Datasetw1a_vs_wt_vs_wt.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp.w1a_vs_wt.cls
#ago1w1a_versus_ago1gfp_repos
Phenotypew1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos
Upregulated in classago1w1a
GeneSetHALLMARK_INFLAMMATORY_RESPONSE
Enrichment Score (ES)0.5178527
Normalized Enrichment Score (NES)2.075998
Nominal p-value0.0
FDR q-value0.0
FWER p-Value0.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_INFLAMMATORY_RESPONSE   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEDESCRIPTION
(from dataset)
GENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1CXCL11NACXCL11
Entrez,  Source
chemokine (C-X-C motif) ligand 1104.8720.0291Yes
2IL7RNAIL7R
Entrez,  Source
interleukin 7 receptor44.7850.0574Yes
3CCL5NACCL5
Entrez,  Source
chemokine (C-C motif) ligand 564.7680.0858Yes
4CXCL10NACXCL10
Entrez,  Source
chemokine (C-X-C motif) ligand 10164.6310.1129Yes
5IL6NAIL6
Entrez,  Source
interleukin 6 (interferon, beta 2)174.5960.1403Yes
6RTP4NARTP4
Entrez,  Source
receptor transporter protein 4284.4780.1665Yes
7PTGER4NAPTGER4
Entrez,  Source
prostaglandin E receptor 4 (subtype EP4)1013.2130.1816Yes
8IRF1NAIRF1
Entrez,  Source
interferon regulatory factor 11123.0670.1994Yes
9MXD1NAMXD1
Entrez,  Source
MAX dimerization protein 11153.0590.2175Yes
10OLR1NAOLR1
Entrez,  Source
oxidised low density lipoprotein (lectin-like) receptor 11302.8730.2338Yes
11PLAURNAPLAUR
Entrez,  Source
plasminogen activator, urokinase receptor1402.7840.2499Yes
12HRH1NAHRH1
Entrez,  Source
histamine receptor H11772.5210.2630Yes
13TLR3NATLR3
Entrez,  Source
toll-like receptor 31902.4430.2769Yes
14SLC31A2NASLC31A2
Entrez,  Source
solute carrier family 31 (copper transporters), member 22692.1040.2851Yes
15EDN1NAEDN1
Entrez,  Source
endothelin 12702.0980.2976Yes
16SERPINE1NASERPINE1
Entrez,  Source
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 12902.0390.3087Yes
17F3NAF3
Entrez,  Source
coagulation factor III (thromboplastin, tissue factor)3011.9810.3199Yes
18ITGA5NAITGA5
Entrez,  Source
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)3421.8480.3287Yes
19TPBGNATPBG
Entrez,  Source
trophoblast glycoprotein4351.6430.3334Yes
20ICAM1NAICAM1
Entrez,  Source
intercellular adhesion molecule 1 (CD54), human rhinovirus receptor4531.6000.3420Yes
21NFKBIANANFKBIA
Entrez,  Source
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha4601.5950.3512Yes
22CCL2NACCL2
Entrez,  Source
chemokine (C-C motif) ligand 24931.5460.3586Yes
23GNA15NAGNA15
Entrez,  Source
guanine nucleotide binding protein (G protein), alpha 15 (Gq class)5001.5400.3675Yes
24IL15RANAIL15RA
Entrez,  Source
interleukin 15 receptor, alpha5401.4950.3742Yes
25IL4RNAIL4R
Entrez,  Source
interleukin 4 receptor5471.4860.3827Yes
26EREGNAEREG
Entrez,  Source
epiregulin5531.4790.3913Yes
27ITGB8NAITGB8
Entrez,  Source
integrin, beta 85571.4760.3999Yes
28NMINANMI
Entrez,  Source
N-myc (and STAT) interactor5801.4410.4073Yes
29LTANALTA
