Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1w1a |
| GeneSet | HALLMARK_INTERFERON_ALPHA_RESPONSE |
| Enrichment Score (ES) | 0.7446563 |
| Normalized Enrichment Score (NES) | 2.6737447 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0 |
| FWER p-Value | 0.0 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | CXCL11 | NA | CXCL11 Entrez, Source | chemokine (C-X-C motif) ligand 11 | 0 | 4.872 | 0.0324 | Yes |
| 2 | ISG15 | NA | ISG15 Entrez, Source | ISG15 ubiquitin-like modifier | 5 | 4.784 | 0.0639 | Yes |
| 3 | OASL | NA | OASL Entrez, Source | 2'-5'-oligoadenylate synthetase-like | 7 | 4.764 | 0.0956 | Yes |
| 4 | IFIT3 | NA | IFIT3 Entrez, Source | interferon-induced protein with tetratricopeptide repeats 3 | 8 | 4.750 | 0.1271 | Yes |
| 5 | IFIT2 | NA | IFIT2 Entrez, Source | interferon-induced protein with tetratricopeptide repeats 2 | 14 | 4.675 | 0.1579 | Yes |
| 6 | CXCL10 | NA | CXCL10 Entrez, Source | chemokine (C-X-C motif) ligand 10 | 16 | 4.631 | 0.1886 | Yes |
| 7 | ISG20 | NA | ISG20 Entrez, Source | interferon stimulated exonuclease gene 20kDa | 19 | 4.561 | 0.2188 | Yes |
| 8 | IFI44 | NA | IFI44 Entrez, Source | interferon-induced protein 44 | 21 | 4.537 | 0.2489 | Yes |
| 9 | RTP4 | NA | RTP4 Entrez, Source | receptor transporter protein 4 | 28 | 4.478 | 0.2783 | Yes |
| 10 | RSAD2 | NA | RSAD2 Entrez, Source | radical S-adenosyl methionine domain containing 2 | 29 | 4.453 | 0.3079 | Yes |
| 11 | TDRD7 | NA | TDRD7 Entrez, Source | tudor domain containing 7 | 35 | 4.368 | 0.3367 | Yes |
| 12 | DHX58 | NA | 40 | 4.231 | 0.3646 | Yes | ||
| 13 | DDX60 | NA | 47 | 4.155 | 0.3919 | Yes | ||
| 14 | WARS | NA | WARS Entrez, Source | tryptophanyl-tRNA synthetase | 49 | 4.108 | 0.4191 | Yes |
| 15 | IFIH1 | NA | IFIH1 Entrez, Source | interferon induced with helicase C domain 1 | 60 | 3.930 | 0.4447 | Yes |
| 16 | SAMD9 | NA | SAMD9 Entrez, Source | sterile alpha motif domain containing 9 | 65 | 3.688 | 0.4690 | Yes |
| 17 | HERC6 | NA | HERC6 Entrez, Source | hect domain and RLD 6 | 71 | 3.641 | 0.4929 | Yes |
| 18 | SAMD9L | NA | SAMD9L Entrez, Source | sterile alpha motif domain containing 9-like | 76 | 3.560 | 0.5163 | Yes |
| 19 | IFI27 | NA | IFI27 Entrez, Source | interferon, alpha-inducible protein 27 | 84 | 3.397 | 0.5385 | Yes |
| 20 | IRF1 | NA | IRF1 Entrez, Source | interferon regulatory factor 1 | 112 | 3.067 | 0.5574 | Yes |
| 21 | IFI44L | NA | IFI44L Entrez, Source | interferon-induced protein 44-like | 126 | 2.904 | 0.5760 | Yes |
| 22 | PSMB9 | NA | PSMB9 Entrez, Source | proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2) | 147 | 2.721 | 0.5929 | Yes |
| 23 | UBA7 | NA | 169 | 2.572 | 0.6089 | Yes | ||
| 24 | TRIM26 | NA | TRIM26 Entrez, Source | tripartite motif-containing 26 | 197 | 2.410 | 0.6234 | Yes |
| 25 | TRIM21 | NA | TRIM21 Entrez, Source | tripartite motif-containing 21 | 202 | 2.388 | 0.6390 | Yes |
| 26 | OAS1 | NA | OAS1 Entrez, Source | 2',5'-oligoadenylate synthetase 1, 40/46kDa | 235 | 2.240 | 0.6522 | Yes |
| 27 | PARP9 | NA | PARP9 Entrez, Source | poly (ADP-ribose) polymerase family, member 9 | 236 | 2.237 | 0.6670 | Yes |
| 28 | USP18 | NA | USP18 Entrez, Source | ubiquitin specific peptidase 18 | 258 | 2.138 | 0.6801 | Yes |
| 29 | TAP1 | NA | TAP1 Entrez, Source | transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) | 315 | 1.921 | 0.6897 | Yes |
| 30 | IRF9 | NA | 502 | 1.537 | 0.6897 | Yes | ||
| 31 | PARP12 | NA | PARP12 Entrez, Source | poly (ADP-ribose) polymerase family, member 12 | 525 | 1.514 | 0.6985 | Yes |
