Source
protein tyrosine phosphatase, non-receptor type 135730.5140.6362No
91XCL1NAXCL1
Entrez,  Source
chemokine (C motif) ligand 135800.5130.6381No
92IFI35NAIFI35
Entrez,  Source
interferon-induced protein 3536560.5020.6361No
93TOR1BNATOR1B
Entrez,  Source
torsin family 1, member B (torsin B)36590.5020.6381No
94CMKLR1NACMKLR1
Entrez,  Source
chemokine-like receptor 139750.4640.6226No
95PTGS2NAPTGS2
Entrez,  Source
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)44060.4100.6004No
96PSMB2NAPSMB2
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 245440.3980.5945No
97NLRC5NA45790.3950.5944No
98SAMHD1NASAMHD1
Entrez,  Source
SAM domain and HD domain 146560.3870.5918No
99CD274NACD274
Entrez,  Source
CD274 molecule46650.3860.5930No
100LGALS3BPNALGALS3BP
Entrez,  Source
lectin, galactoside-binding, soluble, 3 binding protein48210.3710.5860No
101STAT2NASTAT2
Entrez,  Source
signal transducer and activator of transcription 2, 113kDa50310.3480.5759No
102PFKPNAPFKP
Entrez,  Source
phosphofructokinase, platelet50620.3450.5757No
103CD74NACD74
Entrez,  Source
CD74 molecule, major histocompatibility complex, class II invariant chain51870.3330.5702No
104LAP3NALAP3
Entrez,  Source
leucine aminopeptidase 351990.3320.5710No
105GPR18NAGPR18
Entrez,  Source
G protein-coupled receptor 1852280.3290.5709No
106PTPN2NAPTPN2
Entrez,  Source
protein tyrosine phosphatase, non-receptor type 253430.3180.5659No
107BANK1NABANK1
Entrez,  Source
B-cell scaffold protein with ankyrin repeats 154200.3100.5630No
108SOCS3NASOCS3
Entrez,  Source
suppressor of cytokine signaling 354280.3100.5640No
109CASP8NACASP8
Entrez,  Source
caspase 8, apoptosis-related cysteine peptidase56770.2880.5514No
110IRF5NAIRF5
Entrez,  Source
interferon regulatory factor 558500.2740.5430No
111BST2NABST2
Entrez,  Source
bone marrow stromal cell antigen 260290.2610.5343No
112ARL4ANAARL4A
Entrez,  Source
ADP-ribosylation factor-like 4A62800.2380.5214No
113PARP14NAPARP14
Entrez,  Source
poly (ADP-ribose) polymerase family, member 1464360.2260.5137No
114CD38NACD38
Entrez,  Source
CD38 molecule64760.2230.5125No
115RIPK2NARIPK2
Entrez,  Source
receptor-interacting serine-threonine kinase 268040.1960.4952No
116IDO1NA68060.1950.4960No
117IL10RANAIL10RA
Entrez,  Source
interleukin 10 receptor, alpha68370.1930.4951No
118XAF1NA69040.1880.4923No
119HIF1ANAHIF1A
Entrez,  Source
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)72120.1660.4759No
120STAT4NASTAT4
Entrez,  Source
signal transducer and activator of transcription 474240.1500.4648No
121CDKN1ANACDKN1A
Entrez,  Source
cyclin-dependent kinase inhibitor 1A (p21, Cip1)75230.1430.4600No
122HLA-BNAHLA-B
Entrez,  Source
major histocompatibility complex, class I, B75470.1410.4593No
123PSMA3NAPSMA3
Entrez,  Source
proteasome (prosome, macropain) subunit, alpha type, 376250.1350.4556No
124ITGB7NAITGB7
Entrez,  Source
integrin, beta 776280.1340.4561No
125MX1NAMX1
Entrez,  Source
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)76990.1300.4527No
126SELPNASELP
Entrez,  Source
selectin P (granule membrane protein 140kDa, antigen CD62)78230.1210.4464No
127LY6ENALY6E
Entrez,  Source
lymphocyte antigen 6 complex, locus E79380.1120.4406No
128AUTS2NAAUTS2
Entrez,  Source
autism susceptibility candidate 280930.1000.4324No