Entrez,  Source
lymphotoxin alpha (TNF superfamily, member 1)5841.4370.4157Yes
30EMP3NAEMP3
Entrez,  Source
epithelial membrane protein 36251.3940.4218Yes
31IL1ANAIL1A
Entrez,  Source
interleukin 1, alpha6471.3710.4288Yes
32IRAK2NAIRAK2
Entrez,  Source
interleukin-1 receptor-associated kinase 26941.3280.4342Yes
33RNF144BNA7141.3140.4409Yes
34TAPBPNATAPBP
Entrez,  Source
TAP binding protein (tapasin)7171.3130.4486Yes
35IL1BNAIL1B
Entrez,  Source
interleukin 1, beta7791.2620.4528Yes
36SPHK1NASPHK1
Entrez,  Source
sphingosine kinase 17931.2530.4595Yes
37BEST1NA8401.2130.4642Yes
38LDLRNALDLR
Entrez,  Source
low density lipoprotein receptor (familial hypercholesterolemia)9451.1470.4653Yes
39ADRM1NAADRM1
Entrez,  Source
adhesion regulating molecule 110411.0980.4665Yes
40RELANARELA
Entrez,  Source
v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian)11501.0470.4667Yes
41RHOGNARHOG
Entrez,  Source
ras homolog gene family, member G (rho G)12540.9990.4670Yes
42PDE4BNAPDE4B
Entrez,  Source
phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)14460.9300.4619Yes
43OSMRNAOSMR
Entrez,  Source
oncostatin M receptor14900.9120.4649Yes
44GPC3NAGPC3
Entrez,  Source
glypican 315040.9100.4696Yes
45IL1R1NAIL1R1
Entrez,  Source
interleukin 1 receptor, type I16020.8800.4695Yes
46IL12BNAIL12B
Entrez,  Source
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)16070.8800.4745Yes
47CSF1NACSF1
Entrez,  Source
colony stimulating factor 1 (macrophage)16080.8800.4798Yes
48HAS2NAHAS2
Entrez,  Source
hyaluronan synthase 217180.8460.4787Yes
49ADMNAADM
Entrez,  Source
adrenomedullin17220.8450.4836Yes
50SLC31A1NASLC31A1
Entrez,  Source
solute carrier family 31 (copper transporters), member 117290.8440.4883Yes
51CYBBNACYBB
Entrez,  Source
cytochrome b-245, beta polypeptide (chronic granulomatous disease)17380.8410.4929Yes
52NFKB1NANFKB1
Entrez,  Source
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)17670.8350.4963Yes
53P2RX4NAP2RX4
Entrez,  Source
purinergic receptor P2X, ligand-gated ion channel, 417700.8350.5012Yes
54ICOSLGNAICOSLG
Entrez,  Source
inducible T-cell co-stimulator ligand19030.8080.4986Yes
55IL18NAIL18
Entrez,  Source
interleukin 18 (interferon-gamma-inducing factor)19110.8050.5031Yes
56PVRNAPVR
Entrez,  Source
poliovirus receptor19160.8050.5076Yes
57TACR3NATACR3
Entrez,  Source
tachykinin receptor 319480.7990.5107Yes
58GCH1NAGCH1
Entrez,  Source
GTP cyclohydrolase 1 (dopa-responsive dystonia)19760.7920.5139Yes
59LIFNALIF
Entrez,  Source
leukemia inhibitory factor (cholinergic differentiation factor)21410.7550.5093Yes
60IL18R1NAIL18R1
Entrez,  Source
interleukin 18 receptor 121610.7520.5127Yes
61TNFSF10NATNFSF10
Entrez,  Source
tumor necrosis factor (ligand) superfamily, member 1024360.6960.5016Yes
62CX3CL1NACX3CL1
Entrez,  Source
chemokine (C-X3-C motif) ligand 125260.6810.5007Yes
63DCBLD2NADCBLD2
Entrez,  Source
discoidin, CUB and LCCL domain containing 225290.6790.5047Yes
