Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w1a_vs_wt_vs_wt.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp.w1a_vs_wt.cls #ago1w1a_versus_ago1gfp_repos |
| Phenotype | w1a_vs_wt.cls#ago1w1a_versus_ago1gfp_repos |
| Upregulated in class | ago1w1a |
| GeneSet | HALLMARK_IL6_JAK_STAT3_SIGNALING |
| Enrichment Score (ES) | 0.61692506 |
| Normalized Enrichment Score (NES) | 2.2074645 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0 |
| FWER p-Value | 0.0 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | CXCL11 | NA | CXCL11 Entrez, Source | chemokine (C-X-C motif) ligand 11 | 0 | 4.872 | 0.0581 | Yes |
| 2 | CXCL10 | NA | CXCL10 Entrez, Source | chemokine (C-X-C motif) ligand 10 | 16 | 4.631 | 0.1125 | Yes |
| 3 | IL6 | NA | IL6 Entrez, Source | interleukin 6 (interferon, beta 2) | 17 | 4.596 | 0.1674 | Yes |
| 4 | CRLF2 | NA | CRLF2 Entrez, Source | cytokine receptor-like factor 2 | 30 | 4.450 | 0.2198 | Yes |
| 5 | IL2RG | NA | IL2RG Entrez, Source | interleukin 2 receptor, gamma (severe combined immunodeficiency) | 57 | 3.955 | 0.2655 | Yes |
| 6 | IRF1 | NA | IRF1 Entrez, Source | interferon regulatory factor 1 | 112 | 3.067 | 0.2991 | Yes |
| 7 | CNTFR | NA | CNTFR Entrez, Source | ciliary neurotrophic factor receptor | 163 | 2.605 | 0.3274 | Yes |
| 8 | IL12RB1 | NA | IL12RB1 Entrez, Source | interleukin 12 receptor, beta 1 | 178 | 2.509 | 0.3566 | Yes |
| 9 | TNFRSF12A | NA | TNFRSF12A Entrez, Source | tumor necrosis factor receptor superfamily, member 12A | 203 | 2.387 | 0.3838 | Yes |
| 10 | TNFRSF21 | NA | TNFRSF21 Entrez, Source | tumor necrosis factor receptor superfamily, member 21 | 233 | 2.250 | 0.4090 | Yes |
| 11 | CSF2RA | NA | CSF2RA Entrez, Source | colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) | 431 | 1.652 | 0.4178 | Yes |
| 12 | IL1R2 | NA | IL1R2 Entrez, Source | interleukin 1 receptor, type II | 492 | 1.551 | 0.4330 | Yes |
| 13 | IRF9 | NA | 502 | 1.537 | 0.4508 | Yes | ||
| 14 | CD44 | NA | CD44 Entrez, Source | CD44 molecule (Indian blood group) | 515 | 1.523 | 0.4683 | Yes |
| 15 | IL15RA | NA | IL15RA Entrez, Source | interleukin 15 receptor, alpha | 540 | 1.495 | 0.4848 | Yes |
| 16 | IL4R | NA | IL4R Entrez, Source | interleukin 4 receptor | 547 | 1.486 | 0.5022 | Yes |
| 17 | TGFB1 | NA | TGFB1 Entrez, Source | transforming growth factor, beta 1 (Camurati-Engelmann disease) | 593 | 1.425 | 0.5168 | Yes |
| 18 | JUN | NA | JUN Entrez, Source | jun oncogene | 718 | 1.312 | 0.5256 | Yes |
| 19 | TNFRSF1A | NA | TNFRSF1A Entrez, Source | tumor necrosis factor receptor superfamily, member 1A | 755 | 1.279 | 0.5388 | Yes |
| 20 | IL1B | NA | IL1B Entrez, Source | interleukin 1, beta | 779 | 1.262 | 0.5526 | Yes |
| 21 | IL7 | NA | IL7 Entrez, Source | interleukin 7 | 857 | 1.205 | 0.5627 | Yes |
| 22 | IL6ST | NA | IL6ST Entrez, Source | interleukin 6 signal transducer (gp130, oncostatin M receptor) | 1001 | 1.118 | 0.5681 | Yes |
| 23 | TNF | NA | TNF Entrez, Source | tumor necrosis factor (TNF superfamily, member 2) | 1210 | 1.015 | 0.5687 | Yes |
| 24 | OSMR | NA | OSMR Entrez, Source | oncostatin M receptor | 1490 | 0.912 | 0.5642 | Yes |
| 25 | FAS | NA | FAS Entrez, Source | Fas (TNF receptor superfamily, member 6) | 1600 | 0.881 | 0.5687 | Yes |
| 26 | IL1R1 | NA | IL1R1 Entrez, Source | interleukin 1 receptor, type I | 1602 | 0.880 | 0.5791 | Yes |