129PNPT1NAPNPT1
Entrez,  Source
polyribonucleotide nucleotidyltransferase 182100.0920.4264No
130CCL7NACCL7
Entrez,  Source
chemokine (C-C motif) ligand 782110.0920.4268No
131CSF2RBNACSF2RB
Entrez,  Source
colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)84570.0750.4135No
132KLRK1NAKLRK1
Entrez,  Source
killer cell lectin-like receptor subfamily K, member 187960.0510.3949No
133LATS2NALATS2
Entrez,  Source
LATS, large tumor suppressor, homolog 2 (Drosophila)88020.0510.3948No
134IRF7NAIRF7
Entrez,  Source
interferon regulatory factor 791070.0270.3780No
135ZBP1NAZBP1
Entrez,  Source
Z-DNA binding protein 19799-0.0060.3396No
136FPR1NAFPR1
Entrez,  Source
formyl peptide receptor 19985-0.0180.3294No
137RAPGEF6NARAPGEF6
Entrez,  Source
Rap guanine nucleotide exchange factor (GEF) 610176-0.0290.3189No
138MTHFD2NAMTHFD2
Entrez,  Source
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase10233-0.0330.3160No
139MARCH1NAMARCH1
Entrez,  Source
membrane-associated ring finger (C3HC4) 110463-0.0460.3034No
140TNFAIP2NATNFAIP2
Entrez,  Source
tumor necrosis factor, alpha-induced protein 210588-0.0530.2967No
141CXCL9NACXCL9
Entrez,  Source
chemokine (C-X-C motif) ligand 910624-0.0550.2950No
142SSPNNASSPN
Entrez,  Source
sarcospan (Kras oncogene-associated gene)10648-0.0570.2940No
143CD40NACD40
Entrez,  Source
CD40 molecule, TNF receptor superfamily member 510873-0.0700.2818No
144HLA-DRB1NAHLA-DRB1
Entrez,  Source
major histocompatibility complex, class II, DR beta 110903-0.0710.2805No
145PSMA2NAPSMA2
Entrez,  Source
proteasome (prosome, macropain) subunit, alpha type, 211331-0.1010.2572No
146HLA-DQA1NAHLA-DQA1
Entrez,  Source
major histocompatibility complex, class II, DQ alpha 111431-0.1080.2522No
147METTL7BNAMETTL7B
Entrez,  Source
methyltransferase like 7B11569-0.1200.2451No
148ARID5BNAARID5B
Entrez,  Source
AT rich interactive domain 5B (MRF1-like)11599-0.1220.2440No
149EPSTI1NAEPSTI1
Entrez,  Source
epithelial stromal interaction 1 (breast)11706-0.1330.2387No
150CIITANACIITA
Entrez,  Source
class II, major histocompatibility complex, transactivator11714-0.1330.2388No
151LCP2NALCP2
Entrez,  Source
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)11815-0.1410.2339No
152SPPL2ANASPPL2A
Entrez,  Source
-11870-0.1460.2315No
153BATF2NABATF2
Entrez,  Source
basic leucine zipper transcription factor, ATF-like 212181-0.1720.2150No
154TNFAIP6NATNFAIP6
Entrez,  Source
tumor necrosis factor, alpha-induced protein 612429-0.1950.2021No
155IL2RBNAIL2RB
Entrez,  Source
interleukin 2 receptor, beta12478-0.1990.2003No
156RBCK1NARBCK1
Entrez,  Source
RanBP-type and C3HC4-type zinc finger containing 112736-0.2220.1869No
157ST3GAL5NAST3GAL5
Entrez,  Source
ST3 beta-galactoside alpha-2,3-sialyltransferase 513065-0.2500.1698No
158FCGR1ANAFCGR1A
Entrez,  Source
Fc fragment of IgG, high affinity Ia, receptor (CD64)13208-0.2630.1630No
159NCOA3NANCOA3
Entrez,  Source
nuclear receptor coactivator 313227-0.2650.1632No
160CD86NACD86
Entrez,  Source
CD86 molecule13386-0.2800.1556No
161BPGMNABPGM
Entrez,  Source
2,3-bisphosphoglycerate mutase13410-0.2830.1555No
162TRIM25NATRIM25
Entrez,  Source
tripartite motif-containing 2513538-0.2950.1497No
163IFITM2NAIFITM2
Entrez,  Source
interferon induced transmembrane protein 2 (1-8D)13597-0.3000.1478No