64NAMPTNA25410.6770.5081Yes
65CCL17NACCL17
Entrez,  Source
chemokine (C-C motif) ligand 1726770.6510.5044Yes
66AHRNAAHR
Entrez,  Source
aryl hydrocarbon receptor26860.6500.5079Yes
67CCL22NACCL22
Entrez,  Source
chemokine (C-C motif) ligand 2227090.6480.5105Yes
68CCRL2NACCRL2
Entrez,  Source
chemokine (C-C motif) receptor-like 227300.6440.5133Yes
69IL15NAIL15
Entrez,  Source
interleukin 1527740.6350.5146Yes
70IFNAR1NAIFNAR1
Entrez,  Source
interferon (alpha, beta and omega) receptor 128070.6300.5166Yes
71ATP2B1NAATP2B1
Entrez,  Source
ATPase, Ca++ transporting, plasma membrane 128960.6140.5154Yes
72CD14NACD14
Entrez,  Source
CD14 molecule29180.6100.5179Yes
73AXLNAAXL
Entrez,  Source
AXL receptor tyrosine kinase30410.5900.5146No
74EIF2AK2NAEIF2AK2
Entrez,  Source
eukaryotic translation initiation factor 2-alpha kinase 231480.5760.5121No
75CD55NACD55
Entrez,  Source
CD55 molecule, decay accelerating factor for complement (Cromer blood group)32460.5600.5101No
76SLC7A1NASLC7A1
Entrez,  Source
solute carrier family 7 (cationic amino acid transporter, y+ system), member 134870.5240.4998No
77ROS1NAROS1
Entrez,  Source
v-ros UR2 sarcoma virus oncogene homolog 1 (avian)36070.5100.4963No
78NMUR1NANMUR1
Entrez,  Source
neuromedin U receptor 136400.5050.4975No
79TIMP1NATIMP1
Entrez,  Source
TIMP metallopeptidase inhibitor 137970.4860.4917No
80CMKLR1NACMKLR1
Entrez,  Source
chemokine-like receptor 139750.4640.4846No
81MSR1NAMSR1
Entrez,  Source
macrophage scavenger receptor 140520.4540.4831No
82TNFRSF1BNATNFRSF1B
Entrez,  Source
tumor necrosis factor receptor superfamily, member 1B41640.4390.4795No
83PSEN1NAPSEN1
Entrez,  Source
presenilin 1 (Alzheimer disease 3)42030.4340.4800No
84LYNNALYN
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog42440.4280.4803No
85SEMA4DNASEMA4D
Entrez,  Source
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D42840.4240.4807No
86PTGER2NAPTGER2
Entrez,  Source
prostaglandin E receptor 2 (subtype EP2), 53kDa43000.4220.4824No
87PCDH7NAPCDH7
Entrez,  Source
BH-protocadherin (brain-heart)43360.4180.4829No
88PTGIRNAPTGIR
Entrez,  Source
prostaglandin I2 (prostacyclin) receptor (IP)45290.3990.4746No
89TLR2NATLR2
Entrez,  Source
toll-like receptor 246770.3850.4687No
90ADORA2BNAADORA2B
Entrez,  Source
adenosine A2b receptor47070.3820.4694No
91ACVR1BNAACVR1B
Entrez,  Source
activin A receptor, type IB52070.3310.4436No
92GNAI3NAGNAI3
Entrez,  Source
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 354140.3110.4340No
93MEP1ANAMEP1A
Entrez,  Source
meprin A, alpha (PABA peptide hydrolase)55520.2990.4282No
94RGS16NARGS16
Entrez,  Source
regulator of G-protein signalling 1656380.2930.4252No
95BDKRB1NABDKRB1
Entrez,  Source
bradykinin receptor B157150.2850.4227No
96BST2NABST2
Entrez,  Source
bone marrow stromal cell antigen 260290.2610.4068No
97TNFRSF9NATNFRSF9
Entrez,  Source
tumor necrosis factor receptor superfamily, member 963500.2320.3904No
98HBEGFNAHBEGF
Entrez,  Source