| 27 | CSF1 | NA | CSF1 Entrez, Source | colony stimulating factor 1 (macrophage) | 1608 | 0.880 | 0.5893 | Yes |
| 28 | LTBR | NA | LTBR Entrez, Source | lymphotoxin beta receptor (TNFR superfamily, member 3) | 1751 | 0.838 | 0.5915 | Yes |
| 29 | ACVRL1 | NA | ACVRL1 Entrez, Source | activin A receptor type II-like 1 | 1982 | 0.791 | 0.5882 | Yes |
| 30 | IL10RB | NA | IL10RB Entrez, Source | interleukin 10 receptor, beta | 1997 | 0.789 | 0.5968 | Yes |
| 31 | IL18R1 | NA | IL18R1 Entrez, Source | interleukin 18 receptor 1 | 2161 | 0.752 | 0.5968 | Yes |
| 32 | BAK1 | NA | BAK1 Entrez, Source | BCL2-antagonist/killer 1 | 2366 | 0.709 | 0.5940 | Yes |
| 33 | SOCS1 | NA | SOCS1 Entrez, Source | suppressor of cytokine signaling 1 | 2485 | 0.686 | 0.5956 | Yes |
| 34 | IL2RA | NA | IL2RA Entrez, Source | interleukin 2 receptor, alpha | 2605 | 0.665 | 0.5970 | Yes |
| 35 | MYD88 | NA | MYD88 Entrez, Source | myeloid differentiation primary response gene (88) | 2759 | 0.638 | 0.5961 | Yes |
| 36 | IFNAR1 | NA | IFNAR1 Entrez, Source | interferon (alpha, beta and omega) receptor 1 | 2807 | 0.630 | 0.6010 | Yes |
| 37 | STAT1 | NA | STAT1 Entrez, Source | signal transducer and activator of transcription 1, 91kDa | 2854 | 0.622 | 0.6059 | Yes |
| 38 | CD14 | NA | CD14 Entrez, Source | CD14 molecule | 2918 | 0.610 | 0.6097 | Yes |
| 39 | STAM2 | NA | STAM2 Entrez, Source | signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 | 2920 | 0.610 | 0.6169 | Yes |
| 40 | IFNGR1 | NA | IFNGR1 Entrez, Source | interferon gamma receptor 1 | 3151 | 0.575 | 0.6111 | No |
| 41 | STAT3 | NA | STAT3 Entrez, Source | signal transducer and activator of transcription 3 (acute-phase response factor) | 3305 | 0.550 | 0.6092 | No |
| 42 | PTPN1 | NA | PTPN1 Entrez, Source | protein tyrosine phosphatase, non-receptor type 1 | 3573 | 0.514 | 0.6005 | No |
| 43 | IL17RA | NA | IL17RA Entrez, Source | interleukin 17 receptor A | 3935 | 0.470 | 0.5862 | No |
| 44 | TNFRSF1B | NA | TNFRSF1B Entrez, Source | tumor necrosis factor receptor superfamily, member 1B | 4164 | 0.439 | 0.5788 | No |
| 45 | TLR2 | NA | TLR2 Entrez, Source | toll-like receptor 2 | 4677 | 0.385 | 0.5551 | No |
| 46 | MAP3K8 | NA | MAP3K8 Entrez, Source | mitogen-activated protein kinase kinase kinase 8 | 4764 | 0.376 | 0.5548 | No |
| 47 | STAT2 | NA | STAT2 Entrez, Source | signal transducer and activator of transcription 2, 113kDa | 5031 | 0.348 | 0.5442 | No |
| 48 | HMOX1 | NA | HMOX1 Entrez, Source | heme oxygenase (decycling) 1 | 5118 | 0.340 | 0.5435 | No |
| 49 | ACVR1B | NA | ACVR1B Entrez, Source | activin A receptor, type IB | 5207 | 0.331 | 0.5426 | No |
| 50 | PTPN2 | NA | PTPN2 Entrez, Source | protein tyrosine phosphatase, non-receptor type 2 | 5343 | 0.318 | 0.5390 | No |
| 51 | SOCS3 | NA | SOCS3 Entrez, Source | suppressor of cytokine signaling 3 | 5428 | 0.310 | 0.5380 | No |
| 52 | IL9R | NA | IL9R Entrez, Source | interleukin 9 receptor | 5468 | 0.306 | 0.5395 | No |
| 53 | CD38 | NA | CD38 Entrez, Source | CD38 molecule | 6476 | 0.223 | 0.4865 | No |
| 54 | HAX1 | NA | HAX1 Entrez, Source | HCLS1 associated protein X-1 | 6618 | 0.210 | 0.4812 | No |
| 55 | IFNGR2 | NA | IFNGR2 Entrez, Source | interferon gamma receptor 2 (interferon gamma transducer 1) | 7118 | 0.172 | 0.4556 | No |
| 56 | CXCL13 | NA | CXCL13 Entrez, Source | chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant) | 7849 | 0.119 | 0.4167 | No |