| 32 | IL4R | NA | IL4R Entrez, Source | interleukin 4 receptor | 547 | 1.486 | 0.7072 | Yes |
| 33 | NMI | NA | NMI Entrez, Source | N-myc (and STAT) interactor | 580 | 1.441 | 0.7150 | Yes |
| 34 | ELF1 | NA | ELF1 Entrez, Source | E74-like factor 1 (ets domain transcription factor) | 614 | 1.405 | 0.7225 | Yes |
| 35 | IL7 | NA | IL7 Entrez, Source | interleukin 7 | 857 | 1.205 | 0.7172 | Yes |
| 36 | CASP1 | NA | CASP1 Entrez, Source | caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) | 897 | 1.178 | 0.7228 | Yes |
| 37 | HLA-C | NA | HLA-C Entrez, Source | major histocompatibility complex, class I, C | 910 | 1.168 | 0.7299 | Yes |
| 38 | SP110 | NA | SP110 Entrez, Source | SP110 nuclear body protein | 1038 | 1.098 | 0.7302 | Yes |
| 39 | PSME1 | NA | PSME1 Entrez, Source | proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) | 1049 | 1.096 | 0.7369 | Yes |
| 40 | PLSCR1 | NA | PLSCR1 Entrez, Source | phospholipid scramblase 1 | 1071 | 1.083 | 0.7430 | Yes |
| 41 | NCOA7 | NA | NCOA7 Entrez, Source | nuclear receptor coactivator 7 | 1230 | 1.008 | 0.7409 | Yes |
| 42 | IFITM3 | NA | IFITM3 Entrez, Source | interferon induced transmembrane protein 3 (1-8U) | 1361 | 0.959 | 0.7401 | Yes |
| 43 | CSF1 | NA | CSF1 Entrez, Source | colony stimulating factor 1 (macrophage) | 1608 | 0.880 | 0.7323 | Yes |
| 44 | PSME2 | NA | PSME2 Entrez, Source | proteasome (prosome, macropain) activator subunit 2 (PA28 beta) | 1613 | 0.878 | 0.7379 | Yes |
| 45 | CMPK2 | NA | 1792 | 0.832 | 0.7336 | Yes | ||
| 46 | TRIM14 | NA | TRIM14 Entrez, Source | tripartite motif-containing 14 | 1797 | 0.831 | 0.7389 | Yes |
| 47 | B2M | NA | B2M Entrez, Source | beta-2-microglobulin | 1917 | 0.805 | 0.7377 | Yes |
| 48 | ADAR | NA | ADAR Entrez, Source | adenosine deaminase, RNA-specific | 2013 | 0.785 | 0.7376 | Yes |
| 49 | RNF31 | NA | RNF31 Entrez, Source | ring finger protein 31 | 2018 | 0.785 | 0.7426 | Yes |
| 50 | OGFR | NA | OGFR Entrez, Source | opioid growth factor receptor | 2091 | 0.768 | 0.7438 | Yes |
| 51 | CD47 | NA | CD47 Entrez, Source | CD47 molecule | 2166 | 0.751 | 0.7447 | Yes |
| 52 | IRF2 | NA | IRF2 Entrez, Source | interferon regulatory factor 2 | 2386 | 0.705 | 0.7372 | No |
| 53 | TMEM140 | NA | TMEM140 Entrez, Source | transmembrane protein 140 | 2424 | 0.698 | 0.7398 | No |
| 54 | CCRL2 | NA | CCRL2 Entrez, Source | chemokine (C-C motif) receptor-like 2 | 2730 | 0.644 | 0.7272 | No |
| 55 | IL15 | NA | IL15 Entrez, Source | interleukin 15 | 2774 | 0.635 | 0.7291 | No |
| 56 | SLC25A28 | NA | SLC25A28 Entrez, Source | solute carrier family 25, member 28 | 3030 | 0.592 | 0.7189 | No |
| 57 | EIF2AK2 | NA | EIF2AK2 Entrez, Source | eukaryotic translation initiation factor 2-alpha kinase 2 | 3148 | 0.576 | 0.7162 | No |
| 58 | CNP | NA | CNP Entrez, Source | 2',3'-cyclic nucleotide 3' phosphodiesterase | 3552 | 0.516 | 0.6974 | No |
| 59 | IFI35 | NA | IFI35 Entrez, Source | interferon-induced protein 35 | 3656 | 0.502 | 0.6950 | No |
| 60 | MOV10 | NA | MOV10 Entrez, Source | Mov10, Moloney leukemia virus 10, homolog (mouse) | 4245 | 0.428 | 0.6653 | No |
| 61 | LGALS3BP | NA | LGALS3BP Entrez, Source | lectin, galactoside-binding, soluble, 3 binding protein | 4821 | 0.371 | 0.6360 | No |
| 62 | STAT2 | NA | STAT2 Entrez, Source | signal transducer and activator of transcription 2, 113kDa | 5031 | 0.348 | 0.6267 | No |
| 63 | NUB1 | NA | NUB1 Entrez, Source | negative regulator of ubiquitin-like proteins 1 | 5091 | 0.342 | 0.6257 | No |