heparin-binding EGF-like growth factor64350.2260.3870No
99LCKNALCK
Entrez,  Source
lymphocyte-specific protein tyrosine kinase66350.2080.3772No
100ABI1NAABI1
Entrez,  Source
abl-interactor 167390.2010.3727No
101RIPK2NARIPK2
Entrez,  Source
receptor-interacting serine-threonine kinase 268040.1960.3703No
102IL10RANAIL10RA
Entrez,  Source
interleukin 10 receptor, alpha68370.1930.3697No
103APLNRNA69110.1870.3667No
104OSMNAOSM
Entrez,  Source
oncostatin M70700.1760.3590No
105IFNGR2NAIFNGR2
Entrez,  Source
interferon gamma receptor 2 (interferon gamma transducer 1)71180.1720.3574No
106HIF1ANAHIF1A
Entrez,  Source
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)72120.1660.3532No
107HPNNAHPN
Entrez,  Source
hepsin (transmembrane protease, serine 1)72360.1640.3529No
108P2RY2NAP2RY2
Entrez,  Source
purinergic receptor P2Y, G-protein coupled, 272650.1620.3523No
109INHBANAINHBA
Entrez,  Source
inhibin, beta A (activin A, activin AB alpha polypeptide)73090.1590.3509No
110ACVR2ANAACVR2A
Entrez,  Source
activin A receptor, type IIA73650.1550.3487No
111SELLNASELL
Entrez,  Source
selectin L (lymphocyte adhesion molecule 1)74810.1450.3432No
112CDKN1ANACDKN1A
Entrez,  Source
cyclin-dependent kinase inhibitor 1A (p21, Cip1)75230.1430.3418No
113NLRP3NA78670.1170.3234No
114ICAM4NAICAM4
Entrez,  Source
intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)79020.1150.3222No
115LY6ENALY6E
Entrez,  Source
lymphocyte antigen 6 complex, locus E79380.1120.3209No
116CCL7NACCL7
Entrez,  Source
chemokine (C-C motif) ligand 782110.0920.3063No
117FFAR2NAFFAR2
Entrez,  Source
free fatty acid receptor 282810.0870.3030No
118ATP2C1NAATP2C1
Entrez,  Source
ATPase, Ca++ transporting, type 2C, member 185780.0660.2869No
119ATP2A2NAATP2A2
Entrez,  Source
ATPase, Ca++ transporting, cardiac muscle, slow twitch 286610.0600.2827No
120KLF6NAKLF6
Entrez,  Source
Kruppel-like factor 687570.0540.2777No
121CALCRLNACALCRL
Entrez,  Source
calcitonin receptor-like88210.0500.2745No
122TLR1NATLR1
Entrez,  Source
toll-like receptor 189720.0370.2664No
123IRF7NAIRF7
Entrez,  Source
interferon regulatory factor 791070.0270.2591No
124TACR1NATACR1
Entrez,  Source
tachykinin receptor 191330.0250.2579No
125CXCL6NACXCL6
Entrez,  Source
chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)95630.0000.2340No
126FPR1NAFPR1
Entrez,  Source
formyl peptide receptor 19985-0.0180.2107No
127CD48NACD48
Entrez,  Source
CD48 molecule10024-0.0200.2087No
128GABBR1NAGABBR1
Entrez,  Source
gamma-aminobutyric acid (GABA) B receptor, 110237-0.0340.1971No
129MMP14NAMMP14
Entrez,  Source
matrix metallopeptidase 14 (membrane-inserted)10281-0.0370.1949No
130FZD5NAFZD5
Entrez,  Source
frizzled homolog 5 (Drosophila)10529-0.0490.1815No
131CXCL9NACXCL9
Entrez,  Source
chemokine (C-X-C motif) ligand 910624-0.0550.1766No
132CSF3NACSF3
Entrez,  Source
colony stimulating factor 3 (granulocyte)10639-0.0570.1761No
133CD40NACD40
Entrez,  Source