| 57 | DNTT | NA | DNTT Entrez, Source | deoxynucleotidyltransferase, terminal | 8163 | 0.095 | 0.4005 | No |
| 58 | LTB | NA | LTB Entrez, Source | lymphotoxin beta (TNF superfamily, member 3) | 8197 | 0.093 | 0.3998 | No |
| 59 | CCL7 | NA | CCL7 Entrez, Source | chemokine (C-C motif) ligand 7 | 8211 | 0.092 | 0.4002 | No |
| 60 | PF4 | NA | PF4 Entrez, Source | platelet factor 4 (chemokine (C-X-C motif) ligand 4) | 8263 | 0.089 | 0.3984 | No |
| 61 | CSF2RB | NA | CSF2RB Entrez, Source | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) | 8457 | 0.075 | 0.3886 | No |
| 62 | CSF2 | NA | CSF2 Entrez, Source | colony stimulating factor 2 (granulocyte-macrophage) | 9575 | 0.000 | 0.3269 | No |
| 63 | PLA2G2A | NA | PLA2G2A Entrez, Source | phospholipase A2, group IIA (platelets, synovial fluid) | 10147 | -0.029 | 0.2956 | No |
| 64 | ITGA4 | NA | ITGA4 Entrez, Source | integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) | 10392 | -0.042 | 0.2826 | No |
| 65 | CXCL9 | NA | CXCL9 Entrez, Source | chemokine (C-X-C motif) ligand 9 | 10624 | -0.055 | 0.2705 | No |
| 66 | INHBE | NA | INHBE Entrez, Source | inhibin, beta E | 10656 | -0.058 | 0.2695 | No |
| 67 | CXCL3 | NA | CXCL3 Entrez, Source | chemokine (C-X-C motif) ligand 3 | 10925 | -0.073 | 0.2555 | No |
| 68 | PIK3R5 | NA | PIK3R5 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 5, p101 | 11049 | -0.081 | 0.2497 | No |
| 69 | CXCL1 | NA | CXCL1 Entrez, Source | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 11070 | -0.082 | 0.2496 | No |
| 70 | CSF3R | NA | CSF3R Entrez, Source | colony stimulating factor 3 receptor (granulocyte) | 11935 | -0.150 | 0.2036 | No |
| 71 | IL13RA1 | NA | IL13RA1 Entrez, Source | interleukin 13 receptor, alpha 1 | 11942 | -0.151 | 0.2050 | No |
| 72 | TYK2 | NA | TYK2 Entrez, Source | tyrosine kinase 2 | 12261 | -0.178 | 0.1896 | No |
| 73 | CBL | NA | CBL Entrez, Source | Cas-Br-M (murine) ecotropic retroviral transforming sequence | 12715 | -0.220 | 0.1672 | No |
| 74 | IL3RA | NA | IL3RA Entrez, Source | interleukin 3 receptor, alpha (low affinity) | 13810 | -0.322 | 0.1105 | No |
| 75 | GRB2 | NA | GRB2 Entrez, Source | growth factor receptor-bound protein 2 | 14005 | -0.345 | 0.1039 | No |
| 76 | PTPN11 | NA | PTPN11 Entrez, Source | protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) | 14759 | -0.438 | 0.0675 | No |
| 77 | ITGB3 | NA | ITGB3 Entrez, Source | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | 14763 | -0.438 | 0.0725 | No |
| 78 | PDGFC | NA | PDGFC Entrez, Source | platelet derived growth factor C | 14827 | -0.451 | 0.0744 | No |
| 79 | EBI3 | NA | EBI3 Entrez, Source | Epstein-Barr virus induced gene 3 | 15157 | -0.497 | 0.0622 | No |
| 80 | IL17RB | NA | IL17RB Entrez, Source | interleukin 17 receptor B | 15607 | -0.572 | 0.0442 | No |
| 81 | CD9 | NA | CD9 Entrez, Source | CD9 molecule | 16232 | -0.715 | 0.0182 | No |
| 82 | LEPR | NA | LEPR Entrez, Source | leptin receptor | 16372 | -0.755 | 0.0195 | No |
| 83 | CD36 | NA | CD36 Entrez, Source | CD36 molecule (thrombospondin receptor) | 17086 | -1.007 | -0.0079 | No |
| 84 | PIM1 | NA | PIM1 Entrez, Source | pim-1 oncogene | 17087 | -1.007 | 0.0041 | No |
| 85 | CCR1 | NA | CCR1 Entrez, Source | chemokine (C-C motif) receptor 1 | 17913 | -1.895 | -0.0189 | No |
| 86 | A2M | NA | A2M Entrez, Source | alpha-2-macroglobulin | 18074 | -2.760 | 0.0051 | No |