164EIF4E3NAEIF4E3
Entrez,  Source
eukaryotic translation initiation factor 4E member 313624-0.3050.1477No
165BTG1NABTG1
Entrez,  Source
B-cell translocation gene 1, anti-proliferative13694-0.3110.1452No
166PELI1NAPELI1
Entrez,  Source
pellino homolog 1 (Drosophila)13790-0.3190.1413No
167SERPING1NASERPING1
Entrez,  Source
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary)13833-0.3240.1403No
168MX2NAMX2
Entrez,  Source
myxovirus (influenza virus) resistance 2 (mouse)13967-0.3410.1344No
169P2RY14NAP2RY14
Entrez,  Source
purinergic receptor P2Y, G-protein coupled, 1414138-0.3620.1265No
170IRF8NAIRF8
Entrez,  Source
interferon regulatory factor 814315-0.3810.1183No
171PSMB8NAPSMB8
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)14436-0.3970.1134No
172IFI30NAIFI30
Entrez,  Source
interferon, gamma-inducible protein 3014483-0.4040.1126No
173CD69NACD69
Entrez,  Source
CD69 molecule14577-0.4160.1092No
174LYSMD2NALYSMD2
Entrez,  Source
LysM, putative peptidoglycan-binding, domain containing 214578-0.4160.1110No
175ISOC1NAISOC1
Entrez,  Source
isochorismatase domain containing 114630-0.4220.1100No
176FGL2NAFGL2
Entrez,  Source
fibrinogen-like 214664-0.4260.1100No
177UBE2L6NAUBE2L6
Entrez,  Source
ubiquitin-conjugating enzyme E2L 614820-0.4500.1033No
178SRINASRI
Entrez,  Source
sorcin14847-0.4550.1038No
179TXNIPNATXNIP
Entrez,  Source
thioredoxin interacting protein14955-0.4690.0999No
180GZMANAGZMA
Entrez,  Source
granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)14995-0.4740.0997No
181TRAFD1NATRAFD1
Entrez,  Source
TRAF-type zinc finger domain containing 115172-0.4990.0921No
182VAMP8NAVAMP8
Entrez,  Source
vesicle-associated membrane protein 8 (endobrevin)15341-0.5220.0850No
183PLA2G4ANAPLA2G4A
Entrez,  Source
phospholipase A2, group IVA (cytosolic, calcium-dependent)15413-0.5350.0834No
184VCAM1NAVCAM1
Entrez,  Source
vascular cell adhesion molecule 115433-0.5380.0846No
185ST8SIA4NAST8SIA4
Entrez,  Source
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 415666-0.5840.0742No
186IL18BPNAIL18BP
Entrez,  Source
interleukin 18 binding protein15866-0.6250.0659No
187IRF4NAIRF4
Entrez,  Source
interferon regulatory factor 415869-0.6270.0685No
188GBP4NAGBP4
Entrez,  Source
guanylate binding protein 416012-0.6580.0634No
189VAMP5NAVAMP5
Entrez,  Source
vesicle-associated membrane protein 5 (myobrevin)16482-0.7920.0407No
190PIM1NAPIM1
Entrez,  Source
pim-1 oncogene17087-1.0070.0115No
191PTPN6NAPTPN6
Entrez,  Source
protein tyrosine phosphatase, non-receptor type 617170-1.0450.0114No
192C1SNAC1S
Entrez,  Source
complement component 1, s subcomponent17205-1.0610.0141No
193SLAMF7NASLAMF7
Entrez,  Source
SLAM family member 717662-1.428-0.0051No
194C1RNAC1R
Entrez,  Source
complement component 1, r subcomponent17902-1.865-0.0104No
195HLA-DMANAHLA-DMA
Entrez,  Source
major histocompatibility complex, class II, DM alpha18085-2.849-0.0082No
196CFHNACFH
Entrez,  Source
complement factor H18095-2.9400.0040No
Table: GSEA details [plain text format]



Fig 2: HALLMARK_INTERFERON_GAMMA_RESPONSE   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_INTERFERON_GAMMA_RESPONSE: Random ES distribution   
Gene set null distribution of ES for HALLMARK_INTERFERON_GAMMA_RESPONSE