CD40 molecule, TNF receptor superfamily member 510873-0.0700.1636No
134PIK3R5NAPIK3R5
Entrez,  Source
phosphoinositide-3-kinase, regulatory subunit 5, p10111049-0.0810.1543No
135LCP2NALCP2
Entrez,  Source
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)11815-0.1410.1126No
136TNFSF9NATNFSF9
Entrez,  Source
tumor necrosis factor (ligand) superfamily, member 911926-0.1500.1074No
137CSF3RNACSF3R
Entrez,  Source
colony stimulating factor 3 receptor (granulocyte)11935-0.1500.1078No
138PTPRENAPTPRE
Entrez,  Source
protein tyrosine phosphatase, receptor type, E12152-0.1690.0968No
139SGMS2NA12250-0.1780.0925No
140NDPNANDP
Entrez,  Source
Norrie disease (pseudoglioma)12290-0.1820.0914No
141TNFAIP6NATNFAIP6
Entrez,  Source
tumor necrosis factor, alpha-induced protein 612429-0.1950.0849No
142CHST2NACHST2
Entrez,  Source
carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 212453-0.1970.0848No
143IL2RBNAIL2RB
Entrez,  Source
interleukin 2 receptor, beta12478-0.1990.0846No
144TNFSF15NATNFSF15
Entrez,  Source
tumor necrosis factor (ligand) superfamily, member 1512523-0.2030.0834No
145PTAFRNAPTAFR
Entrez,  Source
platelet-activating factor receptor12554-0.2070.0829No
146MARCONAMARCO
Entrez,  Source
macrophage receptor with collagenous structure12732-0.2220.0744No
147CD70NA13024-0.2460.0597No
148PROK2NAPROK2
Entrez,  Source
prokineticin 213096-0.2530.0573No
149MEFVNAMEFV
Entrez,  Source
Mediterranean fever13269-0.2690.0493No
150PDPNNAPDPN
Entrez,  Source
podoplanin13402-0.2820.0436No
151OPRK1NAOPRK1
Entrez,  Source
opioid receptor, kappa 113448-0.2870.0428No
152NOD2NA13543-0.2950.0394No
153LAMP3NALAMP3
Entrez,  Source
lysosomal-associated membrane protein 313692-0.3100.0330No
154MYCNAMYC
Entrez,  Source
v-myc myelocytomatosis viral oncogene homolog (avian)13741-0.3150.0322No
155C3AR1NAC3AR1
Entrez,  Source
complement component 3a receptor 113822-0.3220.0297No
156SELENASELE
Entrez,  Source
selectin E (endothelial adhesion molecule 1)13909-0.3310.0268No
157RAF1NARAF1
Entrez,  Source
v-raf-1 murine leukemia viral oncogene homolog 113934-0.3350.0275No
158GPR132NAGPR132
Entrez,  Source
G protein-coupled receptor 13214120-0.3590.0194No
159CCL20NACCL20
Entrez,  Source
chemokine (C-C motif) ligand 2014330-0.3830.0100No
160RASGRP1NARASGRP1
Entrez,  Source
RAS guanyl releasing protein 1 (calcium and DAG-regulated)14367-0.3870.0103No
161CD69NACD69
Entrez,  Source
CD69 molecule14577-0.4160.0012No
162GPR183NA14643-0.4240.0001No
163NPFFR2NANPFFR2
Entrez,  Source
neuropeptide FF receptor 214654-0.4250.0021No
164LPAR1NA14734-0.4340.0003No
165ITGB3NAITGB3
Entrez,  Source
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)14763-0.4380.0013No
166IL18RAPNAIL18RAP
Entrez,  Source
interleukin 18 receptor accessory protein14782-0.4430.0030No
167SLC4A4NASLC4A4
Entrez,  Source
solute carrier family 4, sodium bicarbonate cotransporter, member 414831-0.4520.0030No
168SRINASRI
Entrez,  Source
sorcin14847-0.4550.0049No
169SCN1BNASCN1B