| 64 | CD74 | NA | CD74 Entrez, Source | CD74 molecule, major histocompatibility complex, class II invariant chain | 5187 | 0.333 | 0.6227 | No |
| 65 | LAP3 | NA | LAP3 Entrez, Source | leucine aminopeptidase 3 | 5199 | 0.332 | 0.6243 | No |
| 66 | TRIM5 | NA | TRIM5 Entrez, Source | tripartite motif-containing 5 | 5658 | 0.291 | 0.6009 | No |
| 67 | CASP8 | NA | CASP8 Entrez, Source | caspase 8, apoptosis-related cysteine peptidase | 5677 | 0.288 | 0.6018 | No |
| 68 | BST2 | NA | BST2 Entrez, Source | bone marrow stromal cell antigen 2 | 6029 | 0.261 | 0.5841 | No |
| 69 | PARP14 | NA | PARP14 Entrez, Source | poly (ADP-ribose) polymerase family, member 14 | 6436 | 0.226 | 0.5631 | No |
| 70 | RIPK2 | NA | RIPK2 Entrez, Source | receptor-interacting serine-threonine kinase 2 | 6804 | 0.196 | 0.5441 | No |
| 71 | SELL | NA | SELL Entrez, Source | selectin L (lymphocyte adhesion molecule 1) | 7481 | 0.145 | 0.5077 | No |
| 72 | PSMA3 | NA | PSMA3 Entrez, Source | proteasome (prosome, macropain) subunit, alpha type, 3 | 7625 | 0.135 | 0.5007 | No |
| 73 | MX1 | NA | MX1 Entrez, Source | myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) | 7699 | 0.130 | 0.4975 | No |
| 74 | LY6E | NA | LY6E Entrez, Source | lymphocyte antigen 6 complex, locus E | 7938 | 0.112 | 0.4851 | No |
| 75 | PNPT1 | NA | PNPT1 Entrez, Source | polyribonucleotide nucleotidyltransferase 1 | 8210 | 0.092 | 0.4707 | No |
| 76 | IRF7 | NA | IRF7 Entrez, Source | interferon regulatory factor 7 | 9107 | 0.027 | 0.4213 | No |
| 77 | EPSTI1 | NA | EPSTI1 Entrez, Source | epithelial stromal interaction 1 (breast) | 11706 | -0.133 | 0.2785 | No |
| 78 | BATF2 | NA | BATF2 Entrez, Source | basic leucine zipper transcription factor, ATF-like 2 | 12181 | -0.172 | 0.2534 | No |
| 79 | GMPR | NA | GMPR Entrez, Source | guanosine monophosphate reductase | 12316 | -0.184 | 0.2472 | No |
| 80 | LPAR6 | NA | 12983 | -0.244 | 0.2120 | No | ||
| 81 | TRIM25 | NA | TRIM25 Entrez, Source | tripartite motif-containing 25 | 13538 | -0.295 | 0.1833 | No |
| 82 | IFITM2 | NA | IFITM2 Entrez, Source | interferon induced transmembrane protein 2 (1-8D) | 13597 | -0.300 | 0.1820 | No |
| 83 | LAMP3 | NA | LAMP3 Entrez, Source | lysosomal-associated membrane protein 3 | 13692 | -0.310 | 0.1789 | No |
| 84 | PSMB8 | NA | PSMB8 Entrez, Source | proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) | 14436 | -0.397 | 0.1404 | No |
| 85 | IFI30 | NA | IFI30 Entrez, Source | interferon, gamma-inducible protein 30 | 14483 | -0.404 | 0.1406 | No |
| 86 | UBE2L6 | NA | UBE2L6 Entrez, Source | ubiquitin-conjugating enzyme E2L 6 | 14820 | -0.450 | 0.1250 | No |
| 87 | TXNIP | NA | TXNIP Entrez, Source | thioredoxin interacting protein | 14955 | -0.469 | 0.1207 | No |
| 88 | FAM46A | NA | FAM46A Entrez, Source | family with sequence similarity 46, member A | 15131 | -0.493 | 0.1143 | No |
| 89 | TRAFD1 | NA | TRAFD1 Entrez, Source | TRAF-type zinc finger domain containing 1 | 15172 | -0.499 | 0.1154 | No |
| 90 | GBP4 | NA | GBP4 Entrez, Source | guanylate binding protein 4 | 16012 | -0.658 | 0.0733 | No |
| 91 | C1S | NA | C1S Entrez, Source | complement component 1, s subcomponent | 17205 | -1.061 | 0.0144 | No |
| 92 | PROCR | NA | PROCR Entrez, Source | protein C receptor, endothelial (EPCR) | 17377 | -1.170 | 0.0127 | No |
| 93 | IFITM1 | NA | IFITM1 Entrez, Source | interferon induced transmembrane protein 1 (9-27) | 17661 | -1.427 | 0.0066 | No |
| 94 | GBP2 | NA | GBP2 Entrez, Source | guanylate binding protein 2, interferon-inducible | 18111 | -3.218 | 0.0031 | No |