Entrez,  Source
sodium channel, voltage-gated, type I, beta14862-0.4570.0068No
170KCNA3NAKCNA3
Entrez,  Source
potassium voltage-gated channel, shaker-related subfamily, member 314994-0.4740.0023No
171EBI3NAEBI3
Entrez,  Source
Epstein-Barr virus induced gene 315157-0.497-0.0037No
172SLC28A2NASLC28A2
Entrez,  Source
solute carrier family 28 (sodium-coupled nucleoside transporter), member 215312-0.518-0.0092No
173IL10NAIL10
Entrez,  Source
interleukin 1015556-0.562-0.0194No
174SLC1A2NASLC1A2
Entrez,  Source
solute carrier family 1 (glial high affinity glutamate transporter), member 215741-0.597-0.0260No
175KCNMB2NAKCNMB2
Entrez,  Source
potassium large conductance calcium-activated channel, subfamily M, beta member 215757-0.600-0.0233No
176SLC7A2NASLC7A2
Entrez,  Source
solute carrier family 7 (cationic amino acid transporter, y+ system), member 215789-0.609-0.0214No
177SCARF1NASCARF1
Entrez,  Source
scavenger receptor class F, member 115816-0.613-0.0192No
178KIF1BNAKIF1B
Entrez,  Source
kinesin family member 1B15954-0.643-0.0230No
179CXCR6NACXCR6
Entrez,  Source
chemokine (C-X-C motif) receptor 615974-0.649-0.0202No
180SLC11A2NASLC11A2
Entrez,  Source
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 216074-0.674-0.0216No
181P2RX7NAP2RX7
Entrez,  Source
purinergic receptor P2X, ligand-gated ion channel, 716327-0.741-0.0313No
182RGS1NARGS1
Entrez,  Source
regulator of G-protein signalling 116621-0.832-0.0426No
183CLEC5ANACLEC5A
Entrez,  Source
C-type lectin domain family 5, member A16629-0.833-0.0380No
184CD82NACD82
Entrez,  Source
CD82 molecule16677-0.847-0.0356No
185GP1BANAGP1BA
Entrez,  Source
glycoprotein Ib (platelet), alpha polypeptide16892-0.922-0.0420No
186AQP9NAAQP9
Entrez,  Source
aquaporin 917009-0.974-0.0426No
187SLAMF1NASLAMF1
Entrez,  Source
signaling lymphocytic activation molecule family member 117143-1.029-0.0439No
188METNAMET
Entrez,  Source
met proto-oncogene (hepatocyte growth factor receptor)17207-1.062-0.0411No
189C5AR1NAC5AR1
Entrez,  Source
complement component 5a receptor 117488-1.249-0.0492No
190IFITM1NAIFITM1
Entrez,  Source
interferon induced transmembrane protein 1 (9-27)17661-1.427-0.0503No
191STAB1NASTAB1
Entrez,  Source
stabilin 117747-1.533-0.0459No
192CCR7NACCR7
Entrez,  Source
chemokine (C-C motif) receptor 717778-1.575-0.0381No
193BTG2NABTG2
Entrez,  Source
BTG family, member 217959-2.061-0.0359No
194ABCA1NAABCA1
Entrez,  Source
ATP-binding cassette, sub-family A (ABC1), member 118056-2.602-0.0257No
195KCNJ2NAKCNJ2
Entrez,  Source
potassium inwardly-rectifying channel, subfamily J, member 218060-2.635-0.0101No
196VIPNAVIP
Entrez,  Source
vasoactive intestinal peptide18066-2.6890.0056No
Table: GSEA details [plain text format]



Fig 2: HALLMARK_INFLAMMATORY_RESPONSE   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_INFLAMMATORY_RESPONSE: Random ES distribution   
Gene set null distribution of ES for HALLMARK_INFLAMMATORY_RESPONSE